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Q9BTY7

- HGH1_HUMAN

UniProt

Q9BTY7 - HGH1_HUMAN

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Protein

Protein HGH1 homolog

Gene

HGH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HGH1 homolog
Gene namesi
Name:HGH1
Synonyms:C8orf30A, C8orf30B, FAM203A, FAM203B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:24161. HGH1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 390389Protein HGH1 homologPRO_0000273318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine2 Publications
Modified residuei388 – 3881Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BTY7.
PaxDbiQ9BTY7.
PRIDEiQ9BTY7.

PTM databases

PhosphoSiteiQ9BTY7.

Expressioni

Gene expression databases

BgeeiQ9BTY7.
CleanExiHS_C8orf30A.
ExpressionAtlasiQ9BTY7. baseline.
GenevestigatoriQ9BTY7.

Organism-specific databases

HPAiHPA042470.

Interactioni

Protein-protein interaction databases

BioGridi119398. 17 interactions.
608507. 4 interactions.
IntActiQ9BTY7. 1 interaction.
MINTiMINT-1379236.
STRINGi9606.ENSP00000321320.

Structurei

3D structure databases

ProteinModelPortaliQ9BTY7.
SMRiQ9BTY7. Positions 34-239, 285-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 151148Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the HGH1 family.Curated

Phylogenomic databases

eggNOGiNOG304399.
GeneTreeiENSGT00390000016546.
HOVERGENiHBG060474.
InParanoidiQ9BTY7.
OMAiHYLAPIF.
OrthoDBiEOG7D59NH.
PhylomeDBiQ9BTY7.
TreeFamiTF313296.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR007206. FAM203_C.
IPR007205. FAM203_N.
[Graphical view]
PfamiPF04063. DUF383. 1 hit.
PF04064. DUF384. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BTY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG
60 70 80 90 100
CGPGRALLAG QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA
110 120 130 140 150
ADPGLPARLM GRALDPQWPW AEEAAAALAN LSREPAPCAA LMAALAAAEP
160 170 180 190 200
ADSGLERLVR ALCTPGYNAR APLHYLAPLL SNLSQRPAAR AFLLDPDRCV
210 220 230 240 250
VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP EVDILPFLLL
260 270 280 290 300
PLAGPEDFSE EEMERLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA
310 320 330 340 350
PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL
360 370 380 390
LEVQVPEDVE QQLQQLDCRE QEQLERELAP EPWVERATPT
Length:390
Mass (Da):42,129
Last modified:June 1, 2001 - v1
Checksum:iDC3AA4E92EA3761D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104592 Genomic DNA. No translation available.
BC003035 mRNA. Translation: AAH03035.1.
BC009915 mRNA. Translation: AAH09915.1.
CCDSiCCDS6417.1.
RefSeqiNP_057542.2. NM_016458.3.
UniGeneiHs.300224.

Genome annotation databases

EnsembliENST00000347708; ENSP00000321320; ENSG00000235173.
GeneIDi51236.
KEGGihsa:51236.
UCSCiuc010mfs.3. human.

Polymorphism databases

DMDMi74733161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104592 Genomic DNA. No translation available.
BC003035 mRNA. Translation: AAH03035.1 .
BC009915 mRNA. Translation: AAH09915.1 .
CCDSi CCDS6417.1.
RefSeqi NP_057542.2. NM_016458.3.
UniGenei Hs.300224.

3D structure databases

ProteinModelPortali Q9BTY7.
SMRi Q9BTY7. Positions 34-239, 285-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119398. 17 interactions.
608507. 4 interactions.
IntActi Q9BTY7. 1 interaction.
MINTi MINT-1379236.
STRINGi 9606.ENSP00000321320.

PTM databases

PhosphoSitei Q9BTY7.

Polymorphism databases

DMDMi 74733161.

Proteomic databases

MaxQBi Q9BTY7.
PaxDbi Q9BTY7.
PRIDEi Q9BTY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347708 ; ENSP00000321320 ; ENSG00000235173 .
GeneIDi 51236.
KEGGi hsa:51236.
UCSCi uc010mfs.3. human.

Organism-specific databases

CTDi 51236.
GeneCardsi GC08P145194.
HGNCi HGNC:24161. HGH1.
HPAi HPA042470.
neXtProti NX_Q9BTY7.
PharmGKBi PA142672348.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304399.
GeneTreei ENSGT00390000016546.
HOVERGENi HBG060474.
InParanoidi Q9BTY7.
OMAi HYLAPIF.
OrthoDBi EOG7D59NH.
PhylomeDBi Q9BTY7.
TreeFami TF313296.

Miscellaneous databases

GenomeRNAii 51236.
NextBioi 126033.
PROi Q9BTY7.

Gene expression databases

Bgeei Q9BTY7.
CleanExi HS_C8orf30A.
ExpressionAtlasi Q9BTY7. baseline.
Genevestigatori Q9BTY7.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR007206. FAM203_C.
IPR007205. FAM203_N.
[Graphical view ]
Pfami PF04063. DUF383. 1 hit.
PF04064. DUF384. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Bienvenut W.V.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-24 AND 56-79, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHGH1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTY7
Secondary accession number(s): P0CB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3