ID   UPK3B_HUMAN             Reviewed;         320 AA.
AC   Q9BT76; A6NHH5; A8K231; A8MZA8; B3KPU5; Q75MM5; Q86W06;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   27-MAR-2024, entry version 158.
DE   RecName: Full=Uroplakin-3b;
DE            Short=UP3b;
DE   AltName: Full=Uroplakin IIIb;
DE            Short=UPIIIb;
DE   AltName: Full=p35;
DE   Flags: Precursor;
GN   Name=UPK3B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH UPK1B, SUBCELLULAR
RP   LOCATION, AND VARIANT ARG-319.
RX   PubMed=12446744; DOI=10.1083/jcb.200204102;
RA   Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A.,
RA   Zhou G., Ding M., Kreibich G., Sun T.-T.;
RT   "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with
RT   uroplakin Ib as an early step of urothelial plaque assembly.";
RL   J. Cell Biol. 159:685-694(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ARG-319.
RC   TISSUE=Placenta, and Subthalamic nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-319.
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the asymmetric unit membrane (AUM); a highly
CC       specialized biomembrane elaborated by terminally differentiated
CC       urothelial cells. May play an important role in AUM-cytoskeleton
CC       interaction in terminally differentiated urothelial cells. It also
CC       contributes to the formation of urothelial glycocalyx which may play an
CC       important role in preventing bacterial adherence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with uroplakin-1B (UPK1B).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B
CC       is a prerequisite to exit out of the endoplasmic reticulum (ER).
CC       {ECO:0000269|PubMed:12446744}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9BT76-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BT76-2; Sequence=VSP_037327;
CC       Name=3;
CC         IsoId=Q9BT76-3; Sequence=VSP_037327, VSP_054295;
CC   -!- SIMILARITY: Belongs to the uroplakin-3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO89507.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAS07526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY233462; AAO89507.1; ALT_FRAME; mRNA.
DR   EMBL; AK056760; BAG51807.1; -; mRNA.
DR   EMBL; AK290096; BAF82785.1; -; mRNA.
DR   EMBL; AC004980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007078; AAS07526.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC004304; AAH04304.1; -; mRNA.
DR   CCDS; CCDS87512.1; -. [Q9BT76-3]
DR   RefSeq; NP_001334613.1; NM_001347684.1. [Q9BT76-3]
DR   RefSeq; NP_085047.1; NM_030570.3.
DR   RefSeq; NP_872624.1; NM_182683.2.
DR   RefSeq; NP_872625.1; NM_182684.2.
DR   RefSeq; XP_005250669.1; XM_005250612.3.
DR   RefSeq; XP_006716203.1; XM_006716140.3.
DR   RefSeq; XP_006716204.1; XM_006716141.3.
DR   AlphaFoldDB; Q9BT76; -.
DR   BioGRID; 123295; 16.
DR   IntAct; Q9BT76; 5.
DR   MINT; Q9BT76; -.
DR   TCDB; 8.A.90.2.2; the uroplakin 2/3 (upk2/3) family.
DR   GlyCosmos; Q9BT76; 1 site, No reported glycans.
DR   GlyGen; Q9BT76; 1 site.
DR   iPTMnet; Q9BT76; -.
DR   PhosphoSitePlus; Q9BT76; -.
DR   BioMuta; UPK3B; -.
DR   MassIVE; Q9BT76; -.
DR   PaxDb; 9606-ENSP00000257632; -.
DR   PeptideAtlas; Q9BT76; -.
DR   ProteomicsDB; 1200; -.
DR   ProteomicsDB; 78956; -. [Q9BT76-1]
DR   ProteomicsDB; 78957; -. [Q9BT76-2]
DR   Antibodypedia; 34816; 124 antibodies from 22 providers.
DR   DNASU; 80761; -.
DR   Ensembl; ENST00000257632.9; ENSP00000257632.5; ENSG00000243566.7. [Q9BT76-1]
DR   Ensembl; ENST00000334348.8; ENSP00000334938.3; ENSG00000243566.7. [Q9BT76-3]
DR   Ensembl; ENST00000394849.1; ENSP00000378319.1; ENSG00000243566.7. [Q9BT76-2]
DR   Ensembl; ENST00000448265.7; ENSP00000441284.2; ENSG00000276184.4.
DR   Ensembl; ENST00000615976.2; ENSP00000479568.1; ENSG00000276184.4.
DR   GeneID; 105375355; -.
DR   KEGG; hsa:105375355; -.
DR   MANE-Select; ENST00000334348.8; ENSP00000334938.3; NM_001347684.2; NP_001334613.1. [Q9BT76-3]
DR   UCSC; uc033ayx.2; human. [Q9BT76-1]
DR   AGR; HGNC:21444; -.
DR   CTD; 105375355; -.
DR   DisGeNET; 105375355; -.
DR   GeneCards; UPK3B; -.
DR   HGNC; HGNC:21444; UPK3B.
DR   HPA; ENSG00000243566; Group enriched (adipose tissue, esophagus, lung, urinary bladder).
DR   MIM; 611887; gene.
DR   neXtProt; NX_Q9BT76; -.
DR   OpenTargets; ENSG00000243566; -.
DR   PharmGKB; PA134952181; -.
DR   VEuPathDB; HostDB:ENSG00000243566; -.
DR   eggNOG; ENOG502RZJD; Eukaryota.
DR   GeneTree; ENSGT00940000153392; -.
DR   HOGENOM; CLU_082608_0_0_1; -.
DR   InParanoid; Q9BT76; -.
DR   OMA; HFSSLWW; -.
DR   OrthoDB; 5318376at2759; -.
DR   PhylomeDB; Q9BT76; -.
DR   TreeFam; TF336628; -.
DR   PathwayCommons; Q9BT76; -.
DR   SignaLink; Q9BT76; -.
DR   BioGRID-ORCS; 105375355; 15 hits in 1047 CRISPR screens.
DR   GenomeRNAi; 105375355; -.
DR   Pharos; Q9BT76; Tbio.
DR   PRO; PR:Q9BT76; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9BT76; Protein.
DR   Bgee; ENSG00000243566; Expressed in lower esophagus mucosa and 91 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR   InterPro; IPR024831; Uroplakin-3.
DR   PANTHER; PTHR15446; UROPLAKIN III; 1.
DR   PANTHER; PTHR15446:SF15; UROPLAKIN-3B; 1.
DR   Genevisible; Q9BT76; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..320
FT                   /note="Uroplakin-3b"
FT                   /id="PRO_0000022640"
FT   TOPO_DOM        30..240
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          273..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         29..83
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:12446744,
FT                   ECO:0000303|PubMed:14702039"
FT                   /id="VSP_037327"
FT   VAR_SEQ         210..320
FT                   /note="EDPRIHRHLARAAKWQHDRHYLHPLFSGRPPTLGLLGSLYHALLQPVVAGGG
FT                   PGAAADRLLHGQALHDPPHPTQRGRHTAGGLQAWPGPPPQPQPLAWPLCMGLGEMGRWE
FT                   -> VKFLLMDTRGSPRAETKWSDPITLHQGKTPGSIDTWPGRRSGSMIVITSILSSLAG
FT                   LLLLAFLAASTMRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPREAATLPVGCKPGLD
FT                   PLPSLSP (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054295"
FT   VARIANT         293
FT                   /note="Q -> R (in dbSNP:rs1636632)"
FT                   /id="VAR_034561"
FT   VARIANT         319
FT                   /note="W -> R (in dbSNP:rs1799126)"
FT                   /evidence="ECO:0000269|PubMed:12446744,
FT                   ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_047805"
SQ   SEQUENCE   320 AA;  33882 MW;  64A1FE268A8BB0EB CRC64;
     MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV IGPWAPAPLR
     LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK VTATTFSLEQ PRCVFDGLAS
     ASDTVWLVVA FSNASRGFQN PETLADIPAS PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG
     APVLRVGHDH GCHQQPFCNA PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP
     TLGLLGSLYH ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP
     QPQPLAWPLC MGLGEMGRWE
//