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Protein

Uroplakin-3b

Gene

UPK3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).By similarity

GO - Biological processi

  1. negative regulation of gene expression Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-3b
Short name:
UP3b
Alternative name(s):
Uroplakin IIIb
Short name:
UPIIIb
p35
Gene namesi
Name:UPK3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 7, Unplaced

Organism-specific databases

HGNCiHGNC:21444. UPK3B.

Subcellular locationi

  1. Cell membrane Curated; Single-pass type I membrane protein Curated

  2. Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 240211LumenalSequence AnalysisAdd
BLAST
Transmembranei241 – 26626HelicalSequence AnalysisAdd
BLAST
Topological domaini267 – 32054CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952181.

Polymorphism and mutation databases

BioMutaiUPK3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 320291Uroplakin-3bPRO_0000022640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9BT76.

PTM databases

PhosphoSiteiQ9BT76.

Expressioni

Gene expression databases

BgeeiQ9BT76.
CleanExiHS_UPK3B.
GenevestigatoriQ9BT76.

Organism-specific databases

HPAiHPA010506.

Interactioni

Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).

Protein-protein interaction databases

BioGridi123295. 2 interactions.
STRINGi9606.ENSP00000257632.

Structurei

3D structure databases

ProteinModelPortaliQ9BT76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43682.
GeneTreeiENSGT00510000048314.
HOGENOMiHOG000154787.
HOVERGENiHBG079326.
InParanoidiQ9BT76.
OMAiRHYLHPL.
OrthoDBiEOG70S768.
PhylomeDBiQ9BT76.
TreeFamiTF336628.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024828. Uroplakin-3b.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF16. PTHR15446:SF16. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BT76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV
60 70 80 90 100
IGPWAPAPLR LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK
110 120 130 140 150
VTATTFSLEQ PRCVFDGLAS ASDTVWLVVA FSNASRGFQN PETLADIPAS
160 170 180 190 200
PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG APVLRVGHDH GCHQQPFCNA
210 220 230 240 250
PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP TLGLLGSLYH
260 270 280 290 300
ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP
310 320
QPQPLAWPLC MGLGEMGRWE
Length:320
Mass (Da):33,882
Last modified:November 25, 2008 - v2
Checksum:i64A1FE268A8BB0EB
GO
Isoform 2 (identifier: Q9BT76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.

Show »
Length:265
Mass (Da):28,537
Checksum:i0709A06F2BC7148F
GO
Isoform 3 (identifier: Q9BT76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-83: Missing.
     210-320: EDPRIHRHLA...MGLGEMGRWE → VKFLLMDTRG...GLDPLPSLSP

Show »
Length:276
Mass (Da):29,791
Checksum:i9A94B2A6E69DEEBD
GO

Sequence cautioni

The sequence AAO89507.1 differs from that shown. Reason: Frameshift at position 210. Curated
The sequence AAS07526.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931Q → R.
Corresponds to variant rs1636632 [ dbSNP | Ensembl ].
VAR_034561
Natural varianti319 – 3191W → R.3 Publications
Corresponds to variant rs1799126 [ dbSNP | Ensembl ].
VAR_047805

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 8355Missing in isoform 2 and isoform 3. 2 PublicationsVSP_037327Add
BLAST
Alternative sequencei210 – 320111EDPRI…MGRWE → VKFLLMDTRGSPRAETKWSD PITLHQGKTPGSIDTWPGRR SGSMIVITSILSSLAGLLLL AFLAASTMRFSSLWWPEEAP EQLRIGSFMGKRYMTHHIPP REAATLPVGCKPGLDPLPSL SP in isoform 3. CuratedVSP_054295Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233462 mRNA. Translation: AAO89507.1. Frameshift.
AK056760 mRNA. Translation: BAG51807.1.
AK290096 mRNA. Translation: BAF82785.1.
AC004980 Genomic DNA. No translation available.
AC006972 Genomic DNA. No translation available.
AC007003 Genomic DNA. No translation available.
AC114737 Genomic DNA. No translation available.
AC007078 Genomic DNA. Translation: AAS07526.1. Sequence problems.
BC004304 mRNA. Translation: AAH04304.1.
CCDSiCCDS5588.1. [Q9BT76-1]
CCDS5589.1. [Q9BT76-3]
CCDS64693.1. [Q9BT76-2]
RefSeqiNP_085047.1. NM_030570.3.
NP_872624.1. NM_182683.2.
NP_872625.1. NM_182684.2.
XP_005250669.1. XM_005250612.2. [Q9BT76-1]
XP_006716203.1. XM_006716140.2. [Q9BT76-3]
XP_006716204.1. XM_006716141.2. [Q9BT76-2]
UniGeneiHs.488861.

Genome annotation databases

EnsembliENST00000257632; ENSP00000257632; ENSG00000243566. [Q9BT76-1]
ENST00000334348; ENSP00000334938; ENSG00000243566. [Q9BT76-3]
ENST00000394849; ENSP00000378319; ENSG00000243566. [Q9BT76-2]
ENST00000448265; ENSP00000441284; ENSG00000276184.
ENST00000615976; ENSP00000479568; ENSG00000276184.
GeneIDi80761.
KEGGihsa:80761.
UCSCiuc003ufq.3. human. [Q9BT76-1]
uc010ldk.2. human. [Q9BT76-2]

Polymorphism and mutation databases

BioMutaiUPK3B.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233462 mRNA. Translation: AAO89507.1. Frameshift.
AK056760 mRNA. Translation: BAG51807.1.
AK290096 mRNA. Translation: BAF82785.1.
AC004980 Genomic DNA. No translation available.
AC006972 Genomic DNA. No translation available.
AC007003 Genomic DNA. No translation available.
AC114737 Genomic DNA. No translation available.
AC007078 Genomic DNA. Translation: AAS07526.1. Sequence problems.
BC004304 mRNA. Translation: AAH04304.1.
CCDSiCCDS5588.1. [Q9BT76-1]
CCDS5589.1. [Q9BT76-3]
CCDS64693.1. [Q9BT76-2]
RefSeqiNP_085047.1. NM_030570.3.
NP_872624.1. NM_182683.2.
NP_872625.1. NM_182684.2.
XP_005250669.1. XM_005250612.2. [Q9BT76-1]
XP_006716203.1. XM_006716140.2. [Q9BT76-3]
XP_006716204.1. XM_006716141.2. [Q9BT76-2]
UniGeneiHs.488861.

3D structure databases

ProteinModelPortaliQ9BT76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123295. 2 interactions.
STRINGi9606.ENSP00000257632.

PTM databases

PhosphoSiteiQ9BT76.

Polymorphism and mutation databases

BioMutaiUPK3B.

Proteomic databases

PRIDEiQ9BT76.

Protocols and materials databases

DNASUi80761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257632; ENSP00000257632; ENSG00000243566. [Q9BT76-1]
ENST00000334348; ENSP00000334938; ENSG00000243566. [Q9BT76-3]
ENST00000394849; ENSP00000378319; ENSG00000243566. [Q9BT76-2]
ENST00000448265; ENSP00000441284; ENSG00000276184.
ENST00000615976; ENSP00000479568; ENSG00000276184.
GeneIDi80761.
KEGGihsa:80761.
UCSCiuc003ufq.3. human. [Q9BT76-1]
uc010ldk.2. human. [Q9BT76-2]

Organism-specific databases

CTDi80761.
GeneCardsiGC07P076139.
HGNCiHGNC:21444. UPK3B.
HPAiHPA010506.
MIMi611887. gene.
neXtProtiNX_Q9BT76.
PharmGKBiPA134952181.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43682.
GeneTreeiENSGT00510000048314.
HOGENOMiHOG000154787.
HOVERGENiHBG079326.
InParanoidiQ9BT76.
OMAiRHYLHPL.
OrthoDBiEOG70S768.
PhylomeDBiQ9BT76.
TreeFamiTF336628.

Miscellaneous databases

GenomeRNAii80761.
NextBioi35462579.
PROiQ9BT76.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BT76.
CleanExiHS_UPK3B.
GenevestigatoriQ9BT76.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024828. Uroplakin-3b.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF16. PTHR15446:SF16. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly."
    Deng F.-M., Liang F.-X., Tu L., Resing K.A., Hu P., Supino M., Hu C.-C.A., Zhou G., Ding M., Kreibich G., Sun T.-T.
    J. Cell Biol. 159:685-694(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH UPK1B, SUBCELLULAR LOCATION, VARIANT ARG-319.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-319.
    Tissue: Placenta and Subthalamic nucleus.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-319.
    Tissue: Uterus.

Entry informationi

Entry nameiUPK3B_HUMAN
AccessioniPrimary (citable) accession number: Q9BT76
Secondary accession number(s): A6NHH5
, A8K231, A8MZA8, B3KPU5, Q75MM5, Q86W06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 25, 2008
Last modified: April 29, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.