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Q9BT76 (UPK3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroplakin-3b

Short name=UP3b
Alternative name(s):
Uroplakin IIIb
Short name=UPIIIb
p35
Gene names
Name:UPK3B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence By similarity.

Subunit structure

Heterodimer with uroplakin-1B (UPK1B).

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential. Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). Ref.1

Sequence similarities

Belongs to the uroplakin-3 family.

Sequence caution

The sequence AAO89507.1 differs from that shown. Reason: Frameshift at position 210.

The sequence AAS07526.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BT76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BT76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.
Isoform 3 (identifier: Q9BT76-3)

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.
     210-320: EDPRIHRHLA...MGLGEMGRWE → VKFLLMDTRG...GLDPLPSLSP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 320291Uroplakin-3b
PRO_0000022640

Regions

Topological domain30 – 240211Lumenal Potential
Transmembrane241 – 26626Helical; Potential
Topological domain267 – 32054Cytoplasmic Potential

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence29 – 8355Missing in isoform 2 and isoform 3.
VSP_037327
Alternative sequence210 – 320111EDPRI…MGRWE → VKFLLMDTRGSPRAETKWSD PITLHQGKTPGSIDTWPGRR SGSMIVITSILSSLAGLLLL AFLAASTMRFSSLWWPEEAP EQLRIGSFMGKRYMTHHIPP REAATLPVGCKPGLDPLPSL SP in isoform 3.
VSP_054295
Natural variant2931Q → R.
Corresponds to variant rs1636632 [ dbSNP | Ensembl ].
VAR_034561
Natural variant3191W → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1799126 [ dbSNP | Ensembl ].
VAR_047805

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 64A1FE268A8BB0EB

FASTA32033,882
        10         20         30         40         50         60 
MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV IGPWAPAPLR 

        70         80         90        100        110        120 
LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK VTATTFSLEQ PRCVFDGLAS 

       130        140        150        160        170        180 
ASDTVWLVVA FSNASRGFQN PETLADIPAS PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG 

       190        200        210        220        230        240 
APVLRVGHDH GCHQQPFCNA PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP 

       250        260        270        280        290        300 
TLGLLGSLYH ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP 

       310        320 
QPQPLAWPLC MGLGEMGRWE 

« Hide

Isoform 2 [UniParc].

Checksum: 0709A06F2BC7148F
Show »

FASTA26528,537
Isoform 3 [UniParc].

Checksum: 9A94B2A6E69DEEBD
Show »

FASTA27629,791

References

« Hide 'large scale' references
[1]"Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly."
Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A., Zhou G., Ding M., Kreibich G., Sun T.-T.
J. Cell Biol. 159:685-694(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH UPK1B, SUBCELLULAR LOCATION, VARIANT ARG-319.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-319.
Tissue: Placenta and Subthalamic nucleus.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-319.
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY233462 mRNA. Translation: AAO89507.1. Frameshift.
AK056760 mRNA. Translation: BAG51807.1.
AK290096 mRNA. Translation: BAF82785.1.
AC004980 Genomic DNA. No translation available.
AC006972 Genomic DNA. No translation available.
AC007003 Genomic DNA. No translation available.
AC114737 Genomic DNA. No translation available.
AC007078 Genomic DNA. Translation: AAS07526.1. Sequence problems.
BC004304 mRNA. Translation: AAH04304.1.
RefSeqNP_085047.1. NM_030570.2.
NP_872624.1. NM_182683.1.
NP_872625.1. NM_182684.1.
XP_005250669.1. XM_005250612.1.
UniGeneHs.488861.

3D structure databases

ProteinModelPortalQ9BT76.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000257632.

PTM databases

PhosphoSiteQ9BT76.

Proteomic databases

PRIDEQ9BT76.

Protocols and materials databases

DNASU80761.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257632; ENSP00000257632; ENSG00000243566. [Q9BT76-1]
ENST00000334348; ENSP00000334938; ENSG00000243566.
ENST00000394849; ENSP00000378319; ENSG00000243566. [Q9BT76-2]
ENST00000419923; ENSP00000441602; ENSG00000243566. [Q9BT76-1]
ENST00000443097; ENSP00000444585; ENSG00000243566.
ENST00000448265; ENSP00000441284; ENSG00000243566. [Q9BT76-1]
GeneID80761.
KEGGhsa:80761.
UCSCuc003ufq.3. human. [Q9BT76-1]
uc010ldk.2. human. [Q9BT76-2]

Organism-specific databases

CTD80761.
GeneCardsGC07P076139.
HGNCHGNC:21444. UPK3B.
HPAHPA010506.
MIM611887. gene.
neXtProtNX_Q9BT76.
PharmGKBPA134952181.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43682.
HOGENOMHOG000154787.
HOVERGENHBG079326.
InParanoidQ9BT76.
OMARHYLHPL.
OrthoDBEOG70S768.
TreeFamTF336628.

Gene expression databases

ArrayExpressQ9BT76.
BgeeQ9BT76.
CleanExHS_UPK3B.
GenevestigatorQ9BT76.

Family and domain databases

InterProIPR024831. Uroplakin-3.
IPR024828. Uroplakin-3b.
[Graphical view]
PANTHERPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF11. PTHR15446:SF11. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi80761.
NextBio71129.
PROQ9BT76.
SOURCESearch...

Entry information

Entry nameUPK3B_HUMAN
AccessionPrimary (citable) accession number: Q9BT76
Secondary accession number(s): A6NHH5 expand/collapse secondary AC list , A8K231, A8MZA8, B3KPU5, Q75MM5, Q86W06
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM