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Q9BTZ2

- DHRS4_HUMAN

UniProt

Q9BTZ2 - DHRS4_HUMAN

Protein

Dehydrogenase/reductase SDR family member 4

Gene

DHRS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones By similarity.By similarity

    Catalytic activityi

    R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691SubstrateBy similarity
    Active sitei182 – 1821Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 6025NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. 3-keto sterol reductase activity Source: UniProtKB
    2. alcohol dehydrogenase [NAD(P)+] activity Source: UniProtKB
    3. carbonyl reductase (NADPH) activity Source: UniProtKB
    4. oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB
    5. receptor binding Source: UniProtKB

    GO - Biological processi

    1. alcohol metabolic process Source: UniProtKB
    2. cellular ketone metabolic process Source: UniProtKB
    3. oxidation-reduction process Source: UniProtKB
    4. protein tetramerization Source: UniProtKB
    5. steroid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
    Alternative name(s):
    NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
    Short name:
    CR
    Short name:
    PHCR
    NADPH-dependent retinol dehydrogenase/reductase
    Short name:
    NRDR
    Short name:
    humNRDR
    Peroxisomal short-chain alcohol dehydrogenase
    Short name:
    PSCD
    SCAD-SRL
    Short-chain dehydrogenase/reductase family member 4
    Gene namesi
    Name:DHRS4
    ORF Names:UNQ851/PRO1800
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:16985. DHRS4.

    Subcellular locationi

    Peroxisome 1 Publication
    Note: Isoform 1 is peroxisomal, while isoform 4 is not.
    Isoform 7 : Nucleus 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. intracellular membrane-bounded organelle Source: HPA
    3. mitochondrion Source: UniProtKB
    4. nuclear membrane Source: HPA
    5. nucleus Source: UniProtKB
    6. peroxisomal membrane Source: UniProtKB
    7. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus, Peroxisome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128395792.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Dehydrogenase/reductase SDR family member 4PRO_0000054647Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei92 – 921N6-acetyllysine; alternateBy similarity
    Modified residuei92 – 921N6-succinyllysine; alternateBy similarity
    Modified residuei105 – 1051N6-acetyllysineBy similarity
    Modified residuei216 – 2161N6-acetyllysine; alternateBy similarity
    Modified residuei216 – 2161N6-succinyllysine; alternateBy similarity
    Modified residuei227 – 2271N6-succinyllysineBy similarity
    Modified residuei234 – 2341N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BTZ2.
    PaxDbiQ9BTZ2.
    PRIDEiQ9BTZ2.

    PTM databases

    PhosphoSiteiQ9BTZ2.

    Expressioni

    Tissue specificityi

    Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

    Gene expression databases

    BgeeiQ9BTZ2.
    GenevestigatoriQ9BTZ2.

    Organism-specific databases

    HPAiHPA023972.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi116107. 4 interactions.
    IntActiQ9BTZ2. 2 interactions.

    Structurei

    Secondary structure

    1
    278
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni29 – 324
    Beta strandi34 – 396
    Helixi43 – 5412
    Beta strandi58 – 647
    Helixi66 – 7813
    Beta strandi83 – 875
    Helixi93 – 10715
    Beta strandi112 – 1154
    Turni126 – 1283
    Helixi131 – 14111
    Helixi143 – 15816
    Beta strandi162 – 1676
    Helixi170 – 1723
    Helixi180 – 20021
    Helixi201 – 2033
    Beta strandi205 – 2128
    Helixi221 – 2233
    Helixi227 – 23711
    Helixi245 – 2484
    Helixi249 – 2557
    Helixi258 – 2603
    Beta strandi267 – 2715

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3O4RX-ray1.70A/B/C/D19-278[»]
    ProteinModelPortaliQ9BTZ2.
    SMRiQ9BTZ2. Positions 25-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BTZ2.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi276 – 2783Microbody targeting signal

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG105779.
    InParanoidiQ9BTZ2.
    KOiK11147.
    OMAiIMDVTEE.
    OrthoDBiEOG73Z2VD.
    PhylomeDBiQ9BTZ2.
    TreeFamiTF315405.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR029511. DHRS4-like.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PANTHERiPTHR24322:SF198. PTHR24322:SF198. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BTZ2-1) [UniParc]FASTAAdd to Basket

    Also known as: SDR-SRL3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR    50
    RLAQDGAHVV VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV 100
    ATAVKLHGGI DILVSNAAVN PFFGSIMDVT EEVWDKTLDI NVKAPALMTK 150
    AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS PYNVSKTALL GLTKTLAIEL 200
    APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR RLGEPEDCAG 250
    IVSFLCSEDA SYITGETVVV GGGTPSRL 278
    Length:278
    Mass (Da):29,537
    Last modified:October 5, 2010 - v3
    Checksum:i3B06A229E1BBE47B
    GO
    Isoform 2 (identifier: Q9BTZ2-2) [UniParc]FASTAAdd to Basket

    Also known as: SDR-SRL1

    The sequence of this isoform differs from the canonical sequence as follows:
         137-222: Missing.

    Show »
    Length:192
    Mass (Da):20,540
    Checksum:i8DA10FF50043F472
    GO
    Isoform 3 (identifier: Q9BTZ2-3) [UniParc]FASTAAdd to Basket

    Also known as: SDR-SRL2

    The sequence of this isoform differs from the canonical sequence as follows:
         103-222: Missing.

    Show »
    Length:158
    Mass (Da):16,885
    Checksum:iDBE966DBD30D0A3E
    GO
    Isoform 4 (identifier: Q9BTZ2-4) [UniParc]FASTAAdd to Basket

    Also known as: NRDRB1

    The sequence of this isoform differs from the canonical sequence as follows:
         103-136: Missing.

    Show »
    Length:244
    Mass (Da):25,882
    Checksum:i25DC4A701E3B76FF
    GO
    Isoform 5 (identifier: Q9BTZ2-5) [UniParc]FASTAAdd to Basket

    Also known as: NRDRB2

    The sequence of this isoform differs from the canonical sequence as follows:
         103-136: Missing.
         178-222: Missing.

    Note: Contains a phosphoserine at position 140.

    Show »
    Length:199
    Mass (Da):21,036
    Checksum:iE6015FD7DA879EA4
    GO
    Isoform 6 (identifier: Q9BTZ2-6) [UniParc]FASTAAdd to Basket

    Also known as: DHRS4L2, NRDRA1

    The sequence of this isoform differs from the canonical sequence as follows:
         19-221: Missing.

    Show »
    Length:75
    Mass (Da):8,288
    Checksum:iA3C9C3CF43B80FA0
    GO
    Isoform 7 (identifier: Q9BTZ2-7) [UniParc]FASTAAdd to Basket

    Also known as: NRDRA2

    The sequence of this isoform differs from the canonical sequence as follows:
         137-188: TLDINVKAPA...FSPYNVSKTA → RRLSGDRVFH...LCWHRVFPVL
         189-278: Missing.

    Note: Mainly localized in the nucleus.

    Show »
    Length:188
    Mass (Da):20,345
    Checksum:i23BD8B69B345AEE8
    GO
    Isoform 8 (identifier: Q9BTZ2-8) [UniParc]FASTAAdd to Basket

    Also known as: NRDRB1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: Missing.
         103-136: Missing.

    Note: Enhanced dicarbonyl reductase activity. high expression in liver.

    Show »
    Length:226
    Mass (Da):23,917
    Checksum:iED701E06FA126565
    GO

    Sequence cautioni

    The sequence AAD02292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAL61824.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB18775.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG37057.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371V → A in BAA91953. (PubMed:14702039)Curated
    Sequence conflicti50 – 501R → W in ABC61321. (PubMed:17230527)Curated
    Sequence conflicti89 – 891H → M in AAQ13444. 1 PublicationCurated
    Sequence conflicti102 – 1021T → M in AAD02292. (PubMed:10333503)Curated
    Sequence conflicti126 – 1261I → L in AAD02292. (PubMed:10333503)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311A → T.
    Corresponds to variant rs1043442 [ dbSNP | Ensembl ].
    VAR_057272
    Natural varianti202 – 2021P → S.
    Corresponds to variant rs1043650 [ dbSNP | Ensembl ].
    VAR_061846

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818Missing in isoform 8. CuratedVSP_044947Add
    BLAST
    Alternative sequencei19 – 221203Missing in isoform 6. 1 PublicationVSP_031435Add
    BLAST
    Alternative sequencei103 – 222120Missing in isoform 3. 1 PublicationVSP_008585Add
    BLAST
    Alternative sequencei103 – 13634Missing in isoform 4, isoform 5 and isoform 8. 1 PublicationVSP_031436Add
    BLAST
    Alternative sequencei137 – 22286Missing in isoform 2. 2 PublicationsVSP_008586Add
    BLAST
    Alternative sequencei137 – 18852TLDIN…VSKTA → RRLSGDRVFHSSLQSISSLD GQGKRGKHERNPADKKVRRA RGLCWHRVFPVL in isoform 7. 1 PublicationVSP_031437Add
    BLAST
    Alternative sequencei178 – 22245Missing in isoform 5. 1 PublicationVSP_031438Add
    BLAST
    Alternative sequencei189 – 27890Missing in isoform 7. 1 PublicationVSP_031439Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044127 mRNA. Translation: AAD02292.1. Different initiation.
    AB045131 mRNA. Translation: BAB18775.1. Different initiation.
    AY071856 mRNA. Translation: AAL61824.2. Different initiation.
    AF064256 mRNA. Translation: AAQ13444.1.
    AY616182 mRNA. Translation: AAT70757.1.
    DQ344810 mRNA. Translation: ABD75823.1.
    AY943857 mRNA. Translation: AAX49568.1.
    DQ325464 mRNA. Translation: ABC61320.1.
    DQ338571 mRNA. Translation: ABC61321.1.
    AK001870 mRNA. Translation: BAA91953.1.
    AK314448 mRNA. Translation: BAG37057.1. Different initiation.
    AY358638 mRNA. Translation: AAQ89001.1.
    AL136419 Genomic DNA. No translation available.
    BC003019 mRNA. Translation: AAH03019.1.
    CCDSiCCDS61408.1. [Q9BTZ2-7]
    CCDS61409.1. [Q9BTZ2-2]
    CCDS61410.1. [Q9BTZ2-4]
    CCDS61411.1. [Q9BTZ2-5]
    CCDS61412.1. [Q9BTZ2-3]
    CCDS9605.1. [Q9BTZ2-1]
    RefSeqiNP_001269916.1. NM_001282987.1. [Q9BTZ2-7]
    NP_001269917.1. NM_001282988.1. [Q9BTZ2-4]
    NP_001269918.1. NM_001282989.1. [Q9BTZ2-2]
    NP_001269919.1. NM_001282990.1. [Q9BTZ2-5]
    NP_001269920.1. NM_001282991.1. [Q9BTZ2-3]
    NP_066284.2. NM_021004.3. [Q9BTZ2-1]
    UniGeneiHs.528385.
    Hs.743442.

    Genome annotation databases

    EnsembliENST00000313250; ENSP00000326219; ENSG00000157326. [Q9BTZ2-1]
    ENST00000397074; ENSP00000380264; ENSG00000157326. [Q9BTZ2-3]
    ENST00000397075; ENSP00000380265; ENSG00000157326. [Q9BTZ2-2]
    ENST00000558263; ENSP00000453367; ENSG00000157326. [Q9BTZ2-7]
    ENST00000558581; ENSP00000452645; ENSG00000157326. [Q9BTZ2-4]
    ENST00000559632; ENSP00000453983; ENSG00000157326. [Q9BTZ2-5]
    GeneIDi10901.
    KEGGihsa:10901.
    UCSCiuc001wla.3. human. [Q9BTZ2-1]
    uc001wlb.3. human. [Q9BTZ2-4]
    uc001wld.4. human. [Q9BTZ2-7]
    uc001wle.4. human. [Q9BTZ2-2]
    uc010akz.3. human. [Q9BTZ2-5]

    Polymorphism databases

    DMDMi308153604.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044127 mRNA. Translation: AAD02292.1 . Different initiation.
    AB045131 mRNA. Translation: BAB18775.1 . Different initiation.
    AY071856 mRNA. Translation: AAL61824.2 . Different initiation.
    AF064256 mRNA. Translation: AAQ13444.1 .
    AY616182 mRNA. Translation: AAT70757.1 .
    DQ344810 mRNA. Translation: ABD75823.1 .
    AY943857 mRNA. Translation: AAX49568.1 .
    DQ325464 mRNA. Translation: ABC61320.1 .
    DQ338571 mRNA. Translation: ABC61321.1 .
    AK001870 mRNA. Translation: BAA91953.1 .
    AK314448 mRNA. Translation: BAG37057.1 . Different initiation.
    AY358638 mRNA. Translation: AAQ89001.1 .
    AL136419 Genomic DNA. No translation available.
    BC003019 mRNA. Translation: AAH03019.1 .
    CCDSi CCDS61408.1. [Q9BTZ2-7 ]
    CCDS61409.1. [Q9BTZ2-2 ]
    CCDS61410.1. [Q9BTZ2-4 ]
    CCDS61411.1. [Q9BTZ2-5 ]
    CCDS61412.1. [Q9BTZ2-3 ]
    CCDS9605.1. [Q9BTZ2-1 ]
    RefSeqi NP_001269916.1. NM_001282987.1. [Q9BTZ2-7 ]
    NP_001269917.1. NM_001282988.1. [Q9BTZ2-4 ]
    NP_001269918.1. NM_001282989.1. [Q9BTZ2-2 ]
    NP_001269919.1. NM_001282990.1. [Q9BTZ2-5 ]
    NP_001269920.1. NM_001282991.1. [Q9BTZ2-3 ]
    NP_066284.2. NM_021004.3. [Q9BTZ2-1 ]
    UniGenei Hs.528385.
    Hs.743442.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3O4R X-ray 1.70 A/B/C/D 19-278 [» ]
    ProteinModelPortali Q9BTZ2.
    SMRi Q9BTZ2. Positions 25-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116107. 4 interactions.
    IntActi Q9BTZ2. 2 interactions.

