Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM domain-containing protein 2

Gene

LIMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein 2
Gene namesi
Name:LIMD2
ORF Names:SB143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28142. LIMD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485528.

Polymorphism and mutation databases

BioMutaiLIMD2.
DMDMi74752322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127LIM domain-containing protein 2PRO_0000251207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BT23.
MaxQBiQ9BT23.
PaxDbiQ9BT23.
PeptideAtlasiQ9BT23.
PRIDEiQ9BT23.

PTM databases

iPTMnetiQ9BT23.
PhosphoSiteiQ9BT23.

Expressioni

Gene expression databases

BgeeiENSG00000136490.
CleanExiHS_LIMD2.
ExpressionAtlasiQ9BT23. baseline and differential.
GenevisibleiQ9BT23. HS.

Organism-specific databases

HPAiHPA062867.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA6P609003EBI-2805292,EBI-357793

Protein-protein interaction databases

BioGridi123306. 1 interaction.
IntActiQ9BT23. 2 interactions.
STRINGi9606.ENSP00000259006.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 433Combined sources
Beta strandi45 – 473Combined sources
Turni49 – 513Combined sources
Beta strandi52 – 554Combined sources
Beta strandi58 – 614Combined sources
Turni62 – 643Combined sources
Beta strandi68 – 703Combined sources
Turni75 – 773Combined sources
Helixi89 – 946Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LZUNMR-A33-104[»]
ProteinModelPortaliQ9BT23.
SMRiQ9BT23. Positions 33-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 9861LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI3. Eukaryota.
ENOG4111S7F. LUCA.
GeneTreeiENSGT00510000046839.
HOGENOMiHOG000111235.
HOVERGENiHBG056520.
InParanoidiQ9BT23.
OMAiQATPSHE.
OrthoDBiEOG091G0043.
PhylomeDBiQ9BT23.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BT23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQAAGAAQA TPSHDAKGGG SSTVQRSKSF SLRAQVKETC AACQKTVYPM
60 70 80 90 100
ERLVADKLIF HNSCFCCKHC HTKLSLGSYA ALHGEFYCKP HFQQLFKSKG
110 120
NYDEGFGRKQ HKELWAHKEV DPGTKTA
Length:127
Mass (Da):14,070
Last modified:June 1, 2001 - v1
Checksum:iB63174FCF0486956
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → E in AAK67634 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092301 mRNA. Translation: BAC03855.1.
AY037154 mRNA. Translation: AAK67634.1.
CH471109 Genomic DNA. Translation: EAW94291.1.
CH471109 Genomic DNA. Translation: EAW94292.1.
CH471109 Genomic DNA. Translation: EAW94294.1.
CH471109 Genomic DNA. Translation: EAW94295.1.
CH471109 Genomic DNA. Translation: EAW94296.1.
BC004400 mRNA. Translation: AAH04400.1.
BC051812 mRNA. Translation: AAH51812.1.
CCDSiCCDS11641.1.
RefSeqiNP_085053.1. NM_030576.3.
XP_005257760.1. XM_005257703.1.
XP_005257762.1. XM_005257705.3.
XP_006722187.1. XM_006722124.1.
UniGeneiHs.591166.

Genome annotation databases

EnsembliENST00000259006; ENSP00000259006; ENSG00000136490.
ENST00000578061; ENSP00000464003; ENSG00000136490.
ENST00000578402; ENSP00000462707; ENSG00000136490.
GeneIDi80774.
KEGGihsa:80774.
UCSCiuc002jbj.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092301 mRNA. Translation: BAC03855.1.
AY037154 mRNA. Translation: AAK67634.1.
CH471109 Genomic DNA. Translation: EAW94291.1.
CH471109 Genomic DNA. Translation: EAW94292.1.
CH471109 Genomic DNA. Translation: EAW94294.1.
CH471109 Genomic DNA. Translation: EAW94295.1.
CH471109 Genomic DNA. Translation: EAW94296.1.
BC004400 mRNA. Translation: AAH04400.1.
BC051812 mRNA. Translation: AAH51812.1.
CCDSiCCDS11641.1.
RefSeqiNP_085053.1. NM_030576.3.
XP_005257760.1. XM_005257703.1.
XP_005257762.1. XM_005257705.3.
XP_006722187.1. XM_006722124.1.
UniGeneiHs.591166.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LZUNMR-A33-104[»]
ProteinModelPortaliQ9BT23.
SMRiQ9BT23. Positions 33-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123306. 1 interaction.
IntActiQ9BT23. 2 interactions.
STRINGi9606.ENSP00000259006.

PTM databases

iPTMnetiQ9BT23.
PhosphoSiteiQ9BT23.

Polymorphism and mutation databases

BioMutaiLIMD2.
DMDMi74752322.

Proteomic databases

EPDiQ9BT23.
MaxQBiQ9BT23.
PaxDbiQ9BT23.
PeptideAtlasiQ9BT23.
PRIDEiQ9BT23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259006; ENSP00000259006; ENSG00000136490.
ENST00000578061; ENSP00000464003; ENSG00000136490.
ENST00000578402; ENSP00000462707; ENSG00000136490.
GeneIDi80774.
KEGGihsa:80774.
UCSCiuc002jbj.5. human.

Organism-specific databases

CTDi80774.
GeneCardsiLIMD2.
H-InvDBHIX0039522.
HGNCiHGNC:28142. LIMD2.
HPAiHPA062867.
neXtProtiNX_Q9BT23.
PharmGKBiPA143485528.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITI3. Eukaryota.
ENOG4111S7F. LUCA.
GeneTreeiENSGT00510000046839.
HOGENOMiHOG000111235.
HOVERGENiHBG056520.
InParanoidiQ9BT23.
OMAiQATPSHE.
OrthoDBiEOG091G0043.
PhylomeDBiQ9BT23.

Miscellaneous databases

ChiTaRSiLIMD2. human.
GenomeRNAii80774.
PROiQ9BT23.

Gene expression databases

BgeeiENSG00000136490.
CleanExiHS_LIMD2.
ExpressionAtlasiQ9BT23. baseline and differential.
GenevisibleiQ9BT23. HS.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIMD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BT23
Secondary accession number(s): D3DU16, Q96S91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.