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Q9BTC8

- MTA3_HUMAN

UniProt

Q9BTC8 - MTA3_HUMAN

Protein

Metastasis-associated protein MTA3

Gene

MTA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (28 Feb 2003)
      Previous versions | rss
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    Functioni

    Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri379 – 40628GATA-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of cell proliferation Source: Ensembl
    2. positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis-associated protein MTA3
    Gene namesi
    Name:MTA3
    Synonyms:KIAA1266
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:23784. MTA3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cohesin complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. intracellular membrane-bounded organelle Source: HPA
    4. nucleus Source: HPA
    5. NuRD complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Metastasis-associated protein MTA3PRO_0000083498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei455 – 4551Phosphothreonine1 Publication
    Modified residuei457 – 4571Phosphoserine1 Publication
    Modified residuei519 – 5191Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BTC8.
    PaxDbiQ9BTC8.
    PRIDEiQ9BTC8.

    PTM databases

    PhosphoSiteiQ9BTC8.

    Expressioni

    Tissue specificityi

    Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.1 Publication

    Inductioni

    By estrogen.1 Publication

    Gene expression databases

    ArrayExpressiQ9BTC8.
    BgeeiQ9BTC8.
    CleanExiHS_MTA3.
    GenevestigatoriQ9BTC8.

    Organism-specific databases

    HPAiHPA039433.

    Interactioni

    Subunit structurei

    Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESR1P033723EBI-2461787,EBI-78473

    Protein-protein interaction databases

    BioGridi121568. 34 interactions.
    IntActiQ9BTC8. 16 interactions.
    MINTiMINT-4538323.
    STRINGi9606.ENSP00000385045.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BTC8.
    SMRiQ9BTC8. Positions 148-324, 377-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 147147BAHPROSITE-ProRule annotationAdd
    BLAST
    Domaini148 – 259112ELM2PROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 31853SANTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAH domain.PROSITE-ProRule annotation
    Contains 1 ELM2 domain.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.Curated
    Contains 1 SANT domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri379 – 40628GATA-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252834.
    HOGENOMiHOG000045387.
    HOVERGENiHBG002598.
    InParanoidiQ9BTC8.
    KOiK11660.
    OMAiHMSRQAT.
    PhylomeDBiQ9BTC8.
    TreeFamiTF106444.

    Family and domain databases

    InterProiIPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view]
    SMARTiSM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BTC8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD    50
    ISNTLIMLAD KHAKEIEEES ETTVEADLTD KQKHQLKHRE LFLSRQYESL 100
    PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSL KTLLADKGEI 150
    RVGPRYQADI PEMLLEGESD EREQSKLEVK VWDPNSPLTD RQIDQFLVVA 200
    RAVGTFARAL DCSSSVRQPS LHMSAAAASR DITLFHAMDT LYRHSYDLSS 250
    AISVLVPLGG PVLCRDEMEE WSASEASLFE EALEKYGKDF NDIRQDFLPW 300
    KSLTSIIEYY YMWKTTDRYV QQKRLKAAEA ESKLKQVYIP TYSKPNPNQI 350
    STSNGKPGAV NGAVGTTFQP QNPLLGRACE SCYATQSHQW YSWGPPNMQC 400
    RLCAICWLYW KKYGGLKMPT QSEEEKLSPS PTTEDPRVRS HVSRQAMQGM 450
    PVRNTGSPKS AVKTRQAFFL HTTYFTKFAR QVCKNTLRLR QAARRPFVAI 500
    NYAAIRAEYA DRHAELSGSP LKSKSTRKPL ACIIGYLEIH PAKKPNVIRS 550
    TPSLQTPTTK RMLTTPNHTS LSILGKRNYS HHNGLDELTC CVSD 594
    Length:594
    Mass (Da):67,504
    Last modified:February 28, 2003 - v2
    Checksum:iE773603F65A16DF1
    GO
    Isoform 2 (identifier: Q9BTC8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         509-515: YADRHAE → CKMLLNS
         516-594: Missing.

    Show »
    Length:515
    Mass (Da):58,814
    Checksum:i55E53C5ABC30528C
    GO

    Sequence cautioni

    The sequence BAA86580.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 99MAANMYRVG → ATGGFPRDR in BAA86580. (PubMed:10574462)Curated
    Sequence conflicti343 – 3431Missing in BAA86580. (PubMed:10574462)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei509 – 5157YADRHAE → CKMLLNS in isoform 2. 2 PublicationsVSP_001603
    Alternative sequencei516 – 59479Missing in isoform 2. 2 PublicationsVSP_001604Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033092 mRNA. Translation: BAA86580.1. Different initiation.
    AK027304 mRNA. Translation: BAB55028.1.
    BC004227 mRNA. Translation: AAH04227.1.
    BC053631 mRNA. Translation: AAH53631.1.
    AL161954 mRNA. Translation: CAB82305.1.
    CCDSiCCDS46267.1. [Q9BTC8-2]
    PIRiT47180.
    RefSeqiNP_001269684.1. NM_001282755.1.
    NP_001269685.1. NM_001282756.1.
    NP_065795.1. NM_020744.3. [Q9BTC8-2]
    XP_005264513.1. XM_005264456.2. [Q9BTC8-1]
    UniGeneiHs.435413.
    Hs.646800.
    Hs.745162.

    Genome annotation databases

    EnsembliENST00000405094; ENSP00000385823; ENSG00000057935. [Q9BTC8-1]
    ENST00000407270; ENSP00000385045; ENSG00000057935. [Q9BTC8-2]
    GeneIDi57504.
    KEGGihsa:57504.
    UCSCiuc002rsq.3. human. [Q9BTC8-2]

    Polymorphism databases

    DMDMi29840798.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033092 mRNA. Translation: BAA86580.1 . Different initiation.
    AK027304 mRNA. Translation: BAB55028.1 .
    BC004227 mRNA. Translation: AAH04227.1 .
    BC053631 mRNA. Translation: AAH53631.1 .
    AL161954 mRNA. Translation: CAB82305.1 .
    CCDSi CCDS46267.1. [Q9BTC8-2 ]
    PIRi T47180.
    RefSeqi NP_001269684.1. NM_001282755.1.
    NP_001269685.1. NM_001282756.1.
    NP_065795.1. NM_020744.3. [Q9BTC8-2 ]
    XP_005264513.1. XM_005264456.2. [Q9BTC8-1 ]
    UniGenei Hs.435413.
    Hs.646800.
    Hs.745162.

    3D structure databases

    ProteinModelPortali Q9BTC8.
    SMRi Q9BTC8. Positions 148-324, 377-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121568. 34 interactions.
    IntActi Q9BTC8. 16 interactions.
    MINTi MINT-4538323.
    STRINGi 9606.ENSP00000385045.

    PTM databases

    PhosphoSitei Q9BTC8.

    Polymorphism databases

    DMDMi 29840798.

    Proteomic databases

    MaxQBi Q9BTC8.
    PaxDbi Q9BTC8.
    PRIDEi Q9BTC8.

    Protocols and materials databases

    DNASUi 57504.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000405094 ; ENSP00000385823 ; ENSG00000057935 . [Q9BTC8-1 ]
    ENST00000407270 ; ENSP00000385045 ; ENSG00000057935 . [Q9BTC8-2 ]
    GeneIDi 57504.
    KEGGi hsa:57504.
    UCSCi uc002rsq.3. human. [Q9BTC8-2 ]

    Organism-specific databases

    CTDi 57504.
    GeneCardsi GC02P042722.
    HGNCi HGNC:23784. MTA3.
    HPAi HPA039433.
    MIMi 609050. gene.
    neXtProti NX_Q9BTC8.
    PharmGKBi PA134953540.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252834.
    HOGENOMi HOG000045387.
    HOVERGENi HBG002598.
    InParanoidi Q9BTC8.
    KOi K11660.
    OMAi HMSRQAT.
    PhylomeDBi Q9BTC8.
    TreeFami TF106444.

    Enzyme and pathway databases

    Reactomei REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    GeneWikii MTA3.
    GenomeRNAii 57504.
    NextBioi 63833.
    PROi Q9BTC8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BTC8.
    Bgeei Q9BTC8.
    CleanExi HS_MTA3.
    Genevestigatori Q9BTC8.

    Family and domain databases

    InterProi IPR001025. BAH_dom.
    IPR000949. ELM2_dom.
    IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR000679. Znf_GATA.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF01448. ELM2. 1 hit.
    PF00320. GATA. 1 hit.
    [Graphical view ]
    SMARTi SM00439. BAH. 1 hit.
    SM00717. SANT. 1 hit.
    SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51038. BAH. 1 hit.
    PS51156. ELM2. 1 hit.
    PS51293. SANT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph and Uterus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-594.
      Tissue: Testis.
    5. "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer."
      Fujita N., Jaye D.L., Kajita M., Geigerman C., Moreno C.S., Wade P.A.
      Cell 113:207-219(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN NURD COMPLEX, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
    6. "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."
      Fujita N., Jaye D.L., Geigerman C., Akyildiz A., Mooney M.R., Boss J.M., Wade P.A.
      Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BCL6, IDENTIFICATION IN THE NURD COMPLEX.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455; SER-457 AND SER-519, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene."
      Xuan C., Wang Q., Han X., Duan Y., Li L., Shi L., Wang Y., Shan L., Yao Z., Shang Y.
      Oncogene 32:3711-3721(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NACC2.

    Entry informationi

    Entry nameiMTA3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BTC8
    Secondary accession number(s): Q9NSP2, Q9ULF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: February 28, 2003
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3