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Protein

Mitochondrial ribosome-associated GTPase 1

Gene

MTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei205GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 86GTPBy similarity4
Nucleotide bindingi153 – 158GTPBy similarity6

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of mitochondrial translation Source: UniProtKB
  • regulation of respiratory system process Source: UniProtKB
  • ribosome biogenesis Source: GO_Central

Keywordsi

Biological processTranslation regulation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribosome-associated GTPase 1
Alternative name(s):
GTP-binding protein 7
Mitochondrial GTPase 1
Gene namesi
Name:MTG1
Synonyms:GTPBP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148824.18
HGNCiHGNC:32159 MTG1
neXtProtiNX_Q9BT17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92170
OpenTargetsiENSG00000148824
PharmGKBiPA142671306

Polymorphism and mutation databases

BioMutaiMTG1
DMDMi134034174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000280262? – 334Mitochondrial ribosome-associated GTPase 1
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9BT17
MaxQBiQ9BT17
PaxDbiQ9BT17
PeptideAtlasiQ9BT17
PRIDEiQ9BT17

PTM databases

iPTMnetiQ9BT17
PhosphoSitePlusiQ9BT17

Expressioni

Gene expression databases

BgeeiENSG00000148824
CleanExiHS_MTG1
ExpressionAtlasiQ9BT17 baseline and differential
GenevisibleiQ9BT17 HS

Organism-specific databases

HPAiHPA037826
HPA037827

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit; the association occurs in a GTP-dependent manner (PubMed:23396448).1 Publication

Protein-protein interaction databases

BioGridi124916, 17 interactors
IntActiQ9BT17, 6 interactors
MINTiQ9BT17
STRINGi9606.ENSP00000323047

Structurei

3D structure databases

ProteinModelPortaliQ9BT17
SMRiQ9BT17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 209CP-type GPROSITE-ProRule annotationAdd BLAST174

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2485 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00500000044923
HOGENOMiHOG000003790
HOVERGENiHBG059228
InParanoidiQ9BT17
KOiK19828
OMAiWFPGHMT
OrthoDBiEOG091G0EC8
PhylomeDBiQ9BT17

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR019991 GTP-bd_ribosome_bgen
IPR006073 GTP_binding_domain
IPR016478 GTPase_MTG1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF006230 MG442, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03596 GTPase_YlqF, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BT17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLTPRALCS AAQAAWRENF PLCGRDVARW FPGHMAKGLK KMQSSLKLVD
60 70 80 90 100
CIIEVHDARI PLSGRNPLFQ ETLGLKPHLL VLNKMDLADL TEQQKIMQHL
110 120 130 140 150
EGEGLKNVIF TNCVKDENVK QIIPMVTELI GRSHRYHRKE NLEYCIMVIG
160 170 180 190 200
VPNVGKSSLI NSLRRQHLRK GKATRVGGEP GITRAVMSKI QVSERPLMFL
210 220 230 240 250
LDTPGVLAPR IESVETGLKL ALCGTVLDHL VGEETMADYL LYTLNKHQRF
260 270 280 290 300
GYVQHYGLGS ACDNVERVLK SVAVKLGKTQ KVKVLTGTGN VNIIQPNYPA
310 320 330
AARDFLQTFR RGLLGSVMLD LDVLRGHPPA ETLP
Length:334
Mass (Da):37,237
Last modified:March 20, 2007 - v2
Checksum:iCEE3812DA5B588DA
GO
Isoform 2 (identifier: Q9BT17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-267: SERPLMFLLD...LGSACDNVER → ESSGARPSTL...GRHAVFPISR
     268-334: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,743
Checksum:i03DA2DED20220435
GO

Sequence cautioni

The sequence AAH04409 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH35721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062181293I → V1 PublicationCorresponds to variant dbSNP:rs2255246Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023581193 – 267SERPL…DNVER → ESSGARPSTLSRALQASGTC RPLCGFRLLTTLPSPPLSVP AEHPRGRHCPCPYSTVVIVF APNLWGRHAVFPISR in isoform 2. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_023582268 – 334Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074976 mRNA Translation: BAC11327.1
AL360181, AL161645 Genomic DNA Translation: CAH70289.1
AL161645, AL360181 Genomic DNA Translation: CAH70046.1
BC000920 mRNA Translation: AAH00920.1
BC004409 mRNA Translation: AAH04409.1 Different initiation.
BC026039 mRNA Translation: AAH26039.1
BC035721 mRNA Translation: AAH35721.1 Different initiation.
CCDSiCCDS31320.1 [Q9BT17-1]
RefSeqiNP_612393.2, NM_138384.2 [Q9BT17-1]
UniGeneiHs.501578

Genome annotation databases

EnsembliENST00000317502; ENSP00000323047; ENSG00000148824 [Q9BT17-1]
GeneIDi92170
KEGGihsa:92170
UCSCiuc001lnd.4 human [Q9BT17-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTG1_HUMAN
AccessioniPrimary (citable) accession number: Q9BT17
Secondary accession number(s): Q5VWX8
, Q6PIY9, Q8IYJ4, Q8NC48, Q9BVU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health