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Q9BTE0

- NAT9_HUMAN

UniProt

Q9BTE0 - NAT9_HUMAN

Protein

N-acetyltransferase 9

Gene

NAT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    SignaLinkiQ9BTE0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyltransferase 9 (EC:2.3.1.-)
    Alternative name(s):
    Embryo brain-specific protein
    Gene namesi
    Name:NAT9
    Synonyms:EBS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:23133. NAT9.

    Subcellular locationi

    GO - Cellular componenti

    1. protein complex Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671281.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207N-acetyltransferase 9PRO_0000286874Add
    BLAST

    Proteomic databases

    MaxQBiQ9BTE0.
    PaxDbiQ9BTE0.
    PRIDEiQ9BTE0.

    PTM databases

    PhosphoSiteiQ9BTE0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BTE0.
    BgeeiQ9BTE0.
    CleanExiHS_NAT9.
    GenevestigatoriQ9BTE0.

    Organism-specific databases

    HPAiHPA021820.
    HPA057149.

    Interactioni

    Protein-protein interaction databases

    BioGridi117582. 10 interactions.
    IntActiQ9BTE0. 9 interactions.
    MINTiMINT-1369693.
    STRINGi9606.ENSP00000350467.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 180146N-acetyltransferaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.Curated

    Phylogenomic databases

    eggNOGiNOG272567.
    HOGENOMiHOG000189068.
    HOVERGENiHBG104444.
    InParanoidiQ9BTE0.
    OrthoDBiEOG712TXF.
    PhylomeDBiQ9BTE0.
    TreeFamiTF315021.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13302. Acetyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BTE0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLNQNTLLL GKKVVLVPYT SEHVPSRYHE WMKSEELQRL TASEPLTLEQ    50
    EYAMQCSWQE DADKCTFIVL DAEKWQAQPG ATEESCMVGD VNLFLTDLED 100
    LTLGEIEVMI AEPSCRGKGL GTEAVLAMLS YGVTTLGLTK FEAKIGQGNE 150
    PSIRMFQKLH FEQVATSSVF QEVTLRLTVS ESEHQWLLEQ TSHVEEKPYR 200
    DGSAEPC 207
    Length:207
    Mass (Da):23,361
    Last modified:June 1, 2001 - v1
    Checksum:i1265AC8D2B2B376F
    GO
    Isoform 2 (identifier: Q9BTE0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-26: Missing.

    Show »
    Length:206
    Mass (Da):23,274
    Checksum:iF79555F806B352BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261L → P in CAB43370. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561C → R.
    Corresponds to variant rs2305213 [ dbSNP | Ensembl ].
    VAR_032225

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 261Missing in isoform 2. 4 PublicationsVSP_025231

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY632082 mRNA. Translation: AAU25819.1.
    AK312958 mRNA. Translation: BAG35797.1.
    AL050269 mRNA. Translation: CAB43370.1.
    CH471099 Genomic DNA. Translation: EAW89197.1.
    BC004195 mRNA. Translation: AAH04195.1.
    BC004225 mRNA. Translation: AAH04225.1.
    CCDSiCCDS11706.1. [Q9BTE0-1]
    PIRiT08699.
    RefSeqiNP_056469.2. NM_015654.3. [Q9BTE0-1]
    XP_005257264.1. XM_005257207.1. [Q9BTE0-2]
    XP_006721875.1. XM_006721812.1. [Q9BTE0-2]
    UniGeneiHs.144058.

    Genome annotation databases

    EnsembliENST00000357814; ENSP00000350467; ENSG00000109065. [Q9BTE0-1]
    ENST00000580301; ENSP00000462019; ENSG00000109065. [Q9BTE0-2]
    GeneIDi26151.
    KEGGihsa:26151.
    UCSCiuc002jlq.3. human. [Q9BTE0-1]
    uc002jlr.3. human. [Q9BTE0-2]

    Polymorphism databases

    DMDMi74752333.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY632082 mRNA. Translation: AAU25819.1 .
    AK312958 mRNA. Translation: BAG35797.1 .
    AL050269 mRNA. Translation: CAB43370.1 .
    CH471099 Genomic DNA. Translation: EAW89197.1 .
    BC004195 mRNA. Translation: AAH04195.1 .
    BC004225 mRNA. Translation: AAH04225.1 .
    CCDSi CCDS11706.1. [Q9BTE0-1 ]
    PIRi T08699.
    RefSeqi NP_056469.2. NM_015654.3. [Q9BTE0-1 ]
    XP_005257264.1. XM_005257207.1. [Q9BTE0-2 ]
    XP_006721875.1. XM_006721812.1. [Q9BTE0-2 ]
    UniGenei Hs.144058.

    3D structure databases

    ProteinModelPortali Q9BTE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117582. 10 interactions.
    IntActi Q9BTE0. 9 interactions.
    MINTi MINT-1369693.
    STRINGi 9606.ENSP00000350467.

    PTM databases

    PhosphoSitei Q9BTE0.

    Polymorphism databases

    DMDMi 74752333.

    Proteomic databases

    MaxQBi Q9BTE0.
    PaxDbi Q9BTE0.
    PRIDEi Q9BTE0.

    Protocols and materials databases

    DNASUi 26151.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357814 ; ENSP00000350467 ; ENSG00000109065 . [Q9BTE0-1 ]
    ENST00000580301 ; ENSP00000462019 ; ENSG00000109065 . [Q9BTE0-2 ]
    GeneIDi 26151.
    KEGGi hsa:26151.
    UCSCi uc002jlq.3. human. [Q9BTE0-1 ]
    uc002jlr.3. human. [Q9BTE0-2 ]

    Organism-specific databases

    CTDi 26151.
    GeneCardsi GC17M072766.
    HGNCi HGNC:23133. NAT9.
    HPAi HPA021820.
    HPA057149.
    neXtProti NX_Q9BTE0.
    PharmGKBi PA142671281.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272567.
    HOGENOMi HOG000189068.
    HOVERGENi HBG104444.
    InParanoidi Q9BTE0.
    OrthoDBi EOG712TXF.
    PhylomeDBi Q9BTE0.
    TreeFami TF315021.

    Enzyme and pathway databases

    SignaLinki Q9BTE0.

    Miscellaneous databases

    GeneWikii NAT9.
    GenomeRNAii 26151.
    NextBioi 48225.
    PROi Q9BTE0.

    Gene expression databases

    ArrayExpressi Q9BTE0.
    Bgeei Q9BTE0.
    CleanExi HS_NAT9.
    Genevestigatori Q9BTE0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13302. Acetyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and primary studies on EBS: a novel human embryo brain-specific gene."
      Chen W., Zou X., Zhang J., Ci H.L., Li Y.P.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Adrenal gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Muscle.

    Entry informationi

    Entry nameiNAT9_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTE0
    Secondary accession number(s): B2R7F0, Q9BTD0, Q9Y3T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3