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Q9BTE7

- DCNL5_HUMAN

UniProt

Q9BTE7 - DCNL5_HUMAN

Protein

DCN1-like protein 5

Gene

DCUN1D5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DCN1-like protein 5
    Alternative name(s):
    DCUN1 domain-containing protein 5
    Defective in cullin neddylation protein 1-like protein 5
    Gene namesi
    Name:DCUN1D5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28409. DCUN1D5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237DCN1-like protein 5PRO_0000254171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BTE7.
    PaxDbiQ9BTE7.
    PeptideAtlasiQ9BTE7.
    PRIDEiQ9BTE7.

    PTM databases

    PhosphoSiteiQ9BTE7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BTE7.
    BgeeiQ9BTE7.
    CleanExiHS_DCUN1D5.
    GenevestigatoriQ9BTE7.

    Organism-specific databases

    HPAiHPA050863.

    Interactioni

    Protein-protein interaction databases

    BioGridi123986. 13 interactions.
    IntActiQ9BTE7. 1 interaction.
    STRINGi9606.ENSP00000260247.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTE7.
    SMRiQ9BTE7. Positions 65-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 232187DCUN1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DCUN1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG279481.
    HOGENOMiHOG000241761.
    HOVERGENiHBG106637.
    InParanoidiQ9BTE7.
    KOiK17824.
    OMAiQCDSIQK.
    PhylomeDBiQ9BTE7.
    TreeFamiTF354270.

    Family and domain databases

    InterProiIPR014764. DCN-prot.
    IPR005176. PONY_dom.
    [Graphical view]
    PANTHERiPTHR12281. PTHR12281. 1 hit.
    PfamiPF03556. Cullin_binding. 1 hit.
    [Graphical view]
    PROSITEiPS51229. DCUN1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BTE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK    50
    CLAWFYEYAG PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF 100
    FTKEEWLKGM TSLQCDCTEK LQNKFDFLRS QLNDISSFKN IYRYAFDFAR 150
    DKDQRSLDID TAKSMLALLL GRTWPLFSVF YQYLEQSKYR VMNKDQWYNV 200
    LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS 237
    Length:237
    Mass (Da):27,508
    Last modified:June 1, 2001 - v1
    Checksum:i4F507B6E5D81EF79
    GO

    Sequence cautioni

    The sequence AAQ76805.1 differs from that shown. Reason: Frameshift at positions 222 and 232.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271F → L in AAQ76805. (PubMed:16533400)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056993 mRNA. Translation: BAB71336.1.
    BC004169 mRNA. Translation: AAH04169.1.
    AY364246 mRNA. Translation: AAQ76805.1. Frameshift.
    CCDSiCCDS8325.1.
    RefSeqiNP_115675.1. NM_032299.3.
    UniGeneiHs.503716.

    Genome annotation databases

    EnsembliENST00000260247; ENSP00000260247; ENSG00000137692.
    GeneIDi84259.
    KEGGihsa:84259.
    UCSCiuc001phm.3. human.

    Polymorphism databases

    DMDMi74733117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056993 mRNA. Translation: BAB71336.1 .
    BC004169 mRNA. Translation: AAH04169.1 .
    AY364246 mRNA. Translation: AAQ76805.1 . Frameshift.
    CCDSi CCDS8325.1.
    RefSeqi NP_115675.1. NM_032299.3.
    UniGenei Hs.503716.

    3D structure databases

    ProteinModelPortali Q9BTE7.
    SMRi Q9BTE7. Positions 65-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123986. 13 interactions.
    IntActi Q9BTE7. 1 interaction.
    STRINGi 9606.ENSP00000260247.

    PTM databases

    PhosphoSitei Q9BTE7.

    Polymorphism databases

    DMDMi 74733117.

    Proteomic databases

    MaxQBi Q9BTE7.
    PaxDbi Q9BTE7.
    PeptideAtlasi Q9BTE7.
    PRIDEi Q9BTE7.

    Protocols and materials databases

    DNASUi 84259.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260247 ; ENSP00000260247 ; ENSG00000137692 .
    GeneIDi 84259.
    KEGGi hsa:84259.
    UCSCi uc001phm.3. human.

    Organism-specific databases

    CTDi 84259.
    GeneCardsi GC11M102924.
    HGNCi HGNC:28409. DCUN1D5.
    HPAi HPA050863.
    neXtProti NX_Q9BTE7.
    PharmGKBi PA142672011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279481.
    HOGENOMi HOG000241761.
    HOVERGENi HBG106637.
    InParanoidi Q9BTE7.
    KOi K17824.
    OMAi QCDSIQK.
    PhylomeDBi Q9BTE7.
    TreeFami TF354270.

    Miscellaneous databases

    GenomeRNAii 84259.
    NextBioi 73782.
    PROi Q9BTE7.

    Gene expression databases

    ArrayExpressi Q9BTE7.
    Bgeei Q9BTE7.
    CleanExi HS_DCUN1D5.
    Genevestigatori Q9BTE7.

    Family and domain databases

    InterProi IPR014764. DCN-prot.
    IPR005176. PONY_dom.
    [Graphical view ]
    PANTHERi PTHR12281. PTHR12281. 1 hit.
    Pfami PF03556. Cullin_binding. 1 hit.
    [Graphical view ]
    PROSITEi PS51229. DCUN1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
      Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
      BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-233.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCNL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTE7
    Secondary accession number(s): Q3ZTT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3