Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plasma alpha-L-fucosidase

Gene

FUCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei294May be important for catalysisPROSITE-ProRule annotation1

GO - Molecular functioni

  • alpha-L-fucosidase activity Source: UniProtKB

GO - Biological processi

  • fucose metabolic process Source: UniProtKB
  • glycoside catabolic process Source: UniProtKB
  • regulation of entry of bacterium into host cell Source: UniProtKB
  • response to bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS00070-MONOMER.
BRENDAi3.2.1.51. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SABIO-RKQ9BTY2.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase 2
Short name:
Alpha-L-fucosidase 2
Gene namesi
Name:FUCA2
ORF Names:PSEC0151, UNQ227/PRO260
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4008. FUCA2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2519.
MIMi136820. gene+phenotype.
OpenTargetsiENSG00000001036.
PharmGKBiPA28424.

Chemistry databases

ChEMBLiCHEMBL2271.

Polymorphism and mutation databases

BioMutaiFUCA2.
DMDMi254763296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001031229 – 467Plasma alpha-L-fucosidaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)1 Publication1
Modified residuei301Phosphoserine; by FAM20C1 Publication1
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BTY2.
MaxQBiQ9BTY2.
PaxDbiQ9BTY2.
PeptideAtlasiQ9BTY2.
PRIDEiQ9BTY2.

PTM databases

iPTMnetiQ9BTY2.
PhosphoSitePlusiQ9BTY2.

Expressioni

Gene expression databases

BgeeiENSG00000001036.
CleanExiHS_FUCA2.
ExpressionAtlasiQ9BTY2. baseline and differential.
GenevisibleiQ9BTY2. HS.

Organism-specific databases

HPAiHPA031659.
HPA031660.
HPA031661.

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-9050116,EBI-10172134

Protein-protein interaction databases

BioGridi108795. 12 interactors.
IntActiQ9BTY2. 2 interactors.
MINTiMINT-7034547.
STRINGi9606.ENSP00000002165.

Chemistry databases

BindingDBiQ9BTY2.

Structurei

3D structure databases

ProteinModelPortaliQ9BTY2.
SMRiQ9BTY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000146429.
HOVERGENiHBG002155.
InParanoidiQ9BTY2.
KOiK01206.
OMAiWNWNAID.
OrthoDBiEOG091G085V.
PhylomeDBiQ9BTY2.
TreeFamiTF313034.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF
60 70 80 90 100
DQAKFGIFIH WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY
110 120 130 140 150
EDFGPLFTAK FFNANQWADI FQASGAKYIV LTSKHHEGFT LWGSEYSWNW
160 170 180 190 200
NAIDEGPKRD IVKELEVAIR NRTDLRFGLY YSLFEWFHPL FLEDESSSFH
210 220 230 240 250
KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS TGFLAWLYNE
260 270 280 290 300
SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL
310 320 330 340 350
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE
360 370 380 390 400
ERLRQMGSWL KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL
410 420 430 440 450
KWPTSGQLFL GHPKAILGAT EVKLLGHGQP LNWISLEQNG IMVELPQLTI
460
HQMPCKWGWA LALTNVI
Length:467
Mass (Da):54,067
Last modified:July 28, 2009 - v2
Checksum:iA42AA6B369A3AC39
GO
Isoform 2 (identifier: Q9BTY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-165: GFTLWGSEYSWNWNAIDEGPKRDIVKEL → ATCRDSFMWRKSFDEYWAHTRWHHFCSF
     166-467: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):19,835
Checksum:i0427DB86CD215820
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti400L → P in BAC11633 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055822233A → E.Corresponds to variant rs11155297dbSNPEnsembl.1
Natural variantiVAR_022444356M → V.3 PublicationsCorresponds to variant rs3762002dbSNPEnsembl.1
Natural variantiVAR_022445371H → Y.3 PublicationsCorresponds to variant rs3762001dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057004138 – 165GFTLW…IVKEL → ATCRDSFMWRKSFDEYWAHT RWHHFCSF in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_057005166 – 467Missing in isoform 2. 1 PublicationAdd BLAST302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358551 mRNA. Translation: AAQ88915.1.
AK296485 mRNA. Translation: BAG59123.1.
AK075458 mRNA. Translation: BAC11633.1.
AL031320 Genomic DNA. Translation: CAB53746.1.
BC003060 mRNA. Translation: AAH03060.1.
BC051268 mRNA. Translation: AAH51268.1.
CCDSiCCDS5200.1. [Q9BTY2-1]
RefSeqiNP_114409.2. NM_032020.4. [Q9BTY2-1]
UniGeneiHs.17680.

