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Q9BUJ0 (ABHEA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha/beta hydrolase domain-containing protein 14A

Short name=Abhydrolase domain-containing protein 14A
EC=3.-.-.-
Gene names
Name:ABHD14A
ORF Names:UNQ1913/PRO4373
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible role in granule neuron development By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. ABHD14 family.

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.

Sequence caution

The sequence AAQ88568.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Alpha/beta hydrolase domain-containing protein 14A
PRO_0000282285

Regions

Transmembrane35 – 5521Helical; Signal-anchor for type II membrane protein; Potential

Sites

Active site1711Charge relay system By similarity
Active site2221Charge relay system By similarity
Active site2491Charge relay system By similarity

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential

Natural variations

Natural variant321R → Q. Ref.3
Corresponds to variant rs17849626 [ dbSNP | Ensembl ].
VAR_031390
Natural variant611C → W.
Corresponds to variant rs404527 [ dbSNP | Ensembl ].
VAR_031391

Experimental info

Sequence conflict1591D → N in CAB43237. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BUJ0 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: B9CAF975D3208F10

FASTA27129,765
        10         20         30         40         50         60 
MVGALCGCWF RLGGARPLIP LGPTVVQTSM SRSQVALLGL SLLLMLLLYV GLPGPPEQTS 

        70         80         90        100        110        120 
CLWGDPNVTV LAGLTPGNSP IFYREVLPLN QAHRVEVVLL HGKAFNSHTW EQLGTLQLLS 

       130        140        150        160        170        180 
QRGYRAVALD LPGFGNSAPS KEASTEAGRA ALLERALRDL EVQNAVLVSP SLSGHYALPF 

       190        200        210        220        230        240 
LMRGHHQLHG FVPIAPTSTQ NYTQEQFWAV KTPTLILYGE LDHILARESL RQLRHLPNHS 

       250        260        270 
VVKLRNAGHA CYLHKPQDFH LVLLAFLDHL P 

« Hide

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-32.
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358201 mRNA. Translation: AAQ88568.1. Different initiation.
AL050015 mRNA. Translation: CAB43237.2.
BC002571 mRNA. Translation: AAH02571.1.
CCDSCCDS2843.1.
PIRT08702.
RefSeqNP_056222.2. NM_015407.4.
UniGeneHs.534400.

3D structure databases

ProteinModelPortalQ9BUJ0.
SMRQ9BUJ0. Positions 81-270.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117383. 12 interactions.
IntActQ9BUJ0. 1 interaction.
MINTMINT-4721393.

Protein family/group databases

MEROPSS33.981.

PTM databases

PhosphoSiteQ9BUJ0.

Polymorphism databases

DMDM143955271.

Proteomic databases

MaxQBQ9BUJ0.
PaxDbQ9BUJ0.
PRIDEQ9BUJ0.

Protocols and materials databases

DNASU25864.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273596; ENSP00000273596; ENSG00000248487.
GeneID25864.
KEGGhsa:25864.
UCSCuc003dco.3. human.

Organism-specific databases

CTD25864.
GeneCardsGC03P052005.
HGNCHGNC:24538. ABHD14A.
HPAHPA038154.
neXtProtNX_Q9BUJ0.
PharmGKBPA142672659.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000028065.
HOVERGENHBG001936.
KOK13706.
OMAALFGCWF.
PhylomeDBQ9BUJ0.
TreeFamTF314465.

Gene expression databases

ArrayExpressQ9BUJ0.
BgeeQ9BUJ0.
CleanExHS_ABHD14A.
GenevestigatorQ9BUJ0.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi25864.
NextBio47235.
PROQ9BUJ0.

Entry information

Entry nameABHEA_HUMAN
AccessionPrimary (citable) accession number: Q9BUJ0
Secondary accession number(s): Q6UXU8, Q9Y3T7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM