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Q9BTV5

- FSD1_HUMAN

UniProt

Q9BTV5 - FSD1_HUMAN

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Protein
Fibronectin type III and SPRY domain-containing protein 1
Gene
FSD1, GLFND, MIR1, VLP27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in microtubule organization and stabilization.2 Publications

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III and SPRY domain-containing protein 1
Alternative name(s):
MID1-related protein 1
Microtubule-associated protein GLFND
Gene namesi
Name:FSD1
Synonyms:GLFND, MIR1
ORF Names:VLP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13745. FSD1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Nucleus. Cytoplasm. Cleavage furrow
Note: Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.2 Publications

GO - Cellular componenti

  1. cleavage furrow Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. microtubule Source: UniProtKB-KW
  4. microtubule organizing center Source: UniProtKB-SubCell
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi313 – 3131S → A in mitosis, remained associated with microtubules; when associated with A-317; A-322 and A-324. 1 Publication
Mutagenesisi313 – 3131S → D: Reduced ability to associate with microtubules; when associated with D-317; E-322 and D-324. 1 Publication
Mutagenesisi317 – 3171S → A in mitosis, remained associated with microtubules; when associated with A-313; A-322 and A-324. 1 Publication
Mutagenesisi317 – 3171S → D: Reduced ability to associate with microtubules; when associated with D-313; E-322 and D-324. 1 Publication
Mutagenesisi322 – 3221T → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-324. 1 Publication
Mutagenesisi322 – 3221T → E: Reduced ability to associate with microtubules; when associated with D-313; D-317 and D-324. 1 Publication
Mutagenesisi324 – 3241S → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-322. 1 Publication
Mutagenesisi324 – 3241S → D: Reduced ability to associate with microtubules; when associated with D-313; D-317 and E-322. 1 Publication

Organism-specific databases

PharmGKBiPA134882882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Fibronectin type III and SPRY domain-containing protein 1
PRO_0000316537Add
BLAST

Proteomic databases

MaxQBiQ9BTV5.
PaxDbiQ9BTV5.
PRIDEiQ9BTV5.

PTM databases

PhosphoSiteiQ9BTV5.

Expressioni

Tissue specificityi

Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.2 Publications

Gene expression databases

ArrayExpressiQ9BTV5.
BgeeiQ9BTV5.
CleanExiHS_FSD1.
GenevestigatoriQ9BTV5.

Organism-specific databases

HPAiHPA043141.

Interactioni

Subunit structurei

Oligomerization is required for binding to microtubules.

Protein-protein interaction databases

BioGridi122600. 3 interactions.
IntActiQ9BTV5. 2 interactions.
MINTiMINT-1368061.
STRINGi9606.ENSP00000221856.

Structurei

3D structure databases

ProteinModelPortaliQ9BTV5.
SMRiQ9BTV5. Positions 51-105, 332-462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 16258COS
Add
BLAST
Domaini164 – 268105Fibronectin type-III
Add
BLAST
Domaini268 – 477210B30.2/SPRY
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 9996 Reviewed prediction
Add
BLAST

Domaini

B30.2 box contains a microtubule-binding site.

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.
Contains 1 COS domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG302398.
HOGENOMiHOG000231656.
HOVERGENiHBG107931.
InParanoidiQ9BTV5.
OMAiASWCIHL.
OrthoDBiEOG7W6WKF.
PhylomeDBiQ9BTV5.
TreeFamiTF333654.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTV5-1 [UniParc]FASTAAdd to Basket

« Hide

MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE    50
FQSLFSLLEE LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET 100
ANQTLQAMDS EDFPQAAKQI KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA 150
QERQMLQALK FLPVPSAPVI DLAESLVADN CVTLVWRMPD EDSKIDHYVL 200
EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK YMNFRVKACN 250
KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI 300
KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL 350
IDGGEHYWEV RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ 400
VSFTAKHANK VKVLDAPVPD CLGVHCDFHQ GLLSFYNART KQVLHTFKTR 450
FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC LQKRGSATSS SNTSLT 496
Length:496
Mass (Da):55,820
Last modified:June 1, 2001 - v1
Checksum:i0FE7B18F14C80D46
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti232 – 2321L → V.1 Publication
Corresponds to variant rs35139245 [ dbSNP | Ensembl ].
VAR_038385

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951G → R in BAB13885. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316829 mRNA. Translation: AAK26747.1.
AY032617 mRNA. Translation: AAK51145.1.
AK021750 mRNA. Translation: BAB13885.1.
AK315661 mRNA. Translation: BAG38027.1.
BC003124 mRNA. Translation: AAH03124.1.
CCDSiCCDS12127.1.
RefSeqiNP_077309.1. NM_024333.2.
UniGeneiHs.28144.

Genome annotation databases

EnsembliENST00000221856; ENSP00000221856; ENSG00000105255.
GeneIDi79187.
KEGGihsa:79187.
UCSCiuc002lzy.2. human.

Polymorphism databases

DMDMi74733152.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF316829 mRNA. Translation: AAK26747.1 .
AY032617 mRNA. Translation: AAK51145.1 .
AK021750 mRNA. Translation: BAB13885.1 .
AK315661 mRNA. Translation: BAG38027.1 .
BC003124 mRNA. Translation: AAH03124.1 .
CCDSi CCDS12127.1.
RefSeqi NP_077309.1. NM_024333.2.
UniGenei Hs.28144.

3D structure databases

ProteinModelPortali Q9BTV5.
SMRi Q9BTV5. Positions 51-105, 332-462.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122600. 3 interactions.
IntActi Q9BTV5. 2 interactions.
MINTi MINT-1368061.
STRINGi 9606.ENSP00000221856.

PTM databases

PhosphoSitei Q9BTV5.

Polymorphism databases

DMDMi 74733152.

Proteomic databases

MaxQBi Q9BTV5.
PaxDbi Q9BTV5.
PRIDEi Q9BTV5.

Protocols and materials databases

DNASUi 79187.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221856 ; ENSP00000221856 ; ENSG00000105255 .
GeneIDi 79187.
KEGGi hsa:79187.
UCSCi uc002lzy.2. human.

Organism-specific databases

CTDi 79187.
GeneCardsi GC19P004304.
HGNCi HGNC:13745. FSD1.
HPAi HPA043141.
MIMi 609828. gene.
neXtProti NX_Q9BTV5.
PharmGKBi PA134882882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302398.
HOGENOMi HOG000231656.
HOVERGENi HBG107931.
InParanoidi Q9BTV5.
OMAi ASWCIHL.
OrthoDBi EOG7W6WKF.
PhylomeDBi Q9BTV5.
TreeFami TF333654.

Miscellaneous databases

GenomeRNAii 79187.
NextBioi 68182.
PROi Q9BTV5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BTV5.
Bgeei Q9BTV5.
CleanExi HS_FSD1.
Genevestigatori Q9BTV5.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00502. BBC. 1 hit.
SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31."
    Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
    Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-232.
  2. "Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy."
    Manabe R., Whitmore L., Weiss J.M., Horwitz A.R.
    Curr. Biol. 12:1946-1951(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Fibrosarcoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "A novel centrosome-associated protein with affinity for microtubules."
    Stein P.A., Toret C.P., Salic A.N., Rolls M.M., Rapoport T.A.
    J. Cell Sci. 115:3389-3402(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-313; SER-317; THR-322 AND SER-324.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFSD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTV5
Secondary accession number(s): B2RDT0, Q9BXN0, Q9HAG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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