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Protein

Transcription factor SOX-7

Gene

SOX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi45 – 11369HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. endoderm formation Source: UniProtKB
  2. negative regulation of cell proliferation Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: UniProtKB
  4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  5. positive regulation of transcription, DNA-templated Source: Ensembl
  6. regulation of canonical Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-7
Gene namesi
Name:SOX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18196. SOX7.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Transcription factor SOX-7PRO_0000048731Add
BLAST

Proteomic databases

MaxQBiQ9BT81.
PRIDEiQ9BT81.

PTM databases

PhosphoSiteiQ9BT81.

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.2 Publications

Developmental stagei

In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae.1 Publication

Gene expression databases

BgeeiQ9BT81.
CleanExiHS_SOX7.
GenevestigatoriQ9BT81.

Organism-specific databases

HPAiHPA009065.

Interactioni

Subunit structurei

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.1 Publication

Protein-protein interaction databases

BioGridi123691. 5 interactions.
IntActiQ9BT81. 3 interactions.
MINTiMINT-1186658.
STRINGi9606.ENSP00000301921.

Structurei

3D structure databases

ProteinModelPortaliQ9BT81.
SMRiQ9BT81. Positions 45-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 388121Sox C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
Contains 1 Sox C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiQ9BT81.
KOiK09270.
OMAiHAHSHRI.
OrthoDBiEOG7QC7VG.
PhylomeDBiQ9BT81.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BT81-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN
60 70 80 90 100
AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER
110 120 130 140 150
LRLQHMQDYP NYKYRPRRKK QAKRLCKRVD PGFLLSSLSR DQNALPEKRS
160 170 180 190 200
GSRGALGEKE DRGEYSPGTA LPSLRGCYHE GPAGGGGGGT PSSVDTYPYG
210 220 230 240 250
LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH PYSPEYAPSP
260 270 280 290 300
LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL
310 320 330 340 350
GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA
360 370 380
LSGHVPVSQV TPTGPTETSL ISVLADATAT YYNSYSVS
Length:388
Mass (Da):42,197
Last modified:June 1, 2001 - v1
Checksum:iDBA0EFE440DC2A74
GO
Isoform 2 (identifier: Q9BT81-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASLLGAYPW...LHNAELSKML → MSMLAERRRK...NRVHYMKFTK

Note: No experimental confirmation available.

Show »
Length:440
Mass (Da):48,522
Checksum:i65DD815F859467D3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MASLL…LSKML → MSMLAERRRKQKWAVDPQNT AWSNDDSKFGQRMLEKMGWS KGKGLGAQEQGATDHIKVQV KNNHLGLGATINNEDNWIAH QDDFNQLLAELNTCHGQETT DSSDKKEKKSFSLEEKSKIS KNRVHYMKFTK in isoform 2. 1 PublicationVSP_056667Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409320 mRNA. Translation: CAC84226.1.
BT006693 mRNA. Translation: AAP35339.1.
AK055556 mRNA. Translation: BAB70955.1.
AK296724 mRNA. Translation: BAG59312.1.
AC011008 Genomic DNA. No translation available.
AC105001 Genomic DNA. No translation available.
BC071947 mRNA. Translation: AAH71947.1.
CCDSiCCDS5977.1. [Q9BT81-1]
RefSeqiNP_113627.1. NM_031439.3. [Q9BT81-1]
UniGeneiHs.709543.

Genome annotation databases

EnsembliENST00000304501; ENSP00000301921; ENSG00000171056. [Q9BT81-1]
GeneIDi83595.
KEGGihsa:83595.
UCSCiuc003wtf.3. human. [Q9BT81-1]

Polymorphism databases

DMDMi20532272.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409320 mRNA. Translation: CAC84226.1.
BT006693 mRNA. Translation: AAP35339.1.
AK055556 mRNA. Translation: BAB70955.1.
AK296724 mRNA. Translation: BAG59312.1.
AC011008 Genomic DNA. No translation available.
AC105001 Genomic DNA. No translation available.
BC071947 mRNA. Translation: AAH71947.1.
CCDSiCCDS5977.1. [Q9BT81-1]
RefSeqiNP_113627.1. NM_031439.3. [Q9BT81-1]
UniGeneiHs.709543.

3D structure databases

ProteinModelPortaliQ9BT81.
SMRiQ9BT81. Positions 45-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123691. 5 interactions.
IntActiQ9BT81. 3 interactions.
MINTiMINT-1186658.
STRINGi9606.ENSP00000301921.

PTM databases

PhosphoSiteiQ9BT81.

Polymorphism databases

DMDMi20532272.

Proteomic databases

MaxQBiQ9BT81.
PRIDEiQ9BT81.

Protocols and materials databases

DNASUi83595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304501; ENSP00000301921; ENSG00000171056. [Q9BT81-1]
GeneIDi83595.
KEGGihsa:83595.
UCSCiuc003wtf.3. human. [Q9BT81-1]

Organism-specific databases

CTDi83595.
GeneCardsiGC08M010581.
HGNCiHGNC:18196. SOX7.
HPAiHPA009065.
MIMi612202. gene.
neXtProtiNX_Q9BT81.
PharmGKBiPA38307.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118988.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiQ9BT81.
KOiK09270.
OMAiHAHSHRI.
OrthoDBiEOG7QC7VG.
PhylomeDBiQ9BT81.

Miscellaneous databases

ChiTaRSiSOX7. human.
GenomeRNAii83595.
NextBioi35472877.
PROiQ9BT81.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BT81.
CleanExiHS_SOX7.
GenevestigatoriQ9BT81.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling."
    Takash W., Canizares J., Bonneaud N., Poulat F., Mattei M.-G., Jay P., Berta P.
    Nucleic Acids Res. 29:4274-4283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Fetal thymus.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Tongue.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  6. "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells."
    Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W.
    Mol. Cancer Res. 6:1421-1430(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSOX7_HUMAN
AccessioniPrimary (citable) accession number: Q9BT81
Secondary accession number(s): B4DKV0, Q53YD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.