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Q9BTX3

- TM208_HUMAN

UniProt

Q9BTX3 - TM208_HUMAN

Protein

Transmembrane protein 208

Gene

TMEM208

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.1 Publication

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy

    Protein family/group databases

    TCDBi9.B.26.1.1. the regulator of er stress and autophagy tmem208 (tmem208) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 208
    Gene namesi
    Name:TMEM208
    ORF Names:HSPC171
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25015. TMEM208.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406408.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Transmembrane protein 208PRO_0000325967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9BTX3.
    PaxDbiQ9BTX3.
    PRIDEiQ9BTX3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BTX3.
    BgeeiQ9BTX3.
    CleanExiHS_TMEM208.
    GenevestigatoriQ9BTX3.

    Organism-specific databases

    HPAiHPA041868.
    HPA041949.

    Interactioni

    Protein-protein interaction databases

    BioGridi118868. 1 interaction.
    STRINGi9606.ENSP00000305892.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 6818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12925HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM208 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283806.
    HOGENOMiHOG000230738.
    HOVERGENiHBG104605.
    InParanoidiQ9BTX3.
    OMAiIWSFWLL.
    OrthoDBiEOG7PCJJN.
    PhylomeDBiQ9BTX3.
    TreeFamiTF318118.

    Family and domain databases

    InterProiIPR008506. DUF788_TMEM208.
    [Graphical view]
    PANTHERiPTHR13505. PTHR13505. 1 hit.
    PfamiPF05620. DUF788. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BTX3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS    50
    FWAWLALGFS LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE 100
    HLKDVILLTA IVQVLSCFSL YVWSFWLLAP GRALYLLWVN VLGPWFTADS 150
    GTPAPEHNEK RQRRQERRQM KRL 173
    Length:173
    Mass (Da):19,642
    Last modified:June 1, 2001 - v1
    Checksum:iF6AE0798B79967A6
    GO
    Isoform 2 (identifier: Q9BTX3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-173: Missing.

    Show »
    Length:100
    Mass (Da):11,039
    Checksum:i0EA9B83659BF0205
    GO

    Sequence cautioni

    The sequence AAF29134.1 differs from that shown. Reason: Frameshift at positions 88, 96 and 114.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901M → T in AAF29134. (PubMed:11042152)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821D → Y.1 Publication
    Corresponds to variant rs17851038 [ dbSNP | Ensembl ].
    VAR_039958
    Natural varianti102 – 1021L → P.
    Corresponds to variant rs11553801 [ dbSNP | Ensembl ].
    VAR_053933

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei101 – 17373Missing in isoform 2. 2 PublicationsVSP_032505Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161519 mRNA. Translation: AAF29134.1. Frameshift.
    CH471092 Genomic DNA. Translation: EAW83106.1.
    CH471092 Genomic DNA. Translation: EAW83107.1.
    BC003080 mRNA. Translation: AAH03080.1.
    BC021109 mRNA. Translation: AAH21109.1.
    BC013412 mRNA. Translation: AAH13412.1.
    CCDSiCCDS45511.1. [Q9BTX3-1]
    RefSeqiNP_054906.2. NM_014187.3. [Q9BTX3-1]
    UniGeneiHs.433203.

    Genome annotation databases

    EnsembliENST00000304800; ENSP00000305892; ENSG00000168701. [Q9BTX3-1]
    ENST00000562235; ENSP00000457502; ENSG00000168701. [Q9BTX3-2]
    GeneIDi29100.
    KEGGihsa:29100.
    UCSCiuc002esi.2. human. [Q9BTX3-1]

    Polymorphism databases

    DMDMi74733157.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161519 mRNA. Translation: AAF29134.1 . Frameshift.
    CH471092 Genomic DNA. Translation: EAW83106.1 .
    CH471092 Genomic DNA. Translation: EAW83107.1 .
    BC003080 mRNA. Translation: AAH03080.1 .
    BC021109 mRNA. Translation: AAH21109.1 .
    BC013412 mRNA. Translation: AAH13412.1 .
    CCDSi CCDS45511.1. [Q9BTX3-1 ]
    RefSeqi NP_054906.2. NM_014187.3. [Q9BTX3-1 ]
    UniGenei Hs.433203.

    3D structure databases

    ProteinModelPortali Q9BTX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118868. 1 interaction.
    STRINGi 9606.ENSP00000305892.

    Protein family/group databases

    TCDBi 9.B.26.1.1. the regulator of er stress and autophagy tmem208 (tmem208) family.

    Polymorphism databases

    DMDMi 74733157.

    Proteomic databases

    MaxQBi Q9BTX3.
    PaxDbi Q9BTX3.
    PRIDEi Q9BTX3.

    Protocols and materials databases

    DNASUi 29100.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304800 ; ENSP00000305892 ; ENSG00000168701 . [Q9BTX3-1 ]
    ENST00000562235 ; ENSP00000457502 ; ENSG00000168701 . [Q9BTX3-2 ]
    GeneIDi 29100.
    KEGGi hsa:29100.
    UCSCi uc002esi.2. human. [Q9BTX3-1 ]

    Organism-specific databases

    CTDi 29100.
    GeneCardsi GC16P067261.
    H-InvDB HIX0013141.
    HGNCi HGNC:25015. TMEM208.
    HPAi HPA041868.
    HPA041949.
    neXtProti NX_Q9BTX3.
    PharmGKBi PA162406408.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283806.
    HOGENOMi HOG000230738.
    HOVERGENi HBG104605.
    InParanoidi Q9BTX3.
    OMAi IWSFWLL.
    OrthoDBi EOG7PCJJN.
    PhylomeDBi Q9BTX3.
    TreeFami TF318118.

    Miscellaneous databases

    ChiTaRSi TMEM208. human.
    GenomeRNAii 29100.
    NextBioi 52134.
    PROi Q9BTX3.

    Gene expression databases

    ArrayExpressi Q9BTX3.
    Bgeei Q9BTX3.
    CleanExi HS_TMEM208.
    Genevestigatori Q9BTX3.

    Family and domain databases

    InterProi IPR008506. DUF788_TMEM208.
    [Graphical view ]
    PANTHERi PTHR13505. PTHR13505. 1 hit.
    Pfami PF05620. DUF788. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Blood.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT TYR-82.
      Tissue: Ovary, Skin and Uterus.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress."
      Zhao Y., Hu J., Miao G., Qu L., Wang Z., Li G., Lv P., Ma D., Chen Y.
      PLoS ONE 8:E64228-E64228(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTM208_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTX3
    Secondary accession number(s): Q05CT0, Q96D25, Q9NZZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3