Q9BTA9 (WAC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WW domain-containing adapter protein with coiled-coil

Gene names

Name:	WAC
Synonyms:	KIAA1844

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. Ref.15 Ref.17
Subunit structure	Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A. Interacts (via WW domain) with RNA polymerase II. Ref.17
Subcellular location	Nucleus speckle By similarity. Nucleus. Note: In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes By similarity. Ref.17
Post-translational modification	Phosphorylated on tyrosine residues By similarity.
Sequence similarities	Contains 1 WW domain.
Sequence caution	The sequence AAH04258.2 differs from that shown. Reason: Frameshift at position 641. The sequence AAH10356.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB47473.1 differs from that shown. Reason: Probable cloning artifact. The sequence CAH70767.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40921.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40923.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Chromatin regulator
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle checkpoint Inferred from mutant phenotype Ref.17. Source: UniProtKB histone H2B conserved C-terminal lysine ubiquitination Inferred from mutant phenotype Ref.17. Source: UniProtKB histone monoubiquitination Inferred from mutant phenotype Ref.17. Source: UniProtKB negative regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from mutant phenotype Ref.15. Source: BHF-UCL positive regulation of macroautophagy Inferred from mutant phenotype Ref.15. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from mutant phenotype Ref.17. Source: UniProtKB response to DNA damage stimulus Inferred from mutant phenotype Ref.17. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Traceable author statement Ref.15. Source: BHF-UCL spliceosomal complex Inferred from electronic annotation. Source: Compara
Molecular_function	RNA polymerase II core binding Inferred from direct assay Ref.17. Source: UniProtKB chromatin binding Inferred from direct assay Ref.17. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BTA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BTA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Isoform 3 (identifier: Q9BTA9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
     430-481: AQPSNQSPMS...PPVSSQPKVS → DIPLHEGIQM...MVQRLLQPSG
     482-647: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9BTA9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     204-307: MEDKHSSDAS...VPAQKTERKE → K

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	WW domain-containing adapter protein with coiled-coil		PRO_0000254558
Regions
	Domain	129 – 162	34	WW
	Coiled coil	618 – 644	27	Potential
Amino acid modifications
	Modified residue	53	1	Phosphoserine Ref.9 Ref.13
	Modified residue	293	1	Phosphothreonine Ref.10
	Modified residue	302	1	N6-acetyllysine Ref.12
	Modified residue	471	1	Phosphothreonine Ref.11
	Modified residue	511	1	Phosphoserine Ref.8
	Modified residue	523	1	Phosphoserine Ref.11
	Modified residue	525	1	Phosphoserine Ref.11
	Modified residue	534	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 45	45	Missing in isoform 2 and isoform 3.		VSP_021230
	Alternative sequence	204 – 307	104	MEDKH…TERKE → K in isoform 4.		VSP_021231
	Alternative sequence	430 – 481	52	AQPSN…QPKVS → DIPLHEGIQMERDTHRSKWE VKGSLCQKADKQQECLVWNG SIMVQRLLQPSG in isoform 3.		VSP_021233
	Alternative sequence	482 – 647	166	Missing in isoform 3.		VSP_021236
	Natural variant	242	1	S → R. Corresponds to variant rs11595926 [ dbSNP | Ensembl ].		VAR_028838
	Natural variant	309	1	T → A. Corresponds to variant rs2232791 [ dbSNP | Ensembl ].		VAR_053448
	Natural variant	475	1	S → L in a colorectal cancer sample; somatic mutation. Ref.16		VAR_036351
	Natural variant	531	1	T → S. Corresponds to variant rs7127 [ dbSNP | Ensembl ].		VAR_028839
Experimental info
	Sequence conflict	426	1	L → F in BAB71029. Ref.1
	Sequence conflict	581	1	K → R in AAH10356. Ref.6
	Sequence conflict	599	1	S → P in BAD97320. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 3. Checksum: 15C32DAAA3A94129	FASTA	647	70,724
	10 20 30 40 50 60 MVMYARKQQR LSDGCHDRRG DSQPYQALKY SSKSHPSSGD HRHEKMRDAG DPSPPNKMLR 70 80 90 100 110 120 RSDSPENKYS DSTGHSKAKN VHTHRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN 130 140 150 160 170 180 PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKMAVNS 190 200 210 220 230 240 FPKDRDYRRE VMQATATSGF ASGMEDKHSS DASSLLPQNI LSQTSRHNDR DYRLPRAETH 250 260 270 280 290 300 SSSTPVQHPI KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTSSVPA 310 320 330 340 350 360 QKTERKESTS GDKPVSHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ SPIPPLLQDP 370 380 390 400 410 420 NLLRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ SIIHKFLTAG PSAFNITSLI 430 440 450 460 470 480 SQAAQLSTQA QPSNQSPMSL TSDASSPRSY VSPRISTPQT NTVPIKPLIS TPPVSSQPKV 490 500 510 520 530 540 STPVVKQGPV SQSATQQPVT ADKQQGHEPV SPRSLQRSSS QRSPSPGPNH TSNSSNASNA 550 560 570 580 590 600 TVVPQNSSAR STCSLTPALA AHFSENLIKH VQGWPADHAE KQASRLREEA HNMGTIHMSE 610 620 630 640 ICTELKNLRS LVRVCEIQAT LREQRILFLR QQIKELEKLK NQNSFMV
	Isoform 2 [UniParc]. Checksum: 8CBBD18CA1EB3243	FASTA	602	65,482
	10 20 30 40 50 60 MRDAGDPSPP NKMLRRSDSP ENKYSDSTGH SKAKNVHTHR VRERDGGTSY SPQENSHNHS 70 80 90 100 110 120 ALHSSNSHSS NPSNNPSKTS DAPYDSADDW SEHISSSGKK YYYNCRTEVS QWEKPKEWLE 130 140 150 160 170 180 REQRQKEANK MAVNSFPKDR DYRREVMQAT ATSGFASGME DKHSSDASSL LPQNILSQTS 190 200 210 220 230 240 RHNDRDYRLP RAETHSSSTP VQHPIKPVVH PTATPSTVPS SPFTLQSDHQ PKKSFDANGA 250 260 270 280 290 300 STLSKLPTPT SSVPAQKTER KESTSGDKPV SHSCTTPSTS SASGLNPTSA PPTSASAVPV 310 320 330 340 350 360 SPVPQSPIPP LLQDPNLLRQ LLPALQATLQ LNNSNVDISK INEVLTAAVT QASLQSIIHK 370 380 390 400 410 420 FLTAGPSAFN ITSLISQAAQ LSTQAQPSNQ SPMSLTSDAS SPRSYVSPRI STPQTNTVPI 430 440 450 460 470 480 KPLISTPPVS SQPKVSTPVV KQGPVSQSAT QQPVTADKQQ GHEPVSPRSL QRSSSQRSPS 490 500 510 520 530 540 PGPNHTSNSS NASNATVVPQ NSSARSTCSL TPALAAHFSE NLIKHVQGWP ADHAEKQASR 550 560 570 580 590 600 LREEAHNMGT IHMSEICTEL KNLRSLVRVC EIQATLREQR ILFLRQQIKE LEKLKNQNSF MV
	Isoform 3 [UniParc]. Checksum: 6C379F47ACC90136	FASTA	436	47,717
	10 20 30 40 50 60 MRDAGDPSPP NKMLRRSDSP ENKYSDSTGH SKAKNVHTHR VRERDGGTSY SPQENSHNHS 70 80 90 100 110 120 ALHSSNSHSS NPSNNPSKTS DAPYDSADDW SEHISSSGKK YYYNCRTEVS QWEKPKEWLE 130 140 150 160 170 180 REQRQKEANK MAVNSFPKDR DYRREVMQAT ATSGFASGME DKHSSDASSL LPQNILSQTS 190 200 210 220 230 240 RHNDRDYRLP RAETHSSSTP VQHPIKPVVH PTATPSTVPS SPFTLQSDHQ PKKSFDANGA 250 260 270 280 290 300 STLSKLPTPT SSVPAQKTER KESTSGDKPV SHSCTTPSTS SASGLNPTSA PPTSASAVPV 310 320 330 340 350 360 SPVPQSPIPP LLQDPNLLRQ LLPALQATLQ LNNSNVDISK INEVLTAAVT QASLQSIIHK 370 380 390 400 410 420 FLTAGPSAFN ITSLISQAAQ LSTQDIPLHE GIQMERDTHR SKWEVKGSLC QKADKQQECL 430 VWNGSIMVQR LLQPSG
	Isoform 4 [UniParc]. Checksum: 93716FBA60085245	FASTA	544	59,505
	10 20 30 40 50 60 MVMYARKQQR LSDGCHDRRG DSQPYQALKY SSKSHPSSGD HRHEKMRDAG DPSPPNKMLR 70 80 90 100 110 120 RSDSPENKYS DSTGHSKAKN VHTHRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN 130 140 150 160 170 180 PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKMAVNS 190 200 210 220 230 240 FPKDRDYRRE VMQATATSGF ASGKSTSGDK PVSHSCTTPS TSSASGLNPT SAPPTSASAV 250 260 270 280 290 300 PVSPVPQSPI PPLLQDPNLL RQLLPALQAT LQLNNSNVDI SKINEVLTAA VTQASLQSII 310 320 330 340 350 360 HKFLTAGPSA FNITSLISQA AQLSTQAQPS NQSPMSLTSD ASSPRSYVSP RISTPQTNTV 370 380 390 400 410 420 PIKPLISTPP VSSQPKVSTP VVKQGPVSQS ATQQPVTADK QQGHEPVSPR SLQRSSSQRS 430 440 450 460 470 480 PSPGPNHTSN SSNASNATVV PQNSSARSTC SLTPALAAHF SENLIKHVQG WPADHAEKQA 490 500 510 520 530 540 SRLREEAHNM GTIHMSEICT ELKNLRSLVR VCEIQATLRE QRILFLRQQI KELEKLKNQN SFMV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney and Thalamus.
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-647 (ISOFORM 4). Tissue: Kidney and Urinary bladder.
[7]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-647 (ISOFORMS 1/2). Tissue: Brain.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-471; SER-523 AND SER-525, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-302, MASS SPECTROMETRY.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC." McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A. EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[16]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-475.
[17]	"WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription." Zhang F., Yu X. Mol. Cell 41:384-397(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RNF20; RNF40 AND UBE2A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055852 mRNA. Translation: BAB71029.1. AK223600 mRNA. Translation: BAD97320.1. AK290174 mRNA. Translation: BAF82863.1. AL713727 mRNA. Translation: CAD28517.1. AL358234, AL161936 Genomic DNA. Translation: CAH70766.1. AL358234, AL161936 Genomic DNA. Translation: CAH70768.1. AL161936, AL358234 Genomic DNA. Translation: CAI40922.1. AL161936, AL358234 Genomic DNA. Translation: CAI40924.1. AL161936 Genomic DNA. Translation: CAI40921.1. Sequence problems. AL358234, AL161936 Genomic DNA. Translation: CAH70767.1. Sequence problems. AL161936, AL358234 Genomic DNA. Translation: CAI40923.1. Sequence problems. CH471072 Genomic DNA. Translation: EAW86032.1. CH471072 Genomic DNA. Translation: EAW86035.1. CH471072 Genomic DNA. Translation: EAW86037.1. CH471072 Genomic DNA. Translation: EAW86039.1. CH471072 Genomic DNA. Translation: EAW86040.1. CH471072 Genomic DNA. Translation: EAW86042.1. BC004258 mRNA. Translation: AAH04258.2. Frameshift. BC010356 mRNA. Translation: AAH10356.1. Different initiation. AB058747 mRNA. Translation: BAB47473.1. Sequence problems.
IPI	IPI00087375. IPI00152381. IPI00256605. IPI00478665.
RefSeq	NP_057712.2. NM_016628.4. NP_567823.1. NM_100486.3.
UniGene	Hs.435610.
3D structure databases
HSSP	HSSP built from PDB template 1YWI based on UniProtKB O75400.
ProteinModelPortal	Q9BTA9.
SMR	Q9BTA9. Positions 134-160.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BTA9. 9 interactions.
MINT	MINT-2873194.
PTM databases
PhosphoSite	Q9BTA9.
Polymorphism databases
DMDM	117949358.
Proteomic databases
PaxDb	Q9BTA9.
PRIDE	Q9BTA9.
Protocols and materials databases
DNASU	51322.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000347934; ENSP00000311106; ENSG00000095787. ENST00000354911; ENSP00000346986; ENSG00000095787. ENST00000375646; ENSP00000364797; ENSG00000095787. ENST00000375664; ENSP00000364816; ENSG00000095787. ENST00000428935; ENSP00000399706; ENSG00000095787. ENST00000439676; ENSP00000415727; ENSG00000095787.
GeneID	51322.
KEGG	hsa:51322.
UCSC	uc001iud.3. human. uc001iue.3. human.
Organism-specific databases
CTD	51322.
GeneCards	GC10P028861.
HGNC	HGNC:17327. WAC.
HPA	HPA036528.
MIM	615049. gene.
neXtProt	NX_Q9BTA9.
PharmGKB	PA134978936.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299824.
HOVERGEN	HBG057585.
InParanoid	Q9BTA9.
OMA	HKILTAG.
Gene expression databases
ArrayExpress	Q9BTA9.
Bgee	Q9BTA9.
CleanEx	HS_WAC.
Genevestigator	Q9BTA9.
GermOnline	ENSG00000095787. Homo sapiens.
Family and domain databases
InterPro	IPR001202. WW_dom. [Graphical view]
Pfam	PF00397. WW. 1 hit. [Graphical view]
SMART	SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WAC. human.
GenomeRNAi	51322.
NextBio	54714.
SOURCE	Search...

Entry information

Entry name

WAC_HUMAN

Accession

Primary (citable) accession number: Q9BTA9
Secondary accession number(s): A8K2A9 , C9JBT9, D3DRW5, D3DRW6, D3DRW7, Q53EN9, Q5JU75, Q5JU77, Q5VXK0, Q5VXK2, Q8TCK1, Q96DP3, Q96FW6, Q96JI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.