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Q9BTE0

- NAT9_HUMAN

UniProt

Q9BTE0 - NAT9_HUMAN

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Protein

N-acetyltransferase 9

Gene
NAT9, EBS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

SignaLinkiQ9BTE0.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyltransferase 9 (EC:2.3.1.-)
Alternative name(s):
Embryo brain-specific protein
Gene namesi
Name:NAT9
Synonyms:EBS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23133. NAT9.

Subcellular locationi

GO - Cellular componenti

  1. protein complex Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207N-acetyltransferase 9PRO_0000286874Add
BLAST

Proteomic databases

MaxQBiQ9BTE0.
PaxDbiQ9BTE0.
PRIDEiQ9BTE0.

PTM databases

PhosphoSiteiQ9BTE0.

Expressioni

Gene expression databases

ArrayExpressiQ9BTE0.
BgeeiQ9BTE0.
CleanExiHS_NAT9.
GenevestigatoriQ9BTE0.

Organism-specific databases

HPAiHPA021820.
HPA057149.

Interactioni

Protein-protein interaction databases

BioGridi117582. 10 interactions.
IntActiQ9BTE0. 9 interactions.
MINTiMINT-1369693.
STRINGi9606.ENSP00000350467.

Structurei

3D structure databases

ProteinModelPortaliQ9BTE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 180146N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG272567.
HOGENOMiHOG000189068.
HOVERGENiHBG104444.
InParanoidiQ9BTE0.
OrthoDBiEOG712TXF.
PhylomeDBiQ9BTE0.
TreeFamiTF315021.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13302. Acetyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BTE0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLNQNTLLL GKKVVLVPYT SEHVPSRYHE WMKSEELQRL TASEPLTLEQ    50
EYAMQCSWQE DADKCTFIVL DAEKWQAQPG ATEESCMVGD VNLFLTDLED 100
LTLGEIEVMI AEPSCRGKGL GTEAVLAMLS YGVTTLGLTK FEAKIGQGNE 150
PSIRMFQKLH FEQVATSSVF QEVTLRLTVS ESEHQWLLEQ TSHVEEKPYR 200
DGSAEPC 207
Length:207
Mass (Da):23,361
Last modified:June 1, 2001 - v1
Checksum:i1265AC8D2B2B376F
GO
Isoform 2 (identifier: Q9BTE0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: Missing.

Show »
Length:206
Mass (Da):23,274
Checksum:iF79555F806B352BF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561C → R.
Corresponds to variant rs2305213 [ dbSNP | Ensembl ].
VAR_032225

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 261Missing in isoform 2. VSP_025231

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261L → P in CAB43370. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY632082 mRNA. Translation: AAU25819.1.
AK312958 mRNA. Translation: BAG35797.1.
AL050269 mRNA. Translation: CAB43370.1.
CH471099 Genomic DNA. Translation: EAW89197.1.
BC004195 mRNA. Translation: AAH04195.1.
BC004225 mRNA. Translation: AAH04225.1.
CCDSiCCDS11706.1. [Q9BTE0-1]
PIRiT08699.
RefSeqiNP_056469.2. NM_015654.3. [Q9BTE0-1]
XP_005257264.1. XM_005257207.1. [Q9BTE0-2]
XP_006721875.1. XM_006721812.1. [Q9BTE0-2]
UniGeneiHs.144058.

Genome annotation databases

EnsembliENST00000357814; ENSP00000350467; ENSG00000109065. [Q9BTE0-1]
ENST00000580301; ENSP00000462019; ENSG00000109065. [Q9BTE0-2]
GeneIDi26151.
KEGGihsa:26151.
UCSCiuc002jlq.3. human. [Q9BTE0-1]
uc002jlr.3. human. [Q9BTE0-2]

Polymorphism databases

DMDMi74752333.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY632082 mRNA. Translation: AAU25819.1 .
AK312958 mRNA. Translation: BAG35797.1 .
AL050269 mRNA. Translation: CAB43370.1 .
CH471099 Genomic DNA. Translation: EAW89197.1 .
BC004195 mRNA. Translation: AAH04195.1 .
BC004225 mRNA. Translation: AAH04225.1 .
CCDSi CCDS11706.1. [Q9BTE0-1 ]
PIRi T08699.
RefSeqi NP_056469.2. NM_015654.3. [Q9BTE0-1 ]
XP_005257264.1. XM_005257207.1. [Q9BTE0-2 ]
XP_006721875.1. XM_006721812.1. [Q9BTE0-2 ]
UniGenei Hs.144058.

3D structure databases

ProteinModelPortali Q9BTE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117582. 10 interactions.
IntActi Q9BTE0. 9 interactions.
MINTi MINT-1369693.
STRINGi 9606.ENSP00000350467.

PTM databases

PhosphoSitei Q9BTE0.

Polymorphism databases

DMDMi 74752333.

Proteomic databases

MaxQBi Q9BTE0.
PaxDbi Q9BTE0.
PRIDEi Q9BTE0.

Protocols and materials databases

DNASUi 26151.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357814 ; ENSP00000350467 ; ENSG00000109065 . [Q9BTE0-1 ]
ENST00000580301 ; ENSP00000462019 ; ENSG00000109065 . [Q9BTE0-2 ]
GeneIDi 26151.
KEGGi hsa:26151.
UCSCi uc002jlq.3. human. [Q9BTE0-1 ]
uc002jlr.3. human. [Q9BTE0-2 ]

Organism-specific databases

CTDi 26151.
GeneCardsi GC17M072766.
HGNCi HGNC:23133. NAT9.
HPAi HPA021820.
HPA057149.
neXtProti NX_Q9BTE0.
PharmGKBi PA142671281.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272567.
HOGENOMi HOG000189068.
HOVERGENi HBG104444.
InParanoidi Q9BTE0.
OrthoDBi EOG712TXF.
PhylomeDBi Q9BTE0.
TreeFami TF315021.

Enzyme and pathway databases

SignaLinki Q9BTE0.

Miscellaneous databases

GeneWikii NAT9.
GenomeRNAii 26151.
NextBioi 48225.
PROi Q9BTE0.

Gene expression databases

ArrayExpressi Q9BTE0.
Bgeei Q9BTE0.
CleanExi HS_NAT9.
Genevestigatori Q9BTE0.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13302. Acetyltransf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and primary studies on EBS: a novel human embryo brain-specific gene."
    Chen W., Zou X., Zhang J., Ci H.L., Li Y.P.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Adrenal gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Muscle.

Entry informationi

Entry nameiNAT9_HUMAN
AccessioniPrimary (citable) accession number: Q9BTE0
Secondary accession number(s): B2R7F0, Q9BTD0, Q9Y3T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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