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Q9BTZ2

- DHRS4_HUMAN

UniProt

Q9BTZ2 - DHRS4_HUMAN

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Protein

Dehydrogenase/reductase SDR family member 4

Gene

DHRS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691SubstrateBy similarity
Active sitei182 – 1821Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 6025NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. 3-keto sterol reductase activity Source: UniProtKB
  2. alcohol dehydrogenase [NAD(P)+] activity Source: UniProtKB
  3. carbonyl reductase (NADPH) activity Source: UniProtKB
  4. oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB
  5. receptor binding Source: UniProtKB

GO - Biological processi

  1. alcohol metabolic process Source: UniProtKB
  2. cellular ketone metabolic process Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB
  4. protein tetramerization Source: UniProtKB
  5. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NRDR
Short name:
humNRDR
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
SCAD-SRL
Short-chain dehydrogenase/reductase family member 4
Gene namesi
Name:DHRS4
ORF Names:UNQ851/PRO1800
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:16985. DHRS4.

Subcellular locationi

Peroxisome 1 Publication
Note: Isoform 1 is peroxisomal, while isoform 4 is not.
Isoform 7 : Nucleus 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. intracellular membrane-bounded organelle Source: HPA
  3. mitochondrion Source: UniProtKB
  4. nuclear membrane Source: HPA
  5. nucleus Source: UniProtKB
  6. peroxisomal membrane Source: UniProtKB
  7. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395792.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Dehydrogenase/reductase SDR family member 4PRO_0000054647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921N6-acetyllysine; alternateBy similarity
Modified residuei92 – 921N6-succinyllysine; alternateBy similarity
Modified residuei105 – 1051N6-acetyllysineBy similarity
Modified residuei216 – 2161N6-acetyllysine; alternateBy similarity
Modified residuei216 – 2161N6-succinyllysine; alternateBy similarity
Modified residuei227 – 2271N6-succinyllysineBy similarity
Modified residuei234 – 2341N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BTZ2.
PaxDbiQ9BTZ2.
PRIDEiQ9BTZ2.

PTM databases

PhosphoSiteiQ9BTZ2.

Expressioni

Tissue specificityi

Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Gene expression databases

BgeeiQ9BTZ2.
ExpressionAtlasiQ9BTZ2. baseline.
GenevestigatoriQ9BTZ2.

Organism-specific databases

HPAiHPA023972.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi116107. 14 interactions.
IntActiQ9BTZ2. 2 interactions.

Structurei

Secondary structure

1
278
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni29 – 324
Beta strandi34 – 396
Helixi43 – 5412
Beta strandi58 – 647
Helixi66 – 7813
Beta strandi83 – 875
Helixi93 – 10715
Beta strandi112 – 1154
Turni126 – 1283
Helixi131 – 14111
Helixi143 – 15816
Beta strandi162 – 1676
Helixi170 – 1723
Helixi180 – 20021
Helixi201 – 2033
Beta strandi205 – 2128
Helixi221 – 2233
Helixi227 – 23711
Helixi245 – 2484
Helixi249 – 2557
Helixi258 – 2603
Beta strandi267 – 2715

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O4RX-ray1.70A/B/C/D19-278[»]
ProteinModelPortaliQ9BTZ2.
SMRiQ9BTZ2. Positions 25-278.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BTZ2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi276 – 2783Microbody targeting signal

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105779.
InParanoidiQ9BTZ2.
KOiK11147.
OMAiIMDVTEE.
OrthoDBiEOG73Z2VD.
PhylomeDBiQ9BTZ2.
TreeFamiTF315405.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR029511. DHRS4-like.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PANTHERiPTHR24322:SF198. PTHR24322:SF198. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BTZ2-1) [UniParc]FASTAAdd to Basket

Also known as: SDR-SRL3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR
60 70 80 90 100
RLAQDGAHVV VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV
110 120 130 140 150
ATAVKLHGGI DILVSNAAVN PFFGSIMDVT EEVWDKTLDI NVKAPALMTK
160 170 180 190 200
AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS PYNVSKTALL GLTKTLAIEL
210 220 230 240 250
APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR RLGEPEDCAG
260 270
IVSFLCSEDA SYITGETVVV GGGTPSRL
Length:278
Mass (Da):29,537
Last modified:October 5, 2010 - v3
Checksum:i3B06A229E1BBE47B
GO
Isoform 2 (identifier: Q9BTZ2-2) [UniParc]FASTAAdd to Basket

Also known as: SDR-SRL1

The sequence of this isoform differs from the canonical sequence as follows:
     137-222: Missing.

