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Protein

Dehydrogenase/reductase SDR family member 4

Gene

DHRS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169SubstrateBy similarity1
Active sitei182Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 60NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • 3-keto sterol reductase activity Source: UniProtKB
  • alcohol dehydrogenase [NAD(P)+] activity Source: UniProtKB
  • carbonyl reductase (NADPH) activity Source: UniProtKB
  • NADP-retinol dehydrogenase activity Source: Reactome
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • alcohol metabolic process Source: UniProtKB
  • cellular ketone metabolic process Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • protein tetramerization Source: UniProtKB
  • steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:HS08202-MONOMER.
BRENDAi1.1.1.300. 2681.
ReactomeiR-HSA-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NRDR
Short name:
humNRDR
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
SCAD-SRL
Short chain dehydrogenase/reductase family 25C member 2
Short-chain dehydrogenase/reductase family member 4
Gene namesi
Name:DHRS4
Synonyms:SDR25C2
ORF Names:UNQ851/PRO1800
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:16985. DHRS4.

Subcellular locationi

  • Peroxisome 1 Publication

  • Note: Isoform 1 is peroxisomal, while isoform 4 is not.
Isoform 7 :

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrion Source: UniProtKB
  • nuclear membrane Source: HPA
  • nucleus Source: UniProtKB
  • peroxisomal membrane Source: UniProtKB
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10901.
OpenTargetsiENSG00000157326.
PharmGKBiPA128395792.

Chemistry databases

DrugBankiDB00162. Vitamin A.

Polymorphism and mutation databases

BioMutaiDHRS4.
DMDMi308153604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546471 – 278Dehydrogenase/reductase SDR family member 4Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92N6-acetyllysine; alternateBy similarity1
Modified residuei92N6-succinyllysine; alternateBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei216N6-acetyllysine; alternateBy similarity1
Modified residuei216N6-succinyllysine; alternateBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei227N6-succinyllysineBy similarity1
Modified residuei234N6-succinyllysineBy similarity1
Isoform 5 (identifier: Q9BTZ2-5)
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BTZ2.
MaxQBiQ9BTZ2.
PaxDbiQ9BTZ2.
PeptideAtlasiQ9BTZ2.
PRIDEiQ9BTZ2.

PTM databases

iPTMnetiQ9BTZ2.
PhosphoSitePlusiQ9BTZ2.

Expressioni

Tissue specificityi

Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Gene expression databases

BgeeiENSG00000157326.
ExpressionAtlasiQ9BTZ2. baseline and differential.
GenevisibleiQ9BTZ2. HS.

Organism-specific databases

HPAiHPA023972.

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116107. 49 interactors.
IntActiQ9BTZ2. 2 interactors.
STRINGi9606.ENSP00000326219.

Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni29 – 32Combined sources4
Beta strandi34 – 39Combined sources6
Helixi43 – 54Combined sources12
Beta strandi58 – 64Combined sources7
Helixi66 – 78Combined sources13
Beta strandi83 – 87Combined sources5
Helixi93 – 107Combined sources15
Beta strandi112 – 115Combined sources4
Turni126 – 128Combined sources3
Helixi131 – 141Combined sources11
Helixi143 – 158Combined sources16
Beta strandi162 – 167Combined sources6
Helixi170 – 172Combined sources3
Helixi180 – 200Combined sources21
Helixi201 – 203Combined sources3
Beta strandi205 – 212Combined sources8
Helixi221 – 223Combined sources3
Helixi227 – 237Combined sources11
Helixi245 – 248Combined sources4
Helixi249 – 255Combined sources7
Helixi258 – 260Combined sources3
Beta strandi267 – 271Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4RX-ray1.70A/B/C/D19-278[»]
ProteinModelPortaliQ9BTZ2.
SMRiQ9BTZ2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BTZ2.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi276 – 278Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105779.
InParanoidiQ9BTZ2.
KOiK11147.
OMAiLWMDKAR.
OrthoDBiEOG091G0G3R.
PhylomeDBiQ9BTZ2.
TreeFamiTF315405.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTZ2-1) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR
60 70 80 90 100
RLAQDGAHVV VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV
110 120 130 140 150
ATAVKLHGGI DILVSNAAVN PFFGSIMDVT EEVWDKTLDI NVKAPALMTK
160 170 180 190 200
AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS PYNVSKTALL GLTKTLAIEL
210 220 230 240 250
APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR RLGEPEDCAG
260 270
IVSFLCSEDA SYITGETVVV GGGTPSRL
Length:278
Mass (Da):29,537
Last modified:October 5, 2010 - v3
Checksum:i3B06A229E1BBE47B
GO
Isoform 2 (identifier: Q9BTZ2-2) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL1

The sequence of this isoform differs from the canonical sequence as follows:
     137-222: Missing.

Show »
Length:192
Mass (Da):20,540
Checksum:i8DA10FF50043F472
GO
Isoform 3 (identifier: Q9BTZ2-3) [UniParc]FASTAAdd to basket
Also known as: SDR-SRL2

The sequence of this isoform differs from the canonical sequence as follows:
     103-222: Missing.

