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Q9BT81 (SOX7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-7
Gene names
Name:SOX7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors By similarity. May be required for the survival of both hematopoietic and endothelial precursors during specification By similarity. Competes with GATA4 for binding and activation of the FGF3 promoter By similarity. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. Ref.5

Subunit structure

Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Ref.5

Subcellular location

Nucleus By similarity. Cytoplasm Ref.5.

Tissue specificity

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. Ref.1 Ref.5

Developmental stage

In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae. Ref.1

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Contains 1 Sox C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Transcription factor SOX-7
PRO_0000048731

Regions

Domain268 – 388121Sox C-terminal
DNA binding45 – 11369HMG box

Sequences

Sequence LengthMass (Da)Tools
Q9BT81 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DBA0EFE440DC2A74

FASTA38842,197
        10         20         30         40         50         60 
MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN AFMVWAKDER 

        70         80         90        100        110        120 
KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER LRLQHMQDYP NYKYRPRRKK 

       130        140        150        160        170        180 
QAKRLCKRVD PGFLLSSLSR DQNALPEKRS GSRGALGEKE DRGEYSPGTA LPSLRGCYHE 

       190        200        210        220        230        240 
GPAGGGGGGT PSSVDTYPYG LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH 

       250        260        270        280        290        300 
PYSPEYAPSP LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL 

       310        320        330        340        350        360 
GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA LSGHVPVSQV 

       370        380 
TPTGPTETSL ISVLADATAT YYNSYSVS 

« Hide

References

« Hide 'large scale' references
[1]"SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling."
Takash W., Canizares J., Bonneaud N., Poulat F., Mattei M.-G., Jay P., Berta P.
Nucleic Acids Res. 29:4274-4283(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Fetal thymus.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells."
Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W.
Mol. Cancer Res. 6:1421-1430(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ409320 mRNA. Translation: CAC84226.1.
AK055556 mRNA. Translation: BAB70955.1.
BT006693 mRNA. Translation: AAP35339.1.
BC071947 mRNA. Translation: AAH71947.1.
CCDSCCDS5977.1.
RefSeqNP_113627.1. NM_031439.3.
UniGeneHs.709543.

3D structure databases

ProteinModelPortalQ9BT81.
SMRQ9BT81. Positions 45-118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123691. 4 interactions.
IntActQ9BT81. 3 interactions.
MINTMINT-1186658.
STRING9606.ENSP00000301921.

PTM databases

PhosphoSiteQ9BT81.

Polymorphism databases

DMDM20532272.

Proteomic databases

MaxQBQ9BT81.
PRIDEQ9BT81.

Protocols and materials databases

DNASU83595.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304501; ENSP00000301921; ENSG00000171056.
GeneID83595.
KEGGhsa:83595.
UCSCuc003wtf.3. human.

Organism-specific databases

CTD83595.
GeneCardsGC08M010618.
HGNCHGNC:18196. SOX7.
HPAHPA009065.
MIM612202. gene.
neXtProtNX_Q9BT81.
PharmGKBPA38307.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000069999.
HOVERGENHBG000517.
InParanoidQ9BT81.
KOK09270.
OrthoDBEOG7QC7VG.
PhylomeDBQ9BT81.

Gene expression databases

ArrayExpressQ9BT81.
BgeeQ9BT81.
CleanExHS_SOX7.
GenevestigatorQ9BT81.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX7. human.
GenomeRNAi83595.
NextBio72529.
PROQ9BT81.
SOURCESearch...

Entry information

Entry nameSOX7_HUMAN
AccessionPrimary (citable) accession number: Q9BT81
Secondary accession number(s): Q53YD0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM