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Protein

DNA-directed RNA polymerase III subunit RPC7-like

Gene

POLR3GL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1834949. Cytosolic sensors of pathogen-associated DNA.
R-HSA-73780. RNA Polymerase III Chain Elongation.
R-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC7-like
Short name:
RNA polymerase III subunit C7-like
Alternative name(s):
DNA-directed RNA polymerase III subunit G-like
RNA polymerase III 32 kDa beta subunit
Short name:
RPC32-beta1 Publication
Gene namesi
Name:POLR3GL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121851.12.
HGNCiHGNC:28466. POLR3GL.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921690.

Polymorphism and mutation databases

BioMutaiPOLR3GL.
DMDMi74733087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003115901 – 218DNA-directed RNA polymerase III subunit RPC7-likeAdd BLAST218

Proteomic databases

EPDiQ9BT43.
MaxQBiQ9BT43.
PaxDbiQ9BT43.
PeptideAtlasiQ9BT43.
PRIDEiQ9BT43.

PTM databases

iPTMnetiQ9BT43.
PhosphoSitePlusiQ9BT43.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Up-regulated in embryonic stem cells upon retinoic acid-induced differentiation into embroid bodies (at protein level) (PubMed:28494942). No significant changes in mRNA levels between dividing and non-dividing cells, although levels tends to be slightly higher in non-dividing cells (PubMed:20154270, PubMed:24107381).3 Publications

Gene expression databases

BgeeiENSG00000121851.
CleanExiHS_POLR3GL.
ExpressionAtlasiQ9BT43. baseline and differential.
GenevisibleiQ9BT43. HS.

Organism-specific databases

HPAiHPA027288.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Found a trimeric complex with POLR3C and POLR3G (PubMed:24107381). Directly interacts with POLR3C (PubMed:21358628, PubMed:24107381, PubMed:26394183).By similarity3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123992. 17 interactors.
DIPiDIP-59080N.
IntActiQ9BT43. 16 interactors.
STRINGi9606.ENSP00000358320.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AFQX-ray7.00D/E50-134[»]
ProteinModelPortaliQ9BT43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 191Glu-richAdd BLAST50

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVW2. Eukaryota.
ENOG4112311. LUCA.
GeneTreeiENSGT00390000002422.
HOGENOMiHOG000293249.
HOVERGENiHBG054922.
InParanoidiQ9BT43.
KOiK03024.
OMAiPRYSDKY.
OrthoDBiEOG091G0TN0.
PhylomeDBiQ9BT43.
TreeFamiTF103052.

Family and domain databases

InterProiView protein in InterPro
IPR024661. RNA_pol_III_Rpc31.
PANTHERiPTHR15367. PTHR15367. 1 hit.
PfamiView protein in Pfam
PF11705. RNA_pol_3_Rpc31. 1 hit.
PIRSFiPIRSF000777. RNA_polIII_C31. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BT43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRGGGRGR GRGQLTFNVE AVGIGKGDAL PPPTLQPSPL FPPLEFRPVP
60 70 80 90 100
LPSGEEGEYV LALKQELRGA MRQLPYFIRP AVPKRDVERY SDKYQMSGPI
110 120 130 140 150
DNAIDWNPDW RRLPRELKIR VRKLQKERIT ILLPKRPPKT TEDKEETIQK
160 170 180 190 200
LETLEKKEEE VTSEEDEEKE EEEEKEEEEE EEYDEEEHEE ETDYIMSYFD
210
NGEDFGGDSD DNMDEAIY
Length:218
Mass (Da):25,334
Last modified:June 1, 2001 - v1
Checksum:i01E3B35D7279E43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ418461 mRNA. Translation: ABD76394.1.
AK056984 mRNA. Translation: BAB71332.1.
BC004355 mRNA. Translation: AAH04355.1.
CCDSiCCDS72875.1.
RefSeqiNP_001317614.1. NM_001330685.1.
NP_115681.1. NM_032305.2.
XP_005277488.1. XM_005277431.4.
UniGeneiHs.591456.

Genome annotation databases

EnsembliENST00000369314; ENSP00000358320; ENSG00000121851.
GeneIDi84265.
KEGGihsa:84265.
UCSCiuc001enp.1. human.

Similar proteinsi

Entry informationi

Entry nameiRPC7L_HUMAN
AccessioniPrimary (citable) accession number: Q9BT43
Secondary accession number(s): B1MVG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families