Show »
Length:192
Mass (Da):20,540
Checksum:i8DA10FF50043F472
GO
Isoform 3 (identifier: Q9BTZ2-3) [UniParc]FASTAAdd to Basket

Also known as: SDR-SRL2

The sequence of this isoform differs from the canonical sequence as follows:
     103-222: Missing.

Show »
Length:158
Mass (Da):16,885
Checksum:iDBE966DBD30D0A3E
GO
Isoform 4 (identifier: Q9BTZ2-4) [UniParc]FASTAAdd to Basket

Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.

Show »
Length:244
Mass (Da):25,882
Checksum:i25DC4A701E3B76FF
GO
Isoform 5 (identifier: Q9BTZ2-5) [UniParc]FASTAAdd to Basket

Also known as: NRDRB2

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.
     178-222: Missing.

Note: Contains a phosphoserine at position 140.

Show »
Length:199
Mass (Da):21,036
Checksum:iE6015FD7DA879EA4
GO
Isoform 6 (identifier: Q9BTZ2-6) [UniParc]FASTAAdd to Basket

Also known as: DHRS4L2, NRDRA1

The sequence of this isoform differs from the canonical sequence as follows:
     19-221: Missing.

Show »
Length:75
Mass (Da):8,288
Checksum:iA3C9C3CF43B80FA0
GO
Isoform 7 (identifier: Q9BTZ2-7) [UniParc]FASTAAdd to Basket

Also known as: NRDRA2

The sequence of this isoform differs from the canonical sequence as follows:
     137-188: TLDINVKAPA...FSPYNVSKTA → RRLSGDRVFH...LCWHRVFPVL
     189-278: Missing.

Note: Mainly localized in the nucleus.

Show »
Length:188
Mass (Da):20,345
Checksum:i23BD8B69B345AEE8
GO
Isoform 8 (identifier: Q9BTZ2-8) [UniParc]FASTAAdd to Basket

Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     103-136: Missing.

Note: Enhanced dicarbonyl reductase activity. high expression in liver.

Show »
Length:226
Mass (Da):23,917
Checksum:iED701E06FA126565
GO

Sequence cautioni

The sequence AAD02292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAL61824.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB18775.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG37057.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → A in BAA91953. (PubMed:14702039)Curated
Sequence conflicti50 – 501R → W in ABC61321. (PubMed:17230527)Curated
Sequence conflicti89 – 891H → M in AAQ13444. 1 PublicationCurated
Sequence conflicti102 – 1021T → M in AAD02292. (PubMed:10333503)Curated
Sequence conflicti126 – 1261I → L in AAD02292. (PubMed:10333503)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311A → T.
Corresponds to variant rs1043442 [ dbSNP | Ensembl ].
VAR_057272
Natural varianti202 – 2021P → S.
Corresponds to variant rs1043650 [ dbSNP | Ensembl ].
VAR_061846

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 8. CuratedVSP_044947Add
BLAST
Alternative sequencei19 – 221203Missing in isoform 6. 1 PublicationVSP_031435Add
BLAST
Alternative sequencei103 – 222120Missing in isoform 3. 1 PublicationVSP_008585Add
BLAST
Alternative sequencei103 – 13634Missing in isoform 4, isoform 5 and isoform 8. 1 PublicationVSP_031436Add
BLAST
Alternative sequencei137 – 22286Missing in isoform 2. 2 PublicationsVSP_008586Add
BLAST
Alternative sequencei137 – 18852TLDIN…VSKTA → RRLSGDRVFHSSLQSISSLD GQGKRGKHERNPADKKVRRA RGLCWHRVFPVL in isoform 7. 1 PublicationVSP_031437Add
BLAST
Alternative sequencei178 – 22245Missing in isoform 5. 1 PublicationVSP_031438Add
BLAST
Alternative sequencei189 – 27890Missing in isoform 7. 1 PublicationVSP_031439Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044127 mRNA. Translation: AAD02292.1. Different initiation.
AB045131 mRNA. Translation: BAB18775.1. Different initiation.
AY071856 mRNA. Translation: AAL61824.2. Different initiation.
AF064256 mRNA. Translation: AAQ13444.1.
AY616182 mRNA. Translation: AAT70757.1.
DQ344810 mRNA. Translation: ABD75823.1.
AY943857 mRNA. Translation: AAX49568.1.
DQ325464 mRNA. Translation: ABC61320.1.
DQ338571 mRNA. Translation: ABC61321.1.
AK001870 mRNA. Translation: BAA91953.1.
AK314448 mRNA. Translation: BAG37057.1. Different initiation.
AY358638 mRNA. Translation: AAQ89001.1.
AL136419 Genomic DNA. No translation available.
BC003019 mRNA. Translation: AAH03019.1.
CCDSiCCDS61408.1. [Q9BTZ2-7]
CCDS61409.1. [Q9BTZ2-2]
CCDS61410.1. [Q9BTZ2-4]
CCDS61411.1. [Q9BTZ2-5]
CCDS61412.1. [Q9BTZ2-3]
CCDS9605.1. [Q9BTZ2-1]
RefSeqiNP_001269916.1. NM_001282987.1. [Q9BTZ2-7]
NP_001269917.1. NM_001282988.1. [Q9BTZ2-4]
NP_001269918.1. NM_001282989.1. [Q9BTZ2-2]
NP_001269919.1. NM_001282990.1. [Q9BTZ2-5]
NP_001269920.1. NM_001282991.1. [Q9BTZ2-3]
NP_066284.2. NM_021004.3. [Q9BTZ2-1]
UniGeneiHs.528385.
Hs.743442.

Genome annotation databases

EnsembliENST00000313250; ENSP00000326219; ENSG00000157326. [Q9BTZ2-1]
ENST00000397074; ENSP00000380264; ENSG00000157326. [Q9BTZ2-3]
ENST00000397075; ENSP00000380265; ENSG00000157326. [Q9BTZ2-2]
ENST00000558263; ENSP00000453367; ENSG00000157326. [Q9BTZ2-7]
ENST00000558581; ENSP00000452645; ENSG00000157326. [Q9BTZ2-4]
ENST00000559632; ENSP00000453983; ENSG00000157326. [Q9BTZ2-5]
GeneIDi10901.
KEGGihsa:10901.
UCSCiuc001wla.3. human. [Q9BTZ2-1]
uc001wlb.3. human. [Q9BTZ2-4]
uc001wld.4. human. [Q9BTZ2-7]
uc001wle.4. human. [Q9BTZ2-2]
uc010akz.3. human. [Q9BTZ2-5]

Polymorphism databases

DMDMi308153604.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044127 mRNA. Translation: AAD02292.1 . Different initiation.
AB045131 mRNA. Translation: BAB18775.1 . Different initiation.
AY071856 mRNA. Translation: AAL61824.2 . Different initiation.
AF064256 mRNA. Translation: AAQ13444.1 .
AY616182 mRNA. Translation: AAT70757.1 .
DQ344810 mRNA. Translation: ABD75823.1 .
AY943857 mRNA. Translation: AAX49568.1 .
DQ325464 mRNA. Translation: ABC61320.1 .
DQ338571 mRNA. Translation: ABC61321.1 .
AK001870 mRNA. Translation: BAA91953.1 .
AK314448 mRNA. Translation: BAG37057.1 . Different initiation.
AY358638 mRNA. Translation: AAQ89001.1 .
AL136419 Genomic DNA. No translation available.
BC003019 mRNA. Translation: AAH03019.1 .
CCDSi CCDS61408.1. [Q9BTZ2-7 ]
CCDS61409.1. [Q9BTZ2-2 ]
CCDS61410.1. [Q9BTZ2-4 ]
CCDS61411.1. [Q9BTZ2-5 ]
CCDS61412.1. [Q9BTZ2-3 ]
CCDS9605.1. [Q9BTZ2-1 ]
RefSeqi NP_001269916.1. NM_001282987.1. [Q9BTZ2-7 ]
NP_001269917.1. NM_001282988.1. [Q9BTZ2-4 ]
NP_001269918.1. NM_001282989.1. [Q9BTZ2-2 ]
NP_001269919.1. NM_001282990.1. [Q9BTZ2-5 ]
NP_001269920.1. NM_001282991.1. [Q9BTZ2-3 ]
NP_066284.2. NM_021004.3. [Q9BTZ2-1 ]
UniGenei Hs.528385.
Hs.743442.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3O4R X-ray 1.70 A/B/C/D 19-278 [» ]
ProteinModelPortali Q9BTZ2.
SMRi Q9BTZ2. Positions 25-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116107. 14 interactions.
IntActi Q9BTZ2. 2 interactions.

Chemistry

DrugBanki DB00162. Vitamin A.

PTM databases

PhosphoSitei Q9BTZ2.

Polymorphism databases

DMDMi 308153604.

