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Protein

Proteasome assembly chaperone 3

Gene

PSMG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.1 Publication

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 3
Short name:
PAC-3
Short name:
hPAC3
Gene namesi
Name:PSMG3
Synonyms:C7orf48, PAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22420. PSMG3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400247.

Chemistry

ChEMBLiCHEMBL1075137.

Polymorphism and mutation databases

BioMutaiPSMG3.
DMDMi74733099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122Proteasome assembly chaperone 3PRO_0000271358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BT73.
MaxQBiQ9BT73.
PaxDbiQ9BT73.
PeptideAtlasiQ9BT73.
PRIDEiQ9BT73.
TopDownProteomicsiQ9BT73.

PTM databases

iPTMnetiQ9BT73.
PhosphoSiteiQ9BT73.

Expressioni

Gene expression databases

BgeeiENSG00000157778.
CleanExiHS_PSMG3.
ExpressionAtlasiQ9BT73. baseline and differential.
GenevisibleiQ9BT73. HS.

Organism-specific databases

HPAiHPA023876.

Interactioni

Subunit structurei

Homodimer. Interacts with PSMG4. Interacts directly with alpha and beta subunits of the 20S proteasome but dissociates before the formation of half-proteasomes, probably upon recruitment of POMP.2 Publications

Protein-protein interaction databases

BioGridi123989. 51 interactions.
IntActiQ9BT73. 2 interactions.
STRINGi9606.ENSP00000252329.

Chemistry

BindingDBiQ9BT73.

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 168Combined sources
Beta strandi19 – 279Combined sources
Beta strandi29 – 3810Combined sources
Beta strandi44 – 507Combined sources
Beta strandi56 – 594Combined sources
Beta strandi62 – 698Combined sources
Helixi73 – 8917Combined sources
Beta strandi94 – 1007Combined sources
Helixi106 – 11813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5EX-ray2.00A/B1-122[»]
ProteinModelPortaliQ9BT73.
SMRiQ9BT73. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BT73.

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.Curated

Phylogenomic databases

eggNOGiKOG4828. Eukaryota.
ENOG410Y6DC. LUCA.
GeneTreeiENSGT00390000000324.
HOGENOMiHOG000006024.
HOVERGENiHBG061282.
InParanoidiQ9BT73.
KOiK11877.
OMAiPLVHVFA.
OrthoDBiEOG091G10BI.
PhylomeDBiQ9BT73.
TreeFamiTF300294.

Family and domain databases

InterProiIPR018788. Proteasome_assmbl_chp_3.
[Graphical view]
PfamiPF10178. PAC3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDTPLVISK QKTEVVCGVP TQVVCTAFSS HILVVVTQFG KMGTLVSLEP
60 70 80 90 100
SSVASDVSKP VLTTKVLLGQ DEPLIHVFAK NLVAFVSQEA GNRAVLLAVA
110 120
VKDKSMEGLK ALREVIRVCQ VW
Length:122
Mass (Da):13,104
Last modified:June 1, 2001 - v1
Checksum:iFA3D42A2CF4B88B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093734 Genomic DNA. Translation: AAP21867.1.
CH236953 Genomic DNA. Translation: EAL23945.1.
CH471144 Genomic DNA. Translation: EAW87212.1.
BC004308 mRNA. Translation: AAH04308.1.
BC027171 mRNA. Translation: AAH27171.1.
BR000337 mRNA. Translation: FAA00325.1.
CCDSiCCDS5327.1.
RefSeqiNP_001127812.1. NM_001134340.1.
NP_115678.1. NM_032302.3.
UniGeneiHs.446311.

Genome annotation databases

EnsembliENST00000252329; ENSP00000252329; ENSG00000157778.
ENST00000288607; ENSP00000288607; ENSG00000157778.
ENST00000404674; ENSP00000384799; ENSG00000157778.
GeneIDi84262.
KEGGihsa:84262.
UCSCiuc003skx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093734 Genomic DNA. Translation: AAP21867.1.
CH236953 Genomic DNA. Translation: EAL23945.1.
CH471144 Genomic DNA. Translation: EAW87212.1.
BC004308 mRNA. Translation: AAH04308.1.
BC027171 mRNA. Translation: AAH27171.1.
BR000337 mRNA. Translation: FAA00325.1.
CCDSiCCDS5327.1.
RefSeqiNP_001127812.1. NM_001134340.1.
NP_115678.1. NM_032302.3.
UniGeneiHs.446311.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5EX-ray2.00A/B1-122[»]
ProteinModelPortaliQ9BT73.
SMRiQ9BT73. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123989. 51 interactions.
IntActiQ9BT73. 2 interactions.
STRINGi9606.ENSP00000252329.

Chemistry

BindingDBiQ9BT73.
ChEMBLiCHEMBL1075137.

PTM databases

iPTMnetiQ9BT73.
PhosphoSiteiQ9BT73.

Polymorphism and mutation databases

BioMutaiPSMG3.
DMDMi74733099.

Proteomic databases

EPDiQ9BT73.
MaxQBiQ9BT73.
PaxDbiQ9BT73.
PeptideAtlasiQ9BT73.
PRIDEiQ9BT73.
TopDownProteomicsiQ9BT73.

Protocols and materials databases

DNASUi84262.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252329; ENSP00000252329; ENSG00000157778.
ENST00000288607; ENSP00000288607; ENSG00000157778.
ENST00000404674; ENSP00000384799; ENSG00000157778.
GeneIDi84262.
KEGGihsa:84262.
UCSCiuc003skx.3. human.

Organism-specific databases

CTDi84262.
GeneCardsiPSMG3.
HGNCiHGNC:22420. PSMG3.
HPAiHPA023876.
neXtProtiNX_Q9BT73.
PharmGKBiPA162400247.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4828. Eukaryota.
ENOG410Y6DC. LUCA.
GeneTreeiENSGT00390000000324.
HOGENOMiHOG000006024.
HOVERGENiHBG061282.
InParanoidiQ9BT73.
KOiK11877.
OMAiPLVHVFA.
OrthoDBiEOG091G10BI.
PhylomeDBiQ9BT73.
TreeFamiTF300294.

Miscellaneous databases

ChiTaRSiPSMG3. human.
EvolutionaryTraceiQ9BT73.
GenomeRNAii84262.
PROiQ9BT73.

Gene expression databases

BgeeiENSG00000157778.
CleanExiHS_PSMG3.
ExpressionAtlasiQ9BT73. baseline and differential.
GenevisibleiQ9BT73. HS.

Family and domain databases

InterProiIPR018788. Proteasome_assmbl_chp_3.
[Graphical view]
PfamiPF10178. PAC3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSMG3_HUMAN
AccessioniPrimary (citable) accession number: Q9BT73
Secondary accession number(s): A4D216, A8MPW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.