Genome annotation databases

EnsembliENST00000002165; ENSP00000002165; ENSG00000001036. [Q9BTY2-1]
GeneIDi2519.
KEGGihsa:2519.
UCSCiuc003qjm.4. human. [Q9BTY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358551 mRNA. Translation: AAQ88915.1.
AK296485 mRNA. Translation: BAG59123.1.
AK075458 mRNA. Translation: BAC11633.1.
AL031320 Genomic DNA. Translation: CAB53746.1.
BC003060 mRNA. Translation: AAH03060.1.
BC051268 mRNA. Translation: AAH51268.1.
CCDSiCCDS5200.1. [Q9BTY2-1]
RefSeqiNP_114409.2. NM_032020.4. [Q9BTY2-1]
UniGeneiHs.17680.

3D structure databases

ProteinModelPortaliQ9BTY2.
SMRiQ9BTY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108795. 12 interactors.
IntActiQ9BTY2. 2 interactors.
MINTiMINT-7034547.
STRINGi9606.ENSP00000002165.

Chemistry databases

BindingDBiQ9BTY2.
ChEMBLiCHEMBL2271.

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

PTM databases

iPTMnetiQ9BTY2.
PhosphoSitePlusiQ9BTY2.

Polymorphism and mutation databases

BioMutaiFUCA2.
DMDMi254763296.

Proteomic databases

EPDiQ9BTY2.
MaxQBiQ9BTY2.
PaxDbiQ9BTY2.
PeptideAtlasiQ9BTY2.
PRIDEiQ9BTY2.

Protocols and materials databases

DNASUi2519.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000002165; ENSP00000002165; ENSG00000001036. [Q9BTY2-1]
GeneIDi2519.
KEGGihsa:2519.
UCSCiuc003qjm.4. human. [Q9BTY2-1]

Organism-specific databases

CTDi2519.
DisGeNETi2519.
GeneCardsiFUCA2.
H-InvDBHIX0006268.
HGNCiHGNC:4008. FUCA2.
HPAiHPA031659.
HPA031660.
HPA031661.
MIMi136820. gene+phenotype.
neXtProtiNX_Q9BTY2.
OpenTargetsiENSG00000001036.
PharmGKBiPA28424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
GeneTreeiENSGT00440000035378.
HOGENOMiHOG000146429.
HOVERGENiHBG002155.
InParanoidiQ9BTY2.
KOiK01206.
OMAiWNWNAID.
OrthoDBiEOG091G085V.
PhylomeDBiQ9BTY2.
TreeFamiTF313034.

Enzyme and pathway databases

BioCyciZFISH:HS00070-MONOMER.
BRENDAi3.2.1.51. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
SABIO-RKQ9BTY2.

Miscellaneous databases

ChiTaRSiFUCA2. human.
GeneWikiiFUCA2.
GenomeRNAii2519.
PROiQ9BTY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000001036.
CleanExiHS_FUCA2.
ExpressionAtlasiQ9BTY2. baseline and differential.
GenevisibleiQ9BTY2. HS.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTY2
Secondary accession number(s): E9PEB6
, Q7Z6V1, Q7Z6Y2, Q8NBK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.