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Q9BT81

- SOX7_HUMAN

UniProt

Q9BT81 - SOX7_HUMAN

Protein

Transcription factor SOX-7

Gene

SOX7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors By similarity. May be required for the survival of both hematopoietic and endothelial precursors during specification By similarity. Competes with GATA4 for binding and activation of the FGF3 promoter By similarity. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi45 – 11369HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    2. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. endoderm formation Source: UniProtKB
    2. negative regulation of cell proliferation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    5. regulation of canonical Wnt signaling pathway Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-7
    Gene namesi
    Name:SOX7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18196. SOX7.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38307.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Transcription factor SOX-7PRO_0000048731Add
    BLAST

    Proteomic databases

    MaxQBiQ9BT81.
    PRIDEiQ9BT81.

    PTM databases

    PhosphoSiteiQ9BT81.

    Expressioni

    Tissue specificityi

    Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.2 Publications

    Developmental stagei

    In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae.1 Publication

    Gene expression databases

    ArrayExpressiQ9BT81.
    BgeeiQ9BT81.
    CleanExiHS_SOX7.
    GenevestigatoriQ9BT81.

    Organism-specific databases

    HPAiHPA009065.

    Interactioni

    Subunit structurei

    Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.1 Publication

    Protein-protein interaction databases

    BioGridi123691. 4 interactions.
    IntActiQ9BT81. 3 interactions.
    MINTiMINT-1186658.
    STRINGi9606.ENSP00000301921.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BT81.
    SMRiQ9BT81. Positions 45-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini268 – 388121Sox C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 Sox C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000069999.
    HOVERGENiHBG000517.
    InParanoidiQ9BT81.
    KOiK09270.
    OrthoDBiEOG7QC7VG.
    PhylomeDBiQ9BT81.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR021934. Sox_C_TAD.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12067. Sox_C_TAD. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    PS51516. SOX_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BT81-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN    50
    AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER 100
    LRLQHMQDYP NYKYRPRRKK QAKRLCKRVD PGFLLSSLSR DQNALPEKRS 150
    GSRGALGEKE DRGEYSPGTA LPSLRGCYHE GPAGGGGGGT PSSVDTYPYG 200
    LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH PYSPEYAPSP 250
    LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL 300
    GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA 350
    LSGHVPVSQV TPTGPTETSL ISVLADATAT YYNSYSVS 388
    Length:388
    Mass (Da):42,197
    Last modified:June 1, 2001 - v1
    Checksum:iDBA0EFE440DC2A74
    GO
    Isoform 2 (identifier: Q9BT81-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MASLLGAYPW...LHNAELSKML → MSMLAERRRK...NRVHYMKFTK

    Note: No experimental confirmation available.

    Show »
    Length:440
    Mass (Da):48,522
    Checksum:i65DD815F859467D3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979MASLL…LSKML → MSMLAERRRKQKWAVDPQNT AWSNDDSKFGQRMLEKMGWS KGKGLGAQEQGATDHIKVQV KNNHLGLGATINNEDNWIAH QDDFNQLLAELNTCHGQETT DSSDKKEKKSFSLEEKSKIS KNRVHYMKFTK in isoform 2. 1 PublicationVSP_056667Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ409320 mRNA. Translation: CAC84226.1.
    BT006693 mRNA. Translation: AAP35339.1.
    AK055556 mRNA. Translation: BAB70955.1.
    AK296724 mRNA. Translation: BAG59312.1.
    AC011008 Genomic DNA. No translation available.
    AC105001 Genomic DNA. No translation available.
    BC071947 mRNA. Translation: AAH71947.1.
    CCDSiCCDS5977.1.
    RefSeqiNP_113627.1. NM_031439.3.
    UniGeneiHs.709543.

    Genome annotation databases

    EnsembliENST00000304501; ENSP00000301921; ENSG00000171056.
    ENST00000553390; ENSP00000452017; ENSG00000171056.
    GeneIDi83595.
    KEGGihsa:83595.
    UCSCiuc003wtf.3. human.

    Polymorphism databases

    DMDMi20532272.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ409320 mRNA. Translation: CAC84226.1 .
    BT006693 mRNA. Translation: AAP35339.1 .
    AK055556 mRNA. Translation: BAB70955.1 .
    AK296724 mRNA. Translation: BAG59312.1 .
    AC011008 Genomic DNA. No translation available.
    AC105001 Genomic DNA. No translation available.
    BC071947 mRNA. Translation: AAH71947.1 .
    CCDSi CCDS5977.1.
    RefSeqi NP_113627.1. NM_031439.3.
    UniGenei Hs.709543.

    3D structure databases

    ProteinModelPortali Q9BT81.
    SMRi Q9BT81. Positions 45-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123691. 4 interactions.
    IntActi Q9BT81. 3 interactions.
    MINTi MINT-1186658.
    STRINGi 9606.ENSP00000301921.

    PTM databases

    PhosphoSitei Q9BT81.

    Polymorphism databases

    DMDMi 20532272.

    Proteomic databases

    MaxQBi Q9BT81.
    PRIDEi Q9BT81.

    Protocols and materials databases

    DNASUi 83595.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304501 ; ENSP00000301921 ; ENSG00000171056 .
    ENST00000553390 ; ENSP00000452017 ; ENSG00000171056 .
    GeneIDi 83595.
    KEGGi hsa:83595.
    UCSCi uc003wtf.3. human.

    Organism-specific databases

    CTDi 83595.
    GeneCardsi GC08M010618.
    HGNCi HGNC:18196. SOX7.
    HPAi HPA009065.
    MIMi 612202. gene.
    neXtProti NX_Q9BT81.
    PharmGKBi PA38307.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000069999.
    HOVERGENi HBG000517.
    InParanoidi Q9BT81.
    KOi K09270.
    OrthoDBi EOG7QC7VG.
    PhylomeDBi Q9BT81.

    Miscellaneous databases

    ChiTaRSi SOX7. human.
    GenomeRNAii 83595.
    NextBioi 72529.
    PROi Q9BT81.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BT81.
    Bgeei Q9BT81.
    CleanExi HS_SOX7.
    Genevestigatori Q9BT81.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR021934. Sox_C_TAD.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12067. Sox_C_TAD. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    PS51516. SOX_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling."
      Takash W., Canizares J., Bonneaud N., Poulat F., Mattei M.-G., Jay P., Berta P.
      Nucleic Acids Res. 29:4274-4283(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Fetal thymus.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Tongue.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells."
      Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W.
      Mol. Cancer Res. 6:1421-1430(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSOX7_HUMAN
    AccessioniPrimary (citable) accession number: Q9BT81
    Secondary accession number(s): B4DKV0, Q53YD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3