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Q9BT88

- SYT11_HUMAN

UniProt

Q9BT88 - SYT11_HUMAN

Protein

Synaptotagmin-11

Gene

SYT11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi188 – 1881Calcium 1By similarity
    Metal bindingi188 – 1881Calcium 2By similarity
    Metal bindingi195 – 1951Calcium 1By similarity
    Metal bindingi249 – 2491Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi250 – 2501Calcium 1By similarity
    Metal bindingi250 – 2501Calcium 2By similarity
    Metal bindingi250 – 2501Calcium 3By similarity
    Metal bindingi253 – 2531Calcium 3By similarity
    Metal bindingi256 – 2561Calcium 2By similarity
    Metal bindingi256 – 2561Calcium 3By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. transporter activity Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-11
    Alternative name(s):
    Synaptotagmin XI
    Short name:
    SytXI
    Gene namesi
    Name:SYT11
    Synonyms:KIAA0080
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19239. SYT11.

    Subcellular locationi

    Membrane 1 Publication; Single-pass membrane protein 1 Publication. Cell junctionsynapse By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Single-pass membrane protein By similarity
    Note: In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: Ensembl
    3. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134898675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Synaptotagmin-11PRO_0000183969Add
    BLAST

    Post-translational modificationi

    Ubiquitinated and targeted to the proteasome complex for degradation.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9BT88.
    PaxDbiQ9BT88.
    PRIDEiQ9BT88.

    PTM databases

    PhosphoSiteiQ9BT88.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BT88.
    BgeeiQ9BT88.
    CleanExiHS_SYT11.
    GenevestigatoriQ9BT88.

    Interactioni

    Subunit structurei

    Homodimer. Can also form heterodimers By similarity. Interacts with PARK2.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPBP2Q926243EBI-751770,EBI-743771
    ATP13A2Q9NQ112EBI-751770,EBI-6308763

    Protein-protein interaction databases

    BioGridi116815. 4 interactions.
    IntActiQ9BT88. 3 interactions.
    MINTiMINT-240234.
    STRINGi9606.ENSP00000357307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BT88.
    SMRiQ9BT88. Positions 158-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515VesicularSequence AnalysisAdd
    BLAST
    Topological domaini37 – 431395CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 26289C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 39794C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292488.
    HOGENOMiHOG000232126.
    HOVERGENiHBG005010.
    InParanoidiQ9BT88.
    OMAiIKVDYGD.
    OrthoDBiEOG75J0N2.
    PhylomeDBiQ9BT88.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028699. SYT11.
    [Graphical view]
    PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BT88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN    50
    PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE 100
    AGLLSRDKDP RGPSSGSCID QLPIKMDYGE ELRSPITSLT PGESKTTSPS 150
    SPEEDVMLGS LTFSVDYNFP KKALVVTIQE AHGLPVMDDQ TQGSDPYIKM 200
    TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL VLHFLVLSFD 250
    RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS 300
    YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV 350
    KKCTLNPIFN ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA 400
    HSVTASGAEH WREVCESPRK PVAKWHSLSE Y 431
    Length:431
    Mass (Da):48,297
    Last modified:November 25, 2008 - v2
    Checksum:i5C8667D2C23D758E
    GO

    Sequence cautioni

    The sequence BAA07527.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501N → S in BAB55186. (PubMed:14702039)Curated
    Sequence conflicti268 – 2681V → A in BAB55186. (PubMed:14702039)Curated
    Sequence conflicti359 – 3591F → L in CAH18653. (PubMed:17974005)Curated
    Sequence conflicti370 – 3701D → G in CAH18653. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481Q → H.4 Publications
    Corresponds to variant rs822522 [ dbSNP | Ensembl ].
    VAR_047656
    Natural varianti231 – 2311G → V.1 Publication
    Corresponds to variant rs17853892 [ dbSNP | Ensembl ].
    VAR_047657

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38522 mRNA. Translation: BAA07527.2. Different initiation.
    AK027540 mRNA. Translation: BAB55186.1.
    AK074931 mRNA. Translation: BAC11300.1.
    CR749792 mRNA. Translation: CAH18653.1.
    AL139128 Genomic DNA. Translation: CAH69948.1.
    BC004291 mRNA. Translation: AAH04291.1.
    BC013690 mRNA. Translation: AAH13690.1.
    BC039205 mRNA. Translation: AAH39205.1.
    CCDSiCCDS1122.1.
    RefSeqiNP_689493.3. NM_152280.4.
    UniGeneiHs.32984.

