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Q9BTX3

- TM208_HUMAN

UniProt

Q9BTX3 - TM208_HUMAN

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Protein

Transmembrane protein 208

Gene

TMEM208

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.1 Publication

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy

Protein family/group databases

TCDBi9.B.26.1.1. the regulator of er stress and autophagy tmem208 (tmem208) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 208
Gene namesi
Name:TMEM208
ORF Names:HSPC171
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25015. TMEM208.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 6818HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12925HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Transmembrane protein 208PRO_0000325967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BTX3.
PaxDbiQ9BTX3.
PRIDEiQ9BTX3.

Expressioni

Gene expression databases

BgeeiQ9BTX3.
CleanExiHS_TMEM208.
ExpressionAtlasiQ9BTX3. baseline and differential.
GenevestigatoriQ9BTX3.

Organism-specific databases

HPAiHPA041868.
HPA041949.

Interactioni

Protein-protein interaction databases

BioGridi118868. 1 interaction.
STRINGi9606.ENSP00000305892.

Structurei

3D structure databases

ProteinModelPortaliQ9BTX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM208 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283806.
GeneTreeiENSGT00390000008139.
HOGENOMiHOG000230738.
HOVERGENiHBG104605.
InParanoidiQ9BTX3.
OMAiIWSFWLL.
OrthoDBiEOG7PCJJN.
PhylomeDBiQ9BTX3.
TreeFamiTF318118.

Family and domain databases

InterProiIPR008506. DUF788_TMEM208.
[Graphical view]
PANTHERiPTHR13505. PTHR13505. 1 hit.
PfamiPF05620. DUF788. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BTX3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS
60 70 80 90 100
FWAWLALGFS LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE
110 120 130 140 150
HLKDVILLTA IVQVLSCFSL YVWSFWLLAP GRALYLLWVN VLGPWFTADS
160 170
GTPAPEHNEK RQRRQERRQM KRL
Length:173
Mass (Da):19,642
Last modified:June 1, 2001 - v1
Checksum:iF6AE0798B79967A6
GO
Isoform 2 (identifier: Q9BTX3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-173: Missing.

Show »
Length:100
Mass (Da):11,039
Checksum:i0EA9B83659BF0205
GO

Sequence cautioni

The sequence AAF29134.1 differs from that shown. Reason: Frameshift at positions 88, 96 and 114. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901M → T in AAF29134. (PubMed:11042152)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821D → Y.1 Publication
Corresponds to variant rs17851038 [ dbSNP | Ensembl ].
VAR_039958
Natural varianti102 – 1021L → P.
Corresponds to variant rs11553801 [ dbSNP | Ensembl ].
VAR_053933

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 17373Missing in isoform 2. 2 PublicationsVSP_032505Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161519 mRNA. Translation: AAF29134.1. Frameshift.
CH471092 Genomic DNA. Translation: EAW83106.1.
CH471092 Genomic DNA. Translation: EAW83107.1.
BC003080 mRNA. Translation: AAH03080.1.
BC021109 mRNA. Translation: AAH21109.1.
BC013412 mRNA. Translation: AAH13412.1.
CCDSiCCDS45511.1. [Q9BTX3-1]
RefSeqiNP_054906.2. NM_014187.3. [Q9BTX3-1]
UniGeneiHs.433203.

Genome annotation databases

EnsembliENST00000304800; ENSP00000305892; ENSG00000168701. [Q9BTX3-1]
ENST00000562235; ENSP00000457502; ENSG00000168701. [Q9BTX3-2]
GeneIDi29100.
KEGGihsa:29100.
UCSCiuc002esi.2. human. [Q9BTX3-1]

Polymorphism databases

DMDMi74733157.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161519 mRNA. Translation: AAF29134.1 . Frameshift.
CH471092 Genomic DNA. Translation: EAW83106.1 .
CH471092 Genomic DNA. Translation: EAW83107.1 .
BC003080 mRNA. Translation: AAH03080.1 .
BC021109 mRNA. Translation: AAH21109.1 .
BC013412 mRNA. Translation: AAH13412.1 .
CCDSi CCDS45511.1. [Q9BTX3-1 ]
RefSeqi NP_054906.2. NM_014187.3. [Q9BTX3-1 ]
UniGenei Hs.433203.

3D structure databases

ProteinModelPortali Q9BTX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118868. 1 interaction.
STRINGi 9606.ENSP00000305892.

Protein family/group databases

TCDBi 9.B.26.1.1. the regulator of er stress and autophagy tmem208 (tmem208) family.

Polymorphism databases

DMDMi 74733157.

Proteomic databases

MaxQBi Q9BTX3.
PaxDbi Q9BTX3.
PRIDEi Q9BTX3.

Protocols and materials databases

DNASUi 29100.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304800 ; ENSP00000305892 ; ENSG00000168701 . [Q9BTX3-1 ]
ENST00000562235 ; ENSP00000457502 ; ENSG00000168701 . [Q9BTX3-2 ]
GeneIDi 29100.
KEGGi hsa:29100.
UCSCi uc002esi.2. human. [Q9BTX3-1 ]

Organism-specific databases

CTDi 29100.
GeneCardsi GC16P067261.
H-InvDB HIX0013141.
HGNCi HGNC:25015. TMEM208.
HPAi HPA041868.
HPA041949.
neXtProti NX_Q9BTX3.
PharmGKBi PA162406408.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283806.
GeneTreei ENSGT00390000008139.
HOGENOMi HOG000230738.
HOVERGENi HBG104605.
InParanoidi Q9BTX3.
OMAi IWSFWLL.
OrthoDBi EOG7PCJJN.
PhylomeDBi Q9BTX3.
TreeFami TF318118.

Miscellaneous databases

ChiTaRSi TMEM208. human.
GenomeRNAii 29100.
NextBioi 52134.
PROi Q9BTX3.

Gene expression databases

Bgeei Q9BTX3.
CleanExi HS_TMEM208.
ExpressionAtlasi Q9BTX3. baseline and differential.
Genevestigatori Q9BTX3.

Family and domain databases

InterProi IPR008506. DUF788_TMEM208.
[Graphical view ]
PANTHERi PTHR13505. PTHR13505. 1 hit.
Pfami PF05620. DUF788. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-82.
    Tissue: Ovary, Skin and Uterus.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress."
    Zhao Y., Hu J., Miao G., Qu L., Wang Z., Li G., Lv P., Ma D., Chen Y.
    PLoS ONE 8:E64228-E64228(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTM208_HUMAN
AccessioniPrimary (citable) accession number: Q9BTX3
Secondary accession number(s): Q05CT0, Q96D25, Q9NZZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3