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Protein

PAXIP1-associated glutamate-rich protein 1

Gene

PAGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).By similarityCurated3 Publications

Caution

The terminology of MLL proteins in mammalia is not consistent also concerning the terminology of MLL protein-containing complexes. The decribed MLL2/MLL3 complex is commonly described as MLL3/MLL4 complex in literature.Curated

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

GO - Biological processi

  • DNA recombination Source: UniProtKB-KW
  • DNA repair Source: UniProtKB-KW
  • positive regulation of cell cycle G1/S phase transition Source: UniProtKB
  • positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkiQ9BTK6

Names & Taxonomyi

Protein namesi
Recommended name:
PAXIP1-associated glutamate-rich protein 1
Alternative name(s):
Glutamate-rich coactivator interacting with SRC11 Publication
Short name:
GAS1 Publication
PAXIP1-associated protein 1
PTIP-associated protein 1
Gene namesi
Name:PAGR1
Synonyms:C16orf53, PA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000280789.1
HGNCiHGNC:28707 PAGR1
MIMi612033 gene
neXtProtiNX_Q9BTK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79447
OpenTargetsiENSG00000280789
PharmGKBiPA142672260

Polymorphism and mutation databases

BioMutaiPAGR1
DMDMi74733129

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483341 – 254PAXIP1-associated glutamate-rich protein 1Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphothreonineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTK6
MaxQBiQ9BTK6
PaxDbiQ9BTK6
PeptideAtlasiQ9BTK6
PRIDEiQ9BTK6

PTM databases

iPTMnetiQ9BTK6
PhosphoSitePlusiQ9BTK6

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000280789
CleanExiHS_C16orf53
GenevisibleiQ9BTK6 HS

Organism-specific databases

HPAiHPA041440
HPA043608

Interactioni

Subunit structurei

Component of the KMT2 family MLL2/MLL3 complex (also named ASCOM complex), at least composed of the HMTs KMT2D and/or KMT2C, the common subunits ASH2L, RBBP5, WDR5 and DPY30, and the complex type-specific subunits PAXIP1/PTIP, PAGR1, NCOA6 and KDM6A; PAXIP1 is required for the association with the MLL2/MLL3 complex (PubMed:17500065). Forms a constitutive complex with PAXIP1/PTIP independently of the MLL2/MLL3 complex (By similarity). Interacts with NCOA1, ESR1, NR3C1, AR (PubMed:19039327,PubMed:19124460, PubMed:23161582).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122672, 14 interactors
CORUMiQ9BTK6
IntActiQ9BTK6, 20 interactors
MINTiQ9BTK6
STRINGi9606.ENSP00000326519

Structurei

3D structure databases

ProteinModelPortaliQ9BTK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 160Sufficient for interaction with NCOA11 PublicationAdd BLAST45
Regioni161 – 254Sufficient for interaction with ESR11 PublicationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 160Glu-richAdd BLAST114

Phylogenomic databases

eggNOGiENOG410IXWI Eukaryota
ENOG4111Q6K LUCA
GeneTreeiENSGT00390000016049
HOGENOMiHOG000115419
HOVERGENiHBG080642
InParanoidiQ9BTK6
KOiK14973
OMAiESEDWCV
OrthoDBiEOG091G0IXS
PhylomeDBiQ9BTK6
TreeFamiTF326621

Family and domain databases

InterProiView protein in InterPro
IPR028213 PA1
PANTHERiPTHR28467 PTHR28467, 1 hit
PfamiView protein in Pfam
PF15364 PAXIP1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BTK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG
60 70 80 90 100
EGGREETERE GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA
110 120 130 140 150
DGQPWMPPPS EIQRLYELLA AHGTLELQAE ILPRRPPTPE AQSEEERSDE
160 170 180 190 200
EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS LIDRRRTPGS SARSQKREAR
210 220 230 240 250
LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL RSSGSSLFPR

QRKY
Length:254
Mass (Da):27,716
Last modified:June 1, 2001 - v1
Checksum:i59E8231535CC12A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF195235 mRNA Translation: ABM69249.1
AC009133 Genomic DNA No translation available.
AC120114 Genomic DNA No translation available.
CH471238 Genomic DNA Translation: EAW79989.1
BC003640 mRNA Translation: AAH03640.1
CCDSiCCDS10655.1
RefSeqiNP_078792.1, NM_024516.3
UniGeneiHs.702841

Genome annotation databases

EnsembliENST00000320330; ENSP00000326519; ENSG00000280789
GeneIDi79447
KEGGihsa:79447
UCSCiuc002dug.5 human

Similar proteinsi

Entry informationi

Entry nameiPAGR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BTK6
Secondary accession number(s): A2ICR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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