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Q9BU40

- CRDL1_HUMAN

UniProt

Q9BU40 - CRDL1_HUMAN

Protein

Chordin-like protein 1

Gene

CHRDL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation By similarity. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.By similarity2 Publications

    GO - Biological processi

    1. BMP signaling pathway Source: Reactome
    2. cell differentiation Source: UniProtKB-KW
    3. compound eye development Source: UniProtKB
    4. eye development Source: UniProtKB
    5. nervous system development Source: UniProtKB-KW
    6. ossification Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_12034. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin-like protein 1
    Alternative name(s):
    Neuralin-1
    Neurogenesin-1
    Ventroptin
    Gene namesi
    Name:CHRDL1
    Synonyms:NRLN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:29861. CHRDL1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541C → F in MGC1. 1 Publication
    VAR_068175

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi309300. phenotype.
    Orphaneti91489. Isolated congenital megalocornea.
    PharmGKBiPA134933380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 450429Chordin-like protein 1PRO_0000005368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9BU40.
    PRIDEiQ9BU40.

    PTM databases

    PhosphoSiteiQ9BU40.

    Expressioni

    Tissue specificityi

    Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.2 Publications

    Inductioni

    By hypoxia in retinal pericytes.1 Publication

    Gene expression databases

    ArrayExpressiQ9BU40.
    BgeeiQ9BU40.
    CleanExiHS_CHRDL1.
    GenevestigatoriQ9BU40.

    Organism-specific databases

    HPAiHPA000226.
    HPA000250.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9BU40. 2 interactions.
    MINTiMINT-8201750.
    STRINGi9606.ENSP00000413419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BU40.
    SMRiQ9BU40. Positions 28-98, 103-174, 250-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 9466VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini107 – 17367VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini252 – 31766VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi173 – 1753Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG147797.
    HOGENOMiHOG000049211.
    HOVERGENiHBG051113.
    InParanoidiQ9BU40.
    OMAiCPRCPED.
    OrthoDBiEOG7XH6S0.
    PhylomeDBiQ9BU40.
    TreeFamiTF106451.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 3 hits.
    [Graphical view]
    SMARTiSM00214. VWC. 3 hits.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BU40-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGMKYIFSL LFFLLLEGGK TEQVKHSETY CMFQDKKYRV GERWHPYLEP    50
    YGLVYCVNCI CSENGNVLCS RVRCPNVHCL SPVHIPHLCC PRCPDSLPPV 100
    NNKVTSKSCE YNGTTYQHGE LFVAEGLFQN RQPNQCTQCS CSEGNVYCGL 150
    KTCPKLTCAF PVSVPDSCCR VCRGDGELSW EHSDGDIFRQ PANREARHSY 200
    HRSHYDPPPS RQAGGLSRFP GARSHRGALM DSQQASGTIV QIVINNKHKH 250
    GQVCVSNGKT YSHGESWHPN LRAFGIVECV LCTCNVTKQE CKKIHCPNRY 300
    PCKYPQKIDG KCCKVCPGKK AKELPGQSFD NKGYFCGEET MPVYESVFME 350
    DGETTRKIAL ETERPPQVEV HVWTIRKGIL QHFHIEKISK RMFEELPHFK 400
    LVTRTTLSQW KIFTEGEAQI SQMCSSRVCR TELEDLVKVL YLERSEKGHC 450
    Length:450
    Mass (Da):51,168
    Last modified:June 1, 2001 - v1
    Checksum:iD5F39AB9E2EE3E71
    GO
    Isoform 2 (identifier: Q9BU40-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-95: D → ED
         323-323: E → EE

    Show »
    Length:452
    Mass (Da):51,426
    Checksum:iE214F9A68D8EE072
    GO
    Isoform 3 (identifier: Q9BU40-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRKKWKM
         95-173: Missing.
         323-323: E → EE

    Note: No experimental confirmation available.

    Show »
    Length:378
    Mass (Da):43,516
    Checksum:iEA581757BD2A66F2
    GO
    Isoform 4 (identifier: Q9BU40-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRKKWKM
         95-95: D → ED
         323-323: E → EE

    Show »
    Length:458
    Mass (Da):52,284
    Checksum:i2E6FD80F2B44960F
    GO
    Isoform 5 (identifier: Q9BU40-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRKKWKM
         323-323: E → EE

    Note: No experimental confirmation available.

    Show »
    Length:457
    Mass (Da):52,155
    Checksum:iE306E04B501FE8D1
    GO
    Isoform 6 (identifier: Q9BU40-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRKKWKM

    Show »
    Length:456
    Mass (Da):52,026
    Checksum:i345A3C739493A545
    GO

    Sequence cautioni

    The sequence AAH02909.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAU25841.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAF85795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541C → F in MGC1. 1 Publication
    VAR_068175

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MRKKWKM in isoform 3, isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_043260
    Alternative sequencei95 – 17379Missing in isoform 3. 1 PublicationVSP_043261Add
    BLAST
    Alternative sequencei95 – 951D → ED in isoform 2 and isoform 4. 2 PublicationsVSP_036469
    Alternative sequencei323 – 3231E → EE in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_036470

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY608914 mRNA. Translation: AAU25841.1. Different initiation.
    AK293106 mRNA. Translation: BAF85795.1. Different initiation.
    AK297563 mRNA. Translation: BAG59955.1.
    AK312270 mRNA. No translation available.
    AL049176, AL591489 Genomic DNA. Translation: CAI42037.1.
    AL591489, AL049176 Genomic DNA. Translation: CAI41336.1.
    AL591489, AL049176 Genomic DNA. Translation: CAI41337.1.
    AL049176, AL591489 Genomic DNA. Translation: CAI42038.1.
    CH471120 Genomic DNA. Translation: EAX02656.1.
    CH471120 Genomic DNA. Translation: EAX02657.1.
    BC002909 mRNA. Translation: AAH02909.2. Different initiation.
    CCDSiCCDS14553.1. [Q9BU40-6]
    CCDS48148.2. [Q9BU40-3]
    CCDS48149.1. [Q9BU40-4]
    CCDS48150.1. [Q9BU40-5]
    RefSeqiNP_001137453.1. NM_001143981.1. [Q9BU40-4]
    NP_001137454.1. NM_001143982.1. [Q9BU40-5]
    NP_001137455.2. NM_001143983.2. [Q9BU40-3]
    NP_660277.2. NM_145234.3. [Q9BU40-6]
    XP_005262278.1. XM_005262221.1. [Q9BU40-4]
    XP_005262279.1. XM_005262222.2. [Q9BU40-5]
    UniGeneiHs.496587.

    Genome annotation databases

    EnsembliENST00000372042; ENSP00000361112; ENSG00000101938. [Q9BU40-4]
    ENST00000372045; ENSP00000361115; ENSG00000101938. [Q9BU40-1]
    ENST00000394797; ENSP00000378276; ENSG00000101938. [Q9BU40-6]
    ENST00000444321; ENSP00000399739; ENSG00000101938. [Q9BU40-5]
    ENST00000482160; ENSP00000418443; ENSG00000101938. [Q9BU40-3]
    GeneIDi91851.
    KEGGihsa:91851.
    UCSCiuc004eou.4. human.
    uc004eov.3. human. [Q9BU40-2]
    uc004eow.3. human. [Q9BU40-1]
    uc011mss.2. human. [Q9BU40-3]

    Polymorphism databases

    DMDMi27805644.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY608914 mRNA. Translation: AAU25841.1 . Different initiation.
    AK293106 mRNA. Translation: BAF85795.1 . Different initiation.
    AK297563 mRNA. Translation: BAG59955.1 .
    AK312270 mRNA. No translation available.
    AL049176 , AL591489 Genomic DNA. Translation: CAI42037.1 .
    AL591489 , AL049176 Genomic DNA. Translation: CAI41336.1 .
    AL591489 , AL049176 Genomic DNA. Translation: CAI41337.1 .
    AL049176 , AL591489 Genomic DNA. Translation: CAI42038.1 .
    CH471120 Genomic DNA. Translation: EAX02656.1 .
    CH471120 Genomic DNA. Translation: EAX02657.1 .
    BC002909 mRNA. Translation: AAH02909.2 . Different initiation.
    CCDSi CCDS14553.1. [Q9BU40-6 ]
    CCDS48148.2. [Q9BU40-3 ]
    CCDS48149.1. [Q9BU40-4 ]
    CCDS48150.1. [Q9BU40-5 ]
    RefSeqi NP_001137453.1. NM_001143981.1. [Q9BU40-4 ]
    NP_001137454.1. NM_001143982.1. [Q9BU40-5 ]
    NP_001137455.2. NM_001143983.2. [Q9BU40-3 ]
    NP_660277.2. NM_145234.3. [Q9BU40-6 ]
    XP_005262278.1. XM_005262221.1. [Q9BU40-4 ]
    XP_005262279.1. XM_005262222.2. [Q9BU40-5 ]
    UniGenei Hs.496587.

    3D structure databases

    ProteinModelPortali Q9BU40.
    SMRi Q9BU40. Positions 28-98, 103-174, 250-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9BU40. 2 interactions.
    MINTi MINT-8201750.
    STRINGi 9606.ENSP00000413419.

    PTM databases

    PhosphoSitei Q9BU40.

    Polymorphism databases

    DMDMi 27805644.

    Proteomic databases

    PaxDbi Q9BU40.
    PRIDEi Q9BU40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372042 ; ENSP00000361112 ; ENSG00000101938 . [Q9BU40-4 ]
    ENST00000372045 ; ENSP00000361115 ; ENSG00000101938 . [Q9BU40-1 ]
    ENST00000394797 ; ENSP00000378276 ; ENSG00000101938 . [Q9BU40-6 ]
    ENST00000444321 ; ENSP00000399739 ; ENSG00000101938 . [Q9BU40-5 ]
    ENST00000482160 ; ENSP00000418443 ; ENSG00000101938 . [Q9BU40-3 ]
    GeneIDi 91851.
    KEGGi hsa:91851.
    UCSCi uc004eou.4. human.
    uc004eov.3. human. [Q9BU40-2 ]
    uc004eow.3. human. [Q9BU40-1 ]
    uc011mss.2. human. [Q9BU40-3 ]

    Organism-specific databases

    CTDi 91851.
    GeneCardsi GC0XM109917.
    HGNCi HGNC:29861. CHRDL1.
    HPAi HPA000226.
    HPA000250.
    MIMi 300350. gene.
    309300. phenotype.
    neXtProti NX_Q9BU40.
    Orphaneti 91489. Isolated congenital megalocornea.
    PharmGKBi PA134933380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147797.
    HOGENOMi HOG000049211.
    HOVERGENi HBG051113.
    InParanoidi Q9BU40.
    OMAi CPRCPED.
    OrthoDBi EOG7XH6S0.
    PhylomeDBi Q9BU40.
    TreeFami TF106451.

    Enzyme and pathway databases

    Reactomei REACT_12034. Signaling by BMP.

    Miscellaneous databases

    ChiTaRSi CHRDL1. human.
    GenomeRNAii 91851.
    NextBioi 77488.
    PROi Q9BU40.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BU40.
    Bgeei Q9BU40.
    CleanExi HS_CHRDL1.
    Genevestigatori Q9BU40.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 3 hits.
    [Graphical view ]
    SMARTi SM00214. VWC. 3 hits.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis."
      Kane R., Godson C., O'Brien C.
      Mol. Vis. 14:1138-1148(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5).
      Tissue: Astrocyte, Brain and Uterus.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. Cited for: FUNCTION, TISSUE SPECIFICITY, VARIANT MGC1 PHE-254.

    Entry informationi

    Entry nameiCRDL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BU40
    Secondary accession number(s): B1AKD0
    , B4DMP3, D3DUY6, E9PGS5, Q539E4, Q9Y3H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3