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Protein

Zinc finger and SCAN domain-containing protein 5A

Gene

ZSCAN5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri356 – 37823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 5A
Alternative name(s):
Zinc finger protein 495
Gene namesi
Name:ZSCAN5A
Synonyms:ZNF495, ZSCAN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23710. ZSCAN5A.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411030.

Polymorphism and mutation databases

BioMutaiZSCAN5A.
DMDMi55976763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Zinc finger and SCAN domain-containing protein 5APRO_0000047752Add
BLAST

Proteomic databases

EPDiQ9BUG6.
MaxQBiQ9BUG6.
PaxDbiQ9BUG6.
PeptideAtlasiQ9BUG6.
PRIDEiQ9BUG6.

PTM databases

iPTMnetiQ9BUG6.
PhosphoSiteiQ9BUG6.

Expressioni

Gene expression databases

BgeeiQ9BUG6.
CleanExiHS_ZSCAN5A.
ExpressionAtlasiQ9BUG6. baseline and differential.
GenevisibleiQ9BUG6. HS.

Organism-specific databases

HPAiHPA041263.
HPA043123.
HPA046836.

Interactioni

Protein-protein interaction databases

BioGridi122567. 21 interactions.
IntActiQ9BUG6. 9 interactions.
STRINGi9606.ENSP00000375593.

Structurei

3D structure databases

ProteinModelPortaliQ9BUG6.
SMRiQ9BUG6. Positions 40-97, 314-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri356 – 37823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiQ9BUG6.
KOiK09230.
OMAiRFMQLIS.
OrthoDBiEOG78PV8X.
PhylomeDBiQ9BUG6.
TreeFamiTF341155.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BUG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANCTSSWS LGESCNRPGL ELPRSMASSE TQLGNHDVDP EISHVNFRMF
60 70 80 90 100
SCPKESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL
110 120 130 140 150
QVLVMMNGVQ SCKDLEDLLR NNRRPKKWSV VTFHGKEYIV QDSDIEMAEA
160 170 180 190 200
PSSVRDDLKD VSSQRASSVN QMRPGEGQAH RELQILPRVP ALSRRQGEDF
210 220 230 240 250
LLHKSIDVTG DPKSLRPKQT LEKDLKENRE ENPGLTSPEP QLPKSPTDLV
260 270 280 290 300
RAKEGKDPPK IASVENVDAD TPSACVVERE ASTHSGNRGD ALNLSSPKRS
310 320 330 340 350
KPDASSISQE EPQGEATPVG NRESPGQAGM NSIHSPGPAS PVSHPDGQEA
360 370 380 390 400
KALPPFACDV CEKRFTCNSK LVIHKRSHTG ERLFQCNLCG KRFMQLISLQ
410 420 430 440 450
FHQRTHTGER PYTCDVCQKQ FTQKSYLKCH KRSHTGEKPF ECKDCKKVFT
460 470 480 490
YRGSLKEHQR IHSGEKPYKC SKCPRAFSRL KLLRRHQKTH PEATSQ
Length:496
Mass (Da):55,865
Last modified:June 1, 2001 - v1
Checksum:iDC8293A660C37329
GO
Isoform 2 (identifier: Q9BUG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAANCTSSWSL → MIVRPPQPRET
     12-128: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,405
Checksum:i8B8FADE2DAFADB29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781H → R in BAD97205 (Ref. 2) Curated
Sequence conflicti155 – 1551R → G in BAD97205 (Ref. 2) Curated
Sequence conflicti247 – 2482TD → N in BAC05386 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461E → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs145011101 [ dbSNP | Ensembl ].
VAR_035603
Natural varianti337 – 3371G → V.1 Publication
Corresponds to variant rs34187696 [ dbSNP | Ensembl ].
VAR_042964

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111MAANCTSSWSL → MIVRPPQPRET in isoform 2. 1 PublicationVSP_055989Add
BLAST
Alternative sequencei12 – 128117Missing in isoform 2. 1 PublicationVSP_055990Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098700 mRNA. Translation: BAC05386.1.
AK301873 mRNA. Translation: BAG63310.1.
AK223485 mRNA. Translation: BAD97205.1.
AC006116 Genomic DNA. No translation available.
AC011506 Genomic DNA. No translation available.
BC002636 mRNA. Translation: AAH02636.1.
BC043232 mRNA. Translation: AAH43232.1.
CCDSiCCDS12941.1. [Q9BUG6-1]
RefSeqiNP_001308991.1. NM_001322062.1.
NP_001308993.1. NM_001322064.1. [Q9BUG6-1]
NP_001308994.1. NM_001322065.1. [Q9BUG6-1]
NP_001308995.1. NM_001322066.1. [Q9BUG6-1]
NP_001308996.1. NM_001322067.1. [Q9BUG6-1]
NP_001308997.1. NM_001322068.1. [Q9BUG6-1]
NP_001308998.1. NM_001322069.1. [Q9BUG6-1]
NP_001308999.1. NM_001322070.1. [Q9BUG6-1]
NP_001309001.1. NM_001322072.1. [Q9BUG6-1]
NP_001309002.1. NM_001322073.1.
NP_001309003.1. NM_001322074.1.
NP_001309004.1. NM_001322075.1.
NP_001309005.1. NM_001322076.1.
NP_001309006.1. NM_001322077.1. [Q9BUG6-2]
NP_001309007.1. NM_001322078.1.
NP_077279.1. NM_024303.2. [Q9BUG6-1]
UniGeneiHs.177688.
Hs.733089.

Genome annotation databases

EnsembliENST00000391713; ENSP00000375593; ENSG00000131848. [Q9BUG6-1]
ENST00000587340; ENSP00000467631; ENSG00000131848. [Q9BUG6-1]
GeneIDi79149.
KEGGihsa:79149.
UCSCiuc002qmq.4. human. [Q9BUG6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098700 mRNA. Translation: BAC05386.1.
AK301873 mRNA. Translation: BAG63310.1.
AK223485 mRNA. Translation: BAD97205.1.
AC006116 Genomic DNA. No translation available.
AC011506 Genomic DNA. No translation available.
BC002636 mRNA. Translation: AAH02636.1.
BC043232 mRNA. Translation: AAH43232.1.
CCDSiCCDS12941.1. [Q9BUG6-1]
RefSeqiNP_001308991.1. NM_001322062.1.
NP_001308993.1. NM_001322064.1. [Q9BUG6-1]
NP_001308994.1. NM_001322065.1. [Q9BUG6-1]
NP_001308995.1. NM_001322066.1. [Q9BUG6-1]
NP_001308996.1. NM_001322067.1. [Q9BUG6-1]
NP_001308997.1. NM_001322068.1. [Q9BUG6-1]
NP_001308998.1. NM_001322069.1. [Q9BUG6-1]
NP_001308999.1. NM_001322070.1. [Q9BUG6-1]
NP_001309001.1. NM_001322072.1. [Q9BUG6-1]
NP_001309002.1. NM_001322073.1.
NP_001309003.1. NM_001322074.1.
NP_001309004.1. NM_001322075.1.
NP_001309005.1. NM_001322076.1.
NP_001309006.1. NM_001322077.1. [Q9BUG6-2]
NP_001309007.1. NM_001322078.1.
NP_077279.1. NM_024303.2. [Q9BUG6-1]
UniGeneiHs.177688.
Hs.733089.

3D structure databases

ProteinModelPortaliQ9BUG6.
SMRiQ9BUG6. Positions 40-97, 314-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122567. 21 interactions.
IntActiQ9BUG6. 9 interactions.
STRINGi9606.ENSP00000375593.

PTM databases

iPTMnetiQ9BUG6.
PhosphoSiteiQ9BUG6.

Polymorphism and mutation databases

BioMutaiZSCAN5A.
DMDMi55976763.

Proteomic databases

EPDiQ9BUG6.
MaxQBiQ9BUG6.
PaxDbiQ9BUG6.
PeptideAtlasiQ9BUG6.
PRIDEiQ9BUG6.

Protocols and materials databases

DNASUi79149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391713; ENSP00000375593; ENSG00000131848. [Q9BUG6-1]
ENST00000587340; ENSP00000467631; ENSG00000131848. [Q9BUG6-1]
GeneIDi79149.
KEGGihsa:79149.
UCSCiuc002qmq.4. human. [Q9BUG6-1]

Organism-specific databases

CTDi79149.
GeneCardsiZSCAN5A.
HGNCiHGNC:23710. ZSCAN5A.
HPAiHPA041263.
HPA043123.
HPA046836.
neXtProtiNX_Q9BUG6.
PharmGKBiPA162411030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiQ9BUG6.
KOiK09230.
OMAiRFMQLIS.
OrthoDBiEOG78PV8X.
PhylomeDBiQ9BUG6.
TreeFamiTF341155.

Miscellaneous databases

ChiTaRSiZSCAN5A. human.
GenomeRNAii79149.
PROiQ9BUG6.

Gene expression databases

BgeeiQ9BUG6.
CleanExiHS_ZSCAN5A.
ExpressionAtlasiQ9BUG6. baseline and differential.
GenevisibleiQ9BUG6. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-337.
    Tissue: Testis and Uterus.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-146.

Entry informationi

Entry nameiZSA5A_HUMAN
AccessioniPrimary (citable) accession number: Q9BUG6
Secondary accession number(s): B4DX98
, Q49A73, Q53F04, Q8N7B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.