Q9BUH8 (BEGIN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-enriched guanylate kinase-associated protein

Gene names

Name:	BEGAIN
Synonyms:	KIAA1446

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	593 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May sustain the structure of the postsynaptic density (PSD).
Subunit structure	Interacts with DLG4 and DLGAP1 and forms a ternary complex By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Sequence caution	The sequence BAA95970.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RBL1	P28749	2	EBI-742722,EBI-971402

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 593	593	Brain-enriched guanylate kinase-associated protein		PRO_0000064904
Amino acid modifications
	Modified residue	137	1	Phosphotyrosine By similarity
	Modified residue	194	1	Phosphoserine By similarity
	Modified residue	246	1	Phosphoserine Ref.4 Ref.8 Ref.9
	Modified residue	265	1	Phosphoserine By similarity
	Modified residue	465	1	Phosphoserine Ref.9
	Modified residue	483	1	Phosphoserine Ref.6
	Modified residue	502	1	Phosphoserine Ref.4 Ref.5 Ref.9
	Modified residue	563	1	Phosphoserine Ref.5 Ref.7 Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Q9BUH8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D4A25A463B8055F4	FASTA	593	64,803
	10 20 30 40 50 60 MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL EKVTEKLRRI 70 80 90 100 110 120 QSNYMALQRI NQELEDKLYR MGQHYEEEKR ALSHEIVALN SHLLEAKVTI DKLSEDNELY 130 140 150 160 170 180 RKDCNLAAQL LQCSQTYGRV HKVSELPSDF QERVSLHMEK HGCSLPSPLC HPAYADSVPT 190 200 210 220 230 240 CVIAKVLEKP DPASLSSRLS DASARDLAFC DGVEKPGPRP PYKGDIYCSD TALYCPEERR 250 260 270 280 290 300 RDRRPSVDAP VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPA GFQHEAFPSY AGSLPTSSSY 310 320 330 340 350 360 SSFSATSEEK EHAQASTLTA SQQAIYLNSR DELFDRKPPA TTYEGSPRFA KATAAVAAPL 370 380 390 400 410 420 EAEVAPGFGR TMSPYPAETF RFPASPGPQQ ALMPPNLWSL RAKPGTARLP GEDMRGQWRP 430 440 450 460 470 480 LSVEDIGAYS YPVSAAGRAS PCSFSERYYG GAGGSPGKKA DGRASPLYAS YKADSFSEGD 490 500 510 520 530 540 DLSQGHLAEP CFLRAGGDLS LSPGRSADPL PGYAPSEGGD GDRLGVQLCG TASSPEPEQG 550 560 570 580 590 SRDSLEPSSM EASPEMHPAA RLSPQQAFPR TGGSGLSRKD SLTKAQLYGT LLN

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-593. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-593. Tissue: Amygdala.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246 AND SER-502, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502 AND SER-563, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-465; SER-502 AND SER-563, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC002607 mRNA. Translation: AAH02607.1. AB040879 mRNA. Translation: BAA95970.1. Different initiation. AL390162 mRNA. Translation: CAB99094.1.
IPI	IPI00010853.
PIR	T51877.
RefSeq	NP_001153003.1. NM_001159531.1. NP_065887.1. NM_020836.3.
UniGene	Hs.211751.
3D structure databases
ProteinModelPortal	Q9BUH8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BUH8. 24 interactions.
MINT	MINT-1453141.
STRING	Q9BUH8.
PTM databases
PhosphoSite	Q9BUH8.
Polymorphism databases
DMDM	62511244.
Proteomic databases
PRIDE	Q9BUH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355173; ENSP00000347301; ENSG00000183092.
GeneID	57596.
KEGG	hsa:57596.
UCSC	uc001yhp.1. human.
Organism-specific databases
CTD	57596.
GeneCards	GC14M101003.
H-InvDB	HIX0018157.
HGNC	HGNC:24163. BEGAIN.
HPA	HPA002899.
neXtProt	NX_Q9BUH8.
PharmGKB	PA162377453.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10190.
GeneTree	ENSGT00530000063778.
HOVERGEN	HBG050683.
InParanoid	Q9BUH8.
OMA	QNNYLAL.
PhylomeDB	Q9BUH8.
Gene expression databases
ArrayExpress	Q9BUH8.
Bgee	Q9BUH8.
CleanEx	HS_BEGAIN.
Genevestigator	Q9BUH8.
GermOnline	ENSG00000183092. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	64202.

Entry information

Entry name

BEGIN_HUMAN

Accession

Primary (citable) accession number: Q9BUH8
Secondary accession number(s): Q9NPU3, Q9P282

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.