Q9BTX3 (TM208_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 208

Gene names

Name:	TMEM208
ORF Names:	HSPC171

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM208 family.
Sequence caution	The sequence AAF29134.1 differs from that shown. Reason: Frameshift at positions 88, 96 and 114.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BTX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BTX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     101-173: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Transmembrane protein 208		PRO_0000325967
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	51 – 68	18	Helical; Potential
	Transmembrane	105 – 129	25	Helical; Potential
	Transmembrane	135 – 154	20	Helical; Potential
Natural variations
	Alternative sequence	101 – 173	73	Missing in isoform 2.		VSP_032505
	Natural variant	82	1	D → Y. Ref.3 Corresponds to variant rs17851038 [ dbSNP | Ensembl ].		VAR_039958
	Natural variant	102	1	L → P. Corresponds to variant rs11553801 [ dbSNP | Ensembl ].		VAR_053933
Experimental info
	Sequence conflict	90	1	M → T in AAF29134. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F6AE0798B79967A6	FASTA	173	19,642
	10 20 30 40 50 60 MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWLALGFS 70 80 90 100 110 120 LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL 130 140 150 160 170 YVWSFWLLAP GRALYLLWVN VLGPWFTADS GTPAPEHNEK RQRRQERRQM KRL
	Isoform 2 [UniParc]. Checksum: 0EA9B83659BF0205	FASTA	100	11,039
	10 20 30 40 50 60 MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWLALGFS 70 80 90 100 LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE

References

[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Blood.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-82. Tissue: Ovary, Skin and Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF161519 mRNA. Translation: AAF29134.1. Frameshift. CH471092 Genomic DNA. Translation: EAW83106.1. CH471092 Genomic DNA. Translation: EAW83107.1. BC003080 mRNA. Translation: AAH03080.1. BC021109 mRNA. Translation: AAH21109.1. BC013412 mRNA. Translation: AAH13412.1.
IPI	IPI00549408. IPI00647208.
RefSeq	NP_054906.2. NM_014187.3.
UniGene	Hs.433203.
3D structure databases
ProteinModelPortal	Q9BTX3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000305892.
Polymorphism databases
DMDM	74733157.
Proteomic databases
PaxDb	Q9BTX3.
PRIDE	Q9BTX3.
Protocols and materials databases
DNASU	29100.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304800; ENSP00000305892; ENSG00000168701. ENST00000562235; ENSP00000457502; ENSG00000168701.
GeneID	29100.
KEGG	hsa:29100.
UCSC	uc002esi.2. human.
Organism-specific databases
CTD	29100.
GeneCards	GC16P067261.
H-InvDB	HIX0013141.
HGNC	HGNC:25015. TMEM208.
HPA	HPA041868. HPA041949.
neXtProt	NX_Q9BTX3.
PharmGKB	PA162406408.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283806.
HOGENOM	HOG000230738.
HOVERGEN	HBG104605.
InParanoid	Q9BTX3.
OMA	IWSFWLL.
OrthoDB	EOG46WZ9M.
PhylomeDB	Q9BTX3.
Gene expression databases
ArrayExpress	Q9BTX3.
Bgee	Q9BTX3.
CleanEx	HS_TMEM208.
Genevestigator	Q9BTX3.
Family and domain databases
InterPro	IPR008506. DUF788_TMEM208. [Graphical view]
PANTHER	PTHR13505. PTHR13505. 1 hit.
Pfam	PF05620. DUF788. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM208. human.
GenomeRNAi	29100.
NextBio	52134.

Entry information

Entry name

TM208_HUMAN

Accession

Primary (citable) accession number: Q9BTX3
Secondary accession number(s): Q05CT0, Q96D25, Q9NZZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.