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Q9BTD3

- TM121_HUMAN

UniProt

Q9BTD3 - TM121_HUMAN

Protein

Transmembrane protein 121

Gene

TMEM121

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in MAPK signaling.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 121
    Gene namesi
    Name:TMEM121
    Synonyms:HHOLE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20511. TMEM121.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated
    Note: May localize to the plasma membrane.1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Transmembrane protein 121PRO_0000251245Add
    BLAST

    Proteomic databases

    PaxDbiQ9BTD3.
    PRIDEiQ9BTD3.

    Expressioni

    Tissue specificityi

    Highly expressed in heart and detected in pancreas, liver and skeletal muscle.1 Publication

    Developmental stagei

    Widely expressed in fetal tissues with high expression in fetal heart.1 Publication

    Gene expression databases

    BgeeiQ9BTD3.
    CleanExiHS_TMEM121.
    GenevestigatoriQ9BTD3.

    Organism-specific databases

    HPAiHPA049857.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi275 – 31642Pro-richAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40918.
    HOGENOMiHOG000088644.
    HOVERGENiHBG083215.
    InParanoidiQ9BTD3.
    OMAiCLTTIVI.
    OrthoDBiEOG7PK8ZZ.
    PhylomeDBiQ9BTD3.
    TreeFamiTF328726.

    Sequencei

    Sequence statusi: Complete.

    Q9BTD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV    50
    CFLLVLRYVA VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA 100
    RRGAADPVAR KALTLLLSVC VPGLFLLLVA LDRMEYVRTF RKREDLRGRL 150
    FWVALDLLDL LDMQASLWEP PRSGLPLWAE GLTFFYCYML LLVLPCVALS 200
    EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF RDSRVSAIFV 250
    GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL 300
    HGPPGRPHMS SPTRDPLDT 319
    Length:319
    Mass (Da):35,814
    Last modified:June 1, 2001 - v1
    Checksum:i931AD92F58D50F62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004221 mRNA. Translation: AAH04221.1.
    CCDSiCCDS10006.1.
    RefSeqiNP_079544.1. NM_025268.2.
    XP_005268158.1. XM_005268101.1.
    XP_006720324.1. XM_006720261.1.
    UniGeneiHs.157527.

    Genome annotation databases

    EnsembliENST00000392519; ENSP00000376304; ENSG00000184986.
    ENST00000431372; ENSP00000407456; ENSG00000184986.
    GeneIDi80757.
    KEGGihsa:80757.
    UCSCiuc001yrp.1. human.

    Polymorphism databases

    DMDMi74733114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC004221 mRNA. Translation: AAH04221.1 .
    CCDSi CCDS10006.1.
    RefSeqi NP_079544.1. NM_025268.2.
    XP_005268158.1. XM_005268101.1.
    XP_006720324.1. XM_006720261.1.
    UniGenei Hs.157527.

    3D structure databases

    ProteinModelPortali Q9BTD3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330146.

    Polymorphism databases

    DMDMi 74733114.

    Proteomic databases

    PaxDbi Q9BTD3.
    PRIDEi Q9BTD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392519 ; ENSP00000376304 ; ENSG00000184986 .
    ENST00000431372 ; ENSP00000407456 ; ENSG00000184986 .
    GeneIDi 80757.
    KEGGi hsa:80757.
    UCSCi uc001yrp.1. human.

    Organism-specific databases

    CTDi 80757.
    GeneCardsi GC14P105992.
    HGNCi HGNC:20511. TMEM121.
    HPAi HPA049857.
    neXtProti NX_Q9BTD3.
    PharmGKBi PA143485641.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40918.
    HOGENOMi HOG000088644.
    HOVERGENi HBG083215.
    InParanoidi Q9BTD3.
    OMAi CLTTIVI.
    OrthoDBi EOG7PK8ZZ.
    PhylomeDBi Q9BTD3.
    TreeFami TF328726.

    Miscellaneous databases

    GenomeRNAii 80757.
    NextBioi 71107.
    PROi Q9BTD3.

    Gene expression databases

    Bgeei Q9BTD3.
    CleanExi HS_TMEM121.
    Genevestigatori Q9BTD3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    2. "A novel six-transmembrane protein hhole functions as a suppressor in MAPK signaling pathways."
      Zhou J., Li Y., Liang P., Yuan W., Ye X., Zhu C., Cheng Y., Wang Y., Li G., Wu X., Liu M.
      Biochem. Biophys. Res. Commun. 333:344-352(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTM121_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM

    External Data

    Dasty 3