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Q9BTV7

- CABL2_HUMAN

UniProt

Q9BTV7 - CABL2_HUMAN

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Protein

CDK5 and ABL1 enzyme substrate 2

Gene

CABLES2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Unknown. Probably involved in G1-S cell cycle transition.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. regulation of cell cycle Source: InterPro
  4. regulation of cell division Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinkiQ9BTV7.

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 2
Alternative name(s):
Interactor with CDK3 2
Short name:
Ik3-2
Gene namesi
Name:CABLES2
Synonyms:C20orf150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16143. CABLES2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478CDK5 and ABL1 enzyme substrate 2PRO_0000080512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301Phosphoserine2 Publications
Modified residuei208 – 2081Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BTV7.
PaxDbiQ9BTV7.
PRIDEiQ9BTV7.

PTM databases

PhosphoSiteiQ9BTV7.

Miscellaneous databases

PMAP-CutDBQ9BTV7.

Expressioni

Gene expression databases

BgeeiQ9BTV7.
CleanExiHS_CABLES2.
GenevestigatoriQ9BTV7.

Organism-specific databases

HPAiHPA048253.
HPA052138.

Interactioni

Subunit structurei

Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi123628. 6 interactions.
IntActiQ9BTV7. 1 interaction.
STRINGi9606.ENSP00000279101.

Structurei

3D structure databases

ProteinModelPortaliQ9BTV7.
SMRiQ9BTV7. Positions 330-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 65Poly-Ala
Compositional biasi10 – 110101Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiNOG256533.
GeneTreeiENSGT00400000022086.
HOGENOMiHOG000231236.
HOVERGENiHBG050759.
InParanoidiQ9BTV7.
OMAiRVTSQRC.
OrthoDBiEOG7P5T0S.
PhylomeDBiQ9BTV7.
TreeFamiTF323936.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR012388. Cdk5/c-Abl_linker_Cables.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF025798. Cables. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BTV7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF
60 70 80 90 100
FLNNISLDGR PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP
110 120 130 140 150
QGLLSPTQVP TGLGLDGQRQ RKRVTSQRCS LEFLEDAVGC APAQRTKHTS
160 170 180 190 200
GSPRHKGLKK THFIKNMRQY DTRNSRIVLI CAKRSLCAAF SVLPYGEGLR
210 220 230 240 250
ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV SYAKFLYPTN
260 270 280 290 300
ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT
310 320 330 340 350
LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE
360 370 380 390 400
KFPHVKLTLS KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS
410 420 430 440 450
KQNRKLCAGA CVLLAAKISS DLRKSGVTQL IDKLEERFRF NRRDLIGFEF
460 470
TVLVALELAL YLPENQVLPH YRRLTQQF
Length:478
Mass (Da):52,235
Last modified:May 30, 2006 - v3
Checksum:i98E99EC72F7573EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771S → P in AAH03122. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti428 – 4281T → K.1 Publication
Corresponds to variant rs6089219 [ dbSNP | Ensembl ].
VAR_026532

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121832 Genomic DNA. Translation: CAI23283.2.
BC003122 mRNA. Translation: AAH03122.1.
CCDSiCCDS33503.1.
RefSeqiNP_112492.2. NM_031215.2.
UniGeneiHs.301040.

Genome annotation databases

EnsembliENST00000279101; ENSP00000279101; ENSG00000149679.
GeneIDi81928.
KEGGihsa:81928.
UCSCiuc002ycv.2. human.

Polymorphism databases

DMDMi109940186.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL121832 Genomic DNA. Translation: CAI23283.2 .
BC003122 mRNA. Translation: AAH03122.1 .
CCDSi CCDS33503.1.
RefSeqi NP_112492.2. NM_031215.2.
UniGenei Hs.301040.

3D structure databases

ProteinModelPortali Q9BTV7.
SMRi Q9BTV7. Positions 330-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123628. 6 interactions.
IntActi Q9BTV7. 1 interaction.
STRINGi 9606.ENSP00000279101.

PTM databases

PhosphoSitei Q9BTV7.

Polymorphism databases

DMDMi 109940186.

Proteomic databases

MaxQBi Q9BTV7.
PaxDbi Q9BTV7.
PRIDEi Q9BTV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279101 ; ENSP00000279101 ; ENSG00000149679 .
GeneIDi 81928.
KEGGi hsa:81928.
UCSCi uc002ycv.2. human.

Organism-specific databases

CTDi 81928.
GeneCardsi GC20M060963.
H-InvDB HIX0040565.
HGNCi HGNC:16143. CABLES2.
HPAi HPA048253.
HPA052138.
neXtProti NX_Q9BTV7.
PharmGKBi PA25692.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256533.
GeneTreei ENSGT00400000022086.
HOGENOMi HOG000231236.
HOVERGENi HBG050759.
InParanoidi Q9BTV7.
OMAi RVTSQRC.
OrthoDBi EOG7P5T0S.
PhylomeDBi Q9BTV7.
TreeFami TF323936.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinki Q9BTV7.

Miscellaneous databases

GenomeRNAii 81928.
NextBioi 72261.
PMAP-CutDB Q9BTV7.
PROi Q9BTV7.

Gene expression databases

Bgeei Q9BTV7.
CleanExi HS_CABLES2.
Genevestigatori Q9BTV7.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR012388. Cdk5/c-Abl_linker_Cables.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF025798. Cables. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-478, VARIANT LYS-428.
    Tissue: Eye.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCABL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTV7
Secondary accession number(s): Q5JWL0, Q9BYK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3