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Protein

Synaptotagmin-17

Gene

SYT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in dendrite formation by melanocytes (PubMed:23999003).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-17
Alternative name(s):
Protein B/K
Synaptotagmin XVII
Short name:
SytXVII
Gene namesi
Name:SYT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24119. SYT17.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51760.
OpenTargetsiENSG00000103528.
PharmGKBiPA142670841.

Polymorphism and mutation databases

BioMutaiSYT17.
DMDMi74752317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119361 – 474Synaptotagmin-17Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineBy similarity1
Modified residuei119PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BSW7.
PaxDbiQ9BSW7.
PeptideAtlasiQ9BSW7.
PRIDEiQ9BSW7.

PTM databases

iPTMnetiQ9BSW7.
PhosphoSitePlusiQ9BSW7.

Expressioni

Tissue specificityi

Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

BgeeiENSG00000103528.
CleanExiHS_SYT17.
ExpressionAtlasiQ9BSW7. baseline and differential.
GenevisibleiQ9BSW7. HS.

Organism-specific databases

HPAiHPA040811.
HPA042059.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119717. 19 interactors.
IntActiQ9BSW7. 41 interactors.
MINTiMINT-1464550.
STRINGi9606.ENSP00000347538.

Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi187 – 195Combined sources9
Turni196 – 199Combined sources4
Beta strandi200 – 209Combined sources10
Beta strandi230 – 236Combined sources7
Helixi266 – 271Combined sources6
Beta strandi272 – 279Combined sources8
Beta strandi291 – 296Combined sources6
Turni297 – 299Combined sources3
Turni302 – 304Combined sources3
Beta strandi308 – 310Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENPNMR-A181-315[»]
ProteinModelPortaliQ9BSW7.
SMRiQ9BSW7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSW7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 294C2 1PROSITE-ProRule annotationAdd BLAST109
Domaini323 – 426C2 2PROSITE-ProRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 40Cys-richAdd BLAST18

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000154478.
HOVERGENiHBG108530.
InParanoidiQ9BSW7.
KOiK19915.
OMAiSCMRGTI.
OrthoDBiEOG091G0E6G.
PhylomeDBiQ9BSW7.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR014705. SYT17.
PANTHERiPTHR10024:SF321. PTHR10024:SF321. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL
60 70 80 90 100
GPFPAQTPPW LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK
110 120 130 140 150
STYSLTRRIS SLESRRPSSP LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP
160 170 180 190 200
DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL SKYQLGMLHF STQYDLLHNH
210 220 230 240 250
LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK NSKQTGVKRK
260 270 280 290 300
TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV
310 320 330 340 350
DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ
360 370 380 390 400
TDVSQGSDPF VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE
410 420 430 440 450
LENASLVFTV FGHNMKSSND FIGRIVIGQY SSGPSETNHW RRMLNTHRTA
460 470
VEQWHSLRSR AECDRVSPAS LEVT
Length:474
Mass (Da):53,849
Last modified:June 1, 2001 - v1
Checksum:iF5D2E86665BCEC8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66S → G in AAF37825 (PubMed:16672768).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220560 mRNA. Translation: AAF37825.1.
CH471186 Genomic DNA. Translation: EAW50274.1.
BC004518 mRNA. Translation: AAH04518.1.
AC003003 Genomic DNA. Translation: AAC05436.1.
CCDSiCCDS10575.1.
RefSeqiNP_057608.2. NM_016524.3.
UniGeneiHs.258326.
Hs.733095.

Genome annotation databases

EnsembliENST00000355377; ENSP00000347538; ENSG00000103528.
GeneIDi51760.
KEGGihsa:51760.
UCSCiuc002dfw.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYT17_HUMAN
AccessioniPrimary (citable) accession number: Q9BSW7
Secondary accession number(s): O43330, Q9NZ18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families