Q9BTX1 (NDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoporin NDC1
Short name=hNDC1

Alternative name(s):
Transmembrane protein 48

Gene names

Name:	TMEM48
Synonyms:	NDC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	674 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. Ref.8
Subunit structure	Interacts with the NUP35/NUP53 By similarity.
Subcellular location	Nucleus › nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note: Central core structure of the nuclear pore complex. Ref.6 Ref.8
Sequence similarities	Belongs to the NDC1 family.
Sequence caution	The sequence BAB14135.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC03665.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW nuclear pore complex assembly Inferred from mutant phenotype Ref.8. Source: UniProtKB nuclear pore distribution Inferred from mutant phenotype Ref.8. Source: UniProtKB protein transport Non-traceable author statement Ref.8. Source: UniProtKB
Cellular_component	nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from direct assay Ref.8. Source: UniProtKB
Molecular_function	structural constituent of nuclear pore Inferred from mutant phenotype Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BTX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BTX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-93: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9BTX1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     376-492: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9BTX1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     509-542: GKTMRQPSVIYSWIQNKREQIKNFLSKRVLIMYF → APRGLHSGCFFRCPNAYLGIRRSVALSSSIIYRG
     543-674: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 674	674	Nucleoporin NDC1		PRO_0000235240
Regions
	Topological domain	1 – 24	24	Cytoplasmic Potential
	Transmembrane	25 – 45	21	Helical; Name=1; Potential
	Topological domain	46 – 68	23	Perinuclear space Potential
	Transmembrane	69 – 89	21	Helical; Name=2; Potential
	Topological domain	90 – 114	25	Cytoplasmic Potential
	Transmembrane	115 – 135	21	Helical; Name=3; Potential
	Topological domain	136 – 165	30	Perinuclear space Potential
	Transmembrane	166 – 186	21	Helical; Name=4; Potential
	Topological domain	187 – 225	39	Cytoplasmic Potential
	Transmembrane	226 – 246	21	Helical; Name=5; Potential
	Topological domain	247 – 272	26	Perinuclear space Potential
	Transmembrane	273 – 293	21	Helical; Name=6; Potential
	Topological domain	294 – 674	381	Cytoplasmic Potential
Amino acid modifications
	Modified residue	406	1	Phosphoserine Ref.7 Ref.9 Ref.12
	Modified residue	414	1	Phosphothreonine Ref.12
	Modified residue	439	1	Phosphoserine Ref.10
	Modified residue	440	1	Phosphothreonine Ref.10
	Modified residue	445	1	Phosphoserine Ref.10 Ref.12
	Modified residue	449	1	Phosphothreonine Ref.10
	Modified residue	471	1	Phosphoserine Ref.10 Ref.12
	Modified residue	474	1	Phosphoserine Ref.10 Ref.12
Natural variations
	Alternative sequence	93	1	Missing in isoform 2.		VSP_018396
	Alternative sequence	376 – 492	117	Missing in isoform 3.		VSP_018397
	Alternative sequence	509 – 542	34	GKTMR…LIMYF → APRGLHSGCFFRCPNAYLGI RRSVALSSSIIYRG in isoform 4.		VSP_018398
	Alternative sequence	543 – 674	132	Missing in isoform 4.		VSP_018399
	Natural variant	154	1	G → D. Ref.1 Ref.5 Corresponds to variant rs17849721 [ dbSNP | Ensembl ].		VAR_026388

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 78368FEB232895D9	FASTA	674	76,305
	10 20 30 40 50 60 MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD 70 80 90 100 110 120 SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYAVVPSIPC SRLALIGKII HPQQLMHSFI 130 140 150 160 170 180 HAAMGMVMAW CAAVITQGQY SFLVVPCTGT NSFGSPAAQT CLNEYHLFFL LTGAFMGYSY 190 200 210 220 230 240 SLLYFVNNMN YLPFPIIQQY KFLRFRRSLL LLVKHSCVES LFLVRNFCIL YYFLGYIPKA 250 260 270 280 290 300 WISTAMNLHI DEQVHRPLDT VSGLLNLSLL YHVWLCGVFL LTTWYVSWIL FKIYATEAHV 310 320 330 340 350 360 FPVQPPFAEG SDECLPKVLN SNPPPIIKYL ALQDLMLLSQ YSPSRRQEVF SLSQPGGHPH 370 380 390 400 410 420 NWTAISRECL NLLNGMTQKL ILYQEAAATN GRVSSSYPVE PKKLNSPEET AFQTPKSSQM 430 440 450 460 470 480 PRPSVPPLVK TSLFSSKLST PDVVSPFGTP FGSSVMNRMA GIFDVNTCYG SPQSPQLIRR 490 500 510 520 530 540 GPRLWTSASD QQMTEFSNPS PSTSISAEGK TMRQPSVIYS WIQNKREQIK NFLSKRVLIM 550 560 570 580 590 600 YFFSKHPEAS IQAVFSDAQM HIWALEGLSH LVAASFTEDR FGVVQTTLPA ILNTLLTLQE 610 620 630 640 650 660 AVDKYFKLPH ASSKPPRISG SLVDTSYKTL RFAFRASLKT AIYRITTTFG EHLNAVQASA 670 EHQKRLQQFL EFKE
	Isoform 2 [UniParc]. Checksum: 27A688260C1B2852	FASTA	673	76,234
	10 20 30 40 50 60 MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD 70 80 90 100 110 120 SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYVVPSIPCS RLALIGKIIH PQQLMHSFIH 130 140 150 160 170 180 AAMGMVMAWC AAVITQGQYS FLVVPCTGTN SFGSPAAQTC LNEYHLFFLL TGAFMGYSYS 190 200 210 220 230 240 LLYFVNNMNY LPFPIIQQYK FLRFRRSLLL LVKHSCVESL FLVRNFCILY YFLGYIPKAW 250 260 270 280 290 300 ISTAMNLHID EQVHRPLDTV SGLLNLSLLY HVWLCGVFLL TTWYVSWILF KIYATEAHVF 310 320 330 340 350 360 PVQPPFAEGS DECLPKVLNS NPPPIIKYLA LQDLMLLSQY SPSRRQEVFS LSQPGGHPHN 370 380 390 400 410 420 WTAISRECLN LLNGMTQKLI LYQEAAATNG RVSSSYPVEP KKLNSPEETA FQTPKSSQMP 430 440 450 460 470 480 RPSVPPLVKT SLFSSKLSTP DVVSPFGTPF GSSVMNRMAG IFDVNTCYGS PQSPQLIRRG 490 500 510 520 530 540 PRLWTSASDQ QMTEFSNPSP STSISAEGKT MRQPSVIYSW IQNKREQIKN FLSKRVLIMY 550 560 570 580 590 600 FFSKHPEASI QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LNTLLTLQEA 610 620 630 640 650 660 VDKYFKLPHA SSKPPRISGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE HLNAVQASAE 670 HQKRLQQFLE FKE
	Isoform 3 [UniParc]. Checksum: C9AC3DCCCF3D5EBE	FASTA	557	63,572
	10 20 30 40 50 60 MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD 70 80 90 100 110 120 SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYAVVPSIPC SRLALIGKII HPQQLMHSFI 130 140 150 160 170 180 HAAMGMVMAW CAAVITQGQY SFLVVPCTGT NSFGSPAAQT CLNEYHLFFL LTGAFMGYSY 190 200 210 220 230 240 SLLYFVNNMN YLPFPIIQQY KFLRFRRSLL LLVKHSCVES LFLVRNFCIL YYFLGYIPKA 250 260 270 280 290 300 WISTAMNLHI DEQVHRPLDT VSGLLNLSLL YHVWLCGVFL LTTWYVSWIL FKIYATEAHV 310 320 330 340 350 360 FPVQPPFAEG SDECLPKVLN SNPPPIIKYL ALQDLMLLSQ YSPSRRQEVF SLSQPGGHPH 370 380 390 400 410 420 NWTAISRECL NLLNGMTEFS NPSPSTSISA EGKTMRQPSV IYSWIQNKRE QIKNFLSKRV 430 440 450 460 470 480 LIMYFFSKHP EASIQAVFSD AQMHIWALEG LSHLVAASFT EDRFGVVQTT LPAILNTLLT 490 500 510 520 530 540 LQEAVDKYFK LPHASSKPPR ISGSLVDTSY KTLRFAFRAS LKTAIYRITT TFGEHLNAVQ 550 ASAEHQKRLQ QFLEFKE
	Isoform 4 [UniParc]. Checksum: 06630F6E487BAC55	FASTA	542	61,009
	10 20 30 40 50 60 MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD 70 80 90 100 110 120 SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYAVVPSIPC SRLALIGKII HPQQLMHSFI 130 140 150 160 170 180 HAAMGMVMAW CAAVITQGQY SFLVVPCTGT NSFGSPAAQT CLNEYHLFFL LTGAFMGYSY 190 200 210 220 230 240 SLLYFVNNMN YLPFPIIQQY KFLRFRRSLL LLVKHSCVES LFLVRNFCIL YYFLGYIPKA 250 260 270 280 290 300 WISTAMNLHI DEQVHRPLDT VSGLLNLSLL YHVWLCGVFL LTTWYVSWIL FKIYATEAHV 310 320 330 340 350 360 FPVQPPFAEG SDECLPKVLN SNPPPIIKYL ALQDLMLLSQ YSPSRRQEVF SLSQPGGHPH 370 380 390 400 410 420 NWTAISRECL NLLNGMTQKL ILYQEAAATN GRVSSSYPVE PKKLNSPEET AFQTPKSSQM 430 440 450 460 470 480 PRPSVPPLVK TSLFSSKLST PDVVSPFGTP FGSSVMNRMA GIFDVNTCYG SPQSPQLIRR 490 500 510 520 530 540 GPRLWTSASD QQMTEFSNPS PSTSISAEAP RGLHSGCFFR CPNAYLGIRR SVALSSSIIY RG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of NDC1 from metazoa." Stavru F., Goerlich D., Hartmann E. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-154.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-674 (ISOFORM 3). Tissue: Brain and Teratocarcinoma.
[3]	Rhodes S., Huckle E. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-154. Tissue: Brain.
[6]	"Nuclear membrane proteins with potential disease links found by subtractive proteomics." Schirmer E.C., Florens L., Guan T., Yates J.R. III, Gerace L. Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells." Mansfeld J., Guettinger S., Hawryluk-Gara L.A., Pante N., Mall M., Galy V., Haselmann U., Muehlhaeusser P., Wozniak R.W., Mattaj I.W., Kutay U., Antonin W. Mol. Cell 22:93-103(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, PHOSPHORYLATION.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; THR-440; SER-445; THR-449; SER-471 AND SER-474, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406; THR-414; SER-445; SER-471 AND SER-474, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ141696 mRNA. Translation: AAZ73087.1. AK001269 mRNA. Translation: BAA91592.1. AK022618 mRNA. Translation: BAB14135.1. Different initiation. AK091439 mRNA. Translation: BAC03665.1. Different initiation. AL354612 mRNA. Translation: CAB89725.1. AL354613 mRNA. Translation: CAB89726.1. AL049745 Genomic DNA. Translation: CAI22180.1. BC003082 mRNA. Translation: AAH03082.1.
IPI	IPI00003455. IPI00074330. IPI00386760. IPI00746642.
RefSeq	NP_001162023.1. NM_001168551.1. NP_060557.3. NM_018087.4.
UniGene	Hs.476525.
3D structure databases
ProteinModelPortal	Q9BTX1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BTX1. 1 interaction.
STRING	9606.ENSP00000360483.
PTM databases
PhosphoSite	Q9BTX1.
Polymorphism databases
DMDM	97180263.
Proteomic databases
PaxDb	Q9BTX1.
PRIDE	Q9BTX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371429; ENSP00000360483; ENSG00000058804. ENST00000540001; ENSP00000440873; ENSG00000058804.
GeneID	55706.
KEGG	hsa:55706.
UCSC	uc001cvs.3. human.
Organism-specific databases
CTD	55706.
GeneCards	GC01M054231.
H-InvDB	HIX0000603.
HGNC	HGNC:25525. TMEM48.
MIM	610115. gene.
neXtProt	NX_Q9BTX1.
PharmGKB	PA142670764.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG298560.
HOGENOM	HOG000231135.
HOVERGEN	HBG080133.
InParanoid	Q9BTX1.
KO	K14315.
OMA	IFNVEFY.
OrthoDB	EOG4KH2TH.
PhylomeDB	Q9BTX1.
Gene expression databases
ArrayExpress	Q9BTX1.
Bgee	Q9BTX1.
CleanEx	HS_TMEM48.
Genevestigator	Q9BTX1.
GermOnline	ENSG00000058804. Homo sapiens.
Family and domain databases
InterPro	IPR019049. Nucleoporin_prot_Ndc1/Nup. [Graphical view]
Pfam	PF09531. Ndc1_Nup. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM48. human.
GenomeRNAi	55706.
NextBio	60563.
SOURCE	Search...

Entry information

Entry name

NDC1_HUMAN

Accession

Primary (citable) accession number: Q9BTX1
Secondary accession number(s): Q8NB76 , Q9H9T6, Q9NSG3, Q9NSG4, Q9NVZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	April 3, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.