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UniProtKB - Q9BU76 (MMTA2_HUMAN)

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Protein

Multiple myeloma tumor-associated protein 2

Gene

MMTAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple myeloma tumor-associated protein 2
Short name:
hMMTAG2
Gene namesi
Name:MMTAG2
Synonyms:C1orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19032. C1orf35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143793.
PharmGKBiPA38781.

Polymorphism and mutation databases

BioMutaiMMTAG2.
DMDMi73621220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965181 – 263Multiple myeloma tumor-associated protein 2Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei123PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei220PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BU76.
MaxQBiQ9BU76.
PaxDbiQ9BU76.
PeptideAtlasiQ9BU76.
PRIDEiQ9BU76.

PTM databases

iPTMnetiQ9BU76.
PhosphoSitePlusiQ9BU76.

Expressioni

Gene expression databases

BgeeiENSG00000143793.
CleanExiHS_C1orf35.
GenevisibleiQ9BU76. HS.

Organism-specific databases

HPAiHPA046175.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122586. 29 interactors.
IntActiQ9BU76. 46 interactors.
MINTiMINT-1443747.
STRINGi9606.ENSP00000272139.

Structurei

3D structure databases

ProteinModelPortaliQ9BU76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 206Lys-richAdd BLAST23
Compositional biasi226 – 229Poly-His4

Phylogenomic databases

eggNOGiKOG4520. Eukaryota.
ENOG41123ER. LUCA.
GeneTreeiENSGT00390000005590.
HOGENOMiHOG000242968.
HOVERGENiHBG066325.
InParanoidiQ9BU76.
OMAiHRENYIG.
OrthoDBiEOG091G0LCC.
PhylomeDBiQ9BU76.
TreeFamiTF332234.

Family and domain databases

InterProiView protein in InterPro
IPR019315. Kinase_phosphorylation_domain.
PfamiView protein in Pfam
PF10159. MMtag. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BU76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGSSRGGVR GGQDQFNWED VKTDKQRENY LGNSLMAPVG RWQKGRDLTW 
        60         70         80         90        100
YAKGRAPCAG PSREEELAAV REAEREALLA ALGYKNVKKQ PTGLSKEDFA 
       110        120        130        140        150
EVCKREGGDP EEKGVDRLLG LGSASGSVGR VAMSREDKEA AKLGLSVFTH 
       160        170        180        190        200
HRVESGGPGT SAASARRKPR AEDQTESSCE SHRKSKKEKK KKKKRKHKKE 
       210        220        230        240        250
KKKKDKEHRR PAEATSSPTS PERPRHHHHD SDSNSPCCKR RKRGHSGDRR 
       260 
SPSRRWHDRG SEA
Length:263
Mass (Da):29,412
Last modified:June 1, 2001 - v1
Checksum:i51A7DEE260DBD787
GO
Isoform 2 (identifier: Q9BU76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-141: SGSVGRVAMSREDKEAA → RCGRVSRGGQHWARLLG
     142-263: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):15,521
Checksum:iF23E1755F88CF093
GO
Isoform 3 (identifier: Q9BU76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-155: HHRVES → VIPRPA
     156-263: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):16,842
Checksum:i437074D523DB3AA1
GO
Isoform 4 (identifier: Q9BU76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-189: SCESHRKSKKEK → RGVSRVTLEERS
     190-263: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,536
Checksum:iDBEC809E97848129
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29N → I in AAN15215 (PubMed:12545221).Curated1
Sequence conflicti154E → K in AAN15215 (PubMed:12545221).Curated1
Sequence conflicti262E → K in AAN15215 (PubMed:12545221).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015129125 – 141SGSVG…DKEAA → RCGRVSRGGQHWARLLG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_015130142 – 263Missing in isoform 2. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_015131150 – 155HHRVES → VIPRPA in isoform 3. 1 Publication6
Alternative sequenceiVSP_015132156 – 263Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_015133178 – 189SCESH…SKKEK → RGVSRVTLEERS in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_015134190 – 263Missing in isoform 4. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY137773 mRNA. Translation: AAN15215.1.
AK123377 mRNA. Translation: BAC85598.1.
AK126087 mRNA. Translation: BAC86431.1.
AL136379 Genomic DNA. Translation: CAI23119.1.
BC002843 mRNA. Translation: AAH02843.1.
BC062585 mRNA. Translation: AAH62585.1.
CCDSiCCDS1566.1. [Q9BU76-1]
RefSeqiNP_077295.1. NM_024319.3. [Q9BU76-1]
UniGeneiHs.445952.

Genome annotation databases

EnsembliENST00000272139; ENSP00000272139; ENSG00000143793. [Q9BU76-1]
GeneIDi79169.
KEGGihsa:79169.
UCSCiuc001hrx.4. human. [Q9BU76-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMMTA2_HUMAN
AccessioniPrimary (citable) accession number: Q9BU76
Secondary accession number(s): Q6P5Y0
, Q6ZTZ6, Q6ZWA6, Q8IZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM