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Protein
Submitted name:

Proto-oncogene tyrosine-protein kinase receptor Ret

Gene

RET

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene tyrosine-protein kinase receptor RetImported
Submitted name:
RET proteinImported
Gene namesi
Name:RETImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9967. RET.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165731.
PharmGKBiPA34335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501014784129 – 458Sequence analysisAdd BLAST430

Expressioni

Gene expression databases

BgeeiENSG00000165731.
ExpressionAtlasiQ9BTX6. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 256CAInterPro annotationAdd BLAST84

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
KOiK05126.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
PfamiView protein in Pfam
PF00028. Cadherin. 1 hit.
SUPFAMiSSF49313. SSF49313. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BTX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL
60 70 80 90 100
LYVHALRDAP EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS
110 120 130 140 150
LDHSSWEKLS VRNRGFPLLT VYLKVFLSPT SLREGECQWP GCARVYFSFF
160 170 180 190 200
NTSFPACSSL KPRELCFPET RPSFRIRENR PPGTFHQFRL LPVQFLCPNI
210 220 230 240 250
SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV AVCTVHAGAR
260 270 280 290 300
EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD
310 320 330 340 350
ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT
360 370 380 390 400
VHDYRLVLNR NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV
410 420 430 440 450
SLHLPSTYSL SVSRRARRFA QIGKVCVENC LADLTGDAVS GRDEARSSGL

GSQKHPGS
Length:458
Mass (Da):51,243
Last modified:June 1, 2001 - v1
Checksum:i2FA93AE64271C414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010864 Genomic DNA. No translation available.
BC003072 mRNA. Translation: AAH03072.1.
RefSeqiNP_065681.1. NM_020630.4.
NP_066124.1. NM_020975.4.
UniGeneiHs.350321.

Genome annotation databases

EnsembliENST00000615310; ENSP00000480088; ENSG00000165731.
GeneIDi5979.
KEGGihsa:5979.
UCSCiuc057svw.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ9BTX6_HUMAN
AccessioniPrimary (citable) accession number: Q9BTX6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported