Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9BTX3 (TM208_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 208
Gene names
Name:TMEM208
ORF Names:HSPC171
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.5.

Sequence similarities

Belongs to the TMEM208 family.

Sequence caution

The sequence AAF29134.1 differs from that shown. Reason: Frameshift at positions 88, 96 and 114.

Ontologies

Keywords
   Biological processAutophagy
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BTX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BTX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     101-173: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Transmembrane protein 208
PRO_0000325967

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane51 – 6818Helical; Potential
Transmembrane105 – 12925Helical; Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4

Natural variations

Alternative sequence101 – 17373Missing in isoform 2.
VSP_032505
Natural variant821D → Y. Ref.3
Corresponds to variant rs17851038 [ dbSNP | Ensembl ].
VAR_039958
Natural variant1021L → P.
Corresponds to variant rs11553801 [ dbSNP | Ensembl ].
VAR_053933

Experimental info

Sequence conflict901M → T in AAF29134. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F6AE0798B79967A6

FASTA17319,642
        10         20         30         40         50         60 
MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWLALGFS 

        70         80         90        100        110        120 
LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL 

       130        140        150        160        170 
YVWSFWLLAP GRALYLLWVN VLGPWFTADS GTPAPEHNEK RQRRQERRQM KRL 

« Hide

Isoform 2 [UniParc].

Checksum: 0EA9B83659BF0205
Show »

FASTA10011,039

References

« Hide 'large scale' references
[1]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Blood.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-82.
Tissue: Ovary, Skin and Uterus.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress."
Zhao Y., Hu J., Miao G., Qu L., Wang Z., Li G., Lv P., Ma D., Chen Y.
PLoS ONE 8:E64228-E64228(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF161519 mRNA. Translation: AAF29134.1. Frameshift.
CH471092 Genomic DNA. Translation: EAW83106.1.
CH471092 Genomic DNA. Translation: EAW83107.1.
BC003080 mRNA. Translation: AAH03080.1.
BC021109 mRNA. Translation: AAH21109.1.
BC013412 mRNA. Translation: AAH13412.1.
RefSeqNP_054906.2. NM_014187.3.
UniGeneHs.433203.

3D structure databases

ProteinModelPortalQ9BTX3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305892.

Protein family/group databases

TCDB9.B.26.1.1. the regulator of er stress and autophagy tmem208 (tmem208) family.

Polymorphism databases

DMDM74733157.

Proteomic databases

PaxDbQ9BTX3.
PRIDEQ9BTX3.

Protocols and materials databases

DNASU29100.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304800; ENSP00000305892; ENSG00000168701. [Q9BTX3-1]
ENST00000562235; ENSP00000457502; ENSG00000168701. [Q9BTX3-2]
GeneID29100.
KEGGhsa:29100.
UCSCuc002esi.2. human. [Q9BTX3-1]

Organism-specific databases

CTD29100.
GeneCardsGC16P067261.
H-InvDBHIX0013141.
HGNCHGNC:25015. TMEM208.
HPAHPA041868.
HPA041949.
neXtProtNX_Q9BTX3.
PharmGKBPA162406408.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283806.
HOGENOMHOG000230738.
HOVERGENHBG104605.
InParanoidQ9BTX3.
OMAIWSFWLL.
OrthoDBEOG7PCJJN.
PhylomeDBQ9BTX3.
TreeFamTF318118.

Gene expression databases

ArrayExpressQ9BTX3.
BgeeQ9BTX3.
CleanExHS_TMEM208.
GenevestigatorQ9BTX3.

Family and domain databases

InterProIPR008506. DUF788_TMEM208.
[Graphical view]
PANTHERPTHR13505. PTHR13505. 1 hit.
PfamPF05620. DUF788. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM208. human.
GenomeRNAi29100.
NextBio52134.
PROQ9BTX3.

Entry information

Entry nameTM208_HUMAN
AccessionPrimary (citable) accession number: Q9BTX3
Secondary accession number(s): Q05CT0, Q96D25, Q9NZZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: March 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM