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Protein

DNA-directed RNA polymerase III subunit RPC7-like

Gene

POLR3GL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS13028-MONOMER.
ReactomeiR-HSA-1834949. Cytosolic sensors of pathogen-associated DNA.
R-HSA-73780. RNA Polymerase III Chain Elongation.
R-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC7-like
Short name:
RNA polymerase III subunit C7-like
Alternative name(s):
DNA-directed RNA polymerase III subunit G-like
Gene namesi
Name:POLR3GL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28466. POLR3GL.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • DNA-directed RNA polymerase III complex Source: MGI
  • nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121851.
PharmGKBiPA134921690.

Polymorphism and mutation databases

BioMutaiPOLR3GL.
DMDMi74733087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003115901 – 218DNA-directed RNA polymerase III subunit RPC7-likeAdd BLAST218

Proteomic databases

EPDiQ9BT43.
MaxQBiQ9BT43.
PaxDbiQ9BT43.
PeptideAtlasiQ9BT43.
PRIDEiQ9BT43.

PTM databases

iPTMnetiQ9BT43.
PhosphoSitePlusiQ9BT43.

Expressioni

Gene expression databases

BgeeiENSG00000121851.
CleanExiHS_POLR3GL.
ExpressionAtlasiQ9BT43. baseline and differential.
GenevisibleiQ9BT43. HS.

Organism-specific databases

HPAiHPA027288.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCND3P302813EBI-2855862,EBI-375013
M1APQ8TC574EBI-2855862,EBI-748182
POLR3CQ9BUI44EBI-2855862,EBI-5452779
TFCP2Q128003EBI-2855862,EBI-717422

Protein-protein interaction databases

BioGridi123992. 17 interactors.
DIPiDIP-59080N.
IntActiQ9BT43. 13 interactors.
STRINGi9606.ENSP00000358320.

Structurei

3D structure databases

ProteinModelPortaliQ9BT43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 191Glu-richAdd BLAST50

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVW2. Eukaryota.
ENOG4112311. LUCA.
GeneTreeiENSGT00390000002422.
HOGENOMiHOG000293249.
HOVERGENiHBG054922.
InParanoidiQ9BT43.
KOiK03024.
OMAiDSAIDWN.
OrthoDBiEOG091G0TN0.
PhylomeDBiQ9BT43.
TreeFamiTF103052.

Family and domain databases

InterProiIPR024661. RNA_pol_III_Rpc31.
[Graphical view]
PANTHERiPTHR15367. PTHR15367. 1 hit.
PfamiPF11705. RNA_pol_3_Rpc31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRGGGRGR GRGQLTFNVE AVGIGKGDAL PPPTLQPSPL FPPLEFRPVP
60 70 80 90 100
LPSGEEGEYV LALKQELRGA MRQLPYFIRP AVPKRDVERY SDKYQMSGPI
110 120 130 140 150
DNAIDWNPDW RRLPRELKIR VRKLQKERIT ILLPKRPPKT TEDKEETIQK
160 170 180 190 200
LETLEKKEEE VTSEEDEEKE EEEEKEEEEE EEYDEEEHEE ETDYIMSYFD
210
NGEDFGGDSD DNMDEAIY
Length:218
Mass (Da):25,334
Last modified:June 1, 2001 - v1
Checksum:i01E3B35D7279E43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ418461 mRNA. Translation: ABD76394.1.
AK056984 mRNA. Translation: BAB71332.1.
BC004355 mRNA. Translation: AAH04355.1.
CCDSiCCDS72875.1.
RefSeqiNP_001317614.1. NM_001330685.1.
NP_115681.1. NM_032305.2.
XP_005277488.1. XM_005277431.4.
UniGeneiHs.591456.

Genome annotation databases

EnsembliENST00000369314; ENSP00000358320; ENSG00000121851.
GeneIDi84265.
KEGGihsa:84265.
UCSCiuc001enp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ418461 mRNA. Translation: ABD76394.1.
AK056984 mRNA. Translation: BAB71332.1.
BC004355 mRNA. Translation: AAH04355.1.
CCDSiCCDS72875.1.
RefSeqiNP_001317614.1. NM_001330685.1.
NP_115681.1. NM_032305.2.
XP_005277488.1. XM_005277431.4.
UniGeneiHs.591456.

3D structure databases

ProteinModelPortaliQ9BT43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123992. 17 interactors.
DIPiDIP-59080N.
IntActiQ9BT43. 13 interactors.
STRINGi9606.ENSP00000358320.

PTM databases

iPTMnetiQ9BT43.
PhosphoSitePlusiQ9BT43.

Polymorphism and mutation databases

BioMutaiPOLR3GL.
DMDMi74733087.

Proteomic databases

EPDiQ9BT43.
MaxQBiQ9BT43.
PaxDbiQ9BT43.
PeptideAtlasiQ9BT43.
PRIDEiQ9BT43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369314; ENSP00000358320; ENSG00000121851.
GeneIDi84265.
KEGGihsa:84265.
UCSCiuc001enp.1. human.

Organism-specific databases

CTDi84265.
GeneCardsiPOLR3GL.
HGNCiHGNC:28466. POLR3GL.
HPAiHPA027288.
neXtProtiNX_Q9BT43.
OpenTargetsiENSG00000121851.
PharmGKBiPA134921690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVW2. Eukaryota.
ENOG4112311. LUCA.
GeneTreeiENSGT00390000002422.
HOGENOMiHOG000293249.
HOVERGENiHBG054922.
InParanoidiQ9BT43.
KOiK03024.
OMAiDSAIDWN.
OrthoDBiEOG091G0TN0.
PhylomeDBiQ9BT43.
TreeFamiTF103052.

Enzyme and pathway databases

BioCyciZFISH:HS13028-MONOMER.
ReactomeiR-HSA-1834949. Cytosolic sensors of pathogen-associated DNA.
R-HSA-73780. RNA Polymerase III Chain Elongation.
R-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

GenomeRNAii84265.
PROiQ9BT43.

Gene expression databases

BgeeiENSG00000121851.
CleanExiHS_POLR3GL.
ExpressionAtlasiQ9BT43. baseline and differential.
GenevisibleiQ9BT43. HS.

Family and domain databases

InterProiIPR024661. RNA_pol_III_Rpc31.
[Graphical view]
PANTHERiPTHR15367. PTHR15367. 1 hit.
PfamiPF11705. RNA_pol_3_Rpc31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPC7L_HUMAN
AccessioniPrimary (citable) accession number: Q9BT43
Secondary accession number(s): B1MVG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.