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Q9BTV5 (FSD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibronectin type III and SPRY domain-containing protein 1
Alternative name(s):
MID1-related protein 1
Microtubule-associated protein GLFND
Gene names
Name:FSD1
Synonyms:GLFND, MIR1
ORF Names:VLP27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in microtubule organization and stabilization. Ref.2 Ref.5

Subunit structure

Oligomerization is required for binding to microtubules.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Nucleus. Cytoplasm. Cleavage furrow. Note: Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle. Ref.2 Ref.5

Tissue specificity

Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord. Ref.1 Ref.5

Domain

B30.2 box contains a microtubule-binding site.

Sequence similarities

Contains 1 B30.2/SPRY domain.

Contains 1 COS domain.

Contains 1 fibronectin type-III domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
Nucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcleavage furrow

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Fibronectin type III and SPRY domain-containing protein 1
PRO_0000316537

Regions

Domain105 – 16258COS
Domain164 – 268105Fibronectin type-III
Domain268 – 477210B30.2/SPRY
Coiled coil4 – 9996 Potential

Natural variations

Natural variant2321L → V. Ref.1
Corresponds to variant rs35139245 [ dbSNP | Ensembl ].
VAR_038385

Experimental info

Mutagenesis3131S → A in mitosis, remained associated with microtubules; when associated with A-317; A-322 and A-324. Ref.5
Mutagenesis3131S → D: Reduced ability to associate with microtubules; when associated with D-317; E-322 and D-324. Ref.5
Mutagenesis3171S → A in mitosis, remained associated with microtubules; when associated with A-313; A-322 and A-324. Ref.5
Mutagenesis3171S → D: Reduced ability to associate with microtubules; when associated with D-313; E-322 and D-324. Ref.5
Mutagenesis3221T → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-324. Ref.5
Mutagenesis3221T → E: Reduced ability to associate with microtubules; when associated with D-313; D-317 and D-324. Ref.5
Mutagenesis3241S → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-322. Ref.5
Mutagenesis3241S → D: Reduced ability to associate with microtubules; when associated with D-313; D-317 and E-322. Ref.5
Sequence conflict2951G → R in BAB13885. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9BTV5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0FE7B18F14C80D46

FASTA49655,820
        10         20         30         40         50         60 
MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE FQSLFSLLEE 

        70         80         90        100        110        120 
LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET ANQTLQAMDS EDFPQAAKQI 

       130        140        150        160        170        180 
KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA QERQMLQALK FLPVPSAPVI DLAESLVADN 

       190        200        210        220        230        240 
CVTLVWRMPD EDSKIDHYVL EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK 

       250        260        270        280        290        300 
YMNFRVKACN KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI 

       310        320        330        340        350        360 
KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL IDGGEHYWEV 

       370        380        390        400        410        420 
RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ VSFTAKHANK VKVLDAPVPD 

       430        440        450        460        470        480 
CLGVHCDFHQ GLLSFYNART KQVLHTFKTR FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC 

       490 
LQKRGSATSS SNTSLT 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31."
Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-232.
[2]"Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy."
Manabe R., Whitmore L., Weiss J.M., Horwitz A.R.
Curr. Biol. 12:1946-1951(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Tissue: Fibrosarcoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"A novel centrosome-associated protein with affinity for microtubules."
Stein P.A., Toret C.P., Salic A.N., Rolls M.M., Rapoport T.A.
J. Cell Sci. 115:3389-3402(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-313; SER-317; THR-322 AND SER-324.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF316829 mRNA. Translation: AAK26747.1.
AY032617 mRNA. Translation: AAK51145.1.
AK021750 mRNA. Translation: BAB13885.1.
AK315661 mRNA. Translation: BAG38027.1.
BC003124 mRNA. Translation: AAH03124.1.
CCDSCCDS12127.1.
RefSeqNP_077309.1. NM_024333.2.
UniGeneHs.28144.

3D structure databases

ProteinModelPortalQ9BTV5.
SMRQ9BTV5. Positions 51-105, 332-462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122600. 3 interactions.
IntActQ9BTV5. 2 interactions.
MINTMINT-1368061.
STRING9606.ENSP00000221856.

PTM databases

PhosphoSiteQ9BTV5.

Polymorphism databases

DMDM74733152.

Proteomic databases

MaxQBQ9BTV5.
PaxDbQ9BTV5.
PRIDEQ9BTV5.

Protocols and materials databases

DNASU79187.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221856; ENSP00000221856; ENSG00000105255.
GeneID79187.
KEGGhsa:79187.
UCSCuc002lzy.2. human.

Organism-specific databases

CTD79187.
GeneCardsGC19P004304.
HGNCHGNC:13745. FSD1.
HPAHPA043141.
MIM609828. gene.
neXtProtNX_Q9BTV5.
PharmGKBPA134882882.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302398.
HOGENOMHOG000231656.
HOVERGENHBG107931.
InParanoidQ9BTV5.
OMAASWCIHL.
OrthoDBEOG7W6WKF.
PhylomeDBQ9BTV5.
TreeFamTF333654.

Gene expression databases

ArrayExpressQ9BTV5.
BgeeQ9BTV5.
CleanExHS_FSD1.
GenevestigatorQ9BTV5.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTSM00502. BBC. 1 hit.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79187.
NextBio68182.
PROQ9BTV5.
SOURCESearch...

Entry information

Entry nameFSD1_HUMAN
AccessionPrimary (citable) accession number: Q9BTV5
Secondary accession number(s): B2RDT0, Q9BXN0, Q9HAG4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM