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Q9BT67

- NFIP1_HUMAN

UniProt

Q9BT67 - NFIP1_HUMAN

Protein

NEDD4 family-interacting protein 1

Gene

NDFIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.By similarity3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB
    2. negative regulation of gene expression Source: UniProtKB
    3. negative regulation of inflammatory response Source: Ensembl
    4. negative regulation of interleukin-4 production Source: Ensembl
    5. negative regulation of isotype switching to IgE isotypes Source: Ensembl
    6. negative regulation of protein transport Source: UniProtKB
    7. negative regulation of T cell proliferation Source: Ensembl
    8. negative regulation of transporter activity Source: UniProtKB
    9. negative regulation of type 2 immune response Source: Ensembl
    10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    11. positive regulation of protein catabolic process Source: Ensembl
    12. positive regulation of protein ubiquitination Source: UniProtKB
    13. regulation of isotype switching to IgG isotypes Source: Ensembl
    14. regulation of lymphocyte differentiation Source: Ensembl
    15. regulation of myeloid leukocyte differentiation Source: Ensembl
    16. signal transduction Source: GOC
    17. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NEDD4 family-interacting protein 1
    Alternative name(s):
    Breast cancer-associated protein SGA-1M
    NEDD4 WW domain-binding protein 5
    Putative MAPK-activating protein PM13
    Putative NF-kappa-B-activating protein 164
    Putative NFKB and MAPK-activating protein
    Gene namesi
    Name:NDFIP1
    Synonyms:N4WBP5
    ORF Names:PSEC0192, PSEC0223
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17592. NDFIP1.

    Subcellular locationi

    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane By similarity. Secreted
    Note: Detected in exosomes and secreted via the exosomal pathway.

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. endosome membrane Source: UniProtKB-SubCell
    3. extracellular region Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi41 – 422PY → AG: Loss of phosphorylation; when associated with 66-S-Y-67 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 66-S-Y-67 and 75-S-Y-76. No effect on PTEN-binding; when associated with 66-S-Y-67 and 75-S-Y-76. 1 Publication
    Mutagenesisi66 – 672SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 75-S-Y-76. No effect on PTEN-binding; when associated with 41-P-Y-42 and 75-S-Y-76. 1 Publication
    Mutagenesisi75 – 762SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 66-S-Y-67. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 66-S-Y-67. No effect on PTEN-binding; when associated with 41-P-Y-42 and 66-S-Y-67. 1 Publication

    Organism-specific databases

    PharmGKBiPA134943402.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 221220NEDD4 family-interacting protein 1PRO_0000076269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Post-translational modificationi

    Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.1 Publication
    Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.1 Publication

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ9BT67.
    PaxDbiQ9BT67.
    PRIDEiQ9BT67.

    PTM databases

    PhosphoSiteiQ9BT67.

    Expressioni

    Tissue specificityi

    Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.1 Publication

    Inductioni

    Increased protein expression in neuronal cells in response to Co2+ or Fe2+ ions.1 Publication

    Gene expression databases

    BgeeiQ9BT67.
    CleanExiHS_NDFIP1.
    GenevestigatoriQ9BT67.

    Organism-specific databases

    HPAiHPA009682.

    Interactioni

    Subunit structurei

    Forms heterodimers with NDFIP2. Interacts with several E3 ubiquitin-protein ligases, including NEDD4, NEDD4L and WWP2. Interacts with ITCH, U2SURP and WWP2 By similarity. The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion. Interacts with SLC11A2/DMT1. Interacts with PTEN. May interact with phosphorylated EGFR.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi123296. 7 interactions.
    DIPiDIP-48958N.
    STRINGi9606.ENSP00000253814.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BT67.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 116115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini138 – 1436ExtracellularSequence Analysis
    Topological domaini165 – 1728CytoplasmicSequence Analysis
    Topological domaini194 – 22128ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 423WW-binding 1
    Motifi65 – 673WW-binding 2
    Motifi74 – 763WW-binding 3

    Domaini

    The PY/WW-binding motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination.

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311167.
    HOGENOMiHOG000038752.
    HOVERGENiHBG057103.
    InParanoidiQ9BT67.
    OMAiTAYFDYK.
    OrthoDBiEOG7Z69DP.
    PhylomeDBiQ9BT67.
    TreeFamiTF324911.

    Family and domain databases

    InterProiIPR019325. NEDD4/BSD2.
    [Graphical view]
    PfamiPF10176. DUF2370. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BT67-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA    50
    AYFDYKDESG FPKPPSYNVA TTLPSYDEAE RTKAEATIPL VPGRDEDFVG 100
    RDDFDDADQL RIGNDGIFML TFFMAFLFNW IGFFLSFCLT TSAAGRYGAI 150
    SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL WWVFLVLGFL LFLRGFINYA 200
    KVRKMPETFS NLPRTRVLFI Y 221
    Length:221
    Mass (Da):24,899
    Last modified:June 1, 2001 - v1
    Checksum:i526A579D7B32FCA4
    GO
    Isoform 2 (identifier: Q9BT67-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-153: YDEAERTKAE...AGRYGAISGF → CFYDISHLIF...VGCLKAKQEN
         154-221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:153
    Mass (Da):16,915
    Checksum:iD8A2706965DD8A23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201Q → W in BAC11670. (PubMed:16303743)Curated
    Sequence conflicti104 – 1041F → L in BAC11670. (PubMed:16303743)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei76 – 15378YDEAE…AISGF → CFYDISHLIFFIFYLRNMKK KYTKMVKLLHKSAPAQSDSC KCPFICCVCISRISIGSRSG YQYIMHRSVGCLKAKQEN in isoform 2. 1 PublicationVSP_016474Add
    BLAST
    Alternative sequencei154 – 22168Missing in isoform 2. 1 PublicationVSP_016475Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY192728 mRNA. Translation: AAP13460.1.
    AB097010 mRNA. Translation: BAC77363.1.
    AB097037 mRNA. Translation: BAC77390.1.
    AK075495 mRNA. Translation: BAC11652.1.
    AK075524 mRNA. Translation: BAC11670.1.
    AK315481 mRNA. Translation: BAG37865.1.
    CH471062 Genomic DNA. Translation: EAW61888.1.
    CH471062 Genomic DNA. Translation: EAW61889.1.
    BC004317 mRNA. Translation: AAH04317.1.
    AL832993 mRNA. Translation: CAH56294.1.
    CCDSiCCDS4273.1. [Q9BT67-1]
    RefSeqiNP_085048.1. NM_030571.3. [Q9BT67-1]
    UniGeneiHs.653510.
    Hs.9788.

    Genome annotation databases

    EnsembliENST00000253814; ENSP00000253814; ENSG00000131507. [Q9BT67-1]
    GeneIDi80762.
    KEGGihsa:80762.
    UCSCiuc003lmi.4. human. [Q9BT67-1]

    Polymorphism databases

    DMDMi74733098.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY192728 mRNA. Translation: AAP13460.1 .
    AB097010 mRNA. Translation: BAC77363.1 .
    AB097037 mRNA. Translation: BAC77390.1 .
    AK075495 mRNA. Translation: BAC11652.1 .
    AK075524 mRNA. Translation: BAC11670.1 .
    AK315481 mRNA. Translation: BAG37865.1 .
    CH471062 Genomic DNA. Translation: EAW61888.1 .
    CH471062 Genomic DNA. Translation: EAW61889.1 .
    BC004317 mRNA. Translation: AAH04317.1 .
    AL832993 mRNA. Translation: CAH56294.1 .
    CCDSi CCDS4273.1. [Q9BT67-1 ]
    RefSeqi NP_085048.1. NM_030571.3. [Q9BT67-1 ]
    UniGenei Hs.653510.
    Hs.9788.

    3D structure databases

    ProteinModelPortali Q9BT67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123296. 7 interactions.
    DIPi DIP-48958N.
    STRINGi 9606.ENSP00000253814.

    PTM databases

    PhosphoSitei Q9BT67.

    Polymorphism databases

    DMDMi 74733098.

    Proteomic databases

    MaxQBi Q9BT67.
    PaxDbi Q9BT67.
    PRIDEi Q9BT67.

    Protocols and materials databases

    DNASUi 80762.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253814 ; ENSP00000253814 ; ENSG00000131507 . [Q9BT67-1 ]
    GeneIDi 80762.
    KEGGi hsa:80762.
    UCSCi uc003lmi.4. human. [Q9BT67-1 ]

    Organism-specific databases

    CTDi 80762.
    GeneCardsi GC05P141468.
    HGNCi HGNC:17592. NDFIP1.
    HPAi HPA009682.
    MIMi 612050. gene.
    neXtProti NX_Q9BT67.
    PharmGKBi PA134943402.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311167.
    HOGENOMi HOG000038752.
    HOVERGENi HBG057103.
    InParanoidi Q9BT67.
    OMAi TAYFDYK.
    OrthoDBi EOG7Z69DP.
    PhylomeDBi Q9BT67.
    TreeFami TF324911.

    Miscellaneous databases

    ChiTaRSi NDFIP1. human.
    GenomeRNAii 80762.
    NextBioi 71137.
    PROi Q9BT67.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BT67.
    CleanExi HS_NDFIP1.
    Genevestigatori Q9BT67.

    Family and domain databases

    InterProi IPR019325. NEDD4/BSD2.
    [Graphical view ]
    Pfami PF10176. DUF2370. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Array analysis of subtractive cDNA libraries identifies SGA-1M: a novel breast cancer-associated gene."
      Petroziello J.M., Westendorf L.E., Gordon K.A., Yamane A.K., Cerveny C.G., Wahl A.F., Law C.L.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung fibroblast.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Embryo.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-221 (ISOFORM 1).
      Tissue: Stomach.
    8. "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
      Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., Kumar S.
      J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."
      Foot N.J., Dalton H.E., Shearwin-Whyatt L.M., Dorstyn L., Tan S.S., Yang B., Kumar S.
      Blood 112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SLC11A2 AND WWP2.
    10. "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins."
      Putz U., Howitt J., Lackovic J., Foot N., Kumar S., Silke J., Tan S.S.
      J. Biol. Chem. 283:32621-32627(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."
      Mund T., Pelham H.R.
      EMBO Rep. 10:501-507(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, UBIQUITINATION.
    12. "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."
      Howitt J., Putz U., Lackovic J., Doan A., Dorstyn L., Cheng H., Yang B., Chan-Ling T., Silke J., Kumar S., Tan S.S.
      Proc. Natl. Acad. Sci. U.S.A. 106:15489-15494(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SLC11A2 AND NEDD4L, INDUCTION BY COBALT AND IRON.
    13. "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2."
      Mund T., Pelham H.R.
      Proc. Natl. Acad. Sci. U.S.A. 107:11429-11434(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NDFIP2; NEDD4 AND PTEN, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF 41-PRO-TYR-42; 66-SER-TYR-67 AND 75-SER-TYR-76.
    14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNFIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BT67
    Secondary accession number(s): B2RDB8
    , D3DQF0, Q658T8, Q8N2E3, Q8N2F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3