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Q9BUH8

- BEGIN_HUMAN

UniProt

Q9BUH8 - BEGIN_HUMAN

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Protein

Brain-enriched guanylate kinase-associated protein

Gene

BEGAIN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May sustain the structure of the postsynaptic density (PSD).

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-enriched guanylate kinase-associated protein
Gene namesi
Name:BEGAIN
Synonyms:KIAA1446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:24163. BEGAIN.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. dendrite Source: Ensembl
  3. membrane Source: UniProtKB-KW
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Brain-enriched guanylate kinase-associated proteinPRO_0000064904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei137 – 1371PhosphotyrosineBy similarity
Modified residuei246 – 2461Phosphoserine5 Publications
Modified residuei465 – 4651Phosphoserine1 Publication
Modified residuei500 – 5001Phosphoserine1 Publication
Modified residuei502 – 5021Phosphoserine3 Publications
Modified residuei563 – 5631Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BUH8.
PaxDbiQ9BUH8.
PRIDEiQ9BUH8.

PTM databases

PhosphoSiteiQ9BUH8.

Expressioni

Gene expression databases

BgeeiQ9BUH8.
CleanExiHS_BEGAIN.
ExpressionAtlasiQ9BUH8. baseline and differential.
GenevestigatoriQ9BUH8.

Organism-specific databases

HPAiHPA002899.

Interactioni

Subunit structurei

Interacts with DLG4 and DLGAP1 and forms a ternary complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RBL1P287492EBI-742722,EBI-971402

Protein-protein interaction databases

BioGridi121647. 27 interactions.
IntActiQ9BUH8. 24 interactions.
MINTiMINT-1453141.
STRINGi9606.ENSP00000347301.

Structurei

3D structure databases

ProteinModelPortaliQ9BUH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG38797.
GeneTreeiENSGT00530000063778.
HOGENOMiHOG000095194.
HOVERGENiHBG050683.
InParanoidiQ9BUH8.
OMAiALSHEII.
OrthoDBiEOG7JT6VT.
PhylomeDBiQ9BUH8.
TreeFamiTF331612.

Sequencei

Sequence statusi: Complete.

Q9BUH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLSALQEQ KGELRKRLSY TTHKLEKLET EFDSTRHYLE IELRRAQEEL
60 70 80 90 100
EKVTEKLRRI QSNYMALQRI NQELEDKLYR MGQHYEEEKR ALSHEIVALN
110 120 130 140 150
SHLLEAKVTI DKLSEDNELY RKDCNLAAQL LQCSQTYGRV HKVSELPSDF
160 170 180 190 200
QERVSLHMEK HGCSLPSPLC HPAYADSVPT CVIAKVLEKP DPASLSSRLS
210 220 230 240 250
DASARDLAFC DGVEKPGPRP PYKGDIYCSD TALYCPEERR RDRRPSVDAP
260 270 280 290 300
VTDVGFLRAQ NSTDSAAEEE EEAEAAAFPA GFQHEAFPSY AGSLPTSSSY
310 320 330 340 350
SSFSATSEEK EHAQASTLTA SQQAIYLNSR DELFDRKPPA TTYEGSPRFA
360 370 380 390 400
KATAAVAAPL EAEVAPGFGR TMSPYPAETF RFPASPGPQQ ALMPPNLWSL
410 420 430 440 450
RAKPGTARLP GEDMRGQWRP LSVEDIGAYS YPVSAAGRAS PCSFSERYYG
460 470 480 490 500
GAGGSPGKKA DGRASPLYAS YKADSFSEGD DLSQGHLAEP CFLRAGGDLS
510 520 530 540 550
LSPGRSADPL PGYAPSEGGD GDRLGVQLCG TASSPEPEQG SRDSLEPSSM
560 570 580 590
EASPEMHPAA RLSPQQAFPR TGGSGLSRKD SLTKAQLYGT LLN
Length:593
Mass (Da):64,803
Last modified:June 1, 2001 - v1
Checksum:iD4A25A463B8055F4
GO

Sequence cautioni

The sequence BAA95970.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002607 mRNA. Translation: AAH02607.1.
AB040879 mRNA. Translation: BAA95970.1. Different initiation.
AL390162 mRNA. Translation: CAB99094.1.
CCDSiCCDS9962.1.
PIRiT51877.
RefSeqiNP_001153003.1. NM_001159531.1.
NP_065887.1. NM_020836.3.
XP_005267978.1. XM_005267921.1.
UniGeneiHs.211751.

Genome annotation databases

EnsembliENST00000355173; ENSP00000347301; ENSG00000183092.
ENST00000443071; ENSP00000411124; ENSG00000183092.
GeneIDi57596.
KEGGihsa:57596.
UCSCiuc001yhp.3. human.

Polymorphism databases

DMDMi62511244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002607 mRNA. Translation: AAH02607.1 .
AB040879 mRNA. Translation: BAA95970.1 . Different initiation.
AL390162 mRNA. Translation: CAB99094.1 .
CCDSi CCDS9962.1.
PIRi T51877.
RefSeqi NP_001153003.1. NM_001159531.1.
NP_065887.1. NM_020836.3.
XP_005267978.1. XM_005267921.1.
UniGenei Hs.211751.

3D structure databases

ProteinModelPortali Q9BUH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121647. 27 interactions.
IntActi Q9BUH8. 24 interactions.
MINTi MINT-1453141.
STRINGi 9606.ENSP00000347301.

PTM databases

PhosphoSitei Q9BUH8.

Polymorphism databases

DMDMi 62511244.

Proteomic databases

MaxQBi Q9BUH8.
PaxDbi Q9BUH8.
PRIDEi Q9BUH8.

Protocols and materials databases

DNASUi 57596.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355173 ; ENSP00000347301 ; ENSG00000183092 .
ENST00000443071 ; ENSP00000411124 ; ENSG00000183092 .
GeneIDi 57596.
KEGGi hsa:57596.
UCSCi uc001yhp.3. human.

Organism-specific databases

CTDi 57596.
GeneCardsi GC14M101003.
HGNCi HGNC:24163. BEGAIN.
HPAi HPA002899.
neXtProti NX_Q9BUH8.
PharmGKBi PA162377453.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38797.
GeneTreei ENSGT00530000063778.
HOGENOMi HOG000095194.
HOVERGENi HBG050683.
InParanoidi Q9BUH8.
OMAi ALSHEII.
OrthoDBi EOG7JT6VT.
PhylomeDBi Q9BUH8.
TreeFami TF331612.

Miscellaneous databases

ChiTaRSi BEGAIN. human.
GeneWikii BEGAIN.
GenomeRNAii 57596.
NextBioi 64202.
PROi Q9BUH8.

Gene expression databases

Bgeei Q9BUH8.
CleanExi HS_BEGAIN.
ExpressionAtlasi Q9BUH8. baseline and differential.
Genevestigatori Q9BUH8.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-593.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-593.
    Tissue: Amygdala.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-465 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-500; SER-502 AND SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBEGIN_HUMAN
AccessioniPrimary (citable) accession number: Q9BUH8
Secondary accession number(s): Q9NPU3, Q9P282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

External Data

Dasty 3