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Protein

Protein ABHD14A

Gene

ABHD14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in granule neuron development.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Charge relay systemBy similarity1
Active sitei222Charge relay systemBy similarity1
Active sitei249Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD14A. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14ACurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14ACurated
Short name:
Abhydrolase domain-containing protein 14AImported
Gene namesi
Name:ABHD14AImported
ORF Names:UNQ1913/PRO4373
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24538. ABHD14A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000248487.
PharmGKBiPA142672659.

Polymorphism and mutation databases

BioMutaiABHD14A.
DMDMi143955271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002822851 – 271Protein ABHD14AAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9BUJ0.
MaxQBiQ9BUJ0.
PaxDbiQ9BUJ0.
PeptideAtlasiQ9BUJ0.
PRIDEiQ9BUJ0.

PTM databases

iPTMnetiQ9BUJ0.
PhosphoSitePlusiQ9BUJ0.

Expressioni

Gene expression databases

BgeeiENSG00000248487.
CleanExiHS_ABHD14A.
ExpressionAtlasiQ9BUJ0. baseline and differential.
GenevisibleiQ9BUJ0. HS.

Organism-specific databases

HPAiHPA038154.
HPA056913.

Interactioni

Protein-protein interaction databases

BioGridi117383. 30 interactors.
IntActiQ9BUJ0. 1 interactor.
MINTiMINT-4721393.
STRINGi9606.ENSP00000273596.

Structurei

3D structure databases

ProteinModelPortaliQ9BUJ0.
SMRiQ9BUJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWCE. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ9BUJ0.
KOiK13706.
OrthoDBiEOG091G0VZR.
PhylomeDBiQ9BUJ0.
TreeFamiTF314465.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BUJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGALCGCWF RLGGARPLIP LGPTVVQTSM SRSQVALLGL SLLLMLLLYV
60 70 80 90 100
GLPGPPEQTS CLWGDPNVTV LAGLTPGNSP IFYREVLPLN QAHRVEVVLL
110 120 130 140 150
HGKAFNSHTW EQLGTLQLLS QRGYRAVALD LPGFGNSAPS KEASTEAGRA
160 170 180 190 200
ALLERALRDL EVQNAVLVSP SLSGHYALPF LMRGHHQLHG FVPIAPTSTQ
210 220 230 240 250
NYTQEQFWAV KTPTLILYGE LDHILARESL RQLRHLPNHS VVKLRNAGHA
260 270
CYLHKPQDFH LVLLAFLDHL P
Length:271
Mass (Da):29,765
Last modified:April 3, 2007 - v2
Checksum:iB9CAF975D3208F10
GO

Sequence cautioni

The sequence AAQ88568 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159D → N in CAB43237 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03139032R → Q.1 PublicationCorresponds to variant rs17849626dbSNPEnsembl.1
Natural variantiVAR_03139161C → W.Corresponds to variant rs404527dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358201 mRNA. Translation: AAQ88568.1. Different initiation.
AL050015 mRNA. Translation: CAB43237.2.
BC002571 mRNA. Translation: AAH02571.1.
CCDSiCCDS2843.1.
PIRiT08702.
RefSeqiNP_056222.2. NM_015407.4.
UniGeneiHs.534400.

Genome annotation databases

EnsembliENST00000273596; ENSP00000273596; ENSG00000248487.
GeneIDi25864.
KEGGihsa:25864.
UCSCiuc003dco.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358201 mRNA. Translation: AAQ88568.1. Different initiation.
AL050015 mRNA. Translation: CAB43237.2.
BC002571 mRNA. Translation: AAH02571.1.
CCDSiCCDS2843.1.
PIRiT08702.
RefSeqiNP_056222.2. NM_015407.4.
UniGeneiHs.534400.

3D structure databases

ProteinModelPortaliQ9BUJ0.
SMRiQ9BUJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117383. 30 interactors.
IntActiQ9BUJ0. 1 interactor.
MINTiMINT-4721393.
STRINGi9606.ENSP00000273596.

Protein family/group databases

ESTHERihuman-ABHD14A. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

PTM databases

iPTMnetiQ9BUJ0.
PhosphoSitePlusiQ9BUJ0.

Polymorphism and mutation databases

BioMutaiABHD14A.
DMDMi143955271.

Proteomic databases

EPDiQ9BUJ0.
MaxQBiQ9BUJ0.
PaxDbiQ9BUJ0.
PeptideAtlasiQ9BUJ0.
PRIDEiQ9BUJ0.

Protocols and materials databases

DNASUi25864.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273596; ENSP00000273596; ENSG00000248487.
GeneIDi25864.
KEGGihsa:25864.
UCSCiuc003dco.4. human.

Organism-specific databases

CTDi25864.
GeneCardsiABHD14A.
HGNCiHGNC:24538. ABHD14A.
HPAiHPA038154.
HPA056913.
neXtProtiNX_Q9BUJ0.
OpenTargetsiENSG00000248487.
PharmGKBiPA142672659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWCE. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ9BUJ0.
KOiK13706.
OrthoDBiEOG091G0VZR.
PhylomeDBiQ9BUJ0.
TreeFamiTF314465.

Miscellaneous databases

GenomeRNAii25864.
PROiQ9BUJ0.

Gene expression databases

BgeeiENSG00000248487.
CleanExiHS_ABHD14A.
ExpressionAtlasiQ9BUJ0. baseline and differential.
GenevisibleiQ9BUJ0. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHEA_HUMAN
AccessioniPrimary (citable) accession number: Q9BUJ0
Secondary accession number(s): Q6UXU8, Q9Y3T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.