Q9BTP6 (ZBED2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger BED domain-containing protein 2

Gene names

Name:

ZBED2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 BED-type zinc finger.
Sequence caution	The sequence AAH03536.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH71956.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 218

218

Zinc finger BED domain-containing protein 2

PRO_0000066561

Regions

Zinc finger

52 – 113

62

BED-type

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

218

Helix Strand Turn

Details...

Helix

56 – 60

5

Beta strand

61 – 63

3

Beta strand

76 – 79

4

Helix

97 – 104

8

Helix

107 – 112

6

Sequences

	Sequence		Length	Mass (Da)
	Q9BTP6 [UniParc]. Last modified July 7, 2009. Version 2. Checksum: 2E2602FA7FC3BEE2	FASTA	218	25,122
	10 20 30 40 50 60 MMRREDEEEE GTMMKAKGDL EMKEEEEISE TGELVGPFVS AMPTPMPHNK GTRFSEAWEY 70 80 90 100 110 120 FHLAPARAGH HPNQYATCRL CGRQVSRGPG VNVGTTALWK HLKSMHREEL EKSGHGQAGQ 130 140 150 160 170 180 RQDPRPHGPQ LPTGIEGNWG RLLEQVGTMA LWASQREKEV LRRERAVEWR ERAVEKRERA 190 200 210 LEEVERAILE MKWKVRAEKE ACQREKELPA AVHPFHFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Uterus.
[4]	"Solution structures of the C2H2 type zinc finger domain of human zinc finger BED domain containing protein 2." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 55-117.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC055748 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79699.1.
CH471052 Genomic DNA. Translation: EAW79700.1.
BC003536 mRNA. Translation: AAH03536.1. Different initiation.
BC071956 mRNA. Translation: AAH71956.1. Different initiation.

IPI

IPI00001576.

RefSeq

NP_078784.2. NM_024508.4.

UniGene

Hs.136912.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DJR	NMR	-	A	55-117	[»]

ProteinModelPortal

Q9BTP6.

SMR

Q9BTP6. Positions 56-119.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BTP6. 2 interactions.

Polymorphism databases

DMDM

251757414.

Proteomic databases

PRIDE

Q9BTP6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000317012; ENSP00000321370; ENSG00000177494.

GeneID

79413.

KEGG

hsa:79413.

UCSC

uc003dxy.1. human.

Organism-specific databases

CTD

79413.

GeneCards

GC03M111311.

HGNC

HGNC:20710. ZBED2.

HPA

HPA029786.

neXtProt

NX_Q9BTP6.

PharmGKB

PA134879520.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG12362.

GeneTree

ENSGT00390000013530.

InParanoid

Q9BTP6.

OMA

WRERAVE.

OrthoDB

EOG48GW4P.

Gene expression databases

ArrayExpress

Q9BTP6.

Bgee

Q9BTP6.

CleanEx

HS_ZBED2.

Genevestigator

Q9BTP6.

GermOnline

ENSG00000177494. Homo sapiens.

Family and domain databases

InterPro

IPR003656. Znf_BED_prd.
[Graphical view]

Pfam

PF02892. zf-BED. 1 hit.
[Graphical view]

SMART

SM00614. ZnF_BED. 1 hit.
[Graphical view]

PROSITE

PS50808. ZF_BED. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

68375.

Entry information

Entry name

ZBED2_HUMAN

Accession

Primary (citable) accession number: Q9BTP6
Secondary accession number(s): D3DN62

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	July 7, 2009
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.