Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BUJ0

- ABHEA_HUMAN

UniProt

Q9BUJ0 - ABHEA_HUMAN

Protein

Alpha/beta hydrolase domain-containing protein 14A

Gene

ABHD14A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Possible role in granule neuron development.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei171 – 1711Charge relay systemBy similarity
    Active sitei222 – 2221Charge relay systemBy similarity
    Active sitei249 – 2491Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.981.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha/beta hydrolase domain-containing protein 14A (EC:3.-.-.-)
    Short name:
    Abhydrolase domain-containing protein 14A
    Gene namesi
    Name:ABHD14A
    ORF Names:UNQ1913/PRO4373
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24538. ABHD14A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Alpha/beta hydrolase domain-containing protein 14APRO_0000282285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9BUJ0.
    PaxDbiQ9BUJ0.
    PRIDEiQ9BUJ0.

    PTM databases

    PhosphoSiteiQ9BUJ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BUJ0.
    BgeeiQ9BUJ0.
    CleanExiHS_ABHD14A.
    GenevestigatoriQ9BUJ0.

    Organism-specific databases

    HPAiHPA038154.

    Interactioni

    Protein-protein interaction databases

    BioGridi117383. 12 interactions.
    IntActiQ9BUJ0. 1 interaction.
    MINTiMINT-4721393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BUJ0.
    SMRiQ9BUJ0. Positions 81-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028065.
    HOVERGENiHBG001936.
    KOiK13706.
    OMAiALFGCWF.
    PhylomeDBiQ9BUJ0.
    TreeFamiTF314465.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view]
    PfamiPF12695. Abhydrolase_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BUJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGALCGCWF RLGGARPLIP LGPTVVQTSM SRSQVALLGL SLLLMLLLYV    50
    GLPGPPEQTS CLWGDPNVTV LAGLTPGNSP IFYREVLPLN QAHRVEVVLL 100
    HGKAFNSHTW EQLGTLQLLS QRGYRAVALD LPGFGNSAPS KEASTEAGRA 150
    ALLERALRDL EVQNAVLVSP SLSGHYALPF LMRGHHQLHG FVPIAPTSTQ 200
    NYTQEQFWAV KTPTLILYGE LDHILARESL RQLRHLPNHS VVKLRNAGHA 250
    CYLHKPQDFH LVLLAFLDHL P 271
    Length:271
    Mass (Da):29,765
    Last modified:April 3, 2007 - v2
    Checksum:iB9CAF975D3208F10
    GO

    Sequence cautioni

    The sequence AAQ88568.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591D → N in CAB43237. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321R → Q.1 Publication
    Corresponds to variant rs17849626 [ dbSNP | Ensembl ].
    VAR_031390
    Natural varianti61 – 611C → W.
    Corresponds to variant rs404527 [ dbSNP | Ensembl ].
    VAR_031391

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358201 mRNA. Translation: AAQ88568.1. Different initiation.
    AL050015 mRNA. Translation: CAB43237.2.
    BC002571 mRNA. Translation: AAH02571.1.
    CCDSiCCDS2843.1.
    PIRiT08702.
    RefSeqiNP_056222.2. NM_015407.4.
    UniGeneiHs.534400.

    Genome annotation databases

    EnsembliENST00000273596; ENSP00000273596; ENSG00000248487.
    GeneIDi25864.
    KEGGihsa:25864.
    UCSCiuc003dco.3. human.

    Polymorphism databases

    DMDMi143955271.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358201 mRNA. Translation: AAQ88568.1 . Different initiation.
    AL050015 mRNA. Translation: CAB43237.2 .
    BC002571 mRNA. Translation: AAH02571.1 .
    CCDSi CCDS2843.1.
    PIRi T08702.
    RefSeqi NP_056222.2. NM_015407.4.
    UniGenei Hs.534400.

    3D structure databases

    ProteinModelPortali Q9BUJ0.
    SMRi Q9BUJ0. Positions 81-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117383. 12 interactions.
    IntActi Q9BUJ0. 1 interaction.
    MINTi MINT-4721393.

    Protein family/group databases

    MEROPSi S33.981.

    PTM databases

    PhosphoSitei Q9BUJ0.

    Polymorphism databases

    DMDMi 143955271.

    Proteomic databases

    MaxQBi Q9BUJ0.
    PaxDbi Q9BUJ0.
    PRIDEi Q9BUJ0.

    Protocols and materials databases

    DNASUi 25864.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273596 ; ENSP00000273596 ; ENSG00000248487 .
    GeneIDi 25864.
    KEGGi hsa:25864.
    UCSCi uc003dco.3. human.

    Organism-specific databases

    CTDi 25864.
    GeneCardsi GC03P052005.
    HGNCi HGNC:24538. ABHD14A.
    HPAi HPA038154.
    neXtProti NX_Q9BUJ0.
    PharmGKBi PA142672659.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028065.
    HOVERGENi HBG001936.
    KOi K13706.
    OMAi ALFGCWF.
    PhylomeDBi Q9BUJ0.
    TreeFami TF314465.

    Miscellaneous databases

    GenomeRNAii 25864.
    NextBioi 47235.
    PROi Q9BUJ0.

    Gene expression databases

    ArrayExpressi Q9BUJ0.
    Bgeei Q9BUJ0.
    CleanExi HS_ABHD14A.
    Genevestigatori Q9BUJ0.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view ]
    Pfami PF12695. Abhydrolase_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-32.
      Tissue: Lymph.

    Entry informationi

    Entry nameiABHEA_HUMAN
    AccessioniPrimary (citable) accession number: Q9BUJ0
    Secondary accession number(s): Q6UXU8, Q9Y3T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-30 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3