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Q9BT88 (SYT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name=SytXI
Gene names
Name:SYT11
Synonyms:KIAA0080
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Homodimer. Can also form heterodimers By similarity. Interacts with PARK2. Ref.7

Subcellular location

Membrane; Single-pass membrane protein. Cell junctionsynapse By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein By similarity. Note: In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. Ref.7

Post-translational modification

Ubiquitinated and targeted to the proteasome complex for degradation. Ref.7

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence caution

The sequence BAA07527.2 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPBP2Q926243EBI-751770,EBI-743771
ATP13A2Q9NQ112EBI-751770,EBI-6308763

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Synaptotagmin-11
PRO_0000183969

Regions

Topological domain1 – 1515Vesicular Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 431395Cytoplasmic Potential
Domain174 – 26289C2 1
Domain304 – 39794C2 2

Sites

Metal binding1881Calcium 1 By similarity
Metal binding1881Calcium 2 By similarity
Metal binding1951Calcium 1 By similarity
Metal binding2491Calcium 1; via carbonyl oxygen By similarity
Metal binding2501Calcium 1 By similarity
Metal binding2501Calcium 2 By similarity
Metal binding2501Calcium 3 By similarity
Metal binding2531Calcium 3 By similarity
Metal binding2561Calcium 2 By similarity
Metal binding2561Calcium 3 By similarity

Natural variations

Natural variant481Q → H. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs822522 [ dbSNP | Ensembl ].
VAR_047656
Natural variant2311G → V. Ref.6
Corresponds to variant rs17853892 [ dbSNP | Ensembl ].
VAR_047657

Experimental info

Sequence conflict501N → S in BAB55186. Ref.3
Sequence conflict2681V → A in BAB55186. Ref.3
Sequence conflict3591F → L in CAH18653. Ref.4
Sequence conflict3701D → G in CAH18653. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9BT88 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 5C8667D2C23D758E

FASTA43148,297
        10         20         30         40         50         60 
MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK 

        70         80         90        100        110        120 
GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID 

       130        140        150        160        170        180 
QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE 

       190        200        210        220        230        240 
AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL 

       250        260        270        280        290        300 
VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS 

       310        320        330        340        350        360 
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN 

       370        380        390        400        410        420 
ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK 

       430 
PVAKWHSLSE Y 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
Tissue: Bone marrow.
[2]Ohara O., Nagase T., Kikuno R., Nomura N.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
Tissue: Amygdala.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-48 AND VAL-231.
Tissue: Brain and Lymph.
[7]"The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI."
Huynh D.P., Scoles D.R., Nguyen D., Pulst S.M.
Hum. Mol. Genet. 12:2587-2597(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PARK2, UBIQUITINATION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38522 mRNA. Translation: BAA07527.2. Different initiation.
AK027540 mRNA. Translation: BAB55186.1.
AK074931 mRNA. Translation: BAC11300.1.
CR749792 mRNA. Translation: CAH18653.1.
AL139128 Genomic DNA. Translation: CAH69948.1.
BC004291 mRNA. Translation: AAH04291.1.
BC013690 mRNA. Translation: AAH13690.1.
BC039205 mRNA. Translation: AAH39205.1.
CCDSCCDS1122.1.
RefSeqNP_689493.3. NM_152280.4.
UniGeneHs.32984.

3D structure databases

ProteinModelPortalQ9BT88.
SMRQ9BT88. Positions 158-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116815. 4 interactions.
IntActQ9BT88. 3 interactions.
MINTMINT-240234.
STRING9606.ENSP00000357307.

PTM databases

PhosphoSiteQ9BT88.

Polymorphism databases

DMDM215273917.

Proteomic databases

MaxQBQ9BT88.
PaxDbQ9BT88.
PRIDEQ9BT88.

Protocols and materials databases

DNASU23208.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368324; ENSP00000357307; ENSG00000132718.
GeneID23208.
KEGGhsa:23208.
UCSCuc001fmg.3. human.

Organism-specific databases

CTD23208.
GeneCardsGC01P155829.
H-InvDBHIX0001138.
HGNCHGNC:19239. SYT11.
MIM608741. gene.
neXtProtNX_Q9BT88.
PharmGKBPA134898675.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292488.
HOGENOMHOG000232126.
HOVERGENHBG005010.
InParanoidQ9BT88.
OMAIKVDYGD.
OrthoDBEOG75J0N2.
PhylomeDBQ9BT88.
TreeFamTF315600.

Gene expression databases

ArrayExpressQ9BT88.
BgeeQ9BT88.
CleanExHS_SYT11.
GenevestigatorQ9BT88.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYT11. human.
GeneWikiSYT11.
GenomeRNAi23208.
NextBio44743.
PROQ9BT88.
SOURCESearch...

Entry information

Entry nameSYT11_HUMAN
AccessionPrimary (citable) accession number: Q9BT88
Secondary accession number(s): Q14998 expand/collapse secondary AC list , Q5W0D4, Q68CT5, Q8IXU3, Q96SU2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM