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Q9BTV7

- CABL2_HUMAN

UniProt

Q9BTV7 - CABL2_HUMAN

Protein

CDK5 and ABL1 enzyme substrate 2

Gene

CABLES2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (30 May 2006)
      Previous versions | rss
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    Functioni

    Unknown. Probably involved in G1-S cell cycle transition.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. regulation of cell cycle Source: InterPro
    4. regulation of cell division Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ9BTV7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 and ABL1 enzyme substrate 2
    Alternative name(s):
    Interactor with CDK3 2
    Short name:
    Ik3-2
    Gene namesi
    Name:CABLES2
    Synonyms:C20orf150
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16143. CABLES2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25692.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478CDK5 and ABL1 enzyme substrate 2PRO_0000080512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301Phosphoserine2 Publications
    Modified residuei208 – 2081Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BTV7.
    PaxDbiQ9BTV7.
    PRIDEiQ9BTV7.

    PTM databases

    PhosphoSiteiQ9BTV7.

    Miscellaneous databases

    PMAP-CutDBQ9BTV7.

    Expressioni

    Gene expression databases

    BgeeiQ9BTV7.
    CleanExiHS_CABLES2.
    GenevestigatoriQ9BTV7.

    Organism-specific databases

    HPAiHPA048253.
    HPA052138.

    Interactioni

    Subunit structurei

    Binds to CDK3, CDK5 and ABL1. The C-terminal cyclin-box-like region binds to CDK5 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi123628. 4 interactions.
    IntActiQ9BTV7. 1 interaction.
    STRINGi9606.ENSP00000279101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTV7.
    SMRiQ9BTV7. Positions 330-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 65Poly-Ala
    Compositional biasi10 – 110101Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiNOG256533.
    HOGENOMiHOG000231236.
    HOVERGENiHBG050759.
    InParanoidiQ9BTV7.
    OMAiRVTSQRC.
    OrthoDBiEOG7P5T0S.
    PhylomeDBiQ9BTV7.
    TreeFamiTF323936.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF025798. Cables. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BTV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF    50
    FLNNISLDGR PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP 100
    QGLLSPTQVP TGLGLDGQRQ RKRVTSQRCS LEFLEDAVGC APAQRTKHTS 150
    GSPRHKGLKK THFIKNMRQY DTRNSRIVLI CAKRSLCAAF SVLPYGEGLR 200
    ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV SYAKFLYPTN 250
    ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT 300
    LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE 350
    KFPHVKLTLS KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS 400
    KQNRKLCAGA CVLLAAKISS DLRKSGVTQL IDKLEERFRF NRRDLIGFEF 450
    TVLVALELAL YLPENQVLPH YRRLTQQF 478
    Length:478
    Mass (Da):52,235
    Last modified:May 30, 2006 - v3
    Checksum:i98E99EC72F7573EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti277 – 2771S → P in AAH03122. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti428 – 4281T → K.1 Publication
    Corresponds to variant rs6089219 [ dbSNP | Ensembl ].
    VAR_026532

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121832 Genomic DNA. Translation: CAI23283.2.
    BC003122 mRNA. Translation: AAH03122.1.
    CCDSiCCDS33503.1.
    RefSeqiNP_112492.2. NM_031215.2.
    UniGeneiHs.301040.

    Genome annotation databases

    EnsembliENST00000279101; ENSP00000279101; ENSG00000149679.
    GeneIDi81928.
    KEGGihsa:81928.
    UCSCiuc002ycv.2. human.

    Polymorphism databases

    DMDMi109940186.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121832 Genomic DNA. Translation: CAI23283.2 .
    BC003122 mRNA. Translation: AAH03122.1 .
    CCDSi CCDS33503.1.
    RefSeqi NP_112492.2. NM_031215.2.
    UniGenei Hs.301040.

    3D structure databases

    ProteinModelPortali Q9BTV7.
    SMRi Q9BTV7. Positions 330-464.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123628. 4 interactions.
    IntActi Q9BTV7. 1 interaction.
    STRINGi 9606.ENSP00000279101.

    PTM databases

    PhosphoSitei Q9BTV7.

    Polymorphism databases

    DMDMi 109940186.

    Proteomic databases

    MaxQBi Q9BTV7.
    PaxDbi Q9BTV7.
    PRIDEi Q9BTV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279101 ; ENSP00000279101 ; ENSG00000149679 .
    GeneIDi 81928.
    KEGGi hsa:81928.
    UCSCi uc002ycv.2. human.

    Organism-specific databases

    CTDi 81928.
    GeneCardsi GC20M060963.
    H-InvDB HIX0040565.
    HGNCi HGNC:16143. CABLES2.
    HPAi HPA048253.
    HPA052138.
    neXtProti NX_Q9BTV7.
    PharmGKBi PA25692.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256533.
    HOGENOMi HOG000231236.
    HOVERGENi HBG050759.
    InParanoidi Q9BTV7.
    OMAi RVTSQRC.
    OrthoDBi EOG7P5T0S.
    PhylomeDBi Q9BTV7.
    TreeFami TF323936.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinki Q9BTV7.

    Miscellaneous databases

    GenomeRNAii 81928.
    NextBioi 72261.
    PMAP-CutDB Q9BTV7.
    PROi Q9BTV7.

    Gene expression databases

    Bgeei Q9BTV7.
    CleanExi HS_CABLES2.
    Genevestigatori Q9BTV7.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF025798. Cables. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-478, VARIANT LYS-428.
      Tissue: Eye.
    3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCABL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTV7
    Secondary accession number(s): Q5JWL0, Q9BYK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3