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Q9BTY7

- HGH1_HUMAN

UniProt

Q9BTY7 - HGH1_HUMAN

Protein

Protein HGH1 homolog

Gene

HGH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein HGH1 homolog
    Gene namesi
    Name:HGH1
    Synonyms:C8orf30A, C8orf30B, FAM203A, FAM203B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:24161. HGH1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672348.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 390389Protein HGH1 homologPRO_0000273318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine2 Publications
    Modified residuei388 – 3881Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BTY7.
    PaxDbiQ9BTY7.
    PRIDEiQ9BTY7.

    PTM databases

    PhosphoSiteiQ9BTY7.

    Expressioni

    Gene expression databases

    BgeeiQ9BTY7.
    CleanExiHS_C8orf30A.
    GenevestigatoriQ9BTY7.

    Organism-specific databases

    HPAiHPA042470.

    Interactioni

    Protein-protein interaction databases

    BioGridi119398. 17 interactions.
    IntActiQ9BTY7. 1 interaction.
    MINTiMINT-1379236.
    STRINGi9606.ENSP00000321320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTY7.
    SMRiQ9BTY7. Positions 34-239, 285-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 151148Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HGH1 family.Curated

    Phylogenomic databases

    eggNOGiNOG304399.
    HOVERGENiHBG060474.
    InParanoidiQ9BTY7.
    OMAiHYLAPIF.
    OrthoDBiEOG7D59NH.
    PhylomeDBiQ9BTY7.
    TreeFamiTF313296.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR007206. FAM203_C.
    IPR007205. FAM203_N.
    [Graphical view]
    PfamiPF04063. DUF383. 1 hit.
    PF04064. DUF384. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BTY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG    50
    CGPGRALLAG QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA 100
    ADPGLPARLM GRALDPQWPW AEEAAAALAN LSREPAPCAA LMAALAAAEP 150
    ADSGLERLVR ALCTPGYNAR APLHYLAPLL SNLSQRPAAR AFLLDPDRCV 200
    VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP EVDILPFLLL 250
    PLAGPEDFSE EEMERLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA 300
    PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL 350
    LEVQVPEDVE QQLQQLDCRE QEQLERELAP EPWVERATPT 390
    Length:390
    Mass (Da):42,129
    Last modified:June 1, 2001 - v1
    Checksum:iDC3AA4E92EA3761D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104592 Genomic DNA. No translation available.
    BC003035 mRNA. Translation: AAH03035.1.
    BC009915 mRNA. Translation: AAH09915.1.
    CCDSiCCDS6417.1.
    RefSeqiNP_057542.2. NM_016458.3.
    UniGeneiHs.300224.

    Genome annotation databases

    EnsembliENST00000347708; ENSP00000321320; ENSG00000235173.
    GeneIDi51236.
    KEGGihsa:51236.
    UCSCiuc010mfs.3. human.

    Polymorphism databases

    DMDMi74733161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104592 Genomic DNA. No translation available.
    BC003035 mRNA. Translation: AAH03035.1 .
    BC009915 mRNA. Translation: AAH09915.1 .
    CCDSi CCDS6417.1.
    RefSeqi NP_057542.2. NM_016458.3.
    UniGenei Hs.300224.

    3D structure databases

    ProteinModelPortali Q9BTY7.
    SMRi Q9BTY7. Positions 34-239, 285-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119398. 17 interactions.
    IntActi Q9BTY7. 1 interaction.
    MINTi MINT-1379236.
    STRINGi 9606.ENSP00000321320.

    PTM databases

    PhosphoSitei Q9BTY7.

    Polymorphism databases

    DMDMi 74733161.

    Proteomic databases

    MaxQBi Q9BTY7.
    PaxDbi Q9BTY7.
    PRIDEi Q9BTY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347708 ; ENSP00000321320 ; ENSG00000235173 .
    GeneIDi 51236.
    KEGGi hsa:51236.
    UCSCi uc010mfs.3. human.

    Organism-specific databases

    CTDi 51236.
    GeneCardsi GC08P145194.
    HGNCi HGNC:24161. HGH1.
    HPAi HPA042470.
    neXtProti NX_Q9BTY7.
    PharmGKBi PA142672348.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304399.
    HOVERGENi HBG060474.
    InParanoidi Q9BTY7.
    OMAi HYLAPIF.
    OrthoDBi EOG7D59NH.
    PhylomeDBi Q9BTY7.
    TreeFami TF313296.

    Miscellaneous databases

    GenomeRNAii 51236.
    NextBioi 54349.
    PROi Q9BTY7.

    Gene expression databases

    Bgeei Q9BTY7.
    CleanExi HS_C8orf30A.
    Genevestigatori Q9BTY7.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR007206. FAM203_C.
    IPR007205. FAM203_N.
    [Graphical view ]
    Pfami PF04063. DUF383. 1 hit.
    PF04064. DUF384. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. Bienvenut W.V.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-24 AND 56-79, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHGH1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTY7
    Secondary accession number(s): P0CB43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3