    Chemistry

    DrugBanki DB00162. Vitamin A.

    PTM databases

    PhosphoSitei Q9BTZ2.

    Polymorphism databases

    DMDMi 308153604.

    Proteomic databases

    MaxQBi Q9BTZ2.
    PaxDbi Q9BTZ2.
    PRIDEi Q9BTZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313250 ; ENSP00000326219 ; ENSG00000157326 . [Q9BTZ2-1 ]
    ENST00000397074 ; ENSP00000380264 ; ENSG00000157326 . [Q9BTZ2-3 ]
    ENST00000397075 ; ENSP00000380265 ; ENSG00000157326 . [Q9BTZ2-2 ]
    ENST00000558263 ; ENSP00000453367 ; ENSG00000157326 . [Q9BTZ2-7 ]
    ENST00000558581 ; ENSP00000452645 ; ENSG00000157326 . [Q9BTZ2-4 ]
    ENST00000559632 ; ENSP00000453983 ; ENSG00000157326 . [Q9BTZ2-5 ]
    GeneIDi 10901.
    KEGGi hsa:10901.
    UCSCi uc001wla.3. human. [Q9BTZ2-1 ]
    uc001wlb.3. human. [Q9BTZ2-4 ]
    uc001wld.4. human. [Q9BTZ2-7 ]
    uc001wle.4. human. [Q9BTZ2-2 ]
    uc010akz.3. human. [Q9BTZ2-5 ]

    Organism-specific databases

    CTDi 10901.
    GeneCardsi GC14P024422.
    HGNCi HGNC:16985. DHRS4.
    HPAi HPA023972.
    MIMi 611596. gene.
    neXtProti NX_Q9BTZ2.
    PharmGKBi PA128395792.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG105779.
    InParanoidi Q9BTZ2.
    KOi K11147.
    OMAi IMDVTEE.
    OrthoDBi EOG73Z2VD.
    PhylomeDBi Q9BTZ2.
    TreeFami TF315405.

    Miscellaneous databases

    EvolutionaryTracei Q9BTZ2.
    GeneWikii DHRS4.
    GenomeRNAii 10901.
    NextBioi 35497048.
    PROi Q9BTZ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BTZ2.
    Genevestigatori Q9BTZ2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR029511. DHRS4-like.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    PANTHERi PTHR24322:SF198. PTHR24322:SF198. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase."
      Fransen M., Van Veldhoven P.P., Subramani S.
      Biochem. J. 340:561-568(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION.
    2. "cDNA cloning and characterization of peroxisomal short-chain dehydrogenase / reductase that reduces all-trans retinal to retinol."
      Furukawa A., Ohnishi T., Huang D., Araki N., Ichikawa Y.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    3. "cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics."
      Du J., Huang D.-Y., Liu G.-F., Wang G.-L., Xu X.-L., Wang B., Zhu L.
      Yi Chuan Xue Bao 31:661-667(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Liver.
    4. "Molecular cloning and expression analysis of a novel human cDNA encoding a protein homologous to human Hep27 protein."
      Tu Q., Yu L., Bi A., Li N., He W., Zhao S.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "A minor misassignment error inside segmental duplication (MMEISD) of DHRS4 gene in human genome sequence."
      Li Y.F., Liu G.-F., Song X.-H., Yang Y.M., Zhong J.C., Du K., Zhu W., Huang D.-Y.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
    6. "cDNA cloning of a short isoform of human neuroblastoma NADP(H)-dependent retinol dehydrogenase/reductase and analysis of its characteristics."
      Li Y.F., Liu G.-F., Song X.-H., Du K., Huang D.-Y.
      Ai Bian Ji Bian Tu Bian 17:321-326(2005)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    7. "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma."
      Song X.-H., Liang B., Liu G.-F., Li R., Xie J.-P., Du K., Huang D.-Y.
      Int. J. Cancer 120:1618-1626(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [MRNA] OF 40-278 (ISOFORM 5), SUBCELLULAR LOCATION (ISOFORM 4), TISSUE SPECIFICITY (ISOFORM 4).
      Tissue: Cervix carcinoma and Neuroblastoma.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skeletal muscle.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 (ISOFORM 5), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil."
      Yan Y., Song X., Liu G., Su Z., Du Y., Sui X., Chang X., Huang D.
      Cell. Physiol. Biochem. 30:1371-1382(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 8).
    15. "Identification of a novel isoform of DHRS4 protein with a nuclear localization signal."
      Su Z., Li R., Song X., Liu G., Li Y., Chang X., Li C., Huang D.
      Gene 494:161-167(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION (ISOFORM 7).

    Entry informationi

    Entry nameiDHRS4_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTZ2
    Secondary accession number(s): B2RB10
    , B7WNS9, D3YTB8, E2QRL8, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9H3N5, Q9NV08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3