Q9BT56 (SPXN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spexin

Alternative name(s):
NPQ

Gene names

Name:

C12orf39

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces contraction of stomach muscle. Ref.5
Subcellular location	Secreted. Cytoplasmic vesicle › secretory vesicle Ref.5.
Tissue specificity	Expressed in submucosal layer of esophagus and stomach fundus. Expressed in brain, pancreas and kidney. Ref.1 Ref.5

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Domain	Signal
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA transport vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Propeptide	27 – 35	9			PRO_0000363216
	Peptide	36 – 49	14	Spexin		PRO_0000042159
	Propeptide	50 – 116	67			PRO_0000363217
Amino acid modifications
	Modified residue	49	1	Glutamine amide Probable

Sequences

	Sequence		Length	Mass (Da)
	Q9BT56 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CCBC3E7BD22E357E	FASTA	116	13,302
	10 20 30 40 50 60 MKGLRSLAAT TLALFLVFVF LGNSSCAPQR LLERRNWTPQ AMLYLKGAQG RRFISDQSRR 70 80 90 100 110 KDLSDRPLPE RRSPNPQLLT IPEAATILLA SLQKSPEDEE KNFDQTRFLE DSLLNW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary sequence modeling for discovery of peptide hormones." Sonmez K., Zaveri N.T., Kerman I.A., Burke S., Neal C.R., Xie X., Watson S.J., Toll L. PLoS Comput. Biol. 5:E1000258-E1000258(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"Identification of novel peptide hormones in the human proteome by hidden Markov model screening." Mirabeau O., Perlas E., Severini C., Audero E., Gascuel O., Possenti R., Birney E., Rosenthal N., Gross C. Genome Res. 17:320-327(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027273 mRNA. Translation: BAG51298.1. AK075342 mRNA. Translation: BAG52117.1. CH471094 Genomic DNA. Translation: EAW96444.1. BC004336 mRNA. Translation: AAH04336.1.
IPI	IPI00012236.
RefSeq	NP_085049.1. NM_030572.2.
UniGene	Hs.130692.
3D structure databases
ProteinModelPortal	Q9BT56.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000256969.
Proteomic databases
PaxDb	Q9BT56.
PRIDE	Q9BT56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256969; ENSP00000256969; ENSG00000134548.
GeneID	80763.
KEGG	hsa:80763.
UCSC	uc001rfa.1. human.
Organism-specific databases
CTD	80763.
GeneCards	GC12P021679.
HGNC	HGNC:28139. C12orf39.
HPA	HPA012890.
neXtProt	NX_Q9BT56.
PharmGKB	PA143485369.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG75104.
HOGENOM	HOG000154403.
HOVERGEN	HBG095171.
InParanoid	Q9BT56.
OMA	ENFDQTR.
OrthoDB	EOG4MW87P.
PhylomeDB	Q9BT56.
Gene expression databases
ArrayExpress	Q9BT56.
Bgee	Q9BT56.
CleanEx	HS_C12orf39.
Genevestigator	Q9BT56.
GermOnline	ENSG00000134548. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	80763.
NextBio	71141.

Entry information

Entry name

SPXN_HUMAN

Accession

Primary (citable) accession number: Q9BT56
Secondary accession number(s): B3KND6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.