Fibronectin type III and SPRY domain-containing protein 1

Names and origin

Protein names

Recommended name:
    Fibronectin type III and SPRY domain-containing protein 1
Alternative name(s):
    Microtubule-associated protein GLFND
    MID1-related protein 1

Gene names

Name:	FSD1
Synonyms:	GLFND, MIR1
ORF Names:	VLP27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May be involved in microtubule organization and stabilization. Ref.2 Ref.5
Subunit structure	Oligomerization is required for binding to microtubules.
Subcellular location	Centrosome. Nucleus. Cytoplasm. Note: Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle. Ref.2 Ref.5
Tissue specificity	Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord. Ref.5 Ref.1
Domain	B30.2 box contains a microtubule-binding site.
Sequence similarities	Contains 1 B30.2/SPRY domain. Contains 1 COS domain. Contains 1 fibronectin type-III domain.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Microtubule Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	centrosome Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 496

496

Fibronectin type III and SPRY domain-containing protein 1

PRO_0000316537

Regions

Domain

105 – 162

58

COS

Domain

165 – 267

103

Fibronectin type-III

Domain

268 – 477

210

B30.2/SPRY

Coiled coil

4 – 99

96

Potential

Natural variations

Natural variant

232

1

L → V: dbSNP rs35139245. Ref.1

VAR_038385

Experimental info

Mutagenesis

313

1

S → A in mitosis, remained associated with microtubules; when associated with A-317; A-322 and A-324. Ref.5

Mutagenesis

313

1

S → D: Reduced ability to associate with microtubules; when associated with D-317; E-322 and D-324. Ref.5

Mutagenesis

317

1

S → A in mitosis, remained associated with microtubules; when associated with A-313; A-322 and A-324. Ref.5

Mutagenesis

317

1

S → D: Reduced ability to associate with microtubules; when associated with D-313; E-322 and D-324. Ref.5

Mutagenesis

322

1

T → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-324. Ref.5

Mutagenesis

322

1

T → E: Reduced ability to associate with microtubules; when associated with D-313; D-317 and D-324. Ref.5

Mutagenesis

324

1

S → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-322. Ref.5

Mutagenesis

324

1

S → D: Reduced ability to associate with microtubules; when associated with D-313; D-317 and E-322. Ref.5

Sequence conflict

295

1

G → R in BAB13885. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9BTV5-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0FE7B18F14C80D46
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FASTA

496

55,820

        10         20         30         40         50         60 
MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE FQSLFSLLEE 

        70         80         90        100        110        120 
LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET ANQTLQAMDS EDFPQAAKQI 

       130        140        150        160        170        180 
KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA QERQMLQALK FLPVPSAPVI DLAESLVADN 

       190        200        210        220        230        240 
CVTLVWRMPD EDSKIDHYVL EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK 

       250        260        270        280        290        300 
YMNFRVKACN KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI 

       310        320        330        340        350        360 
KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL IDGGEHYWEV 

       370        380        390        400        410        420 
RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ VSFTAKHANK VKVLDAPVPD 

       430        440        450        460        470        480 
CLGVHCDFHQ GLLSFYNART KQVLHTFKTR FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC 

       490 
LQKRGSATSS SNTSLT

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31." Carim-Todd L., Escarceller M., Estivill X., Sumoy L. Biochim. Biophys. Acta 1518:200-203(2001) [PubMed: 11267680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-232.
[2]	"Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy." Manabe R., Whitmore L., Weiss J.M., Horwitz A.R. Curr. Biol. 12:1946-1951(2002) [PubMed: 12445389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION. Tissue: Fibrosarcoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"A novel centrosome-associated protein with affinity for microtubules." Stein P.A., Toret C.P., Salic A.N., Rolls M.M., Rapoport T.A. J. Cell Sci. 115:3389-3402(2002) [PubMed: 12154070] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-313; SER-317; THR-322 AND SER-324.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

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Cross-references

Sequence databases
	AF316829 mRNA. Translation: AAK26747.1. AY032617 mRNA. Translation: AAK51145.1. AK021750 mRNA. Translation: BAB13885.1. AK315661 mRNA. Translation: BAG38027.1. BC003124 mRNA. Translation: AAH03124.1.
IPI	IPI00305827.
RefSeq	NP_077309.1.
UniGene	Hs.28144
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BTV5. 2 interactions.
Proteomic databases
PRIDE	Q9BTV5.
Genome annotation databases
Ensembl	ENSG00000105255. Homo sapiens. [Contig view]
GeneID	79187.
KEGG	hsa:79187.
Organism-specific databases
GeneCards	GC19P004255.
HGNC	HGNC:13745. FSD1.
MIM	609828. gene.
PharmGKB	PA134882882.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BTV5.
HOVERGEN	Q9BTV5.
OMA	Q9BTV5. AKHANKA.
Gene expression databases
Bgee	Q9BTV5.
CleanEx	HS_FSD1.
Family and domain databases
InterPro	IPR001870. B302. IPR003649. Bbox_C. IPR017903. COS_domain. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003877. SPRY_rcpt. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 1 hit.
Pfam	PF00041. fn3. 1 hit. PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00502. BBC. 1 hit. SM00060. FN3. 1 hit. [Graphical view]
PROSITE	PS50188. B302_SPRY. 1 hit. PS51262. COS. 1 hit. PS50853. FN3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	68182.
SOURCE	Search...

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Entry information

Entry name

FSD1_HUMAN

Accession

Primary (citable) accession number: Q9BTV5
Secondary accession number(s): B2RDT0, Q9BXN0, Q9HAG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents