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Q9BUB4

- ADAT1_HUMAN

UniProt

Q9BUB4 - ADAT1_HUMAN

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Protein

tRNA-specific adenosine deaminase 1

Gene
ADAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specifically deaminates adenosine-37 to inosine in tRNA-Ala.

Catalytic activityi

Adenine(37) in tRNA(Ala) + H2O = hypoxanthine(37) in tRNA(Ala) + NH3.1 Publication

Cofactori

Binds 1 inositol hexakisphosphate (IP6) per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Zinc By similarity
Active sitei89 – 891Proton donor By similarity
Binding sitei93 – 931Inositol hexakisphosphate By similarity
Binding sitei94 – 941Inositol hexakisphosphate By similarity
Metal bindingi142 – 1421Zinc By similarity
Metal bindingi299 – 2991Zinc By similarity
Binding sitei302 – 3021Inositol hexakisphosphate By similarity
Binding sitei305 – 3051Inositol hexakisphosphate By similarity
Binding sitei435 – 4351Inositol hexakisphosphate By similarity
Binding sitei470 – 4701Inositol hexakisphosphate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB
  3. tRNA-specific adenosine deaminase activity Source: UniProtKB

GO - Biological processi

  1. tRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase 1 (EC:3.5.4.34)
Short name:
hADAT1
Alternative name(s):
tRNA-specific adenosine-37 deaminase
Gene namesi
Name:ADAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:228. ADAT1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502tRNA-specific adenosine deaminase 1PRO_0000287646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BUB4.
PaxDbiQ9BUB4.
PRIDEiQ9BUB4.

PTM databases

PhosphoSiteiQ9BUB4.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiQ9BUB4.
BgeeiQ9BUB4.
CleanExiHS_ADAT1.
GenevestigatoriQ9BUB4.

Organism-specific databases

HPAiHPA040713.
HPA040903.

Interactioni

Protein-protein interaction databases

BioGridi117081. 2 interactions.
STRINGi9606.ENSP00000310015.

Structurei

3D structure databases

ProteinModelPortaliQ9BUB4.
SMRiQ9BUB4. Positions 60-147, 290-501.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 501439A to I editaseAdd
BLAST

Sequence similaritiesi

Belongs to the ADAT1 family.

Phylogenomic databases

eggNOGiNOG269429.
HOGENOMiHOG000237320.
HOVERGENiHBG059724.
InParanoidiQ9BUB4.
KOiK15440.
OMAiVVIGKCP.
PhylomeDBiQ9BUB4.
TreeFamiTF315806.

Family and domain databases

InterProiIPR002466. A_deamin.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BUB4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWTADEIAQL CYEHYGIRLP KKGKPEPNHE WTLLAAVVKI QSPADKACDT    50
PDKPVQVTKE VVSMGTGTKC IGQSKMRKNG DILNDSHAEV IARRSFQRYL 100
LHQLQLAATL KEDSIFVPGT QKGVWKLRRD LIFVFFSSHT PCGDASIIPM 150
LEFEDQPCCP VFRNWAHNSS VEASSNLEAP GNERKCEDPD SPVTKKMRLE 200
PGTAAREVTN GAAHHQSFGK QKSGPISPGI HSCDLTVEGL ATVTRIAPGS 250
AKVIDVYRTG AKCVPGEAGD SGKPGAAFHQ VGLLRVKPGR GDRTRSMSCS 300
DKMARWNVLG CQGALLMHLL EEPIYLSAVV IGKCPYSQEA MQRALIGRCQ 350
NVSALPKGFG VQELKILQSD LLFEQSRSAV QAKRADSPGR LVPCGAAISW 400
SAVPEQPLDV TANGFPQGTT KKTIGSLQAR SQISKVELFR SFQKLLSRIA 450
RDKWPHSLRV QKLDTYQEYK EAASSYQEAW STLRKQVFGS WIRNPPDYHQ 500
FK 502
Length:502
Mass (Da):55,392
Last modified:June 1, 2001 - v1
Checksum:i3664E4C50DA9DFE0
GO
Isoform 2 (identifier: Q9BUB4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.

