Q9BTE0 (NAT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyltransferase 9
EC=2.3.1.-

Alternative name(s):
Embryo brain-specific protein

Gene names

Name:	NAT9
Synonyms:	EBS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the acetyltransferase family. GNAT subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	protein complex Inferred from direct assay. Source: LIFEdb
Molecular function	N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BTE0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BTE0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	N-acetyltransferase 9		PRO_0000286874
Regions
	Domain	35 – 180	146	N-acetyltransferase
Natural variations
	Alternative sequence	26	1	Missing in isoform 2.		VSP_025231
	Natural variant	56	1	C → R. Corresponds to variant rs2305213 [ dbSNP | Ensembl ].		VAR_032225
Experimental info
	Sequence conflict	126	1	L → P in CAB43370. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1265AC8D2B2B376F	FASTA	207	23,361
	10 20 30 40 50 60 MRLNQNTLLL GKKVVLVPYT SEHVPSRYHE WMKSEELQRL TASEPLTLEQ EYAMQCSWQE 70 80 90 100 110 120 DADKCTFIVL DAEKWQAQPG ATEESCMVGD VNLFLTDLED LTLGEIEVMI AEPSCRGKGL 130 140 150 160 170 180 GTEAVLAMLS YGVTTLGLTK FEAKIGQGNE PSIRMFQKLH FEQVATSSVF QEVTLRLTVS 190 200 ESEHQWLLEQ TSHVEEKPYR DGSAEPC
	Isoform 2 [UniParc]. Checksum: F79555F806B352BF	FASTA	206	23,274
	10 20 30 40 50 60 MRLNQNTLLL GKKVVLVPYT SEHVPRYHEW MKSEELQRLT ASEPLTLEQE YAMQCSWQED 70 80 90 100 110 120 ADKCTFIVLD AEKWQAQPGA TEESCMVGDV NLFLTDLEDL TLGEIEVMIA EPSCRGKGLG 130 140 150 160 170 180 TEAVLAMLSY GVTTLGLTKF EAKIGQGNEP SIRMFQKLHF EQVATSSVFQ EVTLRLTVSE 190 200 SEHQWLLEQT SHVEEKPYRD GSAEPC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and primary studies on EBS: a novel human embryo brain-specific gene." Chen W., Zou X., Zhang J., Ci H.L., Li Y.P. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Adrenal gland.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lung and Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY632082 mRNA. Translation: AAU25819.1. AK312958 mRNA. Translation: BAG35797.1. AL050269 mRNA. Translation: CAB43370.1. CH471099 Genomic DNA. Translation: EAW89197.1. BC004195 mRNA. Translation: AAH04195.1. BC004225 mRNA. Translation: AAH04225.1.
IPI	IPI00003789. IPI00790050.
PIR	T08699.
RefSeq	NP_056469.2. NM_015654.3.
UniGene	Hs.144058.
3D structure databases
ProteinModelPortal	Q9BTE0.
SMR	Q9BTE0. Positions 4-170.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BTE0. 6 interactions.
MINT	MINT-1369693.
STRING	Q9BTE0.
Polymorphism databases
DMDM	74752333.
Proteomic databases
PRIDE	Q9BTE0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357814; ENSP00000350467; ENSG00000109065.
GeneID	26151.
KEGG	hsa:26151.
UCSC	uc002jlq.1. human. uc002jlr.1. human.
Organism-specific databases
CTD	26151.
GeneCards	GC17M072766.
H-InvDB	HIX0014152.
HGNC	HGNC:23133. NAT9.
HPA	HPA021820.
neXtProt	NX_Q9BTE0.
PharmGKB	PA142671281.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14299.
GeneTree	ENSGT00390000012745.
HOGENOM	HBG324240.
HOVERGEN	HBG104444.
InParanoid	Q9BTE0.
OMA	EAVLMMM.
OrthoDB	EOG4QNMX5.
PhylomeDB	Q9BTE0.
Gene expression databases
ArrayExpress	Q9BTE0.
Bgee	Q9BTE0.
CleanEx	HS_NAT9.
Genevestigator	Q9BTE0.
Family and domain databases
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	48225.

Entry information

Entry name

NAT9_HUMAN

Accession

Primary (citable) accession number: Q9BTE0
Secondary accession number(s): B2R7F0, Q9BTD0, Q9Y3T3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.