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Q9BTE0 (NAT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyltransferase 9

EC=2.3.1.-
Alternative name(s):
Embryo brain-specific protein
Gene names
Name:NAT9
Synonyms:EBS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the acetyltransferase family. GNAT subfamily.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentprotein complex

Inferred from direct assay. Source: LIFEdb

   Molecular_functionN-acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BTE0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BTE0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207N-acetyltransferase 9
PRO_0000286874

Regions

Domain35 – 180146N-acetyltransferase

Natural variations

Alternative sequence261Missing in isoform 2.
VSP_025231
Natural variant561C → R.
Corresponds to variant rs2305213 [ dbSNP | Ensembl ].
VAR_032225

Experimental info

Sequence conflict1261L → P in CAB43370. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1265AC8D2B2B376F

FASTA20723,361
        10         20         30         40         50         60 
MRLNQNTLLL GKKVVLVPYT SEHVPSRYHE WMKSEELQRL TASEPLTLEQ EYAMQCSWQE 

        70         80         90        100        110        120 
DADKCTFIVL DAEKWQAQPG ATEESCMVGD VNLFLTDLED LTLGEIEVMI AEPSCRGKGL 

       130        140        150        160        170        180 
GTEAVLAMLS YGVTTLGLTK FEAKIGQGNE PSIRMFQKLH FEQVATSSVF QEVTLRLTVS 

       190        200 
ESEHQWLLEQ TSHVEEKPYR DGSAEPC 

« Hide

Isoform 2 [UniParc].

Checksum: F79555F806B352BF
Show »

FASTA20623,274

References

« Hide 'large scale' references
[1]"Molecular cloning and primary studies on EBS: a novel human embryo brain-specific gene."
Chen W., Zou X., Zhang J., Ci H.L., Li Y.P.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Adrenal gland.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Lung and Muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY632082 mRNA. Translation: AAU25819.1.
AK312958 mRNA. Translation: BAG35797.1.
AL050269 mRNA. Translation: CAB43370.1.
CH471099 Genomic DNA. Translation: EAW89197.1.
BC004195 mRNA. Translation: AAH04195.1.
BC004225 mRNA. Translation: AAH04225.1.
CCDSCCDS11706.1. [Q9BTE0-1]
PIRT08699.
RefSeqNP_056469.2. NM_015654.3. [Q9BTE0-1]
XP_005257264.1. XM_005257207.1. [Q9BTE0-2]
XP_006721875.1. XM_006721812.1. [Q9BTE0-2]
UniGeneHs.144058.

3D structure databases

ProteinModelPortalQ9BTE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117582. 10 interactions.
IntActQ9BTE0. 9 interactions.
MINTMINT-1369693.
STRING9606.ENSP00000350467.

PTM databases

PhosphoSiteQ9BTE0.

Polymorphism databases

DMDM74752333.

Proteomic databases

MaxQBQ9BTE0.
PaxDbQ9BTE0.
PRIDEQ9BTE0.

Protocols and materials databases

DNASU26151.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357814; ENSP00000350467; ENSG00000109065. [Q9BTE0-1]
ENST00000580301; ENSP00000462019; ENSG00000109065. [Q9BTE0-2]
GeneID26151.
KEGGhsa:26151.
UCSCuc002jlq.3. human. [Q9BTE0-1]
uc002jlr.3. human. [Q9BTE0-2]

Organism-specific databases

CTD26151.
GeneCardsGC17M072766.
HGNCHGNC:23133. NAT9.
HPAHPA021820.
HPA057149.
neXtProtNX_Q9BTE0.
PharmGKBPA142671281.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272567.
HOGENOMHOG000189068.
HOVERGENHBG104444.
InParanoidQ9BTE0.
OrthoDBEOG712TXF.
PhylomeDBQ9BTE0.
TreeFamTF315021.

Enzyme and pathway databases

SignaLinkQ9BTE0.

Gene expression databases

ArrayExpressQ9BTE0.
BgeeQ9BTE0.
CleanExHS_NAT9.
GenevestigatorQ9BTE0.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF13302. Acetyltransf_3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

GeneWikiNAT9.
GenomeRNAi26151.
NextBio48225.
PROQ9BTE0.

Entry information

Entry nameNAT9_HUMAN
AccessionPrimary (citable) accession number: Q9BTE0
Secondary accession number(s): B2R7F0, Q9BTD0, Q9Y3T3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM