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Protein

DCN1-like protein 5

Gene

DCUN1D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DCN1-like protein 5
Alternative name(s):
DCUN1 domain-containing protein 5
Defective in cullin neddylation protein 1-like protein 5
Gene namesi
Name:DCUN1D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28409. DCUN1D5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137692.
PharmGKBiPA142672011.

Polymorphism and mutation databases

BioMutaiDCUN1D5.
DMDMi74733117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541711 – 237DCN1-like protein 5Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BTE7.
MaxQBiQ9BTE7.
PaxDbiQ9BTE7.
PeptideAtlasiQ9BTE7.
PRIDEiQ9BTE7.

PTM databases

iPTMnetiQ9BTE7.
PhosphoSitePlusiQ9BTE7.

Expressioni

Gene expression databases

BgeeiENSG00000137692.
CleanExiHS_DCUN1D5.
ExpressionAtlasiQ9BTE7. baseline and differential.
GenevisibleiQ9BTE7. HS.

Organism-specific databases

HPAiHPA050863.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-3924013,EBI-739832

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123986. 32 interactors.
IntActiQ9BTE7. 8 interactors.
STRINGi9606.ENSP00000260247.

Structurei

3D structure databases

ProteinModelPortaliQ9BTE7.
SMRiQ9BTE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 232DCUN1PROSITE-ProRule annotationAdd BLAST187

Sequence similaritiesi

Contains 1 DCUN1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3077. Eukaryota.
ENOG410XTIJ. LUCA.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG106637.
InParanoidiQ9BTE7.
KOiK17824.
OMAiCRSQASG.
OrthoDBiEOG091G0L81.
PhylomeDBiQ9BTE7.
TreeFamiTF354270.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK
60 70 80 90 100
CLAWFYEYAG PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF
110 120 130 140 150
FTKEEWLKGM TSLQCDCTEK LQNKFDFLRS QLNDISSFKN IYRYAFDFAR
160 170 180 190 200
DKDQRSLDID TAKSMLALLL GRTWPLFSVF YQYLEQSKYR VMNKDQWYNV
210 220 230
LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS
Length:237
Mass (Da):27,508
Last modified:June 1, 2001 - v1
Checksum:i4F507B6E5D81EF79
GO

Sequence cautioni

The sequence AAQ76805 differs from that shown. Reason: Frameshift at positions 222 and 232.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227F → L in AAQ76805 (PubMed:16533400).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA. Translation: BAB71336.1.
BC004169 mRNA. Translation: AAH04169.1.
AY364246 mRNA. Translation: AAQ76805.1. Frameshift.
CCDSiCCDS8325.1.
RefSeqiNP_115675.1. NM_032299.3.
UniGeneiHs.503716.

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692.
GeneIDi84259.
KEGGihsa:84259.
UCSCiuc001phm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA. Translation: BAB71336.1.
BC004169 mRNA. Translation: AAH04169.1.
AY364246 mRNA. Translation: AAQ76805.1. Frameshift.
CCDSiCCDS8325.1.
RefSeqiNP_115675.1. NM_032299.3.
UniGeneiHs.503716.

3D structure databases

ProteinModelPortaliQ9BTE7.
SMRiQ9BTE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123986. 32 interactors.
IntActiQ9BTE7. 8 interactors.
STRINGi9606.ENSP00000260247.

PTM databases

iPTMnetiQ9BTE7.
PhosphoSitePlusiQ9BTE7.

Polymorphism and mutation databases

BioMutaiDCUN1D5.
DMDMi74733117.

Proteomic databases

EPDiQ9BTE7.
MaxQBiQ9BTE7.
PaxDbiQ9BTE7.
PeptideAtlasiQ9BTE7.
PRIDEiQ9BTE7.

Protocols and materials databases

DNASUi84259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692.
GeneIDi84259.
KEGGihsa:84259.
UCSCiuc001phm.4. human.

Organism-specific databases

CTDi84259.
GeneCardsiDCUN1D5.
HGNCiHGNC:28409. DCUN1D5.
HPAiHPA050863.
MIMi616522. gene.
neXtProtiNX_Q9BTE7.
OpenTargetsiENSG00000137692.
PharmGKBiPA142672011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3077. Eukaryota.
ENOG410XTIJ. LUCA.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG106637.
InParanoidiQ9BTE7.
KOiK17824.
OMAiCRSQASG.
OrthoDBiEOG091G0L81.
PhylomeDBiQ9BTE7.
TreeFamiTF354270.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137692-MONOMER.

Miscellaneous databases

GenomeRNAii84259.
PROiQ9BTE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137692.
CleanExiHS_DCUN1D5.
ExpressionAtlasiQ9BTE7. baseline and differential.
GenevisibleiQ9BTE7. HS.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCNL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE7
Secondary accession number(s): Q3ZTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.