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Q9BT76

- UPK3B_HUMAN

UniProt

Q9BT76 - UPK3B_HUMAN

Protein

Uroplakin-3b

Gene

UPK3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence By similarity.By similarity

    GO - Biological processi

    1. negative regulation of gene expression Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroplakin-3b
    Short name:
    UP3b
    Alternative name(s):
    Uroplakin IIIb
    Short name:
    UPIIIb
    p35
    Gene namesi
    Name:UPK3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21444. UPK3B.

    Subcellular locationi

    Cell membrane Curated; Single-pass type I membrane protein Curated
    Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134952181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 320291Uroplakin-3bPRO_0000022640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9BT76.

    PTM databases

    PhosphoSiteiQ9BT76.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BT76.
    BgeeiQ9BT76.
    CleanExiHS_UPK3B.
    GenevestigatoriQ9BT76.

    Organism-specific databases

    HPAiHPA010506.

    Interactioni

    Subunit structurei

    Heterodimer with uroplakin-1B (UPK1B).

    Protein-protein interaction databases

    STRINGi9606.ENSP00000257632.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BT76.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 240211LumenalSequence AnalysisAdd
    BLAST
    Topological domaini267 – 32054CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei241 – 26626HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uroplakin-3 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43682.
    HOGENOMiHOG000154787.
    HOVERGENiHBG079326.
    InParanoidiQ9BT76.
    OMAiRHYLHPL.
    OrthoDBiEOG70S768.
    PhylomeDBiQ9BT76.
    TreeFamiTF336628.

    Family and domain databases

    InterProiIPR024831. Uroplakin-3.
    IPR024828. Uroplakin-3b.
    [Graphical view]
    PANTHERiPTHR15446. PTHR15446. 1 hit.
    PTHR15446:SF16. PTHR15446:SF16. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BT76-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV    50
    IGPWAPAPLR LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK 100
    VTATTFSLEQ PRCVFDGLAS ASDTVWLVVA FSNASRGFQN PETLADIPAS 150
    PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG APVLRVGHDH GCHQQPFCNA 200
    PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP TLGLLGSLYH 250
    ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP 300
    QPQPLAWPLC MGLGEMGRWE 320
    Length:320
    Mass (Da):33,882
    Last modified:November 25, 2008 - v2
    Checksum:i64A1FE268A8BB0EB
    GO
    Isoform 2 (identifier: Q9BT76-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-83: Missing.

    Show »
    Length:265
    Mass (Da):28,537
    Checksum:i0709A06F2BC7148F
    GO
    Isoform 3 (identifier: Q9BT76-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-83: Missing.
         210-320: EDPRIHRHLA...MGLGEMGRWE → VKFLLMDTRG...GLDPLPSLSP

    Show »
    Length:276
    Mass (Da):29,791
    Checksum:i9A94B2A6E69DEEBD
    GO

    Sequence cautioni

    The sequence AAO89507.1 differs from that shown. Reason: Frameshift at position 210.
    The sequence AAS07526.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931Q → R.
    Corresponds to variant rs1636632 [ dbSNP | Ensembl ].
    VAR_034561
    Natural varianti319 – 3191W → R.3 Publications
    Corresponds to variant rs1799126 [ dbSNP | Ensembl ].
    VAR_047805

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei29 – 8355Missing in isoform 2 and isoform 3. 2 PublicationsVSP_037327Add
    BLAST
    Alternative sequencei210 – 320111EDPRI…MGRWE → VKFLLMDTRGSPRAETKWSD PITLHQGKTPGSIDTWPGRR SGSMIVITSILSSLAGLLLL AFLAASTMRFSSLWWPEEAP EQLRIGSFMGKRYMTHHIPP REAATLPVGCKPGLDPLPSL SP in isoform 3. CuratedVSP_054295Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233462 mRNA. Translation: AAO89507.1. Frameshift.
    AK056760 mRNA. Translation: BAG51807.1.
    AK290096 mRNA. Translation: BAF82785.1.
    AC004980 Genomic DNA. No translation available.
    AC006972 Genomic DNA. No translation available.
    AC007003 Genomic DNA. No translation available.
    AC114737 Genomic DNA. No translation available.
    AC007078 Genomic DNA. Translation: AAS07526.1. Sequence problems.
    BC004304 mRNA. Translation: AAH04304.1.
    CCDSiCCDS5588.1. [Q9BT76-1]
    CCDS5589.1. [Q9BT76-3]
    CCDS64693.1. [Q9BT76-2]
    RefSeqiNP_085047.1. NM_030570.3.
    NP_872624.1. NM_182683.2.
    NP_872625.1. NM_182684.2.
    XP_005250669.1. XM_005250612.1. [Q9BT76-1]
    XP_006716203.1. XM_006716140.1. [Q9BT76-3]
    XP_006716204.1. XM_006716141.1. [Q9BT76-2]
    UniGeneiHs.488861.

    Genome annotation databases

    EnsembliENST00000257632; ENSP00000257632; ENSG00000243566. [Q9BT76-1]
    ENST00000334348; ENSP00000334938; ENSG00000243566. [Q9BT76-3]
    ENST00000394849; ENSP00000378319; ENSG00000243566. [Q9BT76-2]
    GeneIDi80761.
    KEGGihsa:80761.
    UCSCiuc003ufq.3. human. [Q9BT76-1]
    uc010ldk.2. human. [Q9BT76-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233462 mRNA. Translation: AAO89507.1 . Frameshift.
    AK056760 mRNA. Translation: BAG51807.1 .
    AK290096 mRNA. Translation: BAF82785.1 .
    AC004980 Genomic DNA. No translation available.
    AC006972 Genomic DNA. No translation available.
    AC007003 Genomic DNA. No translation available.
    AC114737 Genomic DNA. No translation available.
    AC007078 Genomic DNA. Translation: AAS07526.1 . Sequence problems.
    BC004304 mRNA. Translation: AAH04304.1 .
    CCDSi CCDS5588.1. [Q9BT76-1 ]
    CCDS5589.1. [Q9BT76-3 ]
    CCDS64693.1. [Q9BT76-2 ]
    RefSeqi NP_085047.1. NM_030570.3.
    NP_872624.1. NM_182683.2.
    NP_872625.1. NM_182684.2.
    XP_005250669.1. XM_005250612.1. [Q9BT76-1 ]
    XP_006716203.1. XM_006716140.1. [Q9BT76-3 ]
    XP_006716204.1. XM_006716141.1. [Q9BT76-2 ]
    UniGenei Hs.488861.

    3D structure databases

    ProteinModelPortali Q9BT76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000257632.

    PTM databases

    PhosphoSitei Q9BT76.

    Proteomic databases

    PRIDEi Q9BT76.

    Protocols and materials databases

    DNASUi 80761.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257632 ; ENSP00000257632 ; ENSG00000243566 . [Q9BT76-1 ]
    ENST00000334348 ; ENSP00000334938 ; ENSG00000243566 . [Q9BT76-3 ]
    ENST00000394849 ; ENSP00000378319 ; ENSG00000243566 . [Q9BT76-2 ]
    GeneIDi 80761.
    KEGGi hsa:80761.
    UCSCi uc003ufq.3. human. [Q9BT76-1 ]
    uc010ldk.2. human. [Q9BT76-2 ]

    Organism-specific databases

    CTDi 80761.
    GeneCardsi GC07P076139.
    HGNCi HGNC:21444. UPK3B.
    HPAi HPA010506.
    MIMi 611887. gene.
    neXtProti NX_Q9BT76.
    PharmGKBi PA134952181.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43682.
    HOGENOMi HOG000154787.
    HOVERGENi HBG079326.
    InParanoidi Q9BT76.
    OMAi RHYLHPL.
    OrthoDBi EOG70S768.
    PhylomeDBi Q9BT76.
    TreeFami TF336628.

    Miscellaneous databases

    GenomeRNAii 80761.
    NextBioi 35462579.
    PROi Q9BT76.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BT76.
    Bgeei Q9BT76.
    CleanExi HS_UPK3B.
    Genevestigatori Q9BT76.

    Family and domain databases

    InterProi IPR024831. Uroplakin-3.
    IPR024828. Uroplakin-3b.
    [Graphical view ]
    PANTHERi PTHR15446. PTHR15446. 1 hit.
    PTHR15446:SF16. PTHR15446:SF16. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly."
      Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A., Zhou G., Ding M., Kreibich G., Sun T.-T.
      J. Cell Biol. 159:685-694(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH UPK1B, SUBCELLULAR LOCATION, VARIANT ARG-319.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-319.
      Tissue: Placenta and Subthalamic nucleus.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-319.
      Tissue: Uterus.

    Entry informationi

    Entry nameiUPK3B_HUMAN
    AccessioniPrimary (citable) accession number: Q9BT76
    Secondary accession number(s): A6NHH5
    , A8K231, A8MZA8, B3KPU5, Q75MM5, Q86W06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3