    Genome annotation databases

    EnsembliENST00000368324; ENSP00000357307; ENSG00000132718.
    GeneIDi23208.
    KEGGihsa:23208.
    UCSCiuc001fmg.3. human.

    Polymorphism databases

    DMDMi215273917.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38522 mRNA. Translation: BAA07527.2 . Different initiation.
    AK027540 mRNA. Translation: BAB55186.1 .
    AK074931 mRNA. Translation: BAC11300.1 .
    CR749792 mRNA. Translation: CAH18653.1 .
    AL139128 Genomic DNA. Translation: CAH69948.1 .
    BC004291 mRNA. Translation: AAH04291.1 .
    BC013690 mRNA. Translation: AAH13690.1 .
    BC039205 mRNA. Translation: AAH39205.1 .
    CCDSi CCDS1122.1.
    RefSeqi NP_689493.3. NM_152280.4.
    UniGenei Hs.32984.

    3D structure databases

    ProteinModelPortali Q9BT88.
    SMRi Q9BT88. Positions 158-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116815. 4 interactions.
    IntActi Q9BT88. 3 interactions.
    MINTi MINT-240234.
    STRINGi 9606.ENSP00000357307.

    PTM databases

    PhosphoSitei Q9BT88.

    Polymorphism databases

    DMDMi 215273917.

    Proteomic databases

    MaxQBi Q9BT88.
    PaxDbi Q9BT88.
    PRIDEi Q9BT88.

    Protocols and materials databases

    DNASUi 23208.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368324 ; ENSP00000357307 ; ENSG00000132718 .
    GeneIDi 23208.
    KEGGi hsa:23208.
    UCSCi uc001fmg.3. human.

    Organism-specific databases

    CTDi 23208.
    GeneCardsi GC01P155829.
    H-InvDB HIX0001138.
    HGNCi HGNC:19239. SYT11.
    MIMi 608741. gene.
    neXtProti NX_Q9BT88.
    PharmGKBi PA134898675.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292488.
    HOGENOMi HOG000232126.
    HOVERGENi HBG005010.
    InParanoidi Q9BT88.
    OMAi IKVDYGD.
    OrthoDBi EOG75J0N2.
    PhylomeDBi Q9BT88.
    TreeFami TF315600.

    Miscellaneous databases

    ChiTaRSi SYT11. human.
    GeneWikii SYT11.
    GenomeRNAii 23208.
    NextBioi 44743.
    PROi Q9BT88.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BT88.
    Bgeei Q9BT88.
    CleanExi HS_SYT11.
    Genevestigatori Q9BT88.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028699. SYT11.
    [Graphical view ]
    PANTHERi PTHR10024:SF115. PTHR10024:SF115. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
      Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
      DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
      Tissue: Bone marrow.
    2. Ohara O., Nagase T., Kikuno R., Nomura N.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-48.
      Tissue: Amygdala.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-48 AND VAL-231.
      Tissue: Brain and Lymph.
    7. "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI."
      Huynh D.P., Scoles D.R., Nguyen D., Pulst S.M.
      Hum. Mol. Genet. 12:2587-2597(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARK2, UBIQUITINATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSYT11_HUMAN
    AccessioniPrimary (citable) accession number: Q9BT88
    Secondary accession number(s): Q14998
    , Q5W0D4, Q68CT5, Q8IXU3, Q96SU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3