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Q9BT92 (TCHP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trichoplein keratin filament-binding protein

Short name=Protein TCHP
Alternative name(s):
Mitochondrial protein with oncostatic activity
Short name=Mitostatin
Tumor suppressor protein
Gene names
Name:TCHP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Ref.1 Ref.5

Subunit structure

Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18. Ref.1

Subcellular location

Cytoplasmcytoskeleton. Cytoplasm. Cell membrane. Mitochondrion Ref.1 Ref.5.

Tissue specificity

Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. Ref.5

Sequence similarities

Belongs to the TCHP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Trichoplein keratin filament-binding protein
PRO_0000292609

Regions

Region73 – 498426Interaction with keratin proteins Ref.1
Region259 – 425167Trichohyalin/plectin homology domain Ref.1
Coiled coil11 – 3929 Potential
Coiled coil66 – 13671 Potential
Coiled coil163 – 353191 Potential
Coiled coil380 – 479100 Potential
Compositional bias70 – 482413Glu-rich

Natural variations

Natural variant441S → P in a gastric carcinoma sample. Ref.5
VAR_064056
Natural variant931E → K in a pancreatic carcinoma sample. Ref.5
VAR_064057
Natural variant1271K → R.
Corresponds to variant rs10774978 [ dbSNP | Ensembl ].
VAR_053924
Natural variant4171E → K.
Corresponds to variant rs16940680 [ dbSNP | Ensembl ].
VAR_053925

Experimental info

Sequence conflict3261A → V in BAC03960. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9BT92 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7D1E8A66C56516F8

FASTA49861,072
        10         20         30         40         50         60 
MALPTLPSYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK QAEWSSKTSY 

        70         80         90        100        110        120 
QRSMHAYQRE KMKEEKRRSL EARREKLRQL MQEEQDLLAR ELEELRLSMN LQERRIREQH 

       130        140        150        160        170        180 
GKLKSAKEEQ RKLIAEQLLY EHWKKNNPKL REMELDLHQK HVVNSWEMQK EEKKQQEATA 

       190        200        210        220        230        240 
EQENKRYENE YERARREALE RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE 

       250        260        270        280        290        300 
QENLLKQRWE LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLSRRTQQIQ EELEADRRIL 

       310        320        330        340        350        360 
QALLEKEDES QRLHLARREQ VMADVAWMKQ AIEEQLQLER AREAELQMLL REEAKEMWEK 

       370        380        390        400        410        420 
REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE SLKHREQLIR NLEEVRELAR 

       430        440        450        460        470        480 
REKEESEKLK SARKQELEAQ VAERRLQAWE ADQQEEEEEE EARRVEQLSD ALLQQEAETM 

       490 
AEQGYRPKPY GHPKIAWN 

« Hide

References

« Hide 'large scale' references
[1]"Identification of trichoplein, a novel keratin filament-binding protein."
Nishizawa M., Izawa I., Inoko A., Hayashi Y., Nagata K., Yokoyama T., Usukura J., Inagaki M.
J. Cell Sci. 118:1081-1090(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KRT5; KRT6A; KRT8; KRT14; KRT16 AND KRT18, SUBCELLULAR LOCATION.
Tissue: Liver.
[2]"A novel tumor suppressor gene at 12q (TS12Q)."
Baffa R., Croce C.M., Gomella L.G., Iozzo R.V., Vecchione A.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer."
Vecchione A., Fassan M., Anesti V., Morrione A., Goldoni S., Baldassarre G., Byrne D., D'Arca D., Palazzo J.P., Lloyd J., Scorrano L., Gomella L.G., Iozzo R.V., Baffa R.
Oncogene 28:257-269(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-44 AND LYS-93, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY007230 mRNA. Translation: AAG12971.1.
AK092736 mRNA. Translation: BAC03960.1.
BC004285 mRNA. Translation: AAH04285.1.
CCDSCCDS9137.1.
RefSeqNP_001137324.1. NM_001143852.1.
NP_115676.1. NM_032300.4.
UniGeneHs.410924.

3D structure databases

ProteinModelPortalQ9BT92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123987. 7 interactions.
IntActQ9BT92. 8 interactions.
MINTMINT-1452298.
STRING9606.ENSP00000324404.

PTM databases

PhosphoSiteQ9BT92.

Polymorphism databases

DMDM74733103.

Proteomic databases

MaxQBQ9BT92.
PaxDbQ9BT92.
PRIDEQ9BT92.

Protocols and materials databases

DNASU84260.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312777; ENSP00000324404; ENSG00000139437.
ENST00000405876; ENSP00000384520; ENSG00000139437.
ENST00000544838; ENSP00000440838; ENSG00000139437.
GeneID84260.
KEGGhsa:84260.
UCSCuc001tpn.3. human.

Organism-specific databases

CTD84260.
GeneCardsGC12P110338.
HGNCHGNC:28135. TCHP.
HPAHPA038638.
MIM612654. gene.
neXtProtNX_Q9BT92.
PharmGKBPA143485629.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129785.
HOGENOMHOG000006708.
HOVERGENHBG097262.
InParanoidQ9BT92.
KOK16811.
OMALRQQWDQ.
OrthoDBEOG7Z0JX0.
PhylomeDBQ9BT92.
TreeFamTF329032.

Gene expression databases

ArrayExpressQ9BT92.
BgeeQ9BT92.
CleanExHS_TCHP.
GenevestigatorQ9BT92.

Family and domain databases

InterProIPR026773. TCHP.
[Graphical view]
PANTHERPTHR31183:SF2. PTHR31183:SF2. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTCHP. human.
GeneWikiTCHP.
GenomeRNAi84260.
NextBio73786.
PROQ9BT92.
SOURCESearch...

Entry information

Entry nameTCHP_HUMAN
AccessionPrimary (citable) accession number: Q9BT92
Secondary accession number(s): Q8NAG0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM