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Q9BU64

- CENPO_HUMAN

UniProt

Q9BU64 - CENPO_HUMAN

Protein

Centromere protein O

Gene

CENPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.4 Publications

    GO - Biological processi

    1. CENP-A containing nucleosome assembly Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. nucleosome assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein O
    Short name:
    CENP-O
    Alternative name(s):
    Interphase centromere complex protein 36
    Gene namesi
    Name:CENPO
    Synonyms:ICEN36, MCM21R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:28152. CENPO.

    Subcellular locationi

    Nucleus. Chromosomecentromere. Chromosomecentromerekinetochore
    Note: The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. nucleoplasm Source: Reactome
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145149197.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Centromere protein OPRO_0000249502Add
    BLAST

    Proteomic databases

    MaxQBiQ9BU64.
    PaxDbiQ9BU64.
    PRIDEiQ9BU64.

    PTM databases

    PhosphoSiteiQ9BU64.

    Expressioni

    Gene expression databases

    BgeeiQ9BU64.
    CleanExiHS_CENPO.
    GenevestigatoriQ9BU64.

    Organism-specific databases

    HPAiHPA052458.

    Interactioni

    Subunit structurei

    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

    Protein-protein interaction databases

    BioGridi122589. 15 interactions.
    IntActiQ9BU64. 2 interactions.
    MINTiMINT-1439597.
    STRINGi9606.ENSP00000260662.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BU64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili18 – 4225Sequence AnalysisAdd
    BLAST
    Coiled coili83 – 10927Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39904.
    HOGENOMiHOG000059658.
    HOVERGENiHBG080687.
    InParanoidiQ9BU64.
    KOiK11507.
    OMAiALSTSWE.
    OrthoDBiEOG7VX8WJ.
    PhylomeDBiQ9BU64.
    TreeFamiTF335524.

    Family and domain databases

    InterProiIPR018464. CENP-O.
    [Graphical view]
    PfamiPF09496. CENP-O. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BU64-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQANPLRPD GESKGGVLAH LERLETQVSR SRKQSEELQS VQAQEGALGT    50
    KIHKLRRLRD ELRAVVRHRR ASVKACIANV EPNQTVEINE QEALEEKLEN 100
    VKAILQAYHF TGLSGKLTSR GVCVCISTAF EGNLLDSYFV DLVIQKPLRI 150
    HHHSVPVFIP LEEIAAKYLQ TNIQHFLFSL CEYLNAYSGR KYQADRLQSD 200
    FAALLTGPLQ RNPLCNLLSF TYKLDPGGQS FPFCARLLYK DLTATLPTDV 250
    TVTCQGVEVL STSWEEQRAS HETLFCTKPL HQVFASFTRK GEKLDMSLVS 300
    Length:300
    Mass (Da):33,786
    Last modified:June 1, 2001 - v1
    Checksum:i05A89E12C6847D81
    GO
    Isoform 2 (identifier: Q9BU64-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MEQANPLRPDGESKG → MAGILASGL

    Note: No experimental confirmation available.

    Show »
    Length:294
    Mass (Da):32,989
    Checksum:i76D32EB5C95FD332
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351A → V in BAB55414. (PubMed:14702039)Curated
    Sequence conflicti269 – 2691A → V in BAB55414. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341Q → R.1 Publication
    Corresponds to variant rs1550116 [ dbSNP | Ensembl ].
    VAR_027420

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1515MEQAN…GESKG → MAGILASGL in isoform 2. 1 PublicationVSP_020446Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027859 mRNA. Translation: BAB55414.1.
    AK315483 mRNA. Translation: BAG37867.1.
    AC012073 Genomic DNA. Translation: AAY14786.1.
    AC013459 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00742.1.
    CH471053 Genomic DNA. Translation: EAX00743.1.
    BC002870 mRNA. Translation: AAH02870.1.
    CCDSiCCDS1714.1. [Q9BU64-1]
    CCDS56113.1. [Q9BU64-2]
    RefSeqiNP_001186732.1. NM_001199803.1. [Q9BU64-2]
    NP_077298.1. NM_024322.2. [Q9BU64-1]
    XP_006712165.1. XM_006712102.1. [Q9BU64-1]
    UniGeneiHs.731569.

    Genome annotation databases

    EnsembliENST00000260662; ENSP00000260662; ENSG00000138092. [Q9BU64-1]
    ENST00000380834; ENSP00000370214; ENSG00000138092. [Q9BU64-1]
    ENST00000473706; ENSP00000417787; ENSG00000138092. [Q9BU64-2]
    GeneIDi79172.
    KEGGihsa:79172.
    UCSCiuc002rfp.2. human. [Q9BU64-2]
    uc002rfq.2. human. [Q9BU64-1]

    Polymorphism databases

    DMDMi74733185.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027859 mRNA. Translation: BAB55414.1 .
    AK315483 mRNA. Translation: BAG37867.1 .
    AC012073 Genomic DNA. Translation: AAY14786.1 .
    AC013459 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00742.1 .
    CH471053 Genomic DNA. Translation: EAX00743.1 .
    BC002870 mRNA. Translation: AAH02870.1 .
    CCDSi CCDS1714.1. [Q9BU64-1 ]
    CCDS56113.1. [Q9BU64-2 ]
    RefSeqi NP_001186732.1. NM_001199803.1. [Q9BU64-2 ]
    NP_077298.1. NM_024322.2. [Q9BU64-1 ]
    XP_006712165.1. XM_006712102.1. [Q9BU64-1 ]
    UniGenei Hs.731569.

    3D structure databases

    ProteinModelPortali Q9BU64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122589. 15 interactions.
    IntActi Q9BU64. 2 interactions.
    MINTi MINT-1439597.
    STRINGi 9606.ENSP00000260662.

    PTM databases

    PhosphoSitei Q9BU64.

    Polymorphism databases

    DMDMi 74733185.

    Proteomic databases

    MaxQBi Q9BU64.
    PaxDbi Q9BU64.
    PRIDEi Q9BU64.

    Protocols and materials databases

    DNASUi 79172.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260662 ; ENSP00000260662 ; ENSG00000138092 . [Q9BU64-1 ]
    ENST00000380834 ; ENSP00000370214 ; ENSG00000138092 . [Q9BU64-1 ]
    ENST00000473706 ; ENSP00000417787 ; ENSG00000138092 . [Q9BU64-2 ]
    GeneIDi 79172.
    KEGGi hsa:79172.
    UCSCi uc002rfp.2. human. [Q9BU64-2 ]
    uc002rfq.2. human. [Q9BU64-1 ]

    Organism-specific databases

    CTDi 79172.
    GeneCardsi GC02P025016.
    HGNCi HGNC:28152. CENPO.
    HPAi HPA052458.
    MIMi 611504. gene.
    neXtProti NX_Q9BU64.
    PharmGKBi PA145149197.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39904.
    HOGENOMi HOG000059658.
    HOVERGENi HBG080687.
    InParanoidi Q9BU64.
    KOi K11507.
    OMAi ALSTSWE.
    OrthoDBi EOG7VX8WJ.
    PhylomeDBi Q9BU64.
    TreeFami TF335524.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    ChiTaRSi CENPO. human.
    GeneWikii CENPO.
    GenomeRNAii 79172.
    NextBioi 68137.
    PROi Q9BU64.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BU64.
    CleanExi HS_CENPO.
    Genevestigatori Q9BU64.

    Family and domain databases

    InterProi IPR018464. CENP-O.
    [Graphical view ]
    Pfami PF09496. CENP-O. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-34.
      Tissue: Placenta.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation."
      McAinsh A.D., Meraldi P., Draviam V.M., Toso A., Sorger P.K.
      EMBO J. 25:4033-4049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
      Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
      Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
      Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
      Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPP; CENPQ; CENPR AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPP; CENPQ; CENPR AND CENPS.
    9. "The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity."
      McClelland S.E., Borusu S., Amaro A.C., Winter J.R., Belwal M., McAinsh A.D., Meraldi P.
      EMBO J. 26:5033-5047(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCENPO_HUMAN
    AccessioniPrimary (citable) accession number: Q9BU64
    Secondary accession number(s): B2RDC0
    , D6W536, Q53T55, Q96JV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3