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Protein

REM2- and Rab-like small GTPase 1

Gene

RSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69GTPBy similarity8
Nucleotide bindingi175 – 178GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
REM2- and Rab-like small GTPase 1
Gene namesi
Name:RSG1
Synonyms:C1orf89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28127. RSG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132881.
PharmGKBiPA142672473.

Polymorphism and mutation databases

BioMutaiRSG1.
DMDMi145558869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845381 – 258REM2- and Rab-like small GTPase 1Add BLAST258

Proteomic databases

EPDiQ9BU20.
PaxDbiQ9BU20.
PRIDEiQ9BU20.

PTM databases

iPTMnetiQ9BU20.
PhosphoSitePlusiQ9BU20.

Expressioni

Gene expression databases

BgeeiENSG00000132881.
CleanExiHS_C1orf89.
ExpressionAtlasiQ9BU20. baseline and differential.
GenevisibleiQ9BU20. HS.

Organism-specific databases

HPAiHPA028453.
HPA041672.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUZQ9BT043EBI-750332,EBI-750341
IMPDH2P122683EBI-750332,EBI-353389

Protein-protein interaction databases

BioGridi122652. 7 interactors.
IntActiQ9BU20. 4 interactors.
STRINGi9606.ENSP00000364749.

Structurei

3D structure databases

ProteinModelPortaliQ9BU20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 258Small GTPase-likeAdd BLAST209

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00390000006521.
HOVERGENiHBG106703.
InParanoidiQ9BU20.
OMAiMVIGSKF.
OrthoDBiEOG091G0LUX.
PhylomeDBiQ9BU20.
TreeFamiTF329319.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BU20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPPVPGSV VVPNWHESAE GKEYLACILR KNRRRVFGLL ERPVLLPPVS
60 70 80 90 100
IDTASYKIFV SGKSGVGKTA LVAKLAGLEV PVVHHETTGI QTTVVFWPAK
110 120 130 140 150
LQASSRVVMF RFEFWDCGES ALKKFDHMLL ACMENTDAFL FLFSFTDRAS
160 170 180 190 200
FEDLPGQLAR IAGEAPGVVR MVIGSKFDQY MHTDVPERDL TAFRQAWELP
210 220 230 240 250
LLRVKSVPGR RLADGRTLDG RAGLADVAHI LNGLAEQLWH QDQVAAGLLP

NPPESAPE
Length:258
Mass (Da):28,498
Last modified:April 17, 2007 - v2
Checksum:i1DE50934C59A6BD0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177286E → G.1 PublicationCorresponds to variant rs17849687dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109627 Genomic DNA. Translation: CAI22562.1.
BC002946 mRNA. Translation: AAH02946.1.
BC008702 mRNA. Translation: AAH08702.1.
CCDSiCCDS171.1.
RefSeqiNP_112169.2. NM_030907.3.
UniGeneiHs.546430.

Genome annotation databases

EnsembliENST00000375599; ENSP00000364749; ENSG00000132881.
GeneIDi79363.
KEGGihsa:79363.
UCSCiuc001ayd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109627 Genomic DNA. Translation: CAI22562.1.
BC002946 mRNA. Translation: AAH02946.1.
BC008702 mRNA. Translation: AAH08702.1.
CCDSiCCDS171.1.
RefSeqiNP_112169.2. NM_030907.3.
UniGeneiHs.546430.

3D structure databases

ProteinModelPortaliQ9BU20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122652. 7 interactors.
IntActiQ9BU20. 4 interactors.
STRINGi9606.ENSP00000364749.

PTM databases

iPTMnetiQ9BU20.
PhosphoSitePlusiQ9BU20.

Polymorphism and mutation databases

BioMutaiRSG1.
DMDMi145558869.

Proteomic databases

EPDiQ9BU20.
PaxDbiQ9BU20.
PRIDEiQ9BU20.

Protocols and materials databases

DNASUi79363.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375599; ENSP00000364749; ENSG00000132881.
GeneIDi79363.
KEGGihsa:79363.
UCSCiuc001ayd.4. human.

Organism-specific databases

CTDi79363.
GeneCardsiRSG1.
HGNCiHGNC:28127. RSG1.
HPAiHPA028453.
HPA041672.
neXtProtiNX_Q9BU20.
OpenTargetsiENSG00000132881.
PharmGKBiPA142672473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00390000006521.
HOVERGENiHBG106703.
InParanoidiQ9BU20.
OMAiMVIGSKF.
OrthoDBiEOG091G0LUX.
PhylomeDBiQ9BU20.
TreeFamiTF329319.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132881-MONOMER.

Miscellaneous databases

GenomeRNAii79363.
PROiQ9BU20.

Gene expression databases

BgeeiENSG00000132881.
CleanExiHS_C1orf89.
ExpressionAtlasiQ9BU20. baseline and differential.
GenevisibleiQ9BU20. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSG1_HUMAN
AccessioniPrimary (citable) accession number: Q9BU20
Secondary accession number(s): Q5TEV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.