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Protein

PAXIP1-associated glutamate-rich protein 1

Gene

PAGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).By similarityCurated3 Publications

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

GO - Biological processi

  • DNA recombination Source: UniProtKB-KW
  • DNA repair Source: UniProtKB-KW
  • positive regulation of cell cycle G1/S phase transition Source: UniProtKB
  • positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
SignaLinkiQ9BTK6.

Names & Taxonomyi

Protein namesi
Recommended name:
PAXIP1-associated glutamate-rich protein 1
Alternative name(s):
Glutamate-rich coactivator interacting with SRC11 Publication
Short name:
GAS1 Publication
PAXIP1-associated protein 1
PTIP-associated protein 1
Gene namesi
Name:PAGR1
Synonyms:C16orf53, PA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28707. PAGR1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • histone methyltransferase complex Source: MGI
  • MLL3/4 complex Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672260.

Polymorphism and mutation databases

BioMutaiPAGR1.
DMDMi74733129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254PAXIP1-associated glutamate-rich protein 1PRO_0000248334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei138 – 1381PhosphothreonineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei148 – 1481PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTK6.
MaxQBiQ9BTK6.
PaxDbiQ9BTK6.
PeptideAtlasiQ9BTK6.
PRIDEiQ9BTK6.

PTM databases

iPTMnetiQ9BTK6.
PhosphoSiteiQ9BTK6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000185928.
CleanExiHS_C16orf53.
GenevisibleiQ9BTK6. HS.

Organism-specific databases

HPAiHPA041440.
HPA043608.

Interactioni

Subunit structurei

Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (PubMed:17500065). Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (By similarity). Interacts with NCOA1, ESR1, NR3C1, AR (PubMed:19039327,PubMed:19124460, PubMed:23161582).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033725EBI-2372223,EBI-78473
NCOA1Q157884EBI-2372223,EBI-455189
Nr3c1P065362EBI-2372223,EBI-1187143From a different organism.
PAXIP1Q6ZW498EBI-2372223,EBI-743225
Paxip1Q6NZQ45EBI-2372223,EBI-1395317From a different organism.

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122672. 14 interactions.
IntActiQ9BTK6. 20 interactions.
MINTiMINT-7013330.
STRINGi9606.ENSP00000326519.

Structurei

3D structure databases

ProteinModelPortaliQ9BTK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 16045Sufficient for interaction with NCOA11 PublicationAdd
BLAST
Regioni161 – 25494Sufficient for interaction with ESR11 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 160114Glu-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IXWI. Eukaryota.
ENOG4111Q6K. LUCA.
GeneTreeiENSGT00390000016049.
HOGENOMiHOG000115419.
HOVERGENiHBG080642.
InParanoidiQ9BTK6.
KOiK14973.
OMAiPHIPTEF.
OrthoDBiEOG091G0IXS.
PhylomeDBiQ9BTK6.
TreeFamiTF326621.

Family and domain databases

InterProiIPR028213. PA1.
[Graphical view]
PfamiPF15364. PAXIP1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG
60 70 80 90 100
EGGREETERE GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA
110 120 130 140 150
DGQPWMPPPS EIQRLYELLA AHGTLELQAE ILPRRPPTPE AQSEEERSDE
160 170 180 190 200
EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS LIDRRRTPGS SARSQKREAR
210 220 230 240 250
LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL RSSGSSLFPR

QRKY
Length:254
Mass (Da):27,716
Last modified:June 1, 2001 - v1
Checksum:i59E8231535CC12A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF195235 mRNA. Translation: ABM69249.1.
AC009133 Genomic DNA. No translation available.
AC120114 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79989.1.
BC003640 mRNA. Translation: AAH03640.1.
CCDSiCCDS10655.1.
RefSeqiNP_078792.1. NM_024516.3.
UniGeneiHs.702841.

Genome annotation databases

EnsembliENST00000320330; ENSP00000326519; ENSG00000280789.
GeneIDi79447.
KEGGihsa:79447.
UCSCiuc002dug.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF195235 mRNA. Translation: ABM69249.1.
AC009133 Genomic DNA. No translation available.
AC120114 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79989.1.
BC003640 mRNA. Translation: AAH03640.1.
CCDSiCCDS10655.1.
RefSeqiNP_078792.1. NM_024516.3.
UniGeneiHs.702841.

3D structure databases

ProteinModelPortaliQ9BTK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122672. 14 interactions.
IntActiQ9BTK6. 20 interactions.
MINTiMINT-7013330.
STRINGi9606.ENSP00000326519.

PTM databases

iPTMnetiQ9BTK6.
PhosphoSiteiQ9BTK6.

Polymorphism and mutation databases

BioMutaiPAGR1.
DMDMi74733129.

Proteomic databases

EPDiQ9BTK6.
MaxQBiQ9BTK6.
PaxDbiQ9BTK6.
PeptideAtlasiQ9BTK6.
PRIDEiQ9BTK6.

Protocols and materials databases

DNASUi79447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320330; ENSP00000326519; ENSG00000280789.
GeneIDi79447.
KEGGihsa:79447.
UCSCiuc002dug.5. human.

Organism-specific databases

CTDi79447.
GeneCardsiPAGR1.
HGNCiHGNC:28707. PAGR1.
HPAiHPA041440.
HPA043608.
MIMi612033. gene.
neXtProtiNX_Q9BTK6.
PharmGKBiPA142672260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWI. Eukaryota.
ENOG4111Q6K. LUCA.
GeneTreeiENSGT00390000016049.
HOGENOMiHOG000115419.
HOVERGENiHBG080642.
InParanoidiQ9BTK6.
KOiK14973.
OMAiPHIPTEF.
OrthoDBiEOG091G0IXS.
PhylomeDBiQ9BTK6.
TreeFamiTF326621.

Enzyme and pathway databases

ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
SignaLinkiQ9BTK6.

Miscellaneous databases

GenomeRNAii79447.
PROiQ9BTK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185928.
CleanExiHS_C16orf53.
GenevisibleiQ9BTK6. HS.

Family and domain databases

InterProiIPR028213. PA1.
[Graphical view]
PfamiPF15364. PAXIP1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAGR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTK6
Secondary accession number(s): A2ICR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.