Show »
Length:158
Mass (Da):16,885
Checksum:iDBE966DBD30D0A3E
GO
Isoform 4 (identifier: Q9BTZ2-4) [UniParc]FASTAAdd to basket
Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.

Show »
Length:244
Mass (Da):25,882
Checksum:i25DC4A701E3B76FF
GO
Isoform 5 (identifier: Q9BTZ2-5) [UniParc]FASTAAdd to basket
Also known as: NRDRB2

The sequence of this isoform differs from the canonical sequence as follows:
     103-136: Missing.
     178-222: Missing.

Show »
Length:199
Mass (Da):21,036
Checksum:iE6015FD7DA879EA4
GO
Isoform 6 (identifier: Q9BTZ2-6) [UniParc]FASTAAdd to basket
Also known as: DHRS4L2, NRDRA1

The sequence of this isoform differs from the canonical sequence as follows:
     19-221: Missing.

Show »
Length:75
Mass (Da):8,288
Checksum:iA3C9C3CF43B80FA0
GO
Isoform 7 (identifier: Q9BTZ2-7) [UniParc]FASTAAdd to basket
Also known as: NRDRA2

The sequence of this isoform differs from the canonical sequence as follows:
     137-188: TLDINVKAPA...FSPYNVSKTA → RRLSGDRVFH...LCWHRVFPVL
     189-278: Missing.

Note: Mainly localized in the nucleus.
Show »
Length:188
Mass (Da):20,345
Checksum:i23BD8B69B345AEE8
GO
Isoform 8 (identifier: Q9BTZ2-8) [UniParc]FASTAAdd to basket
Also known as: NRDRB1

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     103-136: Missing.

Note: Enhanced dicarbonyl reductase activity. high expression in liver.
Show »
Length:226
Mass (Da):23,917
Checksum:iED701E06FA126565
GO

Sequence cautioni

The sequence AAD02292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL61824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB18775 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37V → A in BAA91953 (PubMed:14702039).Curated1
Sequence conflicti50R → W in ABC61321 (PubMed:17230527).Curated1
Sequence conflicti89H → M in AAQ13444 (Ref. 4) Curated1
Sequence conflicti102T → M in AAD02292 (PubMed:10333503).Curated1
Sequence conflicti126I → L in AAD02292 (PubMed:10333503).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05727231A → T.Corresponds to variant rs1043442dbSNPEnsembl.1
Natural variantiVAR_061846202P → S.Corresponds to variant rs1043650dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449471 – 18Missing in isoform 8. CuratedAdd BLAST18
Alternative sequenceiVSP_03143519 – 221Missing in isoform 6. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_008585103 – 222Missing in isoform 3. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_031436103 – 136Missing in isoform 4, isoform 5 and isoform 8. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_008586137 – 222Missing in isoform 2. 2 PublicationsAdd BLAST86
Alternative sequenceiVSP_031437137 – 188TLDIN…VSKTA → RRLSGDRVFHSSLQSISSLD GQGKRGKHERNPADKKVRRA RGLCWHRVFPVL in isoform 7. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_031438178 – 222Missing in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_031439189 – 278Missing in isoform 7. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044127 mRNA. Translation: AAD02292.1. Different initiation.
AB045131 mRNA. Translation: BAB18775.1. Different initiation.
AY071856 mRNA. Translation: AAL61824.2. Different initiation.
AF064256 mRNA. Translation: AAQ13444.1.
AY616182 mRNA. Translation: AAT70757.1.
DQ344810 mRNA. Translation: ABD75823.1.
AY943857 mRNA. Translation: AAX49568.1.
DQ325464 mRNA. Translation: ABC61320.1.
DQ338571 mRNA. Translation: ABC61321.1.
AK001870 mRNA. Translation: BAA91953.1.
AK314448 mRNA. Translation: BAG37057.1. Different initiation.
AY358638 mRNA. Translation: AAQ89001.1.
AL136419 Genomic DNA. No translation available.
BC003019 mRNA. Translation: AAH03019.1.
CCDSiCCDS61408.1. [Q9BTZ2-7]
CCDS61409.1. [Q9BTZ2-2]
CCDS61410.1. [Q9BTZ2-4]
CCDS61411.1. [Q9BTZ2-5]
CCDS61412.1. [Q9BTZ2-3]
CCDS9605.1. [Q9BTZ2-1]
RefSeqiNP_001269916.1. NM_001282987.1. [Q9BTZ2-7]
NP_001269917.1. NM_001282988.1. [Q9BTZ2-4]
NP_001269918.1. NM_001282989.1. [Q9BTZ2-2]
NP_001269919.1. NM_001282990.1. [Q9BTZ2-5]
NP_001269920.1. NM_001282991.1. [Q9BTZ2-3]
NP_066284.2. NM_021004.3. [Q9BTZ2-1]
UniGeneiHs.528385.
Hs.743442.

Genome annotation databases

EnsembliENST00000313250; ENSP00000326219; ENSG00000157326. [Q9BTZ2-1]
ENST00000397074; ENSP00000380264; ENSG00000157326. [Q9BTZ2-3]
ENST00000397075; ENSP00000380265; ENSG00000157326. [Q9BTZ2-2]
ENST00000558263; ENSP00000453367; ENSG00000157326. [Q9BTZ2-7]
ENST00000558581; ENSP00000452645; ENSG00000157326. [Q9BTZ2-4]
ENST00000559632; ENSP00000453983; ENSG00000157326. [Q9BTZ2-5]
GeneIDi10901.
KEGGihsa:10901.
UCSCiuc001wla.5. human. [Q9BTZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044127 mRNA. Translation: AAD02292.1. Different initiation.
AB045131 mRNA. Translation: BAB18775.1. Different initiation.
AY071856 mRNA. Translation: AAL61824.2. Different initiation.
AF064256 mRNA. Translation: AAQ13444.1.
AY616182 mRNA. Translation: AAT70757.1.
DQ344810 mRNA. Translation: ABD75823.1.
AY943857 mRNA. Translation: AAX49568.1.
DQ325464 mRNA. Translation: ABC61320.1.
DQ338571 mRNA. Translation: ABC61321.1.
AK001870 mRNA. Translation: BAA91953.1.
AK314448 mRNA. Translation: BAG37057.1. Different initiation.
AY358638 mRNA. Translation: AAQ89001.1.
AL136419 Genomic DNA. No translation available.
BC003019 mRNA. Translation: AAH03019.1.
CCDSiCCDS61408.1. [Q9BTZ2-7]
CCDS61409.1. [Q9BTZ2-2]
CCDS61410.1. [Q9BTZ2-4]
CCDS61411.1. [Q9BTZ2-5]
CCDS61412.1. [Q9BTZ2-3]
CCDS9605.1. [Q9BTZ2-1]
RefSeqiNP_001269916.1. NM_001282987.1. [Q9BTZ2-7]
NP_001269917.1. NM_001282988.1. [Q9BTZ2-4]
NP_001269918.1. NM_001282989.1. [Q9BTZ2-2]
NP_001269919.1. NM_001282990.1. [Q9BTZ2-5]
NP_001269920.1. NM_001282991.1. [Q9BTZ2-3]
NP_066284.2. NM_021004.3. [Q9BTZ2-1]
UniGeneiHs.528385.
Hs.743442.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4RX-ray1.70A/B/C/D19-278[»]
ProteinModelPortaliQ9BTZ2.
SMRiQ9BTZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116107. 49 interactors.
IntActiQ9BTZ2. 2 interactors.
STRINGi9606.ENSP00000326219.

Chemistry databases

DrugBankiDB00162. Vitamin A.

PTM databases

iPTMnetiQ9BTZ2.
PhosphoSitePlusiQ9BTZ2.

Polymorphism and mutation databases

BioMutaiDHRS4.
DMDMi308153604.

Proteomic databases

EPDiQ9BTZ2.
MaxQBiQ9BTZ2.
PaxDbiQ9BTZ2.
PeptideAtlasiQ9BTZ2.
PRIDEiQ9BTZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313250; ENSP00000326219; ENSG00000157326. [Q9BTZ2-1]
ENST00000397074; ENSP00000380264; ENSG00000157326. [Q9BTZ2-3]
ENST00000397075; ENSP00000380265; ENSG00000157326. [Q9BTZ2-2]
ENST00000558263; ENSP00000453367; ENSG00000157326. [Q9BTZ2-7]
ENST00000558581; ENSP00000452645; ENSG00000157326. [Q9BTZ2-4]
ENST00000559632; ENSP00000453983; ENSG00000157326. [Q9BTZ2-5]
GeneIDi10901.
KEGGihsa:10901.
UCSCiuc001wla.5. human. [Q9BTZ2-1]

Organism-specific databases

CTDi10901.
DisGeNETi10901.
GeneCardsiDHRS4.
HGNCiHGNC:16985. DHRS4.
HPAiHPA023972.
MIMi611596. gene.
neXtProtiNX_Q9BTZ2.
OpenTargetsiENSG00000157326.
PharmGKBiPA128395792.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105779.
InParanoidiQ9BTZ2.
KOiK11147.
OMAiLWMDKAR.
OrthoDBiEOG091G0G3R.
PhylomeDBiQ9BTZ2.
TreeFamiTF315405.

Enzyme and pathway databases

BioCyciZFISH:HS08202-MONOMER.
BRENDAi1.1.1.300. 2681.
ReactomeiR-HSA-5365859. RA biosynthesis pathway.

Miscellaneous databases

EvolutionaryTraceiQ9BTZ2.
GeneWikiiDHRS4.
GenomeRNAii10901.
PROiQ9BTZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157326.
ExpressionAtlasiQ9BTZ2. baseline and differential.
GenevisibleiQ9BTZ2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS4_HUMAN
AccessioniPrimary (citable) accession number: Q9BTZ2
Secondary accession number(s): B2RB10
, B7WNS9, D3YTB8, E2QRL8, O95162, Q20CR0, Q2LC19, Q2LE81, Q58IU4, Q6E0Y1, Q6UWU3, Q71UQ6, Q8TD03, Q9H3N5, Q9NV08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.