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Q9BTD3

- TM121_HUMAN

UniProt

Q9BTD3 - TM121_HUMAN

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Protein
Transmembrane protein 121
Gene
TMEM121
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 121
Gene namesi
Name:TMEM121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20511. TMEM121.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Transmembrane protein 121
PRO_0000251245Add
BLAST

Proteomic databases

PaxDbiQ9BTD3.
PRIDEiQ9BTD3.

Expressioni

Gene expression databases

BgeeiQ9BTD3.
CleanExiHS_TMEM121.
GenevestigatoriQ9BTD3.

Organism-specific databases

HPAiHPA049857.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330146.

Structurei

3D structure databases

ProteinModelPortaliQ9BTD3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 31642Pro-rich
Add
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40918.
HOGENOMiHOG000088644.
HOVERGENiHBG083215.
InParanoidiQ9BTD3.
OMAiCLTTIVI.
OrthoDBiEOG7PK8ZZ.
PhylomeDBiQ9BTD3.
TreeFamiTF328726.

Sequencei

Sequence statusi: Complete.

Q9BTD3-1 [UniParc]FASTAAdd to Basket

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MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV    50
CFLLVLRYVA VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA 100
RRGAADPVAR KALTLLLSVC VPGLFLLLVA LDRMEYVRTF RKREDLRGRL 150
FWVALDLLDL LDMQASLWEP PRSGLPLWAE GLTFFYCYML LLVLPCVALS 200
EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF RDSRVSAIFV 250
GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL 300
HGPPGRPHMS SPTRDPLDT 319
Length:319
Mass (Da):35,814
Last modified:June 1, 2001 - v1
Checksum:i931AD92F58D50F62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004221 mRNA. Translation: AAH04221.1.
CCDSiCCDS10006.1.
RefSeqiNP_079544.1. NM_025268.2.
XP_005268158.1. XM_005268101.1.
XP_006720324.1. XM_006720261.1.
UniGeneiHs.157527.

Genome annotation databases

EnsembliENST00000392519; ENSP00000376304; ENSG00000184986.
ENST00000431372; ENSP00000407456; ENSG00000184986.
ENST00000604701; ENSP00000473832; ENSG00000271694.
ENST00000605646; ENSP00000474187; ENSG00000271694.
GeneIDi80757.
KEGGihsa:80757.
UCSCiuc001yrp.1. human.

Polymorphism databases

DMDMi74733114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC004221 mRNA. Translation: AAH04221.1 .
CCDSi CCDS10006.1.
RefSeqi NP_079544.1. NM_025268.2.
XP_005268158.1. XM_005268101.1.
XP_006720324.1. XM_006720261.1.
UniGenei Hs.157527.

3D structure databases

ProteinModelPortali Q9BTD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330146.

Polymorphism databases

DMDMi 74733114.

Proteomic databases

PaxDbi Q9BTD3.
PRIDEi Q9BTD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392519 ; ENSP00000376304 ; ENSG00000184986 .
ENST00000431372 ; ENSP00000407456 ; ENSG00000184986 .
ENST00000604701 ; ENSP00000473832 ; ENSG00000271694 .
ENST00000605646 ; ENSP00000474187 ; ENSG00000271694 .
GeneIDi 80757.
KEGGi hsa:80757.
UCSCi uc001yrp.1. human.

Organism-specific databases

CTDi 80757.
GeneCardsi GC14P105992.
HGNCi HGNC:20511. TMEM121.
HPAi HPA049857.
neXtProti NX_Q9BTD3.
PharmGKBi PA143485641.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40918.
HOGENOMi HOG000088644.
HOVERGENi HBG083215.
InParanoidi Q9BTD3.
OMAi CLTTIVI.
OrthoDBi EOG7PK8ZZ.
PhylomeDBi Q9BTD3.
TreeFami TF328726.

Miscellaneous databases

GenomeRNAii 80757.
NextBioi 71107.
PROi Q9BTD3.

Gene expression databases

Bgeei Q9BTD3.
CleanExi HS_TMEM121.
Genevestigatori Q9BTD3.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiTM121_HUMAN
AccessioniPrimary (citable) accession number: Q9BTD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM

External Data

Dasty 3

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