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Protein

THUMP domain-containing protein 2

Gene

THUMPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 2
Gene namesi
Name:THUMPD2
Synonyms:C2orf8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138050.14
HGNCiHGNC:14890 THUMPD2
MIMi611751 gene
neXtProtiNX_Q9BTF0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138050
PharmGKBiPA134976355

Polymorphism and mutation databases

BioMutaiTHUMPD2
DMDMi342187042

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725321 – 503THUMP domain-containing protein 2Add BLAST503

Proteomic databases

EPDiQ9BTF0
MaxQBiQ9BTF0
PaxDbiQ9BTF0
PeptideAtlasiQ9BTF0
PRIDEiQ9BTF0

PTM databases

iPTMnetiQ9BTF0
PhosphoSitePlusiQ9BTF0

Expressioni

Tissue specificityi

Expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000138050
CleanExiHS_THUMPD2
ExpressionAtlasiQ9BTF0 baseline and differential
GenevisibleiQ9BTF0 HS

Organism-specific databases

HPAiHPA043042
HPA058025

Interactioni

Protein-protein interaction databases

BioGridi123287, 7 interactors
IntActiQ9BTF0, 1 interactor
STRINGi9606.ENSP00000423933

Structurei

3D structure databases

ProteinModelPortaliQ9BTF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 266THUMPPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IVBE Eukaryota
COG0116 LUCA
GeneTreeiENSGT00530000063557
HOGENOMiHOG000013141
HOVERGENiHBG061192
InParanoidiQ9BTF0
OMAiWKADLRN
OrthoDBiEOG091G1D46
PhylomeDBiQ9BTF0
TreeFamiTF313093

Family and domain databases

InterProiView protein in InterPro
IPR000241 RNA_methylase_dom
IPR029063 SAM-dependent_MTases
IPR004114 THUMP_dom
PfamiView protein in Pfam
PF02926 THUMP, 1 hit
PF01170 UPF0020, 1 hit
SMARTiView protein in SMART
SM00981 THUMP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51165 THUMP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BTF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEARGEPGS GPEAGARFFC TAGRGLEPFV MREVRARLAA TQVEYISGKV
60 70 80 90 100
FFTTCSDLNM LKKLKSAERL FLLIKKQFPL IISSVSKGKI FNEMQRLINE
110 120 130 140 150
DPGSWLNAIS IWKNLLELDA KKEKLSQRDD NQLKRKVGEN EIIAKKLKIE
160 170 180 190 200
QMQKIEENRD CQLEKQIKEE TLEQRDFTTK SEKFQEEEFQ NDIEKAIDTH
210 220 230 240 250
NQNDLTFRVS CRCSGTIGKA FTAQEVGKVI GIAIMKHFGW KADLRNPQLE
260 270 280 290 300
IFIHLNDIYS VVGIPVFRVS LASRAYIKTA GLRSTIAWAM ASLADIKAGA
310 320 330 340 350
FVLDPMCGLG TILLEAAKEW PDVYYVGADV SDSQLLGTWD NLKAAGLEDK
360 370 380 390 400
IELLKISVIE LPLPSESVDI IISDIPFGKK FKLGKDIKSI LQEMERVLHV
410 420 430 440 450
GGTIVLLLSE DHHRRLTDCK ESNIPFNSKD SHTDEPGIKK CLNPEEKTGA
460 470 480 490 500
FKTASTSFEA SNHKFLDRMS PFGSLVPVEC YKVSLGKTDA FICKYKKSHS

SGL
Length:503
Mass (Da):56,433
Last modified:July 27, 2011 - v2
Checksum:i8CBF950B5EDED103
GO
Isoform 2 (identifier: Q9BTF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-303: AGAFVL → VPYGSD
     304-503: Missing.

Show »
Length:303
Mass (Da):34,414
Checksum:i62032C585061E55A
GO

Sequence cautioni

The sequence AAH04163 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH13299 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL26317 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAY14769 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041645298 – 303AGAFVL → VPYGSD in isoform 2. 1 Publication6
Alternative sequenceiVSP_041646304 – 503Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380576
, AF380566, AF380567, AF380568, AF380569, AF380570, AF380571, AF380573, AF380574, AF380575 Genomic DNA Translation: AAL26317.1 Different initiation.
AK292002 mRNA Translation: BAF84691.1
AK093580 mRNA Translation: BAG52741.1
AC007246 Genomic DNA Translation: AAX93065.1
AC007253 Genomic DNA Translation: AAY14769.1 Different initiation.
CH471053 Genomic DNA Translation: EAX00339.1
CH471053 Genomic DNA Translation: EAX00340.1
BC004163 mRNA Translation: AAH04163.1 Different initiation.
BC013299 mRNA Translation: AAH13299.1 Different initiation.
CCDSiCCDS1805.2 [Q9BTF0-1]
RefSeqiNP_079540.2, NM_025264.4 [Q9BTF0-1]
UniGeneiHs.468254

Genome annotation databases

EnsembliENST00000378727; ENSP00000368001; ENSG00000138050 [Q9BTF0-2]
ENST00000505747; ENSP00000423933; ENSG00000138050 [Q9BTF0-1]
GeneIDi80745
KEGGihsa:80745
UCSCiuc002rru.3 human [Q9BTF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTHUM2_HUMAN
AccessioniPrimary (citable) accession number: Q9BTF0
Secondary accession number(s): A8K7I7, Q53TT8, Q53TV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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