Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

THAP domain-containing protein 7

Gene

THAP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 7
Gene namesi
Name:THAP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:23190. THAP7.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184436.
PharmGKBiPA134964580.

Polymorphism and mutation databases

BioMutaiTHAP7.
DMDMi296452927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686481 – 309THAP domain-containing protein 7Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BT49.
PaxDbiQ9BT49.
PeptideAtlasiQ9BT49.
PRIDEiQ9BT49.

PTM databases

iPTMnetiQ9BT49.
PhosphoSitePlusiQ9BT49.

Expressioni

Gene expression databases

BgeeiENSG00000184436.
CleanExiHS_THAP7.
GenevisibleiQ9BT49. HS.

Organism-specific databases

HPAiHPA003083.

Interactioni

Subunit structurei

Interacts with HDAC3 and nuclear hormone receptor corepressors.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-741350,EBI-741350
CCNDBP1O952733EBI-741350,EBI-748961
GOLGA2Q083793EBI-741350,EBI-618309
KRT31Q153235EBI-741350,EBI-948001
KRT40Q6A1623EBI-741350,EBI-10171697
KRTAP10-8P604105EBI-741350,EBI-10171774
LNX1Q8TBB13EBI-741350,EBI-739832
LZTS2Q9BRK45EBI-741350,EBI-741037
MID2Q9UJV3-25EBI-741350,EBI-10172526
MTUS2Q5JR593EBI-741350,EBI-742948
NOTCH2NLQ7Z3S95EBI-741350,EBI-945833
PHC2Q8IXK03EBI-741350,EBI-713786
PIN1Q135263EBI-741350,EBI-714158
SETQ011056EBI-741350,EBI-1053182
TFIP11Q9UBB95EBI-741350,EBI-1105213
TRAF1Q130775EBI-741350,EBI-359224
TRAF2Q129336EBI-741350,EBI-355744

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123298. 62 interactors.
IntActiQ9BT49. 42 interactors.
MINTiMINT-1463983.
STRINGi9606.ENSP00000215742.

Structurei

3D structure databases

ProteinModelPortaliQ9BT49.
SMRiQ9BT49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi229 – 232HCFC1-binding motif (HBM)By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 142Poly-Pro4

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVKX. Eukaryota.
ENOG410YA1P. LUCA.
GeneTreeiENSGT00730000111394.
HOGENOMiHOG000264238.
HOVERGENiHBG056757.
InParanoidiQ9BT49.
OMAiYPPGPPD.
OrthoDBiEOG091G0FJ7.
PhylomeDBiQ9BT49.
TreeFamiTF335838.

Family and domain databases

InterProiIPR026519. THAP7.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF14. PTHR23080:SF14. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG
60 70 80 90 100
QGLWDPASEY IYFCSKHFEE DCFELVGISG YHRLKEGAVP TIFESFSKLR
110 120 130 140 150
RTTKTKGHSY PPGPAEVSRL RRCRKRCSEG RGPTTPFSPP PPADVTCFPV
160 170 180 190 200
EEASAPATLP ASPAGRLEPG LSSPFSDLLG PLGAQADEAG CSAQPSPERQ
210 220 230 240 250
PSPLEPRPVS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW KRRAEAALDA
260 270 280 290 300
LDKAQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKEHVQDF

AMQLSSSMA
Length:309
Mass (Da):34,414
Last modified:May 18, 2010 - v2
Checksum:i7B58685CA759D424
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060277115A → P.3 PublicationsCorresponds to variant rs426938dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456343 mRNA. Translation: CAG30229.1.
AK315457 mRNA. Translation: BAG37844.1.
AC002472 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02919.1.
CH471176 Genomic DNA. Translation: EAX02921.1.
BC004346 mRNA. Translation: AAH04346.1.
CCDSiCCDS13787.1.
RefSeqiNP_001008695.1. NM_001008695.1.
NP_085050.2. NM_030573.2.
UniGeneiHs.512756.

Genome annotation databases

EnsembliENST00000215742; ENSP00000215742; ENSG00000184436.
ENST00000399133; ENSP00000382084; ENSG00000184436.
GeneIDi80764.
KEGGihsa:80764.
UCSCiuc002ztr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456343 mRNA. Translation: CAG30229.1.
AK315457 mRNA. Translation: BAG37844.1.
AC002472 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02919.1.
CH471176 Genomic DNA. Translation: EAX02921.1.
BC004346 mRNA. Translation: AAH04346.1.
CCDSiCCDS13787.1.
RefSeqiNP_001008695.1. NM_001008695.1.
NP_085050.2. NM_030573.2.
UniGeneiHs.512756.

3D structure databases

ProteinModelPortaliQ9BT49.
SMRiQ9BT49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123298. 62 interactors.
IntActiQ9BT49. 42 interactors.
MINTiMINT-1463983.
STRINGi9606.ENSP00000215742.

PTM databases

iPTMnetiQ9BT49.
PhosphoSitePlusiQ9BT49.

Polymorphism and mutation databases

BioMutaiTHAP7.
DMDMi296452927.

Proteomic databases

MaxQBiQ9BT49.
PaxDbiQ9BT49.
PeptideAtlasiQ9BT49.
PRIDEiQ9BT49.

Protocols and materials databases

DNASUi80764.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215742; ENSP00000215742; ENSG00000184436.
ENST00000399133; ENSP00000382084; ENSG00000184436.
GeneIDi80764.
KEGGihsa:80764.
UCSCiuc002ztr.2. human.

Organism-specific databases

CTDi80764.
GeneCardsiTHAP7.
H-InvDBHIX0016267.
HGNCiHGNC:23190. THAP7.
HPAiHPA003083.
MIMi609518. gene.
neXtProtiNX_Q9BT49.
OpenTargetsiENSG00000184436.
PharmGKBiPA134964580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVKX. Eukaryota.
ENOG410YA1P. LUCA.
GeneTreeiENSGT00730000111394.
HOGENOMiHOG000264238.
HOVERGENiHBG056757.
InParanoidiQ9BT49.
OMAiYPPGPPD.
OrthoDBiEOG091G0FJ7.
PhylomeDBiQ9BT49.
TreeFamiTF335838.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161149-MONOMER.

Miscellaneous databases

ChiTaRSiTHAP7. human.
GeneWikiiTHAP7.
GenomeRNAii80764.
PROiQ9BT49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184436.
CleanExiHS_THAP7.
GenevisibleiQ9BT49. HS.

Family and domain databases

InterProiIPR026519. THAP7.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF14. PTHR23080:SF14. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP7_HUMAN
AccessioniPrimary (citable) accession number: Q9BT49
Secondary accession number(s): B2RD97, D3DX40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.