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Protein

Spexin

Gene

SPX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).By similarity
Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).By similarity2 Publications
Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB
  • type 2 galanin receptor binding Source: UniProtKB
  • type 3 galanin receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Spexin
Alternative name(s):
NPQ
Neuropeptide Q
Spexin hormone
Cleaved into the following 2 chains:
Alternative name(s):
NPQ 53-70
Gene namesi
Name:SPX
Synonyms:C12orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134548.9.
HGNCiHGNC:28139. SPX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80763.
OpenTargetsiENSG00000134548.
PharmGKBiPA143485369.

Polymorphism and mutation databases

BioMutaiC12orf39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000043021327 – 116SpexinAdd BLAST90
PropeptideiPRO_000036321627 – 359
PeptideiPRO_000004215936 – 49Spexin-1Add BLAST14
PropeptideiPRO_000036321750 – 116Add BLAST67
PeptideiPRO_000043021453 – 70Spexin-2Add BLAST18
PropeptideiPRO_000043021574 – 116Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Glutamine amide1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei35 – 36Cleavage; by prohormone convertase 22
Sitei52 – 53Cleavage; by prohormone convertase 22
Sitei72 – 73Cleavage; by prohormone convertase 22

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

EPDiQ9BT56.
PaxDbiQ9BT56.
PeptideAtlasiQ9BT56.
PRIDEiQ9BT56.

Expressioni

Tissue specificityi

Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus.4 Publications

Inductioni

Down-regulated in omental and subcutaneous fat of obese subjects.1 Publication

Gene expression databases

BgeeiENSG00000134548.
CleanExiHS_C12orf39.
ExpressionAtlasiQ9BT56. baseline and differential.
GenevisibleiQ9BT56. HS.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB
  • type 2 galanin receptor binding Source: UniProtKB
  • type 3 galanin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123297. 1 interactor.
STRINGi9606.ENSP00000256969.

Structurei

3D structure databases

ProteinModelPortaliQ9BT56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J03K. Eukaryota.
ENOG410YWQF. LUCA.
GeneTreeiENSGT00390000012501.
HOGENOMiHOG000154403.
HOVERGENiHBG095171.
InParanoidiQ9BT56.
OMAiENFDQTR.
OrthoDBiEOG091G0YRD.
PhylomeDBiQ9BT56.
TreeFamiTF333402.

Family and domain databases

InterProiView protein in InterPro
IPR028126. Spexin.
PfamiView protein in Pfam
PF15171. Spexin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BT56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLRSLAAT TLALFLVFVF LGNSSCAPQR LLERRNWTPQ AMLYLKGAQG
60 70 80 90 100
RRFISDQSRR KDLSDRPLPE RRSPNPQLLT IPEAATILLA SLQKSPEDEE
110
KNFDQTRFLE DSLLNW
Length:116
Mass (Da):13,302
Last modified:June 1, 2001 - v1
Checksum:iCCBC3E7BD22E357E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027273 mRNA. Translation: BAG51298.1.
AK075342 mRNA. Translation: BAG52117.1.
CH471094 Genomic DNA. Translation: EAW96444.1.
BC004336 mRNA. Translation: AAH04336.1.
CCDSiCCDS31757.1.
RefSeqiNP_085049.1. NM_030572.3.
UniGeneiHs.130692.

Genome annotation databases

EnsembliENST00000256969; ENSP00000256969; ENSG00000134548.
GeneIDi80763.
KEGGihsa:80763.
UCSCiuc001rfa.2. human.

Similar proteinsi

Entry informationi

Entry nameiSPXN_HUMAN
AccessioniPrimary (citable) accession number: Q9BT56
Secondary accession number(s): B3KND6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM