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Protein

tRNA (adenine(37)-N6)-methyltransferase

Gene

TRMO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m6t6A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m6t6A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).By similarity1 Publication

GO - Molecular functioni

  • tRNA (adenine-N6-)-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • tRNA methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136932-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (adenine(37)-N6)-methyltransferaseCurated (EC:2.1.1.-1 Publication)
Alternative name(s):
tRNA methyltransferase O1 PublicationImported
Gene namesi
Name:TRMO1 PublicationImported
Synonyms:C9orf156
ORF Names:HSPC219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30967. TRMO.

Pathology & Biotechi

Organism-specific databases

DisGeNETi51531.
OpenTargetsiENSG00000136932.
PharmGKBiPA134875112.

Polymorphism and mutation databases

BioMutaiC9orf156.
DMDMi152112517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002888861 – 441tRNA (adenine(37)-N6)-methyltransferaseAdd BLAST441

Proteomic databases

EPDiQ9BU70.
MaxQBiQ9BU70.
PaxDbiQ9BU70.
PeptideAtlasiQ9BU70.
PRIDEiQ9BU70.

PTM databases

iPTMnetiQ9BU70.
PhosphoSitePlusiQ9BU70.

Expressioni

Gene expression databases

BgeeiENSG00000136932.
CleanExiHS_C9orf156.
ExpressionAtlasiQ9BU70. baseline and differential.
GenevisibleiQ9BU70. HS.

Organism-specific databases

HPAiHPA021281.
HPA052197.

Interactioni

Protein-protein interaction databases

BioGridi119593. 6 interactors.
IntActiQ9BU70. 23 interactors.
STRINGi9606.ENSP00000364260.

Structurei

3D structure databases

ProteinModelPortaliQ9BU70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 168TsaA-likePROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Contains 1 TsaA-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2942. Eukaryota.
COG1720. LUCA.
GeneTreeiENSGT00390000004643.
HOGENOMiHOG000231645.
HOVERGENiHBG054288.
InParanoidiQ9BU70.
OMAiFKYFQSA.
OrthoDBiEOG091G0DXG.
PhylomeDBiQ9BU70.
TreeFamiTF331670.

Family and domain databases

CDDicd09281. UPF0066. 1 hit.
Gene3Di2.40.30.70. 1 hit.
InterProiIPR023370. TsaA-like.
IPR023368. UPF0066_cons_site.
[Graphical view]
PfamiPF01980. UPF0066. 1 hit.
[Graphical view]
SUPFAMiSSF118196. SSF118196. 2 hits.
TIGRFAMsiTIGR00104. tRNA_TsaA. 1 hit.
PROSITEiPS01318. TSAA_1. 1 hit.
PS51668. TSAA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BU70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP
60 70 80 90 100
SICSYSRACL RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK
110 120 130 140 150
VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG
160 170 180 190 200
TPVLDIKPYI AEYDSPQNVM EPLADFNLQN NQHTPNTVSQ SDSKTDSCDQ
210 220 230 240 250
RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI QQAFPMHREI
260 270 280 290 300
AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG
310 320 330 340 350
SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG
360 370 380 390 400
QLSSQDVGQA SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT
410 420 430 440
VDIAHVTCWF GDGFAEVLRI KPASEPVHMT GPVGSLVSLG S
Length:441
Mass (Da):48,587
Last modified:May 29, 2007 - v2
Checksum:i84E6CF8BD294EDD2
GO

Sequence cautioni

The sequence AAF36139 differs from that shown. Contaminating sequence.Curated
The sequence AAF36139 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341F → V in CAA60025 (PubMed:9153233).Curated1
Sequence conflicti358G → D in BAA91013 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0325277S → P.2 PublicationsCorresponds to variant rs3183927dbSNPEnsembl.1
Natural variantiVAR_032528252V → A.Corresponds to variant rs35606344dbSNPEnsembl.1
Natural variantiVAR_032529324V → M.Corresponds to variant rs2282192dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000213 mRNA. Translation: BAA91013.1.
AL499604 Genomic DNA. Translation: CAI12805.1.
BC002863 mRNA. Translation: AAH02863.1.
AF151053 mRNA. Translation: AAF36139.1. Sequence problems.
X86033 mRNA. Translation: CAA60025.1.
CCDSiCCDS6730.1.
RefSeqiNP_001317654.1. NM_001330725.1.
NP_057565.3. NM_016481.4.
UniGeneiHs.9196.

Genome annotation databases

EnsembliENST00000375119; ENSP00000364260; ENSG00000136932.
GeneIDi51531.
KEGGihsa:51531.
UCSCiuc004axv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000213 mRNA. Translation: BAA91013.1.
AL499604 Genomic DNA. Translation: CAI12805.1.
BC002863 mRNA. Translation: AAH02863.1.
AF151053 mRNA. Translation: AAF36139.1. Sequence problems.
X86033 mRNA. Translation: CAA60025.1.
CCDSiCCDS6730.1.
RefSeqiNP_001317654.1. NM_001330725.1.
NP_057565.3. NM_016481.4.
UniGeneiHs.9196.

3D structure databases

ProteinModelPortaliQ9BU70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119593. 6 interactors.
IntActiQ9BU70. 23 interactors.
STRINGi9606.ENSP00000364260.

PTM databases

iPTMnetiQ9BU70.
PhosphoSitePlusiQ9BU70.

Polymorphism and mutation databases

BioMutaiC9orf156.
DMDMi152112517.

Proteomic databases

EPDiQ9BU70.
MaxQBiQ9BU70.
PaxDbiQ9BU70.
PeptideAtlasiQ9BU70.
PRIDEiQ9BU70.

Protocols and materials databases

DNASUi51531.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375119; ENSP00000364260; ENSG00000136932.
GeneIDi51531.
KEGGihsa:51531.
UCSCiuc004axv.2. human.

Organism-specific databases

CTDi51531.
DisGeNETi51531.
GeneCardsiC9orf156.
H-InvDBHIX0008217.
HGNCiHGNC:30967. TRMO.
HPAiHPA021281.
HPA052197.
neXtProtiNX_Q9BU70.
OpenTargetsiENSG00000136932.
PharmGKBiPA134875112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2942. Eukaryota.
COG1720. LUCA.
GeneTreeiENSGT00390000004643.
HOGENOMiHOG000231645.
HOVERGENiHBG054288.
InParanoidiQ9BU70.
OMAiFKYFQSA.
OrthoDBiEOG091G0DXG.
PhylomeDBiQ9BU70.
TreeFamiTF331670.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136932-MONOMER.

Miscellaneous databases

GenomeRNAii51531.
PROiQ9BU70.

Gene expression databases

BgeeiENSG00000136932.
CleanExiHS_C9orf156.
ExpressionAtlasiQ9BU70. baseline and differential.
GenevisibleiQ9BU70. HS.

Family and domain databases

CDDicd09281. UPF0066. 1 hit.
Gene3Di2.40.30.70. 1 hit.
InterProiIPR023370. TsaA-like.
IPR023368. UPF0066_cons_site.
[Graphical view]
PfamiPF01980. UPF0066. 1 hit.
[Graphical view]
SUPFAMiSSF118196. SSF118196. 2 hits.
TIGRFAMsiTIGR00104. tRNA_TsaA. 1 hit.
PROSITEiPS01318. TSAA_1. 1 hit.
PS51668. TSAA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRMO_HUMAN
AccessioniPrimary (citable) accession number: Q9BU70
Secondary accession number(s): Q5T113
, Q86SK0, Q9NXJ7, Q9P0Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.