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Protein
Submitted name:

Proto-oncogene tyrosine-protein kinase receptor Ret

Gene

RET

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene tyrosine-protein kinase receptor RetImported
Submitted name:
RET proteinImported
Gene namesi
Name:RETImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9967. RET.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165731.
PharmGKBiPA34335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500878550429 – 458Sequence analysisAdd BLAST430

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 272CadherinInterPro annotationAdd BLAST105

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
KOiK05126.

Family and domain databases

Gene3Di2.60.40.60. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 1 hit.
PROSITEiPS50268. CADHERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL
60 70 80 90 100
LYVHALRDAP EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS
110 120 130 140 150
LDHSSWEKLS VRNRGFPLLT VYLKVFLSPT SLREGECQWP GCARVYFSFF
160 170 180 190 200
NTSFPACSSL KPRELCFPET RPSFRIRENR PPGTFHQFRL LPVQFLCPNI
210 220 230 240 250
SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV AVCTVHAGAR
260 270 280 290 300
EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD
310 320 330 340 350
ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT
360 370 380 390 400
VHDYRLVLNR NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV
410 420 430 440 450
SLHLPSTYSL SVSRRARRFA QIGKVCVENC LADLTGDAVS GRDEARSSGL

GSQKHPGS
Length:458
Mass (Da):51,243
Last modified:June 1, 2001 - v1
Checksum:i2FA93AE64271C414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010864 Genomic DNA. No translation available.
BC003072 mRNA. Translation: AAH03072.1.
RefSeqiNP_065681.1. NM_020630.4.
NP_066124.1. NM_020975.4.
UniGeneiHs.350321.

Genome annotation databases

EnsembliENST00000615310; ENSP00000480088; ENSG00000165731.
GeneIDi5979.
KEGGihsa:5979.
UCSCiuc057svw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010864 Genomic DNA. No translation available.
BC003072 mRNA. Translation: AAH03072.1.
RefSeqiNP_065681.1. NM_020630.4.
NP_066124.1. NM_020975.4.
UniGeneiHs.350321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347942.

Protocols and materials databases

DNASUi5979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615310; ENSP00000480088; ENSG00000165731.
GeneIDi5979.
KEGGihsa:5979.
UCSCiuc057svw.1. human.

Organism-specific databases

CTDi5979.
HGNCiHGNC:9967. RET.
OpenTargetsiENSG00000165731.
PharmGKBiPA34335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
KOiK05126.

Miscellaneous databases

ChiTaRSiRET. human.
GenomeRNAii5979.

Family and domain databases

Gene3Di2.60.40.60. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 1 hit.
PROSITEiPS50268. CADHERIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9BTX6_HUMAN
AccessioniPrimary (citable) accession number: Q9BTX6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.