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Protein

THUMP domain-containing protein 2

Gene

THUMPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 2
Gene namesi
Name:THUMPD2
Synonyms:C2orf8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14890. THUMPD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976355.

Polymorphism and mutation databases

BioMutaiTHUMPD2.
DMDMi342187042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503THUMP domain-containing protein 2PRO_0000072532Add
BLAST

Proteomic databases

EPDiQ9BTF0.
MaxQBiQ9BTF0.
PaxDbiQ9BTF0.
PRIDEiQ9BTF0.

PTM databases

iPTMnetiQ9BTF0.
PhosphoSiteiQ9BTF0.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiQ9BTF0.
CleanExiHS_THUMPD2.
ExpressionAtlasiQ9BTF0. baseline and differential.
GenevisibleiQ9BTF0. HS.

Organism-specific databases

HPAiHPA043042.

Interactioni

Protein-protein interaction databases

BioGridi123287. 6 interactions.
STRINGi9606.ENSP00000423933.

Structurei

3D structure databases

ProteinModelPortaliQ9BTF0.
SMRiQ9BTF0. Positions 206-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 266106THUMPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated
Contains 1 THUMP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVBE. Eukaryota.
COG0116. LUCA.
GeneTreeiENSGT00530000063557.
HOGENOMiHOG000013141.
HOVERGENiHBG061192.
InParanoidiQ9BTF0.
OMAiAFICKYK.
OrthoDBiEOG7HQN8B.
PhylomeDBiQ9BTF0.
TreeFamiTF313093.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51165. THUMP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEARGEPGS GPEAGARFFC TAGRGLEPFV MREVRARLAA TQVEYISGKV
60 70 80 90 100
FFTTCSDLNM LKKLKSAERL FLLIKKQFPL IISSVSKGKI FNEMQRLINE
110 120 130 140 150
DPGSWLNAIS IWKNLLELDA KKEKLSQRDD NQLKRKVGEN EIIAKKLKIE
160 170 180 190 200
QMQKIEENRD CQLEKQIKEE TLEQRDFTTK SEKFQEEEFQ NDIEKAIDTH
210 220 230 240 250
NQNDLTFRVS CRCSGTIGKA FTAQEVGKVI GIAIMKHFGW KADLRNPQLE
260 270 280 290 300
IFIHLNDIYS VVGIPVFRVS LASRAYIKTA GLRSTIAWAM ASLADIKAGA
310 320 330 340 350
FVLDPMCGLG TILLEAAKEW PDVYYVGADV SDSQLLGTWD NLKAAGLEDK
360 370 380 390 400
IELLKISVIE LPLPSESVDI IISDIPFGKK FKLGKDIKSI LQEMERVLHV
410 420 430 440 450
GGTIVLLLSE DHHRRLTDCK ESNIPFNSKD SHTDEPGIKK CLNPEEKTGA
460 470 480 490 500
FKTASTSFEA SNHKFLDRMS PFGSLVPVEC YKVSLGKTDA FICKYKKSHS

SGL
Length:503
Mass (Da):56,433
Last modified:July 27, 2011 - v2
Checksum:i8CBF950B5EDED103
GO
Isoform 2 (identifier: Q9BTF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-303: AGAFVL → VPYGSD
     304-503: Missing.

Show »
Length:303
Mass (Da):34,414
Checksum:i62032C585061E55A
GO

Sequence cautioni

The sequence AAH04163.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH13299.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL26317.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAY14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei298 – 3036AGAFVL → VPYGSD in isoform 2. 1 PublicationVSP_041645
Alternative sequencei304 – 503200Missing in isoform 2. 1 PublicationVSP_041646Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380576
, AF380566, AF380567, AF380568, AF380569, AF380570, AF380571, AF380573, AF380574, AF380575 Genomic DNA. Translation: AAL26317.1. Different initiation.
AK292002 mRNA. Translation: BAF84691.1.
AK093580 mRNA. Translation: BAG52741.1.
AC007246 Genomic DNA. Translation: AAX93065.1.
AC007253 Genomic DNA. Translation: AAY14769.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00339.1.
CH471053 Genomic DNA. Translation: EAX00340.1.
BC004163 mRNA. Translation: AAH04163.1. Different initiation.
BC013299 mRNA. Translation: AAH13299.1. Different initiation.
CCDSiCCDS1805.2. [Q9BTF0-1]
RefSeqiNP_079540.2. NM_025264.4. [Q9BTF0-1]
UniGeneiHs.468254.

Genome annotation databases

EnsembliENST00000378727; ENSP00000368001; ENSG00000138050. [Q9BTF0-2]
ENST00000505747; ENSP00000423933; ENSG00000138050. [Q9BTF0-1]
GeneIDi80745.
KEGGihsa:80745.
UCSCiuc002rru.3. human. [Q9BTF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380576
, AF380566, AF380567, AF380568, AF380569, AF380570, AF380571, AF380573, AF380574, AF380575 Genomic DNA. Translation: AAL26317.1. Different initiation.
AK292002 mRNA. Translation: BAF84691.1.
AK093580 mRNA. Translation: BAG52741.1.
AC007246 Genomic DNA. Translation: AAX93065.1.
AC007253 Genomic DNA. Translation: AAY14769.1. Different initiation.
CH471053 Genomic DNA. Translation: EAX00339.1.
CH471053 Genomic DNA. Translation: EAX00340.1.
BC004163 mRNA. Translation: AAH04163.1. Different initiation.
BC013299 mRNA. Translation: AAH13299.1. Different initiation.
CCDSiCCDS1805.2. [Q9BTF0-1]
RefSeqiNP_079540.2. NM_025264.4. [Q9BTF0-1]
UniGeneiHs.468254.

3D structure databases

ProteinModelPortaliQ9BTF0.
SMRiQ9BTF0. Positions 206-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123287. 6 interactions.
STRINGi9606.ENSP00000423933.

PTM databases

iPTMnetiQ9BTF0.
PhosphoSiteiQ9BTF0.

Polymorphism and mutation databases

BioMutaiTHUMPD2.
DMDMi342187042.

Proteomic databases

EPDiQ9BTF0.
MaxQBiQ9BTF0.
PaxDbiQ9BTF0.
PRIDEiQ9BTF0.

Protocols and materials databases

DNASUi80745.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378727; ENSP00000368001; ENSG00000138050. [Q9BTF0-2]
ENST00000505747; ENSP00000423933; ENSG00000138050. [Q9BTF0-1]
GeneIDi80745.
KEGGihsa:80745.
UCSCiuc002rru.3. human. [Q9BTF0-1]

Organism-specific databases

CTDi80745.
GeneCardsiTHUMPD2.
H-InvDBHIX0002000.
HGNCiHGNC:14890. THUMPD2.
HPAiHPA043042.
MIMi611751. gene.
neXtProtiNX_Q9BTF0.
PharmGKBiPA134976355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVBE. Eukaryota.
COG0116. LUCA.
GeneTreeiENSGT00530000063557.
HOGENOMiHOG000013141.
HOVERGENiHBG061192.
InParanoidiQ9BTF0.
OMAiAFICKYK.
OrthoDBiEOG7HQN8B.
PhylomeDBiQ9BTF0.
TreeFamiTF313093.

Miscellaneous databases

ChiTaRSiTHUMPD2. human.
GenomeRNAii80745.
PROiQ9BTF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BTF0.
CleanExiHS_THUMPD2.
ExpressionAtlasiQ9BTF0. baseline and differential.
GenevisibleiQ9BTF0. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51165. THUMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21."
    Zhang Y., Gorry M.C., Hart P.S., Pettenati M.J., Wang L., Marks J.J., Lu X., Hart T.C.
    Cytogenet. Cell Genet. 95:146-152(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine and Thymus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-503 (ISOFORM 1).
    Tissue: Muscle.

Entry informationi

Entry nameiTHUM2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTF0
Secondary accession number(s): A8K7I7, Q53TT8, Q53TV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.