Show »
Length:353
Mass (Da):38,706
Checksum:i8251C7D7E53A9EDA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671H → N.1 Publication
Corresponds to variant rs3743598 [ dbSNP | Ensembl ].
VAR_032340
Natural varianti203 – 2031T → N.
Corresponds to variant rs3743599 [ dbSNP | Ensembl ].
VAR_032341
Natural varianti226 – 2261I → V.
Corresponds to variant rs56029288 [ dbSNP | Ensembl ].
VAR_061098
Natural varianti242 – 2421T → P.
Corresponds to variant rs3743600 [ dbSNP | Ensembl ].
VAR_055649

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 149149Missing in isoform 2. VSP_025579Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611V → I in AAD48376. 1 Publication
Sequence conflicti153 – 1531F → L in BAA91837. 1 Publication
Sequence conflicti254 – 2541I → T in AAD48376. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125188 mRNA. Translation: AAD48376.1.
AK001687 mRNA. Translation: BAA91837.1.
BC002758 mRNA. Translation: AAH02758.1.
CCDSiCCDS10922.1. [Q9BUB4-1]
RefSeqiNP_036223.2. NM_012091.3. [Q9BUB4-1]
UniGeneiHs.729312.

Genome annotation databases

EnsembliENST00000307921; ENSP00000310015; ENSG00000065457. [Q9BUB4-1]
GeneIDi23536.
KEGGihsa:23536.
UCSCiuc002feo.2. human. [Q9BUB4-1]

Polymorphism databases

DMDMi74733201.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125188 mRNA. Translation: AAD48376.1 .
AK001687 mRNA. Translation: BAA91837.1 .
BC002758 mRNA. Translation: AAH02758.1 .
CCDSi CCDS10922.1. [Q9BUB4-1 ]
RefSeqi NP_036223.2. NM_012091.3. [Q9BUB4-1 ]
UniGenei Hs.729312.

3D structure databases

ProteinModelPortali Q9BUB4.
SMRi Q9BUB4. Positions 60-147, 290-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117081. 2 interactions.
STRINGi 9606.ENSP00000310015.

PTM databases

PhosphoSitei Q9BUB4.

Polymorphism databases

DMDMi 74733201.

Proteomic databases

MaxQBi Q9BUB4.
PaxDbi Q9BUB4.
PRIDEi Q9BUB4.

Protocols and materials databases

DNASUi 23536.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307921 ; ENSP00000310015 ; ENSG00000065457 . [Q9BUB4-1 ]
GeneIDi 23536.
KEGGi hsa:23536.
UCSCi uc002feo.2. human. [Q9BUB4-1 ]

Organism-specific databases

CTDi 23536.
GeneCardsi GC16M075632.
HGNCi HGNC:228. ADAT1.
HPAi HPA040713.
HPA040903.
MIMi 604230. gene.
neXtProti NX_Q9BUB4.
PharmGKBi PA24558.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269429.
HOGENOMi HOG000237320.
HOVERGENi HBG059724.
InParanoidi Q9BUB4.
KOi K15440.
OMAi VVIGKCP.
PhylomeDBi Q9BUB4.
TreeFami TF315806.

Miscellaneous databases

GenomeRNAii 23536.
NextBioi 46034.
PROi Q9BUB4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BUB4.
Bgeei Q9BUB4.
CleanExi HS_ADAT1.
Genevestigatori Q9BUB4.

Family and domain databases

InterProi IPR002466. A_deamin.
[Graphical view ]
Pfami PF02137. A_deamin. 1 hit.
[Graphical view ]
SMARTi SM00552. ADEAMc. 1 hit.
[Graphical view ]
PROSITEi PS50141. A_DEAMIN_EDITASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes."
    Maas S., Gerber A.P., Rich A.
    Proc. Natl. Acad. Sci. U.S.A. 96:8895-8900(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CATALYTIC ACTIVITY, TISSUE SPECIFICITY, VARIANT ASN-167.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiADAT1_HUMAN
AccessioniPrimary (citable) accession number: Q9BUB4
Secondary accession number(s): Q9NVB7, Q9UNG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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