Proteomic databases

MaxQBi Q9BTZ2.
PaxDbi Q9BTZ2.
PRIDEi Q9BTZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313250 ; ENSP00000326219 ; ENSG00000157326 . [Q9BTZ2-1 ]
ENST00000397074 ; ENSP00000380264 ; ENSG00000157326 . [Q9BTZ2-3 ]
ENST00000397075 ; ENSP00000380265 ; ENSG00000157326 . [Q9BTZ2-2 ]
ENST00000558263 ; ENSP00000453367 ; ENSG00000157326 . [Q9BTZ2-7 ]
ENST00000558581 ; ENSP00000452645 ; ENSG00000157326 . [Q9BTZ2-4 ]
ENST00000559632 ; ENSP00000453983 ; ENSG00000157326 . [Q9BTZ2-5 ]
GeneIDi 10901.
KEGGi hsa:10901.
UCSCi uc001wla.3. human. [Q9BTZ2-1 ]
uc001wlb.3. human. [Q9BTZ2-4 ]
uc001wld.4. human. [Q9BTZ2-7 ]
uc001wle.4. human. [Q9BTZ2-2 ]
uc010akz.3. human. [Q9BTZ2-5 ]

Organism-specific databases

CTDi 10901.
GeneCardsi GC14P024422.
HGNCi HGNC:16985. DHRS4.
HPAi HPA023972.
MIMi 611596. gene.
neXtProti NX_Q9BTZ2.
PharmGKBi PA128395792.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118868.
HOVERGENi HBG105779.
InParanoidi Q9BTZ2.
KOi K11147.
OMAi IMDVTEE.
OrthoDBi EOG73Z2VD.
PhylomeDBi Q9BTZ2.
TreeFami TF315405.

Miscellaneous databases

EvolutionaryTracei Q9BTZ2.
GeneWikii DHRS4.
GenomeRNAii 10901.
NextBioi 35497048.
PROi Q9BTZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9BTZ2.
ExpressionAtlasi Q9BTZ2. baseline.
Genevestigatori Q9BTZ2.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR029511. DHRS4-like.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
PANTHERi PTHR24322:SF198. PTHR24322:SF198. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase."
    Fransen M., Van Veldhoven P.P., Subramani S.
    Biochem. J. 340:561-568(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION.
  2. "cDNA cloning and characterization of peroxisomal short-chain dehydrogenase / reductase that reduces all-trans retinal to retinol."
    Furukawa A., Ohnishi T., Huang D., Araki N., Ichikawa Y.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics."
    Du J., Huang D.-Y., Liu G.-F., Wang G.-L., Xu X.-L., Wang B., Zhu L.
    Yi Chuan Xue Bao 31:661-667(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. "Molecular cloning and expression analysis of a novel human cDNA encoding a protein homologous to human Hep27 protein."
    Tu Q., Yu L., Bi A., Li N., He W., Zhao S.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "A minor misassignment error inside segmental duplication (MMEISD) of DHRS4 gene in human genome sequence."
    Li Y.F., Liu G.-F., Song X.-H., Yang Y.M., Zhong J.C., Du K., Zhu W., Huang D.-Y.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
  6. "cDNA cloning of a short isoform of human neuroblastoma NADP(H)-dependent retinol dehydrogenase/reductase and analysis of its characteristics."
    Li Y.F., Liu G.-F., Song X.-H., Du K., Huang D.-Y.
    Ai Bian Ji Bian Tu Bian 17:321-326(2005)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  7. "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma."
    Song X.-H., Liang B., Liu G.-F., Li R., Xie J.-P., Du K., Huang D.-Y.
    Int. J. Cancer 120:1618-1626(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [MRNA] OF 40-278 (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 4), TISSUE SPECIFICITY (ISOFORM 4).
    Tissue: Cervix carcinoma and Neuroblastoma.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Skeletal muscle.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 (ISOFORM 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil."
    Yan Y., Song X., Liu G., Su Z., Du Y., Sui X., Chang X., Huang D.
    Cell. Physiol. Biochem. 30:1371-1382(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 8).
  15. "Identification of a novel isoform of DHRS4 protein with a nuclear localization signal."
    Su Z., Li R., Song X., Liu G., Li Y., Chang X., Li C., Huang D.
    Gene 494:161-167(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION (ISOFORM 7).

Entry informationi

Entry nameiDHRS4_HUMAN
AccessioniPrimary (citable) accession number: Q9BTZ2
Secondary accession number(s): B2RB10
, B7WNS9, D3YTB8, E2QRL8, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9H3N5, Q9NV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3