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Q9BTD3 (TM121_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 121
Gene names
Name:TMEM121
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Transmembrane protein 121
PRO_0000251245

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane214 – 23421Helical; Potential
Compositional bias275 – 31642Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q9BTD3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 931AD92F58D50F62

FASTA31935,814
        10         20         30         40         50         60 
MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV CFLLVLRYVA 

        70         80         90        100        110        120 
VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA RRGAADPVAR KALTLLLSVC 

       130        140        150        160        170        180 
VPGLFLLLVA LDRMEYVRTF RKREDLRGRL FWVALDLLDL LDMQASLWEP PRSGLPLWAE 

       190        200        210        220        230        240 
GLTFFYCYML LLVLPCVALS EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF 

       250        260        270        280        290        300 
RDSRVSAIFV GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL 

       310 
HGPPGRPHMS SPTRDPLDT 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC004221 mRNA. Translation: AAH04221.1.
CCDSCCDS10006.1.
RefSeqNP_079544.1. NM_025268.2.
XP_005268158.1. XM_005268101.1.
XP_006720324.1. XM_006720261.1.
UniGeneHs.157527.

3D structure databases

ProteinModelPortalQ9BTD3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330146.

Polymorphism databases

DMDM74733114.

Proteomic databases

PaxDbQ9BTD3.
PRIDEQ9BTD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000392519; ENSP00000376304; ENSG00000184986.
ENST00000431372; ENSP00000407456; ENSG00000184986.
ENST00000604701; ENSP00000473832; ENSG00000271694.
ENST00000605646; ENSP00000474187; ENSG00000271694.
GeneID80757.
KEGGhsa:80757.
UCSCuc001yrp.1. human.

Organism-specific databases

CTD80757.
GeneCardsGC14P105992.
HGNCHGNC:20511. TMEM121.
HPAHPA049857.
neXtProtNX_Q9BTD3.
PharmGKBPA143485641.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40918.
HOGENOMHOG000088644.
HOVERGENHBG083215.
InParanoidQ9BTD3.
OMACLTTIVI.
OrthoDBEOG7PK8ZZ.
PhylomeDBQ9BTD3.
TreeFamTF328726.

Gene expression databases

BgeeQ9BTD3.
CleanExHS_TMEM121.
GenevestigatorQ9BTD3.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi80757.
NextBio71107.
PROQ9BTD3.

Entry information

Entry nameTM121_HUMAN
AccessionPrimary (citable) accession number: Q9BTD3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM