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Protein

Inositol polyphosphate 5-phosphatase K

Gene

INPP5K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.1 Publication

Catalytic activityi

D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS05626-MONOMER.
ZFISH:ENSG00000100603-MONOMER.
ZFISH:HS05626-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Chemistry databases

SwissLipidsiSLP:000000957.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 5-phosphatase K (EC:3.1.3.56)
Alternative name(s):
Skeletal muscle and kidney-enriched inositol phosphatase
Gene namesi
Name:INPP5K
Synonyms:PPS, SKIP
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33882. INPP5K.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • membrane Source: UniProtKB
  • neuron projection Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • ruffle Source: MGI
  • ruffle membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi349Y → A or F: No effect on EGF-induced ruffle localization. 1 Publication1
Mutagenesisi361D → A: Significant decrease in EGF-induced ruffle localization. 1 Publication1
Mutagenesisi362W → A: Significant decrease in EGF-induced ruffle localization. 1 Publication1
Mutagenesisi376Y → A or F: No effect on EGF-induced ruffle localization. 1 Publication1

Organism-specific databases

DisGeNETi51763.
OpenTargetsiENSG00000132376.
PharmGKBiPA164720951.

Polymorphism and mutation databases

BioMutaiINPP5K.
DMDMi116242791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097271 – 448Inositol polyphosphate 5-phosphatase KAdd BLAST448

Proteomic databases

EPDiQ9BT40.
MaxQBiQ9BT40.
PaxDbiQ9BT40.
PeptideAtlasiQ9BT40.
PRIDEiQ9BT40.

PTM databases

DEPODiQ9BT40.
iPTMnetiQ9BT40.
PhosphoSitePlusiQ9BT40.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.1 Publication

Gene expression databases

BgeeiENSG00000132376.
CleanExiHS_INPP5K.
ExpressionAtlasiQ9BT40. baseline and differential.
GenevisibleiQ9BT40. HS.

Organism-specific databases

HPAiHPA031044.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-749162,EBI-714543
FATE1Q969F05EBI-749162,EBI-743099
KRT31Q153235EBI-749162,EBI-948001
LNX1Q8TBB13EBI-749162,EBI-739832
MAD2L1BPQ150135EBI-749162,EBI-712181

Protein-protein interaction databases

BioGridi119720. 32 interactors.
IntActiQ9BT40. 18 interactors.
MINTiMINT-1445023.
STRINGi9606.ENSP00000413937.

Structurei

3D structure databases

ProteinModelPortaliQ9BT40.
SMRiQ9BT40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 318CatalyticSequence analysisAdd BLAST303
Regioni321 – 448Required for ruffle localizationAdd BLAST128

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000046051.
HOVERGENiHBG082135.
InParanoidiQ9BT40.
KOiK01106.
OMAiYYSNNLH.
OrthoDBiEOG091G055L.
PhylomeDBiQ9BT40.
TreeFamiTF317034.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9BT40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNLDIYVI
60 70 80 90 100
GLQELNSGII SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV
110 120 130 140 150
FAKYQHLPYI QILSTKSTPT GLFGYWGNKG GVNICLKLYG YYVSIINCHL
160 170 180 190 200
PPHISNNYQR LEHFDRILEM QNCEGRDIPN ILDHDLIIWF GDMNFRIEDF
210 220 230 240 250
GLHFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR LLFPPTYKFD
260 270 280 290 300
RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY
310 320 330 340 350
SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS
360 370 380 390 400
STSDFPSSPW DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI
410 420 430 440
SNIPTTEDEF LLCYYSNSLR SVVGISRPFQ IPPGSLREDP LGEAQPQI
Length:448
Mass (Da):51,090
Last modified:October 17, 2006 - v3
Checksum:i46FAA48C6E2EEAD4
GO
Isoform 21 Publication (identifier: Q9BT40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:372
Mass (Da):42,784
Checksum:iE257B4890DCD44F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120T → A in AAB03214 (Ref. 5) Curated1
Sequence conflicti416S → R in BAA92340 (PubMed:10753883).Curated1
Sequence conflicti416S → R in BAA92341 (PubMed:10753883).Curated1
Sequence conflicti416S → R in BAA92342 (PubMed:10753883).Curated1
Sequence conflicti416S → R in AAB03214 (Ref. 5) Curated1
Sequence conflicti426S → R in BAA92340 (PubMed:10753883).Curated1
Sequence conflicti426S → R in BAA92341 (PubMed:10753883).Curated1
Sequence conflicti426S → R in BAA92342 (PubMed:10753883).Curated1
Sequence conflicti426S → R in AAB03214 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036497315S → F in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0506121 – 76Missing in isoform 2. 2 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036829 mRNA. Translation: BAA92340.1.
AB036830 mRNA. Translation: BAA92341.1.
AB036831 Genomic DNA. Translation: BAA92342.1.
AK312585 mRNA. Translation: BAG35479.1.
AK312844 mRNA. Translation: BAG35697.1.
CH471108 Genomic DNA. Translation: EAW90614.1.
CH471108 Genomic DNA. Translation: EAW90615.1.
CH471108 Genomic DNA. Translation: EAW90618.1.
BC004362 mRNA. Translation: AAH04362.1.
U45973 mRNA. Translation: AAB03214.1.
CCDSiCCDS11004.1. [Q9BT40-1]
CCDS11005.1. [Q9BT40-2]
RefSeqiNP_001129114.1. NM_001135642.1. [Q9BT40-2]
NP_057616.2. NM_016532.3. [Q9BT40-1]
NP_570122.1. NM_130766.2. [Q9BT40-2]
XP_005256740.1. XM_005256683.2. [Q9BT40-2]
XP_011522236.1. XM_011523934.1. [Q9BT40-2]
XP_016880244.1. XM_017024755.1. [Q9BT40-2]
XP_016880245.1. XM_017024756.1. [Q9BT40-2]
UniGeneiHs.632238.

Genome annotation databases

EnsembliENST00000320345; ENSP00000318476; ENSG00000132376. [Q9BT40-2]
ENST00000406424; ENSP00000385177; ENSG00000132376. [Q9BT40-2]
ENST00000421807; ENSP00000413937; ENSG00000132376. [Q9BT40-1]
GeneIDi51763.
KEGGihsa:51763.
UCSCiuc002fsr.4. human. [Q9BT40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036829 mRNA. Translation: BAA92340.1.
AB036830 mRNA. Translation: BAA92341.1.
AB036831 Genomic DNA. Translation: BAA92342.1.
AK312585 mRNA. Translation: BAG35479.1.
AK312844 mRNA. Translation: BAG35697.1.
CH471108 Genomic DNA. Translation: EAW90614.1.
CH471108 Genomic DNA. Translation: EAW90615.1.
CH471108 Genomic DNA. Translation: EAW90618.1.
BC004362 mRNA. Translation: AAH04362.1.
U45973 mRNA. Translation: AAB03214.1.
CCDSiCCDS11004.1. [Q9BT40-1]
CCDS11005.1. [Q9BT40-2]
RefSeqiNP_001129114.1. NM_001135642.1. [Q9BT40-2]
NP_057616.2. NM_016532.3. [Q9BT40-1]
NP_570122.1. NM_130766.2. [Q9BT40-2]
XP_005256740.1. XM_005256683.2. [Q9BT40-2]
XP_011522236.1. XM_011523934.1. [Q9BT40-2]
XP_016880244.1. XM_017024755.1. [Q9BT40-2]
XP_016880245.1. XM_017024756.1. [Q9BT40-2]
UniGeneiHs.632238.

3D structure databases

ProteinModelPortaliQ9BT40.
SMRiQ9BT40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119720. 32 interactors.
IntActiQ9BT40. 18 interactors.
MINTiMINT-1445023.
STRINGi9606.ENSP00000413937.

Chemistry databases

SwissLipidsiSLP:000000957.

PTM databases

DEPODiQ9BT40.
iPTMnetiQ9BT40.
PhosphoSitePlusiQ9BT40.

Polymorphism and mutation databases

BioMutaiINPP5K.
DMDMi116242791.

Proteomic databases

EPDiQ9BT40.
MaxQBiQ9BT40.
PaxDbiQ9BT40.
PeptideAtlasiQ9BT40.
PRIDEiQ9BT40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320345; ENSP00000318476; ENSG00000132376. [Q9BT40-2]
ENST00000406424; ENSP00000385177; ENSG00000132376. [Q9BT40-2]
ENST00000421807; ENSP00000413937; ENSG00000132376. [Q9BT40-1]
GeneIDi51763.
KEGGihsa:51763.
UCSCiuc002fsr.4. human. [Q9BT40-1]

Organism-specific databases

CTDi51763.
DisGeNETi51763.
GeneCardsiINPP5K.
HGNCiHGNC:33882. INPP5K.
HPAiHPA031044.
MIMi607875. gene.
neXtProtiNX_Q9BT40.
OpenTargetsiENSG00000132376.
PharmGKBiPA164720951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000046051.
HOVERGENiHBG082135.
InParanoidiQ9BT40.
KOiK01106.
OMAiYYSNNLH.
OrthoDBiEOG091G055L.
PhylomeDBiQ9BT40.
TreeFamiTF317034.

Enzyme and pathway databases

BioCyciMetaCyc:HS05626-MONOMER.
ZFISH:ENSG00000100603-MONOMER.
ZFISH:HS05626-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

ChiTaRSiINPP5K. human.
GeneWikiiSKIP.
GenomeRNAii51763.
PROiQ9BT40.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132376.
CleanExiHS_INPP5K.
ExpressionAtlasiQ9BT40. baseline and differential.
GenevisibleiQ9BT40. HS.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINP5K_HUMAN
AccessioniPrimary (citable) accession number: Q9BT40
Secondary accession number(s): B2R6I2
, B2R750, D3DTH8, Q15733, Q9NPJ5, Q9P2R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.