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Protein

Alpha-tocopherol transfer protein-like

Gene

TTPAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a protein that binds a hydrophobic ligand.Curated

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-tocopherol transfer protein-like
Gene namesi
Name:TTPAL
Synonyms:C20orf121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124120.10.
HGNCiHGNC:16114. TTPAL.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124120.
PharmGKBiPA162407296.

Polymorphism and mutation databases

BioMutaiTTPAL.
DMDMi76803550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107721 – 342Alpha-tocopherol transfer protein-likeAdd BLAST342

Proteomic databases

EPDiQ9BTX7.
MaxQBiQ9BTX7.
PaxDbiQ9BTX7.
PeptideAtlasiQ9BTX7.
PRIDEiQ9BTX7.

PTM databases

iPTMnetiQ9BTX7.
PhosphoSitePlusiQ9BTX7.

Expressioni

Gene expression databases

BgeeiENSG00000124120.
CleanExiHS_TTPAL.
ExpressionAtlasiQ9BTX7. baseline and differential.
GenevisibleiQ9BTX7. HS.

Organism-specific databases

HPAiHPA046957.
HPA066532.

Interactioni

Protein-protein interaction databases

BioGridi122598. 9 interactors.
IntActiQ9BTX7. 1 interactor.
STRINGi9606.ENSP00000262605.

Structurei

3D structure databases

ProteinModelPortaliQ9BTX7.
SMRiQ9BTX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 282CRAL-TRIOPROSITE-ProRule annotationAdd BLAST166

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000293421.
HOVERGENiHBG101124.
InParanoidiQ9BTX7.
OMAiHKQVTLD.
OrthoDBiEOG091G0KN0.
PhylomeDBiQ9BTX7.

Family and domain databases

CDDicd00170. SEC14. 1 hit.
Gene3Di3.40.525.10. 1 hit.
InterProiView protein in InterPro
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR036865. CRAL-TRIO_dom_sf.
IPR011074. CRAL/TRIO_N_dom.
IPR036273. CRAL/TRIO_N_dom_sf.
PfamiView protein in Pfam
PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PRINTSiPR00180. CRETINALDHBP.
SMARTiView protein in SMART
SM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiView protein in PROSITE
PS50191. CRAL_TRIO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BTX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEESDSLRT SPSVASLSEN ELPPPPEPPG YVCSLTEDLV TKAREELQEK
60 70 80 90 100
PEWRLRDVQA LRDMVRKEYP NLSTSLDDAF LLRFLRARKF DYDRALQLLV
110 120 130 140 150
NYHSCRRSWP EVFNNLKPSA LKDVLASGFL TVLPHTDPRG CHVVCIRPDR
160 170 180 190 200
WIPSNYPITE NIRAIYLTLE KLIQSEETQV NGIVILADYK GVSLSKASHF
210 220 230 240 250
GPFIAKKVIG ILQDGFPIRI KAVHVVNEPR IFKGIFAIIK PFLKEKIANR
260 270 280 290 300
FFLHGSDLNS LHTNLPRSIL PKEYGGTAGE LDTATWNAVL LASEDDFVKE
310 320 330 340
FCQPVPACDS ILGQTLLPEG LTSDAQCDDS LRAVKSQLYS CY
Length:342
Mass (Da):38,515
Last modified:September 27, 2005 - v2
Checksum:i56EDFC06C6D85CFB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061788278A → G. Corresponds to variant dbSNP:rs59069332Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132772, Z97053 Genomic DNA. Translation: CAI18861.1.
Z97053, AL132772 Genomic DNA. Translation: CAI19686.1.
CH471077 Genomic DNA. Translation: EAW75918.1.
CH471077 Genomic DNA. Translation: EAW75919.1.
BC003071 mRNA. Translation: AAH03071.2.
CCDSiCCDS13332.2.
RefSeqiNP_001034288.1. NM_001039199.2.
NP_077307.2. NM_024331.4.
XP_011527345.1. XM_011529043.2.
XP_011527346.1. XM_011529044.2.
UniGeneiHs.283869.

Genome annotation databases

EnsembliENST00000262605; ENSP00000262605; ENSG00000124120.
ENST00000372904; ENSP00000361995; ENSG00000124120.
GeneIDi79183.
KEGGihsa:79183.
UCSCiuc002xmc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTPAL_HUMAN
AccessioniPrimary (citable) accession number: Q9BTX7
Secondary accession number(s): E1P5X3
, Q5QPC1, Q9H1G2, Q9NQG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: September 27, 2005
Last modified: October 25, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations