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Protein

SPIN1-docking protein

Gene

C11orf84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SPIN1-docking protein1 Publication
Short name:
SPIN-DOC1 Publication
Gene namesi
Name:C11orf84
Synonyms:SPINDOC1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168005.8
HGNCiHGNC:25115 C11orf84
neXtProtiNX_Q9BUA3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168005
PharmGKBiPA162377769

Polymorphism and mutation databases

BioMutaiC11orf84
DMDMi74733196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215281 – 381SPIN1-docking proteinAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei121PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei308PhosphoserineCombined sources1 Publication1
Modified residuei310PhosphoserineCombined sources1
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BUA3
MaxQBiQ9BUA3
PaxDbiQ9BUA3
PeptideAtlasiQ9BUA3
PRIDEiQ9BUA3

PTM databases

iPTMnetiQ9BUA3
PhosphoSitePlusiQ9BUA3

Expressioni

Gene expression databases

BgeeiENSG00000168005
CleanExiHS_C11orf84
ExpressionAtlasiQ9BUA3 baseline and differential
GenevisibleiQ9BUA3 HS

Organism-specific databases

HPAiHPA040128
HPA050313

Interactioni

Subunit structurei

Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Interacts with TCF7L2 in a SPIN1-dependent manner (PubMed:29061846).1 Publication

Protein-protein interaction databases

BioGridi12682722 interactors.
IntActiQ9BUA3 3 interactors.
STRINGi9606.ENSP00000294244

Structurei

3D structure databases

ProteinModelPortaliQ9BUA3
SMRiQ9BUA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 252Pro-richAdd BLAST106

Phylogenomic databases

eggNOGiENOG410IS1G Eukaryota
ENOG4111DW1 LUCA
GeneTreeiENSGT00410000025985
HOGENOMiHOG000111741
HOVERGENiHBG094884
InParanoidiQ9BUA3
OMAiLQDWSKH
OrthoDBiEOG091G0D36
PhylomeDBiQ9BUA3
TreeFamiTF337165

Sequencei

Sequence statusi: Complete.

Q9BUA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKAEGAAL DCFEVTLKCE EGEDEEEAMV VAVIPRPEPM LRVTQQEKTP
60 70 80 90 100
PPRPSPLEAG SDGCEEPKQQ VSWEQEFLVG SSPGGSGRAL CMVCGAEIRA
110 120 130 140 150
PSADTARSHI LEQHPHTLDL SPSEKSNILE AWSEGVALLQ DVRAEQPSPP
160 170 180 190 200
NSDSGQDAHP DPDANPDAAR MPAEIVVLLD SEDNPSLPKR SRPRGLRPLE
210 220 230 240 250
LPAVPATEPG NKKPRGQRWK EPPGEEPVRK KRGRPMTKNL DPDPEPPSPD
260 270 280 290 300
SPTETFAAPA EVRHFTDGSF PAGFVLQLFS HTQLRGPDSK DSPKDREVAE
310 320 330 340 350
GGLPRAESPS PAPPPGLRGT LDLQVIRVRM EEPPAVSLLQ DWSRHPQGTK
360 370 380
RVGAGDTSDW PTVLSESSTT VAGKPEKGNG V
Length:381
Mass (Da):41,037
Last modified:November 23, 2004 - v3
Checksum:iDC8AB56B1B224D73
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06160758E → Q. Corresponds to variant dbSNP:rs35875163Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW74172.1
BC002782 mRNA Translation: AAH02782.3
BC007540 mRNA Translation: AAH07540.2
BC056402 mRNA Translation: AAH56402.1
CR749697 mRNA Translation: CAH18477.1
CCDSiCCDS31594.1
RefSeqiNP_612480.1, NM_138471.2
UniGeneiHs.502793

Genome annotation databases

EnsembliENST00000294244; ENSP00000294244; ENSG00000168005
GeneIDi144097
KEGGihsa:144097
UCSCiuc001nxt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPNDC_HUMAN
AccessioniPrimary (citable) accession number: Q9BUA3
Secondary accession number(s): Q68CV7, Q6PHS2, Q96IH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome