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Q9BT88

- SYT11_HUMAN

UniProt

Q9BT88 - SYT11_HUMAN

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Protein

Synaptotagmin-11

Gene

SYT11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi188 – 1881Calcium 1By similarity
Metal bindingi188 – 1881Calcium 2By similarity
Metal bindingi195 – 1951Calcium 1By similarity
Metal bindingi249 – 2491Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi250 – 2501Calcium 1By similarity
Metal bindingi250 – 2501Calcium 2By similarity
Metal bindingi250 – 2501Calcium 3By similarity
Metal bindingi253 – 2531Calcium 3By similarity
Metal bindingi256 – 2561Calcium 2By similarity
Metal bindingi256 – 2561Calcium 3By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro

GO - Biological processi

  1. negative regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:SYT11
Synonyms:KIAA0080
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19239. SYT11.

Subcellular locationi

Membrane 1 Publication; Single-pass membrane protein 1 Publication. Cell junctionsynapse By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Single-pass membrane protein By similarity
Note: In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: Ensembl
  3. synaptic vesicle Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Synaptotagmin-11PRO_0000183969Add
BLAST

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9BT88.
PaxDbiQ9BT88.
PRIDEiQ9BT88.

PTM databases

PhosphoSiteiQ9BT88.

Expressioni

Gene expression databases

BgeeiQ9BT88.
CleanExiHS_SYT11.
ExpressionAtlasiQ9BT88. baseline and differential.
GenevestigatoriQ9BT88.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-751770,EBI-743771
ATP13A2Q9NQ112EBI-751770,EBI-6308763

Protein-protein interaction databases

BioGridi116815. 9 interactions.
IntActiQ9BT88. 3 interactions.
MINTiMINT-240234.
STRINGi9606.ENSP00000357307.

Structurei

3D structure databases

ProteinModelPortaliQ9BT88.
SMRiQ9BT88. Positions 158-430.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515VesicularSequence AnalysisAdd
BLAST
Topological domaini37 – 431395CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 26289C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini304 – 39794C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292488.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiQ9BT88.
OMAiIKVDYGD.
OrthoDBiEOG75J0N2.
PhylomeDBiQ9BT88.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE
110 120 130 140 150
AGLLSRDKDP RGPSSGSCID QLPIKMDYGE ELRSPITSLT PGESKTTSPS
160 170 180 190 200
SPEEDVMLGS LTFSVDYNFP KKALVVTIQE AHGLPVMDDQ TQGSDPYIKM
210 220 230 240 250
TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL VLHFLVLSFD
260 270 280 290 300
RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS
310 320 330 340 350
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV
360 370 380 390 400
KKCTLNPIFN ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA
410 420 430
HSVTASGAEH WREVCESPRK PVAKWHSLSE Y
Length:431
Mass (Da):48,297
Last modified:November 25, 2008 - v2
Checksum:i5C8667D2C23D758E
GO

Sequence cautioni

The sequence BAA07527.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501N → S in BAB55186. (PubMed:14702039)Curated
Sequence conflicti268 – 2681V → A in BAB55186. (PubMed:14702039)Curated
Sequence conflicti359 – 3591F → L in CAH18653. (PubMed:17974005)Curated
Sequence conflicti370 – 3701D → G in CAH18653. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481Q → H.4 Publications
Corresponds to variant rs822522 [ dbSNP | Ensembl ].
VAR_047656
Natural varianti231 – 2311G → V.1 Publication
Corresponds to variant rs17853892 [ dbSNP | Ensembl ].
VAR_047657

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38522 mRNA. Translation: BAA07527.2. Different initiation.
AK027540 mRNA. Translation: BAB55186.1.
AK074931 mRNA. Translation: BAC11300.1.
CR749792 mRNA. Translation: CAH18653.1.
AL139128 Genomic DNA. Translation: CAH69948.1.
BC004291 mRNA. Translation: AAH04291.1.
BC013690 mRNA. Translation: AAH13690.1.
BC039205 mRNA. Translation: AAH39205.1.
CCDSiCCDS1122.1.
RefSeqiNP_689493.3. NM_152280.4.
UniGeneiHs.32984.

Genome annotation databases

EnsembliENST00000368324; ENSP00000357307; ENSG00000132718.
GeneIDi23208.
KEGGihsa:23208.
UCSCiuc001fmg.3. human.

Polymorphism databases

DMDMi215273917.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38522 mRNA. Translation: BAA07527.2 . Different initiation.
AK027540 mRNA. Translation: BAB55186.1 .
AK074931 mRNA. Translation: BAC11300.1 .
CR749792 mRNA. Translation: CAH18653.1 .
AL139128 Genomic DNA. Translation: CAH69948.1 .
BC004291 mRNA. Translation: AAH04291.1 .
BC013690 mRNA. Translation: AAH13690.1 .
BC039205 mRNA. Translation: AAH39205.1 .
CCDSi CCDS1122.1.
RefSeqi NP_689493.3. NM_152280.4.
UniGenei Hs.32984.

3D structure databases

ProteinModelPortali Q9BT88.
SMRi Q9BT88. Positions 158-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116815. 9 interactions.
IntActi Q9BT88. 3 interactions.
MINTi MINT-240234.
STRINGi 9606.ENSP00000357307.

PTM databases

PhosphoSitei Q9BT88.

Polymorphism databases

DMDMi 215273917.

Proteomic databases

MaxQBi Q9BT88.
PaxDbi Q9BT88.
PRIDEi Q9BT88.

Protocols and materials databases

DNASUi 23208.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368324 ; ENSP00000357307 ; ENSG00000132718 .
GeneIDi 23208.
KEGGi hsa:23208.
UCSCi uc001fmg.3. human.

Organism-specific databases

CTDi 23208.
GeneCardsi GC01P155829.
H-InvDB HIX0001138.
HGNCi HGNC:19239. SYT11.
MIMi 608741. gene.
neXtProti NX_Q9BT88.
PharmGKBi PA134898675.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292488.
GeneTreei ENSGT00760000118973.
HOGENOMi HOG000232126.
HOVERGENi HBG005010.
InParanoidi Q9BT88.
OMAi IKVDYGD.
OrthoDBi EOG75J0N2.
PhylomeDBi Q9BT88.
TreeFami TF315600.

Miscellaneous databases

ChiTaRSi SYT11. human.
GeneWikii SYT11.
GenomeRNAii 23208.
NextBioi 44743.
PROi Q9BT88.
SOURCEi Search...

Gene expression databases

Bgeei Q9BT88.
CleanExi HS_SYT11.
ExpressionAtlasi Q9BT88. baseline and differential.
Genevestigatori Q9BT88.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view ]
PANTHERi PTHR10024:SF115. PTHR10024:SF115. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
    Tissue: Bone marrow.
  2. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
    Tissue: Amygdala.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-48 AND VAL-231.
    Tissue: Brain and Lymph.
  7. "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI."
    Huynh D.P., Scoles D.R., Nguyen D., Pulst S.M.
    Hum. Mol. Genet. 12:2587-2597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARK2, UBIQUITINATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSYT11_HUMAN
AccessioniPrimary (citable) accession number: Q9BT88
Secondary accession number(s): Q14998
, Q5W0D4, Q68CT5, Q8IXU3, Q96SU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3