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Q9BT92

- TCHP_HUMAN

UniProt

Q9BT92 - TCHP_HUMAN

Protein

Trichoplein keratin filament-binding protein

Gene

TCHP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.2 Publications

    GO - Molecular functioni

    1. protein binding Source: HGNC

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. negative regulation of cell growth Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trichoplein keratin filament-binding protein
    Short name:
    Protein TCHP
    Alternative name(s):
    Mitochondrial protein with oncostatic activity
    Short name:
    Mitostatin
    Tumor suppressor protein
    Gene namesi
    Name:TCHPImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28135. TCHP.

    Subcellular locationi

    GO - Cellular componenti

    1. apical cortex Source: HGNC
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. keratin filament Source: HGNC
    5. mitochondrion Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA143485629.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Trichoplein keratin filament-binding proteinPRO_0000292609Add
    BLAST

    Proteomic databases

    MaxQBiQ9BT92.
    PaxDbiQ9BT92.
    PRIDEiQ9BT92.

    PTM databases

    PhosphoSiteiQ9BT92.

    Expressioni

    Tissue specificityi

    Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9BT92.
    BgeeiQ9BT92.
    CleanExiHS_TCHP.
    GenevestigatoriQ9BT92.

    Organism-specific databases

    HPAiHPA038638.

    Interactioni

    Subunit structurei

    Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18.1 Publication

    Protein-protein interaction databases

    BioGridi123987. 8 interactions.
    IntActiQ9BT92. 8 interactions.
    MINTiMINT-1452298.
    STRINGi9606.ENSP00000324404.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BT92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 498426Interaction with keratin proteins1 PublicationAdd
    BLAST
    Regioni259 – 425167Trichohyalin/plectin homology domain1 PublicationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili11 – 3929Sequence AnalysisAdd
    BLAST
    Coiled coili66 – 13671Sequence AnalysisAdd
    BLAST
    Coiled coili163 – 353191Sequence AnalysisAdd
    BLAST
    Coiled coili380 – 479100Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi70 – 482413Glu-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TCHP family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG129785.
    HOGENOMiHOG000006708.
    HOVERGENiHBG097262.
    InParanoidiQ9BT92.
    KOiK16811.
    OMAiLRQQWDQ.
    OrthoDBiEOG7Z0JX0.
    PhylomeDBiQ9BT92.
    TreeFamiTF329032.

    Family and domain databases

    InterProiIPR026773. TCHP.
    [Graphical view]
    PANTHERiPTHR31183:SF2. PTHR31183:SF2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9BT92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPTLPSYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK    50
    QAEWSSKTSY QRSMHAYQRE KMKEEKRRSL EARREKLRQL MQEEQDLLAR 100
    ELEELRLSMN LQERRIREQH GKLKSAKEEQ RKLIAEQLLY EHWKKNNPKL 150
    REMELDLHQK HVVNSWEMQK EEKKQQEATA EQENKRYENE YERARREALE 200
    RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE QENLLKQRWE 250
    LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLSRRTQQIQ EELEADRRIL 300
    QALLEKEDES QRLHLARREQ VMADVAWMKQ AIEEQLQLER AREAELQMLL 350
    REEAKEMWEK REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE 400
    SLKHREQLIR NLEEVRELAR REKEESEKLK SARKQELEAQ VAERRLQAWE 450
    ADQQEEEEEE EARRVEQLSD ALLQQEAETM AEQGYRPKPY GHPKIAWN 498
    Length:498
    Mass (Da):61,072
    Last modified:June 1, 2001 - v1
    Checksum:i7D1E8A66C56516F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti326 – 3261A → V in BAC03960. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441S → P in a gastric carcinoma sample. 1 Publication
    VAR_064056
    Natural varianti93 – 931E → K in a pancreatic carcinoma sample. 1 Publication
    VAR_064057
    Natural varianti127 – 1271K → R.
    Corresponds to variant rs10774978 [ dbSNP | Ensembl ].
    VAR_053924
    Natural varianti417 – 4171E → K.
    Corresponds to variant rs16940680 [ dbSNP | Ensembl ].
    VAR_053925

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY007230 mRNA. Translation: AAG12971.1.
    AK092736 mRNA. Translation: BAC03960.1.
    BC004285 mRNA. Translation: AAH04285.1.
    CCDSiCCDS9137.1.
    RefSeqiNP_001137324.1. NM_001143852.1.
    NP_115676.1. NM_032300.4.
    UniGeneiHs.410924.

    Genome annotation databases

    EnsembliENST00000312777; ENSP00000324404; ENSG00000139437.
    ENST00000405876; ENSP00000384520; ENSG00000139437.
    ENST00000544838; ENSP00000440838; ENSG00000139437.
    GeneIDi84260.
    KEGGihsa:84260.
    UCSCiuc001tpn.3. human.

    Polymorphism databases

    DMDMi74733103.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY007230 mRNA. Translation: AAG12971.1 .
    AK092736 mRNA. Translation: BAC03960.1 .
    BC004285 mRNA. Translation: AAH04285.1 .
    CCDSi CCDS9137.1.
    RefSeqi NP_001137324.1. NM_001143852.1.
    NP_115676.1. NM_032300.4.
    UniGenei Hs.410924.

    3D structure databases

    ProteinModelPortali Q9BT92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123987. 8 interactions.
    IntActi Q9BT92. 8 interactions.
    MINTi MINT-1452298.
    STRINGi 9606.ENSP00000324404.

    PTM databases

    PhosphoSitei Q9BT92.

    Polymorphism databases

    DMDMi 74733103.

    Proteomic databases

    MaxQBi Q9BT92.
    PaxDbi Q9BT92.
    PRIDEi Q9BT92.

    Protocols and materials databases

    DNASUi 84260.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312777 ; ENSP00000324404 ; ENSG00000139437 .
    ENST00000405876 ; ENSP00000384520 ; ENSG00000139437 .
    ENST00000544838 ; ENSP00000440838 ; ENSG00000139437 .
    GeneIDi 84260.
    KEGGi hsa:84260.
    UCSCi uc001tpn.3. human.

    Organism-specific databases

    CTDi 84260.
    GeneCardsi GC12P110338.
    HGNCi HGNC:28135. TCHP.
    HPAi HPA038638.
    MIMi 612654. gene.
    neXtProti NX_Q9BT92.
    PharmGKBi PA143485629.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG129785.
    HOGENOMi HOG000006708.
    HOVERGENi HBG097262.
    InParanoidi Q9BT92.
    KOi K16811.
    OMAi LRQQWDQ.
    OrthoDBi EOG7Z0JX0.
    PhylomeDBi Q9BT92.
    TreeFami TF329032.

    Miscellaneous databases

    ChiTaRSi TCHP. human.
    GeneWikii TCHP.
    GenomeRNAii 84260.
    NextBioi 73786.
    PROi Q9BT92.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BT92.
    Bgeei Q9BT92.
    CleanExi HS_TCHP.
    Genevestigatori Q9BT92.

    Family and domain databases

    InterProi IPR026773. TCHP.
    [Graphical view ]
    PANTHERi PTHR31183:SF2. PTHR31183:SF2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of trichoplein, a novel keratin filament-binding protein."
      Nishizawa M., Izawa I., Inoko A., Hayashi Y., Nagata K., Yokoyama T., Usukura J., Inagaki M.
      J. Cell Sci. 118:1081-1090(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KRT5; KRT6A; KRT8; KRT14; KRT16 AND KRT18, SUBCELLULAR LOCATION.
      Tissue: Liver1 Publication.
    2. "A novel tumor suppressor gene at 12q (TS12Q)."
      Baffa R., Croce C.M., Gomella L.G., Iozzo R.V., Vecchione A.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestineImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SkinImported.
    5. "MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer."
      Vecchione A., Fassan M., Anesti V., Morrione A., Goldoni S., Baldassarre G., Byrne D., D'Arca D., Palazzo J.P., Lloyd J., Scorrano L., Gomella L.G., Iozzo R.V., Baffa R.
      Oncogene 28:257-269(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-44 AND LYS-93, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTCHP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BT92
    Secondary accession number(s): Q8NAG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3