Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptotagmin-11

Gene

SYT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188Calcium 1By similarity1
Metal bindingi188Calcium 2By similarity1
Metal bindingi195Calcium 1By similarity1
Metal bindingi249Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi250Calcium 1By similarity1
Metal bindingi250Calcium 2By similarity1
Metal bindingi250Calcium 3By similarity1
Metal bindingi253Calcium 3By similarity1
Metal bindingi256Calcium 2By similarity1
Metal bindingi256Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132718-MONOMER.
ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:SYT11
Synonyms:KIAA0080
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19239. SYT11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15VesicularSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 431CytoplasmicSequence analysisAdd BLAST395

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23208.
OpenTargetsiENSG00000132718.
PharmGKBiPA134898675.

Polymorphism and mutation databases

BioMutaiSYT11.
DMDMi215273917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839691 – 431Synaptotagmin-11Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BT88.
MaxQBiQ9BT88.
PaxDbiQ9BT88.
PeptideAtlasiQ9BT88.
PRIDEiQ9BT88.

PTM databases

iPTMnetiQ9BT88.
PhosphoSitePlusiQ9BT88.

Expressioni

Gene expression databases

BgeeiENSG00000132718.
CleanExiHS_SYT11.
GenevisibleiQ9BT88. HS.

Organism-specific databases

HPAiHPA064091.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-751770,EBI-743771
ATP13A2Q9NQ112EBI-751770,EBI-6308763
SGTAO437656EBI-751770,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116815. 10 interactors.
IntActiQ9BT88. 4 interactors.
MINTiMINT-240234.
STRINGi9606.ENSP00000357307.

Structurei

3D structure databases

ProteinModelPortaliQ9BT88.
SMRiQ9BT88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 262C2 1PROSITE-ProRule annotationAdd BLAST89
Domaini304 – 397C2 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9BT88.
KOiK19911.
OMAiIKVDYGD.
OrthoDBiEOG091G09ZN.
PhylomeDBiQ9BT88.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE
110 120 130 140 150
AGLLSRDKDP RGPSSGSCID QLPIKMDYGE ELRSPITSLT PGESKTTSPS
160 170 180 190 200
SPEEDVMLGS LTFSVDYNFP KKALVVTIQE AHGLPVMDDQ TQGSDPYIKM
210 220 230 240 250
TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL VLHFLVLSFD
260 270 280 290 300
RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS
310 320 330 340 350
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV
360 370 380 390 400
KKCTLNPIFN ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA
410 420 430
HSVTASGAEH WREVCESPRK PVAKWHSLSE Y
Length:431
Mass (Da):48,297
Last modified:November 25, 2008 - v2
Checksum:i5C8667D2C23D758E
GO

Sequence cautioni

The sequence BAA07527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50N → S in BAB55186 (PubMed:14702039).Curated1
Sequence conflicti268V → A in BAB55186 (PubMed:14702039).Curated1
Sequence conflicti359F → L in CAH18653 (PubMed:17974005).Curated1
Sequence conflicti370D → G in CAH18653 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04765648Q → H.4 PublicationsCorresponds to variant rs822522dbSNPEnsembl.1
Natural variantiVAR_047657231G → V.1 PublicationCorresponds to variant rs17853892dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38522 mRNA. Translation: BAA07527.2. Different initiation.
AK027540 mRNA. Translation: BAB55186.1.
AK074931 mRNA. Translation: BAC11300.1.
CR749792 mRNA. Translation: CAH18653.1.
AL139128 Genomic DNA. Translation: CAH69948.1.
BC004291 mRNA. Translation: AAH04291.1.
BC013690 mRNA. Translation: AAH13690.1.
BC039205 mRNA. Translation: AAH39205.1.
CCDSiCCDS1122.1.
RefSeqiNP_689493.3. NM_152280.4.
UniGeneiHs.32984.

Genome annotation databases

EnsembliENST00000368324; ENSP00000357307; ENSG00000132718.
GeneIDi23208.
KEGGihsa:23208.
UCSCiuc001fmg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38522 mRNA. Translation: BAA07527.2. Different initiation.
AK027540 mRNA. Translation: BAB55186.1.
AK074931 mRNA. Translation: BAC11300.1.
CR749792 mRNA. Translation: CAH18653.1.
AL139128 Genomic DNA. Translation: CAH69948.1.
BC004291 mRNA. Translation: AAH04291.1.
BC013690 mRNA. Translation: AAH13690.1.
BC039205 mRNA. Translation: AAH39205.1.
CCDSiCCDS1122.1.
RefSeqiNP_689493.3. NM_152280.4.
UniGeneiHs.32984.

3D structure databases

ProteinModelPortaliQ9BT88.
SMRiQ9BT88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116815. 10 interactors.
IntActiQ9BT88. 4 interactors.
MINTiMINT-240234.
STRINGi9606.ENSP00000357307.

PTM databases

iPTMnetiQ9BT88.
PhosphoSitePlusiQ9BT88.

Polymorphism and mutation databases

BioMutaiSYT11.
DMDMi215273917.

Proteomic databases

EPDiQ9BT88.
MaxQBiQ9BT88.
PaxDbiQ9BT88.
PeptideAtlasiQ9BT88.
PRIDEiQ9BT88.

Protocols and materials databases

DNASUi23208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368324; ENSP00000357307; ENSG00000132718.
GeneIDi23208.
KEGGihsa:23208.
UCSCiuc001fmg.4. human.

Organism-specific databases

CTDi23208.
DisGeNETi23208.
GeneCardsiSYT11.
H-InvDBHIX0001138.
HGNCiHGNC:19239. SYT11.
HPAiHPA064091.
MIMi608741. gene.
neXtProtiNX_Q9BT88.
OpenTargetsiENSG00000132718.
PharmGKBiPA134898675.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9BT88.
KOiK19911.
OMAiIKVDYGD.
OrthoDBiEOG091G09ZN.
PhylomeDBiQ9BT88.
TreeFamiTF315600.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132718-MONOMER.
ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiSYT11. human.
GeneWikiiSYT11.
GenomeRNAii23208.
PROiQ9BT88.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132718.
CleanExiHS_SYT11.
GenevisibleiQ9BT88. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT11_HUMAN
AccessioniPrimary (citable) accession number: Q9BT88
Secondary accession number(s): Q14998
, Q5W0D4, Q68CT5, Q8IXU3, Q96SU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.