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Protein

Desumoylating isopeptidase 2

Gene

DESI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protease which may deconjugate SUMO from some substrate proteins.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100212-MONOMER.
ZFISH:ENSG00000121644-MONOMER.

Protein family/group databases

MEROPSiC97.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Desumoylating isopeptidase 2 (EC:3.4.-.-)
Short name:
DeSI-2
Alternative name(s):
PPPDE peptidase domain-containing protein 1
Protein FAM152A
Gene namesi
Name:DESI2
Synonyms:C1orf121, FAM152A, PPPDE1
ORF Names:CGI-146, PNAS-4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24264. DESI2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51029.
OpenTargetsiENSG00000121644.
PharmGKBiPA164724993.

Polymorphism and mutation databases

BioMutaiDESI2.
DMDMi51827943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002216301 – 194Desumoylating isopeptidase 2Add BLAST194

Proteomic databases

EPDiQ9BSY9.
MaxQBiQ9BSY9.
PaxDbiQ9BSY9.
PeptideAtlasiQ9BSY9.
PRIDEiQ9BSY9.

PTM databases

iPTMnetiQ9BSY9.
PhosphoSitePlusiQ9BSY9.
SwissPalmiQ9BSY9.

Expressioni

Gene expression databases

BgeeiENSG00000121644.
ExpressionAtlasiQ9BSY9. baseline and differential.
GenevisibleiQ9BSY9. HS.

Organism-specific databases

HPAiHPA049950.
HPA059246.

Interactioni

Protein-protein interaction databases

BioGridi119235. 1 interactor.
STRINGi9606.ENSP00000306528.

Structurei

3D structure databases

ProteinModelPortaliQ9BSY9.
SMRiQ9BSY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 149PPPDE peptidaseAdd BLAST145

Sequence similaritiesi

Belongs to the DeSI family.Curated
Contains 1 PPPDE peptidase domain.Curated

Phylogenomic databases

eggNOGiKOG0324. Eukaryota.
ENOG4111H3Z. LUCA.
GeneTreeiENSGT00730000111005.
HOGENOMiHOG000241907.
InParanoidiQ9BSY9.
OMAiKYWMNEY.
OrthoDBiEOG091G0KPX.
PhylomeDBiQ9BSY9.
TreeFamiTF313188.

Family and domain databases

InterProiIPR008580. PPPDE_dom.
[Graphical view]
PfamiPF05903. Peptidase_C97. 1 hit.
[Graphical view]
SMARTiSM01179. DUF862. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANQLVVLN VYDMYWMNEY TSSIGIGVFH SGIEVYGREF AYGGHPYPFS
60 70 80 90 100
GIFEISPGNA SELGETFKFK EAVVLGSTDF LEDDIEKIVE ELGKEYKGNA
110 120 130 140 150
YHLMHKNCNH FSSALSEILC GKEIPRWINR LAYFSSCIPF LQSCLPKEWL
160 170 180 190
TPAALQSSVS QELQDELEEA EDAAASASVA STAAGSRPGR HTKL
Length:194
Mass (Da):21,444
Last modified:June 1, 2001 - v1
Checksum:i9EADC1A33642EFFF
GO
Isoform 2 (identifier: Q9BSY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-71: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):17,808
Checksum:iD51A8879C5E71BEA
GO

Sequence cautioni

The sequence AAD34141 differs from that shown. Reason: Frameshift at positions 149 and 175.Curated
The sequence AAF42919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180A → V in AAF42919 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01142239 – 71Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229834 mRNA. Translation: AAF42919.1. Different initiation.
AF151904 mRNA. Translation: AAD34141.1. Frameshift.
AL451007, AC099757 Genomic DNA. Translation: CAH70879.1.
AL451007, AC099757 Genomic DNA. Translation: CAH70880.1.
CH471148 Genomic DNA. Translation: EAW77114.1.
CH471148 Genomic DNA. Translation: EAW77116.1.
BC004485 mRNA. Translation: AAH04485.1.
CCDSiCCDS1626.1. [Q9BSY9-1]
CCDS73055.1. [Q9BSY9-2]
RefSeqiNP_001284675.1. NM_001297746.1. [Q9BSY9-2]
NP_057160.2. NM_016076.4. [Q9BSY9-1]
UniGeneiHs.498317.

Genome annotation databases

EnsembliENST00000263831; ENSP00000263831; ENSG00000121644. [Q9BSY9-2]
ENST00000302550; ENSP00000306528; ENSG00000121644. [Q9BSY9-1]
GeneIDi51029.
KEGGihsa:51029.
UCSCiuc001iao.4. human. [Q9BSY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229834 mRNA. Translation: AAF42919.1. Different initiation.
AF151904 mRNA. Translation: AAD34141.1. Frameshift.
AL451007, AC099757 Genomic DNA. Translation: CAH70879.1.
AL451007, AC099757 Genomic DNA. Translation: CAH70880.1.
CH471148 Genomic DNA. Translation: EAW77114.1.
CH471148 Genomic DNA. Translation: EAW77116.1.
BC004485 mRNA. Translation: AAH04485.1.
CCDSiCCDS1626.1. [Q9BSY9-1]
CCDS73055.1. [Q9BSY9-2]
RefSeqiNP_001284675.1. NM_001297746.1. [Q9BSY9-2]
NP_057160.2. NM_016076.4. [Q9BSY9-1]
UniGeneiHs.498317.

3D structure databases

ProteinModelPortaliQ9BSY9.
SMRiQ9BSY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119235. 1 interactor.
STRINGi9606.ENSP00000306528.

Protein family/group databases

MEROPSiC97.002.

PTM databases

iPTMnetiQ9BSY9.
PhosphoSitePlusiQ9BSY9.
SwissPalmiQ9BSY9.

Polymorphism and mutation databases

BioMutaiDESI2.
DMDMi51827943.

Proteomic databases

EPDiQ9BSY9.
MaxQBiQ9BSY9.
PaxDbiQ9BSY9.
PeptideAtlasiQ9BSY9.
PRIDEiQ9BSY9.

Protocols and materials databases

DNASUi51029.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263831; ENSP00000263831; ENSG00000121644. [Q9BSY9-2]
ENST00000302550; ENSP00000306528; ENSG00000121644. [Q9BSY9-1]
GeneIDi51029.
KEGGihsa:51029.
UCSCiuc001iao.4. human. [Q9BSY9-1]

Organism-specific databases

CTDi51029.
DisGeNETi51029.
GeneCardsiDESI2.
H-InvDBHIX0001750.
HGNCiHGNC:24264. DESI2.
HPAiHPA049950.
HPA059246.
MIMi614638. gene.
neXtProtiNX_Q9BSY9.
OpenTargetsiENSG00000121644.
PharmGKBiPA164724993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0324. Eukaryota.
ENOG4111H3Z. LUCA.
GeneTreeiENSGT00730000111005.
HOGENOMiHOG000241907.
InParanoidiQ9BSY9.
OMAiKYWMNEY.
OrthoDBiEOG091G0KPX.
PhylomeDBiQ9BSY9.
TreeFamiTF313188.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100212-MONOMER.
ZFISH:ENSG00000121644-MONOMER.

Miscellaneous databases

ChiTaRSiDESI2. human.
GenomeRNAii51029.
PROiQ9BSY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121644.
ExpressionAtlasiQ9BSY9. baseline and differential.
GenevisibleiQ9BSY9. HS.

Family and domain databases

InterProiIPR008580. PPPDE_dom.
[Graphical view]
PfamiPF05903. Peptidase_C97. 1 hit.
[Graphical view]
SMARTiSM01179. DUF862. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDESI2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSY9
Secondary accession number(s): B1APK6
, Q5VVC6, Q9NYS2, Q9Y3E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.