Q9BT81 (SOX7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-7

Gene names

Name:

SOX7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors By similarity. May be required for the survival of both hematopoietic and endothelial precursors during specification By similarity. Competes with GATA4 for binding and activation of the FGF3 promoter By similarity. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. Ref.5
Subunit structure	Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Ref.5
Subcellular location	Nucleus By similarity. Cytoplasm Ref.5.
Tissue specificity	Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. Ref.1 Ref.5
Developmental stage	In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae. Ref.1
Sequence similarities	Contains 1 HMG box DNA-binding domain. Contains 1 Sox C-terminal domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endoderm formation Inferred from direct assay PubMed 18682240. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay PubMed 19108950. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 19108950. Source: UniProtKB positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay PubMed 19108950. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 19108950. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: UniProtKB nucleus Inferred from direct assay PubMed 18682240PubMed 19108950. Source: UniProtKB
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 19108950. Source: UniProtKB transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Transcription factor SOX-7		PRO_0000048731
Regions
	Domain	268 – 388	121	Sox C-terminal
	DNA binding	45 – 113	69	HMG box

Sequences

	Sequence		Length	Mass (Da)
	Q9BT81 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: DBA0EFE440DC2A74	FASTA	388	42,197
	10 20 30 40 50 60 MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN AFMVWAKDER 70 80 90 100 110 120 KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER LRLQHMQDYP NYKYRPRRKK 130 140 150 160 170 180 QAKRLCKRVD PGFLLSSLSR DQNALPEKRS GSRGALGEKE DRGEYSPGTA LPSLRGCYHE 190 200 210 220 230 240 GPAGGGGGGT PSSVDTYPYG LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH 250 260 270 280 290 300 PYSPEYAPSP LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL 310 320 330 340 350 360 GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA LSGHVPVSQV 370 380 TPTGPTETSL ISVLADATAT YYNSYSVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling." Takash W., Canizares J., Bonneaud N., Poulat F., Mattei M.-G., Jay P., Berta P. Nucleic Acids Res. 29:4274-4283(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Fetal thymus.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells." Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W. Mol. Cancer Res. 6:1421-1430(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ409320 mRNA. Translation: CAC84226.1. AK055556 mRNA. Translation: BAB70955.1. BT006693 mRNA. Translation: AAP35339.1. BC071947 mRNA. Translation: AAH71947.1.
IPI	IPI00027779.
RefSeq	NP_113627.1. NM_031439.2.
UniGene	Hs.709543.
3D structure databases
ProteinModelPortal	Q9BT81.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1186658.
STRING	9606.ENSP00000301921.
PTM databases
PhosphoSite	Q9BT81.
Polymorphism databases
DMDM	20532272.
Proteomic databases
PRIDE	Q9BT81.
Protocols and materials databases
DNASU	83595.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304501; ENSP00000301921; ENSG00000171056.
GeneID	83595.
KEGG	hsa:83595.
UCSC	uc003wtf.3. human.
Organism-specific databases
CTD	83595.
GeneCards	GC08M010618.
HGNC	HGNC:18196. SOX7.
HPA	HPA009065.
MIM	612202. gene.
neXtProt	NX_Q9BT81.
PharmGKB	PA38307.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000069999.
HOVERGEN	HBG000517.
InParanoid	Q9BT81.
KO	K09270.
OrthoDB	EOG447FTC.
PhylomeDB	Q9BT81.
Gene expression databases
ArrayExpress	Q9BT81.
Bgee	Q9BT81.
CleanEx	HS_SOX7.
Genevestigator	Q9BT81.
GermOnline	ENSG00000171056. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR021934. Sox_C_TAD. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. PF12067. Sox_C_TAD. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. PS51516. SOX_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX7. human.
GenomeRNAi	83595.
NextBio	72529.
SOURCE	Search...

Entry information

Entry name

SOX7_HUMAN

Accession

Primary (citable) accession number: Q9BT81
Secondary accession number(s): Q53YD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.