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Q9BTV5

- FSD1_HUMAN

UniProt

Q9BTV5 - FSD1_HUMAN

Protein

Fibronectin type III and SPRY domain-containing protein 1

Gene

FSD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in microtubule organization and stabilization.2 Publications

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 1
    Alternative name(s):
    MID1-related protein 1
    Microtubule-associated protein GLFND
    Gene namesi
    Name:FSD1
    Synonyms:GLFND, MIR1
    ORF Names:VLP27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13745. FSD1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Nucleus. Cytoplasm. Cleavage furrow
    Note: Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. microtubule Source: UniProtKB-KW
    4. microtubule organizing center Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi313 – 3131S → A in mitosis, remained associated with microtubules; when associated with A-317; A-322 and A-324. 1 Publication
    Mutagenesisi313 – 3131S → D: Reduced ability to associate with microtubules; when associated with D-317; E-322 and D-324. 1 Publication
    Mutagenesisi317 – 3171S → A in mitosis, remained associated with microtubules; when associated with A-313; A-322 and A-324. 1 Publication
    Mutagenesisi317 – 3171S → D: Reduced ability to associate with microtubules; when associated with D-313; E-322 and D-324. 1 Publication
    Mutagenesisi322 – 3221T → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-324. 1 Publication
    Mutagenesisi322 – 3221T → E: Reduced ability to associate with microtubules; when associated with D-313; D-317 and D-324. 1 Publication
    Mutagenesisi324 – 3241S → A in mitosis, remained associated with microtubules; when associated with A-313; A-317 and A-322. 1 Publication
    Mutagenesisi324 – 3241S → D: Reduced ability to associate with microtubules; when associated with D-313; D-317 and E-322. 1 Publication

    Organism-specific databases

    PharmGKBiPA134882882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Fibronectin type III and SPRY domain-containing protein 1PRO_0000316537Add
    BLAST

    Proteomic databases

    MaxQBiQ9BTV5.
    PaxDbiQ9BTV5.
    PRIDEiQ9BTV5.

    PTM databases

    PhosphoSiteiQ9BTV5.

    Expressioni

    Tissue specificityi

    Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.2 Publications

    Gene expression databases

    ArrayExpressiQ9BTV5.
    BgeeiQ9BTV5.
    CleanExiHS_FSD1.
    GenevestigatoriQ9BTV5.

    Organism-specific databases

    HPAiHPA043141.

    Interactioni

    Subunit structurei

    Oligomerization is required for binding to microtubules.

    Protein-protein interaction databases

    BioGridi122600. 3 interactions.
    IntActiQ9BTV5. 3 interactions.
    MINTiMINT-1368061.
    STRINGi9606.ENSP00000221856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTV5.
    SMRiQ9BTV5. Positions 51-105, 332-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 16258COSPROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 268105Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 477210B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili4 – 9996Sequence AnalysisAdd
    BLAST

    Domaini

    B30.2 box contains a microtubule-binding site.

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 COS domain.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG302398.
    HOGENOMiHOG000231656.
    HOVERGENiHBG107931.
    InParanoidiQ9BTV5.
    OMAiASWCIHL.
    OrthoDBiEOG7W6WKF.
    PhylomeDBiQ9BTV5.
    TreeFamiTF333654.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003649. Bbox_C.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00502. BBC. 1 hit.
    SM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BTV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE    50
    FQSLFSLLEE LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET 100
    ANQTLQAMDS EDFPQAAKQI KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA 150
    QERQMLQALK FLPVPSAPVI DLAESLVADN CVTLVWRMPD EDSKIDHYVL 200
    EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK YMNFRVKACN 250
    KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI 300
    KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL 350
    IDGGEHYWEV RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ 400
    VSFTAKHANK VKVLDAPVPD CLGVHCDFHQ GLLSFYNART KQVLHTFKTR 450
    FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC LQKRGSATSS SNTSLT 496
    Length:496
    Mass (Da):55,820
    Last modified:June 1, 2001 - v1
    Checksum:i0FE7B18F14C80D46
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951G → R in BAB13885. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti232 – 2321L → V.1 Publication
    Corresponds to variant rs35139245 [ dbSNP | Ensembl ].
    VAR_038385

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316829 mRNA. Translation: AAK26747.1.
    AY032617 mRNA. Translation: AAK51145.1.
    AK021750 mRNA. Translation: BAB13885.1.
    AK315661 mRNA. Translation: BAG38027.1.
    BC003124 mRNA. Translation: AAH03124.1.
    CCDSiCCDS12127.1.
    RefSeqiNP_077309.1. NM_024333.2.
    UniGeneiHs.28144.

    Genome annotation databases

    EnsembliENST00000221856; ENSP00000221856; ENSG00000105255.
    GeneIDi79187.
    KEGGihsa:79187.
    UCSCiuc002lzy.2. human.

    Polymorphism databases

    DMDMi74733152.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF316829 mRNA. Translation: AAK26747.1 .
    AY032617 mRNA. Translation: AAK51145.1 .
    AK021750 mRNA. Translation: BAB13885.1 .
    AK315661 mRNA. Translation: BAG38027.1 .
    BC003124 mRNA. Translation: AAH03124.1 .
    CCDSi CCDS12127.1.
    RefSeqi NP_077309.1. NM_024333.2.
    UniGenei Hs.28144.

    3D structure databases

    ProteinModelPortali Q9BTV5.
    SMRi Q9BTV5. Positions 51-105, 332-462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122600. 3 interactions.
    IntActi Q9BTV5. 3 interactions.
    MINTi MINT-1368061.
    STRINGi 9606.ENSP00000221856.

    PTM databases

    PhosphoSitei Q9BTV5.

    Polymorphism databases

    DMDMi 74733152.

    Proteomic databases

    MaxQBi Q9BTV5.
    PaxDbi Q9BTV5.
    PRIDEi Q9BTV5.

    Protocols and materials databases

    DNASUi 79187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221856 ; ENSP00000221856 ; ENSG00000105255 .
    GeneIDi 79187.
    KEGGi hsa:79187.
    UCSCi uc002lzy.2. human.

    Organism-specific databases

    CTDi 79187.
    GeneCardsi GC19P004304.
    HGNCi HGNC:13745. FSD1.
    HPAi HPA043141.
    MIMi 609828. gene.
    neXtProti NX_Q9BTV5.
    PharmGKBi PA134882882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302398.
    HOGENOMi HOG000231656.
    HOVERGENi HBG107931.
    InParanoidi Q9BTV5.
    OMAi ASWCIHL.
    OrthoDBi EOG7W6WKF.
    PhylomeDBi Q9BTV5.
    TreeFami TF333654.

    Miscellaneous databases

    GenomeRNAii 79187.
    NextBioi 68182.
    PROi Q9BTV5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BTV5.
    Bgeei Q9BTV5.
    CleanExi HS_FSD1.
    Genevestigatori Q9BTV5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003649. Bbox_C.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00502. BBC. 1 hit.
    SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31."
      Carim-Todd L., Escarceller M., Estivill X., Sumoy L.
      Biochim. Biophys. Acta 1518:200-203(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-232.
    2. "Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy."
      Manabe R., Whitmore L., Weiss J.M., Horwitz A.R.
      Curr. Biol. 12:1946-1951(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Fibrosarcoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo and Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "A novel centrosome-associated protein with affinity for microtubules."
      Stein P.A., Toret C.P., Salic A.N., Rolls M.M., Rapoport T.A.
      J. Cell Sci. 115:3389-3402(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF SER-313; SER-317; THR-322 AND SER-324.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFSD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTV5
    Secondary accession number(s): B2RDT0, Q9BXN0, Q9HAG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3