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Protein

Myosin regulatory light chain 10

Gene

MYL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi97 – 108121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 10
Alternative name(s):
Myosin light chain 2, lymphocyte-specific
Precursor lymphocyte-specific regulatory light chain
Gene namesi
Name:MYL10
Synonyms:MYLC2PL, PLRLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29825. MYL10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723254.

Polymorphism and mutation databases

BioMutaiMYL10.
DMDMi74761268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Myosin regulatory light chain 10PRO_0000322130Add
BLAST

Proteomic databases

PaxDbiQ9BUA6.
PeptideAtlasiQ9BUA6.
PRIDEiQ9BUA6.

PTM databases

iPTMnetiQ9BUA6.
PhosphoSiteiQ9BUA6.

Expressioni

Gene expression databases

BgeeiENSG00000106436.
GenevisibleiQ9BUA6. HS.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi125022. 3 interactions.
STRINGi9606.ENSP00000223167.

Structurei

3D structure databases

ProteinModelPortaliQ9BUA6.
SMRiQ9BUA6. Positions 42-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 11936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 18936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini190 – 22536EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
InParanoidiQ9BUA6.
KOiK12756.
OMAiNQMFAAF.
OrthoDBiEOG091G0QF6.
PhylomeDBiQ9BUA6.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BUA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRLVSNSW PQVILPPRPP KVLGLQAPRR ARKRAEGTAS SNVFSMFDQS
60 70 80 90 100
QIQEFKESLA LSPRLERNGM ISAHCNLCLT GSSNSPASAS QAFTIMDQNR
110 120 130 140 150
DGFIDKEDLR DTFAALGRIN VKNEELEAMV KEAPGPINFT VFLTMFGEKL
160 170 180 190 200
KGTDPEETIL HAFKVFDTEG KGFVKADVIK EKLMTQADRF SEEEVKQMFA
210 220
AFPPDVCGNL DYRNLCYVIT HGEEKD
Length:226
Mass (Da):25,308
Last modified:March 1, 2004 - v2
Checksum:iBC9E7976D178D0B9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461M → T.
Corresponds to variant rs12216595 [ dbSNP | Ensembl ].
VAR_039401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471197 Genomic DNA. Translation: EAW50226.1.
BC002778 mRNA. Translation: AAH02778.2.
CCDSiCCDS34713.1.
RefSeqiNP_612412.2. NM_138403.4.
UniGeneiHs.247831.

Genome annotation databases

EnsembliENST00000223167; ENSP00000223167; ENSG00000106436.
GeneIDi93408.
KEGGihsa:93408.
UCSCiuc003uyr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471197 Genomic DNA. Translation: EAW50226.1.
BC002778 mRNA. Translation: AAH02778.2.
CCDSiCCDS34713.1.
RefSeqiNP_612412.2. NM_138403.4.
UniGeneiHs.247831.

3D structure databases

ProteinModelPortaliQ9BUA6.
SMRiQ9BUA6. Positions 42-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125022. 3 interactions.
STRINGi9606.ENSP00000223167.

PTM databases

iPTMnetiQ9BUA6.
PhosphoSiteiQ9BUA6.

Polymorphism and mutation databases

BioMutaiMYL10.
DMDMi74761268.

Proteomic databases

PaxDbiQ9BUA6.
PeptideAtlasiQ9BUA6.
PRIDEiQ9BUA6.

Protocols and materials databases

DNASUi93408.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223167; ENSP00000223167; ENSG00000106436.
GeneIDi93408.
KEGGihsa:93408.
UCSCiuc003uyr.3. human.

Organism-specific databases

CTDi93408.
GeneCardsiMYL10.
HGNCiHGNC:29825. MYL10.
neXtProtiNX_Q9BUA6.
PharmGKBiPA164723254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
InParanoidiQ9BUA6.
KOiK12756.
OMAiNQMFAAF.
OrthoDBiEOG091G0QF6.
PhylomeDBiQ9BUA6.
TreeFamiTF314218.

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

GenomeRNAii93408.
PROiQ9BUA6.

Gene expression databases

BgeeiENSG00000106436.
GenevisibleiQ9BUA6. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYL10_HUMAN
AccessioniPrimary (citable) accession number: Q9BUA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2004
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This chain binds calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.