Q9BT76 (UPK3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroplakin-3b
Short name=UP3b

Alternative name(s):
Uroplakin IIIb
Short name=UPIIIb
p35

Gene names

Name:

UPK3B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence By similarity.
Subunit structure	Heterodimer with uroplakin-1B (UPK1B).
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential. Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). Ref.1
Sequence similarities	Belongs to the uroplakin-3 family.
Sequence caution	The sequence AAO89507.1 differs from that shown. Reason: Frameshift at position 210. The sequence AAS07526.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of gene expression Inferred from mutant phenotype PubMed 18776082. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BT76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BT76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 320	291	Uroplakin-3b		PRO_0000022640
Regions
	Topological domain	30 – 240	211	Lumenal Potential
	Transmembrane	241 – 266	26	Helical; Potential
	Topological domain	267 – 320	54	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	133	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	29 – 83	55	Missing in isoform 2.		VSP_037327
	Natural variant	293	1	Q → R. Corresponds to variant rs1636632 [ dbSNP | Ensembl ].		VAR_034561
	Natural variant	319	1	W → R. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1799126 [ dbSNP | Ensembl ].		VAR_047805

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 64A1FE268A8BB0EB	FASTA	320	33,882
	10 20 30 40 50 60 MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV IGPWAPAPLR 70 80 90 100 110 120 LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK VTATTFSLEQ PRCVFDGLAS 130 140 150 160 170 180 ASDTVWLVVA FSNASRGFQN PETLADIPAS PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG 190 200 210 220 230 240 APVLRVGHDH GCHQQPFCNA PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP 250 260 270 280 290 300 TLGLLGSLYH ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP 310 320 QPQPLAWPLC MGLGEMGRWE
	Isoform 2 [UniParc]. Checksum: 0709A06F2BC7148F	FASTA	265	28,537
	10 20 30 40 50 60 MGLPWGQPHL GLQMLLLALN CLRPSLSLEL VPYTPQITAW DLEGKVTATT FSLEQPRCVF 70 80 90 100 110 120 DGLASASDTV WLVVAFSNAS RGFQNPETLA DIPASPQLLT DGHYMTLPLS PDQLPCGDPM 130 140 150 160 170 180 AGSGGAPVLR VGHDHGCHQQ PFCNAPLPGP GPYREDPRIH RHLARAAKWQ HDRHYLHPLF 190 200 210 220 230 240 SGRPPTLGLL GSLYHALLQP VVAGGGPGAA ADRLLHGQAL HDPPHPTQRG RHTAGGLQAW 250 260 PGPPPQPQPL AWPLCMGLGE MGRWE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly." Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A., Zhou G., Ding M., Kreibich G., Sun T.-T. J. Cell Biol. 159:685-694(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH UPK1B, SUBCELLULAR LOCATION, VARIANT ARG-319.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-319. Tissue: Placenta and Subthalamic nucleus.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-319. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY233462 mRNA. Translation: AAO89507.1. Frameshift. AK056760 mRNA. Translation: BAG51807.1. AK290096 mRNA. Translation: BAF82785.1. AC007078 Genomic DNA. Translation: AAS07526.1. Sequence problems. BC004304 mRNA. Translation: AAH04304.1.
IPI	IPI00012234. IPI00853071.
RefSeq	NP_085047.1. NM_030570.2. NP_872624.1. NM_182683.1. NP_872625.1. NM_182684.1.
UniGene	Hs.488861.
3D structure databases
ProteinModelPortal	Q9BT76.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000257632.
PTM databases
PhosphoSite	Q9BT76.
Proteomic databases
PRIDE	Q9BT76.
Protocols and materials databases
DNASU	80761.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257632; ENSP00000257632; ENSG00000243566. ENST00000394849; ENSP00000378319; ENSG00000243566. ENST00000419923; ENSP00000441602; ENSG00000243566. ENST00000448265; ENSP00000441284; ENSG00000243566.
GeneID	80761.
KEGG	hsa:80761.
UCSC	uc003ufq.3. human. uc010ldk.1. human.
Organism-specific databases
CTD	80761.
GeneCards	GC07P076139.
HGNC	HGNC:21444. UPK3B.
HPA	HPA010506.
MIM	611887. gene.
neXtProt	NX_Q9BT76.
PharmGKB	PA134952181.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43682.
HOGENOM	HOG000154787.
InParanoid	Q9BT76.
OMA	LHRHVAR.
Gene expression databases
ArrayExpress	Q9BT76.
Bgee	Q9BT76.
CleanEx	HS_UPK3B.
Genevestigator	Q9BT76.
GermOnline	ENSG00000135180. Homo sapiens.
Family and domain databases
InterPro	IPR024831. Uroplakin-3. IPR024828. Uroplakin-3b. [Graphical view]
PANTHER	PTHR15446. PTHR15446. 1 hit. PTHR15446:SF11. PTHR15446:SF11. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	80761.
NextBio	71129.
SOURCE	Search...

Entry information

Entry name

UPK3B_HUMAN

Accession

Primary (citable) accession number: Q9BT76
Secondary accession number(s): A8K231 , A8MZA8, B3KPU5, Q75MM5, Q86W06

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	November 25, 2008
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.