Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ubiquitin protein ligase E3A

Gene

UBE3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported, TransferaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin protein ligase E3AImported
Gene namesi
Name:UBE3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37144.

PTM / Processingi

Proteomic databases

PaxDbiQ9BUI6.
PeptideAtlasiQ9BUI6.
PRIDEiQ9BUI6.

Expressioni

Gene expression databases

GenevisibleiQ9BUI6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381045.

Structurei

3D structure databases

ProteinModelPortaliQ9BUI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini544 – 872HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd BLAST329

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000261634.
HOVERGENiHBG059326.
KOiK10587.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR032353. AZUL.
IPR000569. HECT_dom.
IPR017134. UBE3A.
[Graphical view]
PfamiPF16558. AZUL. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
PIRSFiPIRSF037201. Ubiquitin-protein_ligase_E6-AP. 1 hit.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BUI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATACKRSGE PQSDDIEASR MKRAAAKHLI ERYYHQLTEG CGNEACTNEF
60 70 80 90 100
CASCPTFLRM DNNAAAIKAL ELYKINAKLC DPHPSKKGAS SAYLENSKGA
110 120 130 140 150
PNNSCSEIKM NKKGARIDFK DVTYLTEEKV YEILELCRER EDYSPLIRVI
160 170 180 190 200
GRVFSSAEAL VQSFRKVKQH TKEELKSLQA KDEDKDEDEK EKAACSAAAM
210 220 230 240 250
EEDSEASSSR IGDSSQGDNN LQKLGPDDVS VDIDAIRRVY TRLLSNEKIE
260 270 280 290 300
TAFLNALVYL SPNVECDLTY HNVYSRDPNY LNLFIIVMEN RNLHSPEYLE
310 320 330 340 350
MALPLFCKAM SKLPLAAQGK LIRLWSKYNA DQIRRMMETF QQLITYKVIS
360 370 380 390 400
NEFNSRNLVN DDDAIVAASK CLKMVYYANV VGGEVDTNHN EEDDEEPIPE
410 420 430 440 450
SSELTLQELL GEERRNKKGP RVDPLETELG VKTLDCRKPL IPFEEFINEP
460 470 480 490 500
LNEVLEMDKD YTFFKVETEN KFSFMTCPFI LNAVTKNLGL YYDNRIRMYS
510 520 530 540 550
ERRITVLYSL VQGQQLNPYL RLKVRRDHII DDALVRLEMI AMENPADLKK
560 570 580 590 600
QLYVEFEGEQ GVDEGGVSKE FFQLVVEEIF NPDIGMFTYD ESTKLFWFNP
610 620 630 640 650
SSFETEGQFT LIGIVLGLAI YNNCILDVHF PMVVYRKLMG KKGTFRDLGD
660 670 680 690 700
SHPVLYQSLK DLLEYEGNVE DDMMITFQIS QTDLFGNPMM YDLKENGDKI
710 720 730 740 750
PITNENRKEF VNLYSDYILN KSVEKQFKAF RRGFHMVTNE SPLKYLFRPE
760 770 780 790 800
EIELLICGSR NLGFQALEET TEYDGGYTRD SVLIREFWEI VHSFTDEQKR
810 820 830 840 850
LFLQFTTGTD RAPVGGLGKL KMIIAKNGPD TERLPTSHTC FNVLLLPEYS
860 870
SKEKLKERLL KAITYAKGFG ML
Length:872
Mass (Da):100,044
Last modified:March 1, 2004 - v2
Checksum:i30212DFB11FF656A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002582 mRNA. Translation: AAH02582.2.
RefSeqiNP_000453.2. NM_000462.3.
NP_570854.1. NM_130839.2.
UniGeneiHs.598862.

Genome annotation databases

GeneIDi7337.
KEGGihsa:7337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002582 mRNA. Translation: AAH02582.2.
RefSeqiNP_000453.2. NM_000462.3.
NP_570854.1. NM_130839.2.
UniGeneiHs.598862.

3D structure databases

ProteinModelPortaliQ9BUI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381045.

Proteomic databases

PaxDbiQ9BUI6.
PeptideAtlasiQ9BUI6.
PRIDEiQ9BUI6.

Protocols and materials databases

DNASUi7337.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7337.
KEGGihsa:7337.

Organism-specific databases

CTDi7337.
PharmGKBiPA37144.

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000261634.
HOVERGENiHBG059326.
KOiK10587.

Miscellaneous databases

GenomeRNAii7337.

Gene expression databases

GenevisibleiQ9BUI6. HS.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR032353. AZUL.
IPR000569. HECT_dom.
IPR017134. UBE3A.
[Graphical view]
PfamiPF16558. AZUL. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
PIRSFiPIRSF037201. Ubiquitin-protein_ligase_E6-AP. 1 hit.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BUI6_HUMAN
AccessioniPrimary (citable) accession number: Q9BUI6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.