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Protein

Immediate early response gene 2 protein

Gene

IER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).By similarity2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • cell motility Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • response to fibroblast growth factor Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 2 protein
Alternative name(s):
Protein ETR101
Gene namesi
Name:IER2Imported
Synonyms:ETR1011 Publication, PIP921 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28871. IER2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982230.

Polymorphism and mutation databases

BioMutaiIER2.
DMDMi73920026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Immediate early response gene 2 proteinPRO_0000190435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9BTL4.
PaxDbiQ9BTL4.
PRIDEiQ9BTL4.

PTM databases

iPTMnetiQ9BTL4.
PhosphoSiteiQ9BTL4.

Expressioni

Tissue specificityi

Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713).1 Publication

Inductioni

By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA).1 Publication

Gene expression databases

BgeeiQ9BTL4.
CleanExiHS_IER2.
ExpressionAtlasiQ9BTL4. baseline and differential.
GenevisibleiQ9BTL4. HS.

Interactioni

Protein-protein interaction databases

BioGridi114959. 29 interactions.
IntActiQ9BTL4. 1 interaction.
STRINGi9606.ENSP00000292433.

Structurei

3D structure databases

ProteinModelPortaliQ9BTL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
GeneTreeiENSGT00730000111404.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiQ9BTL4.
OMAiCEAKPAC.
OrthoDBiEOG7N8ZX2.
PhylomeDBiQ9BTL4.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA
60 70 80 90 100
KVEALEPEVS LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE
110 120 130 140 150
APTAEETSAC CAPRPAKVSR KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE
160 170 180 190 200
GASSEVADRL QPPPAQAEGA FPNLARVLQR RFSGLLNCSP AAPPTAPPAC
210 220
EAKPACRPAD SMLNVLVRAV VAF
Length:223
Mass (Da):24,196
Last modified:June 1, 2001 - v1
Checksum:iCDC40214CCE0C2EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651A → G in AAA35814 (PubMed:2061303).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331A → V.1 Publication
Corresponds to variant rs1042164 [ dbSNP | Ensembl ].
VAR_057581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62831 mRNA. Translation: AAA35814.1.
CR450352 mRNA. Translation: CAG29348.1.
BT019466 mRNA. Translation: AAV38273.1.
BC003625 mRNA. Translation: AAH03625.1.
BC072432 mRNA. Translation: AAH72432.1.
BC110647 mRNA. Translation: AAI10648.1.
CCDSiCCDS12295.1.
PIRiA40866.
RefSeqiNP_004898.2. NM_004907.2.
UniGeneiHs.501629.

Genome annotation databases

EnsembliENST00000292433; ENSP00000292433; ENSG00000160888.
ENST00000587885; ENSP00000467294; ENSG00000160888.
ENST00000588173; ENSP00000465617; ENSG00000160888.
GeneIDi9592.
KEGGihsa:9592.
UCSCiuc002mwr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62831 mRNA. Translation: AAA35814.1.
CR450352 mRNA. Translation: CAG29348.1.
BT019466 mRNA. Translation: AAV38273.1.
BC003625 mRNA. Translation: AAH03625.1.
BC072432 mRNA. Translation: AAH72432.1.
BC110647 mRNA. Translation: AAI10648.1.
CCDSiCCDS12295.1.
PIRiA40866.
RefSeqiNP_004898.2. NM_004907.2.
UniGeneiHs.501629.

3D structure databases

ProteinModelPortaliQ9BTL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114959. 29 interactions.
IntActiQ9BTL4. 1 interaction.
STRINGi9606.ENSP00000292433.

PTM databases

iPTMnetiQ9BTL4.
PhosphoSiteiQ9BTL4.

Polymorphism and mutation databases

BioMutaiIER2.
DMDMi73920026.

Proteomic databases

MaxQBiQ9BTL4.
PaxDbiQ9BTL4.
PRIDEiQ9BTL4.

Protocols and materials databases

DNASUi9592.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292433; ENSP00000292433; ENSG00000160888.
ENST00000587885; ENSP00000467294; ENSG00000160888.
ENST00000588173; ENSP00000465617; ENSG00000160888.
GeneIDi9592.
KEGGihsa:9592.
UCSCiuc002mwr.4. human.

Organism-specific databases

CTDi9592.
GeneCardsiIER2.
H-InvDBHIX0174309.
HGNCiHGNC:28871. IER2.
neXtProtiNX_Q9BTL4.
PharmGKBiPA134982230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
GeneTreeiENSGT00730000111404.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiQ9BTL4.
OMAiCEAKPAC.
OrthoDBiEOG7N8ZX2.
PhylomeDBiQ9BTL4.

Miscellaneous databases

ChiTaRSiIER2. human.
GenomeRNAii9592.
NextBioi35997.
PROiQ9BTL4.

Gene expression databases

BgeeiQ9BTL4.
CleanExiHS_IER2.
ExpressionAtlasiQ9BTL4. baseline and differential.
GenevisibleiQ9BTL4. HS.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells."
    Shimizu N., Ohta M., Fujiwara C., Sagara J., Mochizuki N., Oda T., Utlyama H.
    J. Biol. Chem. 266:12157-12161(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, VARIANT VAL-133.
    Tissue: Promyelocytic leukemia.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Duodenum and Lymph.
  5. "Functional analyses of immediate early gene ETR101 expressed in yeast."
    Takaya T., Kasatani K., Noguchi S., Nikawa J.
    Biosci. Biotechnol. Biochem. 73:1653-1660(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  6. "The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients."
    Neeb A., Wallbaum S., Novac N., Dukovic-Schulze S., Scholl I., Schreiber C., Schlag P., Moll J., Stein U., Sleeman J.P.
    Oncogene 31:3796-3806(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIER2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTL4
Secondary accession number(s): Q03827, Q2TAZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.