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Protein

Transmembrane protein 121

Gene

TMEM121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in MAPK signaling.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 121
Gene namesi
Name:TMEM121
Synonyms:HHOLE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20511. TMEM121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485641.

Polymorphism and mutation databases

BioMutaiTMEM121.
DMDMi74733114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Transmembrane protein 121PRO_0000251245Add
BLAST

Proteomic databases

PaxDbiQ9BTD3.
PRIDEiQ9BTD3.

Expressioni

Tissue specificityi

Highly expressed in heart and detected in pancreas, liver and skeletal muscle.1 Publication

Developmental stagei

Widely expressed in fetal tissues with high expression in fetal heart.1 Publication

Gene expression databases

BgeeiQ9BTD3.
CleanExiHS_TMEM121.
GenevisibleiQ9BTD3. HS.

Organism-specific databases

HPAiHPA049857.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376304.

Structurei

3D structure databases

ProteinModelPortaliQ9BTD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 31642Pro-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40918.
GeneTreeiENSGT00390000003866.
HOGENOMiHOG000088644.
HOVERGENiHBG083215.
InParanoidiQ9BTD3.
OMAiFQNYKAD.
OrthoDBiEOG7PK8ZZ.
PhylomeDBiQ9BTD3.
TreeFamiTF328726.

Sequencei

Sequence statusi: Complete.

Q9BTD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV
60 70 80 90 100
CFLLVLRYVA VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA
110 120 130 140 150
RRGAADPVAR KALTLLLSVC VPGLFLLLVA LDRMEYVRTF RKREDLRGRL
160 170 180 190 200
FWVALDLLDL LDMQASLWEP PRSGLPLWAE GLTFFYCYML LLVLPCVALS
210 220 230 240 250
EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF RDSRVSAIFV
260 270 280 290 300
GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL
310
HGPPGRPHMS SPTRDPLDT
Length:319
Mass (Da):35,814
Last modified:June 1, 2001 - v1
Checksum:i931AD92F58D50F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004221 mRNA. Translation: AAH04221.1.
CCDSiCCDS10006.1.
RefSeqiNP_079544.1. NM_025268.2.
XP_005268158.1. XM_005268101.2.
XP_006720324.1. XM_006720261.2.
UniGeneiHs.157527.

Genome annotation databases

EnsembliENST00000392519; ENSP00000376304; ENSG00000184986.
ENST00000431372; ENSP00000407456; ENSG00000184986.
GeneIDi80757.
KEGGihsa:80757.
UCSCiuc001yrp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004221 mRNA. Translation: AAH04221.1.
CCDSiCCDS10006.1.
RefSeqiNP_079544.1. NM_025268.2.
XP_005268158.1. XM_005268101.2.
XP_006720324.1. XM_006720261.2.
UniGeneiHs.157527.

3D structure databases

ProteinModelPortaliQ9BTD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376304.

Polymorphism and mutation databases

BioMutaiTMEM121.
DMDMi74733114.

Proteomic databases

PaxDbiQ9BTD3.
PRIDEiQ9BTD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392519; ENSP00000376304; ENSG00000184986.
ENST00000431372; ENSP00000407456; ENSG00000184986.
GeneIDi80757.
KEGGihsa:80757.
UCSCiuc001yrp.1. human.

Organism-specific databases

CTDi80757.
GeneCardsiGC14P105992.
HGNCiHGNC:20511. TMEM121.
HPAiHPA049857.
neXtProtiNX_Q9BTD3.
PharmGKBiPA143485641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40918.
GeneTreeiENSGT00390000003866.
HOGENOMiHOG000088644.
HOVERGENiHBG083215.
InParanoidiQ9BTD3.
OMAiFQNYKAD.
OrthoDBiEOG7PK8ZZ.
PhylomeDBiQ9BTD3.
TreeFamiTF328726.

Miscellaneous databases

ChiTaRSiTMEM121. human.
GenomeRNAii80757.
NextBioi71107.
PROiQ9BTD3.

Gene expression databases

BgeeiQ9BTD3.
CleanExiHS_TMEM121.
GenevisibleiQ9BTD3. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  2. "A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways."
    Zhou J., Li Y., Liang P., Yuan W., Ye X., Zhu C., Cheng Y., Wang Y., Li G., Wu X., Liu M.
    Biochem. Biophys. Res. Commun. 333:344-352(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTM121_HUMAN
AccessioniPrimary (citable) accession number: Q9BTD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.