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Q9BT56 (SPXN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spexin
Alternative name(s):
NPQ
Gene names
Name:C12orf39
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces contraction of stomach muscle. Ref.5

Subcellular location

Secreted. Cytoplasmic vesiclesecretory vesicle Ref.5.

Tissue specificity

Expressed in submucosal layer of esophagus and stomach fundus. Expressed in brain, pancreas and kidney. Ref.1 Ref.5

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
Secreted
   DomainSignal
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

transport vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 359
PRO_0000363216
Peptide36 – 4914Spexin
PRO_0000042159
Propeptide50 – 11667
PRO_0000363217

Amino acid modifications

Modified residue491Glutamine amide Probable

Sequences

Sequence LengthMass (Da)Tools
Q9BT56 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: CCBC3E7BD22E357E

FASTA11613,302
        10         20         30         40         50         60 
MKGLRSLAAT TLALFLVFVF LGNSSCAPQR LLERRNWTPQ AMLYLKGAQG RRFISDQSRR 

        70         80         90        100        110 
KDLSDRPLPE RRSPNPQLLT IPEAATILLA SLQKSPEDEE KNFDQTRFLE DSLLNW 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary sequence modeling for discovery of peptide hormones."
Sonmez K., Zaveri N.T., Kerman I.A., Burke S., Neal C.R., Xie X., Watson S.J., Toll L.
PLoS Comput. Biol. 5:E1000258-E1000258(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"Identification of novel peptide hormones in the human proteome by hidden Markov model screening."
Mirabeau O., Perlas E., Severini C., Audero E., Gascuel O., Possenti R., Birney E., Rosenthal N., Gross C.
Genome Res. 17:320-327(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027273 mRNA. Translation: BAG51298.1.
AK075342 mRNA. Translation: BAG52117.1.
CH471094 Genomic DNA. Translation: EAW96444.1.
BC004336 mRNA. Translation: AAH04336.1.
CCDSCCDS31757.1.
RefSeqNP_085049.1. NM_030572.2.
UniGeneHs.130692.

3D structure databases

ProteinModelPortalQ9BT56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123297. 1 interaction.
STRING9606.ENSP00000256969.

Proteomic databases

PaxDbQ9BT56.
PRIDEQ9BT56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256969; ENSP00000256969; ENSG00000134548.
GeneID80763.
KEGGhsa:80763.
UCSCuc001rfa.1. human.

Organism-specific databases

CTD80763.
GeneCardsGC12P021679.
HGNCHGNC:28139. C12orf39.
HPAHPA012890.
neXtProtNX_Q9BT56.
PharmGKBPA143485369.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75104.
HOGENOMHOG000154403.
HOVERGENHBG095171.
InParanoidQ9BT56.
OMAWSAPQAH.
OrthoDBEOG741Z4Q.
PhylomeDBQ9BT56.
TreeFamTF333402.

Gene expression databases

ArrayExpressQ9BT56.
BgeeQ9BT56.
CleanExHS_C12orf39.
GenevestigatorQ9BT56.

Family and domain databases

InterProIPR028126. Spexin.
[Graphical view]
PfamPF15171. Spexin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80763.
NextBio71141.

Entry information

Entry nameSPXN_HUMAN
AccessionPrimary (citable) accession number: Q9BT56
Secondary accession number(s): B3KND6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM