Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin regulatory light chain 10

Gene

MYL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

This chain binds calcium.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi97 – 1081PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 10
Alternative name(s):
Myosin light chain 2, lymphocyte-specific
Precursor lymphocyte-specific regulatory light chain
Gene namesi
Name:MYL10
Synonyms:MYLC2PL, PLRLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29825. MYL10.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106436.
PharmGKBiPA164723254.

Polymorphism and mutation databases

BioMutaiMYL10.
DMDMi74761268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003221301 – 226Myosin regulatory light chain 10Add BLAST226

Proteomic databases

PaxDbiQ9BUA6.
PeptideAtlasiQ9BUA6.
PRIDEiQ9BUA6.

PTM databases

iPTMnetiQ9BUA6.
PhosphoSitePlusiQ9BUA6.

Expressioni

Gene expression databases

BgeeiENSG00000106436.
GenevisibleiQ9BUA6. HS.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi125022. 3 interactors.
STRINGi9606.ENSP00000223167.

Structurei

3D structure databases

ProteinModelPortaliQ9BUA6.
SMRiQ9BUA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 119EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini154 – 189EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini190 – 225EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
InParanoidiQ9BUA6.
KOiK12756.
OMAiFKIFDPE.
OrthoDBiEOG091G0QF6.
PhylomeDBiQ9BUA6.
TreeFamiTF314218.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13405. EF-hand_6. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9BUA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRLVSNSW PQVILPPRPP KVLGLQAPRR ARKRAEGTAS SNVFSMFDQS
60 70 80 90 100
QIQEFKESLA LSPRLERNGM ISAHCNLCLT GSSNSPASAS QAFTIMDQNR
110 120 130 140 150
DGFIDKEDLR DTFAALGRIN VKNEELEAMV KEAPGPINFT VFLTMFGEKL
160 170 180 190 200
KGTDPEETIL HAFKVFDTEG KGFVKADVIK EKLMTQADRF SEEEVKQMFA
210 220
AFPPDVCGNL DYRNLCYVIT HGEEKD
Length:226
Mass (Da):25,308
Last modified:March 1, 2004 - v2
Checksum:iBC9E7976D178D0B9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03940146M → T. Corresponds to variant dbSNP:rs12216595Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471197 Genomic DNA. Translation: EAW50226.1.
BC002778 mRNA. Translation: AAH02778.2.
CCDSiCCDS34713.1.
RefSeqiNP_612412.2. NM_138403.4.
UniGeneiHs.247831.

Genome annotation databases

EnsembliENST00000223167; ENSP00000223167; ENSG00000106436.
GeneIDi93408.
KEGGihsa:93408.
UCSCiuc003uyr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYL10_HUMAN
AccessioniPrimary (citable) accession number: Q9BUA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2004
Last modified: June 7, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations