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Q9BT67

- NFIP1_HUMAN

UniProt

Q9BT67 - NFIP1_HUMAN

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Protein
NEDD4 family-interacting protein 1
Gene
NDFIP1, N4WBP5, PSEC0192, PSEC0223
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.3 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB
  2. negative regulation of T cell proliferation Source: Ensembl
  3. negative regulation of gene expression Source: UniProtKB
  4. negative regulation of inflammatory response Source: Ensembl
  5. negative regulation of interleukin-4 production Source: Ensembl
  6. negative regulation of isotype switching to IgE isotypes Source: Ensembl
  7. negative regulation of protein transport Source: UniProtKB
  8. negative regulation of transporter activity Source: UniProtKB
  9. negative regulation of type 2 immune response Source: Ensembl
  10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  11. positive regulation of protein catabolic process Source: Ensembl
  12. positive regulation of protein ubiquitination Source: UniProtKB
  13. regulation of isotype switching to IgG isotypes Source: Ensembl
  14. regulation of lymphocyte differentiation Source: Ensembl
  15. regulation of myeloid leukocyte differentiation Source: Ensembl
  16. signal transduction Source: GOC
  17. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4 family-interacting protein 1
Alternative name(s):
Breast cancer-associated protein SGA-1M
NEDD4 WW domain-binding protein 5
Putative MAPK-activating protein PM13
Putative NF-kappa-B-activating protein 164
Putative NFKB and MAPK-activating protein
Gene namesi
Name:NDFIP1
Synonyms:N4WBP5
ORF Names:PSEC0192, PSEC0223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17592. NDFIP1.

Subcellular locationi

Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane By similarity. Secreted
Note: Detected in exosomes and secreted via the exosomal pathway.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 116115Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Topological domaini138 – 1436Extracellular Reviewed prediction
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Topological domaini165 – 1728Cytoplasmic Reviewed prediction
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Topological domaini194 – 22128Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. cell cortex Source: Ensembl
  3. endosome membrane Source: UniProtKB-SubCell
  4. extracellular region Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
  6. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi41 – 422PY → AG: Loss of phosphorylation; when associated with 66-S-Y-67 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 66-S-Y-67 and 75-S-Y-76. No effect on PTEN-binding; when associated with 66-S-Y-67 and 75-S-Y-76. 1 Publication
Mutagenesisi66 – 672SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 75-S-Y-76. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 75-S-Y-76. No effect on PTEN-binding; when associated with 41-P-Y-42 and 75-S-Y-76. 1 Publication
Mutagenesisi75 – 762SY → AG: Loss of phosphorylation; when associated with 41-P-Y-42 and 66-S-Y-67. Greatly decreases NEDD4-binding; when associated with 41-P-Y-42 and 66-S-Y-67. No effect on PTEN-binding; when associated with 41-P-Y-42 and 66-S-Y-67. 1 Publication

Organism-specific databases

PharmGKBiPA134943402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 221220NEDD4 family-interacting protein 1
PRO_0000076269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Post-translational modificationi

Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.1 Publication
Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ9BT67.
PaxDbiQ9BT67.
PRIDEiQ9BT67.

PTM databases

PhosphoSiteiQ9BT67.

Expressioni

Tissue specificityi

Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.1 Publication

Inductioni

Increased protein expression in neuronal cells in response to Co2+ or Fe2+ ions.1 Publication

Gene expression databases

BgeeiQ9BT67.
CleanExiHS_NDFIP1.
GenevestigatoriQ9BT67.

Organism-specific databases

HPAiHPA009682.

Interactioni

Subunit structurei

Forms heterodimers with NDFIP2. Interacts with several E3 ubiquitin-protein ligases, including NEDD4, NEDD4L and WWP2. Interacts with ITCH, U2SURP and WWP2 By similarity. The interaction with NEDD4, NEDD4L and ITCH leads to relocalization of these proteins to exosomes and eventually to exosomal secretion. Interacts with SLC11A2/DMT1. Interacts with PTEN. May interact with phosphorylated EGFR.3 Publications

Protein-protein interaction databases

BioGridi123296. 7 interactions.
DIPiDIP-48958N.
STRINGi9606.ENSP00000253814.

Structurei

3D structure databases

ProteinModelPortaliQ9BT67.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 423PY 1
Motifi65 – 673PY 2
Motifi74 – 763PY 3

Domaini

The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311167.
HOGENOMiHOG000038752.
HOVERGENiHBG057103.
InParanoidiQ9BT67.
OMAiTAYFDYK.
OrthoDBiEOG7Z69DP.
PhylomeDBiQ9BT67.
TreeFamiTF324911.

Family and domain databases

InterProiIPR019325. NEDD4/BSD2.
[Graphical view]
PfamiPF10176. DUF2370. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BT67-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA    50
AYFDYKDESG FPKPPSYNVA TTLPSYDEAE RTKAEATIPL VPGRDEDFVG 100
RDDFDDADQL RIGNDGIFML TFFMAFLFNW IGFFLSFCLT TSAAGRYGAI 150
SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL WWVFLVLGFL LFLRGFINYA 200
KVRKMPETFS NLPRTRVLFI Y 221
Length:221
Mass (Da):24,899
Last modified:June 1, 2001 - v1
Checksum:i526A579D7B32FCA4
GO
Isoform 2 (identifier: Q9BT67-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-153: YDEAERTKAE...AGRYGAISGF → CFYDISHLIF...VGCLKAKQEN
     154-221: Missing.

Note: No experimental confirmation available.

Show »
Length:153
Mass (Da):16,915
Checksum:iD8A2706965DD8A23
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 15378YDEAE…AISGF → CFYDISHLIFFIFYLRNMKK KYTKMVKLLHKSAPAQSDSC KCPFICCVCISRISIGSRSG YQYIMHRSVGCLKAKQEN in isoform 2.
VSP_016474Add
BLAST
Alternative sequencei154 – 22168Missing in isoform 2.
VSP_016475Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201Q → W in BAC11670. 1 Publication
Sequence conflicti104 – 1041F → L in BAC11670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY192728 mRNA. Translation: AAP13460.1.
AB097010 mRNA. Translation: BAC77363.1.
AB097037 mRNA. Translation: BAC77390.1.
AK075495 mRNA. Translation: BAC11652.1.
AK075524 mRNA. Translation: BAC11670.1.
AK315481 mRNA. Translation: BAG37865.1.
CH471062 Genomic DNA. Translation: EAW61888.1.
CH471062 Genomic DNA. Translation: EAW61889.1.
BC004317 mRNA. Translation: AAH04317.1.
AL832993 mRNA. Translation: CAH56294.1.
CCDSiCCDS4273.1. [Q9BT67-1]
RefSeqiNP_085048.1. NM_030571.3. [Q9BT67-1]
UniGeneiHs.653510.
Hs.9788.

Genome annotation databases

EnsembliENST00000253814; ENSP00000253814; ENSG00000131507. [Q9BT67-1]
GeneIDi80762.
KEGGihsa:80762.
UCSCiuc003lmi.4. human. [Q9BT67-1]

Polymorphism databases

DMDMi74733098.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY192728 mRNA. Translation: AAP13460.1 .
AB097010 mRNA. Translation: BAC77363.1 .
AB097037 mRNA. Translation: BAC77390.1 .
AK075495 mRNA. Translation: BAC11652.1 .
AK075524 mRNA. Translation: BAC11670.1 .
AK315481 mRNA. Translation: BAG37865.1 .
CH471062 Genomic DNA. Translation: EAW61888.1 .
CH471062 Genomic DNA. Translation: EAW61889.1 .
BC004317 mRNA. Translation: AAH04317.1 .
AL832993 mRNA. Translation: CAH56294.1 .
CCDSi CCDS4273.1. [Q9BT67-1 ]
RefSeqi NP_085048.1. NM_030571.3. [Q9BT67-1 ]
UniGenei Hs.653510.
Hs.9788.

3D structure databases

ProteinModelPortali Q9BT67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123296. 7 interactions.
DIPi DIP-48958N.
STRINGi 9606.ENSP00000253814.

PTM databases

PhosphoSitei Q9BT67.

Polymorphism databases

DMDMi 74733098.

Proteomic databases

MaxQBi Q9BT67.
PaxDbi Q9BT67.
PRIDEi Q9BT67.

Protocols and materials databases

DNASUi 80762.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253814 ; ENSP00000253814 ; ENSG00000131507 . [Q9BT67-1 ]
GeneIDi 80762.
KEGGi hsa:80762.
UCSCi uc003lmi.4. human. [Q9BT67-1 ]

Organism-specific databases

CTDi 80762.
GeneCardsi GC05P141468.
HGNCi HGNC:17592. NDFIP1.
HPAi HPA009682.
MIMi 612050. gene.
neXtProti NX_Q9BT67.
PharmGKBi PA134943402.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311167.
HOGENOMi HOG000038752.
HOVERGENi HBG057103.
InParanoidi Q9BT67.
OMAi TAYFDYK.
OrthoDBi EOG7Z69DP.
PhylomeDBi Q9BT67.
TreeFami TF324911.

Miscellaneous databases

ChiTaRSi NDFIP1. human.
GenomeRNAii 80762.
NextBioi 71137.
PROi Q9BT67.
SOURCEi Search...

Gene expression databases

Bgeei Q9BT67.
CleanExi HS_NDFIP1.
Genevestigatori Q9BT67.

Family and domain databases

InterProi IPR019325. NEDD4/BSD2.
[Graphical view ]
Pfami PF10176. DUF2370. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Array analysis of subtractive cDNA libraries identifies SGA-1M: a novel breast cancer-associated gene."
    Petroziello J.M., Westendorf L.E., Gordon K.A., Yamane A.K., Cerveny C.G., Wahl A.F., Law C.L.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung fibroblast.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-221 (ISOFORM 1).
    Tissue: Stomach.
  8. "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
    Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., Kumar S.
    J. Biol. Chem. 277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."
    Foot N.J., Dalton H.E., Shearwin-Whyatt L.M., Dorstyn L., Tan S.S., Yang B., Kumar S.
    Blood 112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SLC11A2 AND WWP2.
  10. "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins."
    Putz U., Howitt J., Lackovic J., Foot N., Kumar S., Silke J., Tan S.S.
    J. Biol. Chem. 283:32621-32627(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."
    Mund T., Pelham H.R.
    EMBO Rep. 10:501-507(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, UBIQUITINATION.
  12. "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."
    Howitt J., Putz U., Lackovic J., Doan A., Dorstyn L., Cheng H., Yang B., Chan-Ling T., Silke J., Kumar S., Tan S.S.
    Proc. Natl. Acad. Sci. U.S.A. 106:15489-15494(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLC11A2 AND NEDD4L, INDUCTION BY COBALT AND IRON.
  13. "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2."
    Mund T., Pelham H.R.
    Proc. Natl. Acad. Sci. U.S.A. 107:11429-11434(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NDFIP2; NEDD4 AND PTEN, SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF 41-PRO-TYR-42; 66-SER-TYR-67 AND 75-SER-TYR-76.
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNFIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BT67
Secondary accession number(s): B2RDB8
, D3DQF0, Q658T8, Q8N2E3, Q8N2F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi