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Protein

DCN1-like protein 5

Gene

DCUN1D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DCN1-like protein 5
Alternative name(s):
DCUN1 domain-containing protein 5
Defective in cullin neddylation protein 1-like protein 5
Gene namesi
Name:DCUN1D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28409. DCUN1D5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672011.

Polymorphism and mutation databases

BioMutaiDCUN1D5.
DMDMi74733117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237DCN1-like protein 5PRO_0000254171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BTE7.
PaxDbiQ9BTE7.
PeptideAtlasiQ9BTE7.
PRIDEiQ9BTE7.

PTM databases

PhosphoSiteiQ9BTE7.

Expressioni

Gene expression databases

BgeeiQ9BTE7.
CleanExiHS_DCUN1D5.
ExpressionAtlasiQ9BTE7. baseline and differential.
GenevisibleiQ9BTE7. HS.

Organism-specific databases

HPAiHPA050863.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB13EBI-3924013,EBI-739832

Protein-protein interaction databases

BioGridi123986. 20 interactions.
IntActiQ9BTE7. 2 interactions.
STRINGi9606.ENSP00000260247.

Structurei

3D structure databases

ProteinModelPortaliQ9BTE7.
SMRiQ9BTE7. Positions 65-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 232187DCUN1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DCUN1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG279481.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG106637.
InParanoidiQ9BTE7.
KOiK17824.
OMAiEFSRTVN.
PhylomeDBiQ9BTE7.
TreeFamiTF354270.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BTE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK
60 70 80 90 100
CLAWFYEYAG PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF
110 120 130 140 150
FTKEEWLKGM TSLQCDCTEK LQNKFDFLRS QLNDISSFKN IYRYAFDFAR
160 170 180 190 200
DKDQRSLDID TAKSMLALLL GRTWPLFSVF YQYLEQSKYR VMNKDQWYNV
210 220 230
LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS
Length:237
Mass (Da):27,508
Last modified:June 1, 2001 - v1
Checksum:i4F507B6E5D81EF79
GO

Sequence cautioni

The sequence AAQ76805.1 differs from that shown. Reason: Frameshift at positions 222 and 232. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271F → L in AAQ76805 (PubMed:16533400).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA. Translation: BAB71336.1.
BC004169 mRNA. Translation: AAH04169.1.
AY364246 mRNA. Translation: AAQ76805.1. Frameshift.
CCDSiCCDS8325.1.
RefSeqiNP_115675.1. NM_032299.3.
UniGeneiHs.503716.

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692.
GeneIDi84259.
KEGGihsa:84259.
UCSCiuc001phm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056993 mRNA. Translation: BAB71336.1.
BC004169 mRNA. Translation: AAH04169.1.
AY364246 mRNA. Translation: AAQ76805.1. Frameshift.
CCDSiCCDS8325.1.
RefSeqiNP_115675.1. NM_032299.3.
UniGeneiHs.503716.

3D structure databases

ProteinModelPortaliQ9BTE7.
SMRiQ9BTE7. Positions 65-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123986. 20 interactions.
IntActiQ9BTE7. 2 interactions.
STRINGi9606.ENSP00000260247.

PTM databases

PhosphoSiteiQ9BTE7.

Polymorphism and mutation databases

BioMutaiDCUN1D5.
DMDMi74733117.

Proteomic databases

MaxQBiQ9BTE7.
PaxDbiQ9BTE7.
PeptideAtlasiQ9BTE7.
PRIDEiQ9BTE7.

Protocols and materials databases

DNASUi84259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260247; ENSP00000260247; ENSG00000137692.
GeneIDi84259.
KEGGihsa:84259.
UCSCiuc001phm.3. human.

Organism-specific databases

CTDi84259.
GeneCardsiGC11M102924.
HGNCiHGNC:28409. DCUN1D5.
HPAiHPA050863.
neXtProtiNX_Q9BTE7.
PharmGKBiPA142672011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279481.
GeneTreeiENSGT00550000074529.
HOGENOMiHOG000241761.
HOVERGENiHBG106637.
InParanoidiQ9BTE7.
KOiK17824.
OMAiEFSRTVN.
PhylomeDBiQ9BTE7.
TreeFamiTF354270.

Miscellaneous databases

GenomeRNAii84259.
NextBioi73782.
PROiQ9BTE7.

Gene expression databases

BgeeiQ9BTE7.
CleanExiHS_DCUN1D5.
ExpressionAtlasiQ9BTE7. baseline and differential.
GenevisibleiQ9BTE7. HS.

Family and domain databases

InterProiIPR014764. DCN-prot.
IPR005176. PONY_dom.
[Graphical view]
PANTHERiPTHR12281. PTHR12281. 1 hit.
PfamiPF03556. Cullin_binding. 1 hit.
[Graphical view]
PROSITEiPS51229. DCUN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
    Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
    BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-233.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCNL5_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE7
Secondary accession number(s): Q3ZTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.