Q9BTL4 (IER2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immediate early response gene 2 protein

Alternative name(s):
Protein ETR101

Gene names

Name:	IER2
Synonyms:	ETR101

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Induction	By growth factors and 12-O-tetradecanoylphorbol-13-acetate (TPA). Ref.1
Sequence similarities	Belongs to the IER family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Immediate early response gene 2 protein		PRO_0000190435
Natural variations
	Natural variant	133	1	A → V. Ref.1 Corresponds to variant rs1042164 [ dbSNP | Ensembl ].		VAR_057581
Experimental info
	Sequence conflict	165	1	A → G in AAA35814. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BTL4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CDC40214CCE0C2EE	FASTA	223	24,196
	10 20 30 40 50 60 MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA KVEALEPEVS 70 80 90 100 110 120 LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE APTAEETSAC CAPRPAKVSR 130 140 150 160 170 180 KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE GASSEVADRL QPPPAQAEGA FPNLARVLQR 190 200 210 220 RFSGLLNCSP AAPPTAPPAC EAKPACRPAD SMLNVLVRAV VAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells." Shimizu N., Ohta M., Fujiwara C., Sagara J., Mochizuki N., Oda T., Utlyama H. J. Biol. Chem. 266:12157-12161(1991) [PubMed: 2061303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, VARIANT VAL-133. Tissue: Promyelocytic leukemia.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Duodenum and Lymph.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M62831 mRNA. Translation: AAA35814.1. CR450352 mRNA. Translation: CAG29348.1. BT019466 mRNA. Translation: AAV38273.1. BC003625 mRNA. Translation: AAH03625.1. BC072432 mRNA. Translation: AAH72432.1. BC110647 mRNA. Translation: AAI10648.1.
IPI	IPI00006876.
PIR	A40866.
RefSeq	NP_004898.2. NM_004907.2.
UniGene	Hs.501629.
3D structure databases
ProteinModelPortal	Q9BTL4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BTL4. 1 interaction.
STRING	Q9BTL4.
Polymorphism databases
DMDM	73920026.
Proteomic databases
PRIDE	Q9BTL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292433; ENSP00000292433; ENSG00000160888. ENST00000393152; ENSP00000376859; ENSG00000160888.
GeneID	9592.
KEGG	hsa:9592.
UCSC	uc002mwr.1. human.
Organism-specific databases
CTD	9592.
GeneCards	GC19P013261.
H-InvDB	HIX0014822.
HGNC	HGNC:28871. IER2.
neXtProt	NX_Q9BTL4.
PharmGKB	PA134982230.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08310.
GeneTree	ENSGT00530000064009.
HOGENOM	HBG127096.
HOVERGEN	HBG068883.
InParanoid	Q9BTL4.
OMA	EGAFPNL.
OrthoDB	EOG43210D.
PhylomeDB	Q9BTL4.
Gene expression databases
ArrayExpress	Q9BTL4.
Bgee	Q9BTL4.
CleanEx	HS_IER2.
Genevestigator	Q9BTL4.
GermOnline	ENSG00000160888. Homo sapiens.
Family and domain databases
InterPro	IPR008653. IER. [Graphical view]
PANTHER	PTHR15895. IER. 1 hit.
Pfam	PF05760. IER. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35997.

Entry information

Entry name

IER2_HUMAN

Accession

Primary (citable) accession number: Q9BTL4
Secondary accession number(s): Q03827, Q2TAZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.