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Protein

Synaptotagmin-17

Gene

SYT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in dendrite formation by melanocytes (PubMed:23999003).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-17
Alternative name(s):
Protein B/K
Synaptotagmin XVII
Short name:
SytXVII
Gene namesi
Name:SYT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24119. SYT17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670841.

Polymorphism and mutation databases

BioMutaiSYT17.
DMDMi74752317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Synaptotagmin-17PRO_0000311936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei119 – 1191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BSW7.
PaxDbiQ9BSW7.
PeptideAtlasiQ9BSW7.
PRIDEiQ9BSW7.

PTM databases

iPTMnetiQ9BSW7.
PhosphoSiteiQ9BSW7.

Expressioni

Tissue specificityi

Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

BgeeiENSG00000103528.
CleanExiHS_SYT17.
ExpressionAtlasiQ9BSW7. baseline and differential.
GenevisibleiQ9BSW7. HS.

Organism-specific databases

HPAiHPA040811.
HPA042059.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP63Q96MT83EBI-745392,EBI-741977
CEP70Q8NHQ13EBI-745392,EBI-739624
CHMP4AQ9BY435EBI-745392,EBI-747981
FAM9BQ8IZU03EBI-745392,EBI-10175124
FLJ13057Q53SE73EBI-745392,EBI-10172181
IKZF1Q134223EBI-745392,EBI-745305
MEOX1P502213EBI-745392,EBI-2864512
MEOX2A4D1273EBI-745392,EBI-10172134
MID2Q9UJV3-23EBI-745392,EBI-10172526
NIF3L1Q9GZT83EBI-745392,EBI-740897
RUNDC3AQ59EK93EBI-745392,EBI-747225
SSX2IPQ9Y2D83EBI-745392,EBI-2212028
TRAF2Q129333EBI-745392,EBI-355744

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119717. 19 interactions.
IntActiQ9BSW7. 17 interactions.
MINTiMINT-1464550.
STRINGi9606.ENSP00000347538.

Structurei

Secondary structure

1
474
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi187 – 1959Combined sources
Turni196 – 1994Combined sources
Beta strandi200 – 20910Combined sources
Beta strandi230 – 2367Combined sources
Helixi266 – 2716Combined sources
Beta strandi272 – 2798Combined sources
Beta strandi291 – 2966Combined sources
Turni297 – 2993Combined sources
Turni302 – 3043Combined sources
Beta strandi308 – 3103Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENPNMR-A181-315[»]
ProteinModelPortaliQ9BSW7.
SMRiQ9BSW7. Positions 154-464.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSW7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 294109C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 426104C2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 4018Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000154478.
HOVERGENiHBG108530.
InParanoidiQ9BSW7.
KOiK19915.
OMAiDGARQDM.
OrthoDBiEOG091G0E6G.
PhylomeDBiQ9BSW7.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR014705. SYT17.
[Graphical view]
PANTHERiPTHR10024:SF251. PTHR10024:SF251. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL
60 70 80 90 100
GPFPAQTPPW LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK
110 120 130 140 150
STYSLTRRIS SLESRRPSSP LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP
160 170 180 190 200
DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL SKYQLGMLHF STQYDLLHNH
210 220 230 240 250
LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK NSKQTGVKRK
260 270 280 290 300
TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV
310 320 330 340 350
DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ
360 370 380 390 400
TDVSQGSDPF VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE
410 420 430 440 450
LENASLVFTV FGHNMKSSND FIGRIVIGQY SSGPSETNHW RRMLNTHRTA
460 470
VEQWHSLRSR AECDRVSPAS LEVT
Length:474
Mass (Da):53,849
Last modified:June 1, 2001 - v1
Checksum:iF5D2E86665BCEC8C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661S → G in AAF37825 (PubMed:16672768).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220560 mRNA. Translation: AAF37825.1.
CH471186 Genomic DNA. Translation: EAW50274.1.
BC004518 mRNA. Translation: AAH04518.1.
AC003003 Genomic DNA. Translation: AAC05436.1.
CCDSiCCDS10575.1.
RefSeqiNP_057608.2. NM_016524.3.
UniGeneiHs.258326.
Hs.733095.

Genome annotation databases

EnsembliENST00000355377; ENSP00000347538; ENSG00000103528.
GeneIDi51760.
KEGGihsa:51760.
UCSCiuc002dfw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220560 mRNA. Translation: AAF37825.1.
CH471186 Genomic DNA. Translation: EAW50274.1.
BC004518 mRNA. Translation: AAH04518.1.
AC003003 Genomic DNA. Translation: AAC05436.1.
CCDSiCCDS10575.1.
RefSeqiNP_057608.2. NM_016524.3.
UniGeneiHs.258326.
Hs.733095.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENPNMR-A181-315[»]
ProteinModelPortaliQ9BSW7.
SMRiQ9BSW7. Positions 154-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119717. 19 interactions.
IntActiQ9BSW7. 17 interactions.
MINTiMINT-1464550.
STRINGi9606.ENSP00000347538.

PTM databases

iPTMnetiQ9BSW7.
PhosphoSiteiQ9BSW7.

Polymorphism and mutation databases

BioMutaiSYT17.
DMDMi74752317.

Proteomic databases

MaxQBiQ9BSW7.
PaxDbiQ9BSW7.
PeptideAtlasiQ9BSW7.
PRIDEiQ9BSW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355377; ENSP00000347538; ENSG00000103528.
GeneIDi51760.
KEGGihsa:51760.
UCSCiuc002dfw.4. human.

Organism-specific databases

CTDi51760.
GeneCardsiSYT17.
HGNCiHGNC:24119. SYT17.
HPAiHPA040811.
HPA042059.
neXtProtiNX_Q9BSW7.
PharmGKBiPA142670841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000154478.
HOVERGENiHBG108530.
InParanoidiQ9BSW7.
KOiK19915.
OMAiDGARQDM.
OrthoDBiEOG091G0E6G.
PhylomeDBiQ9BSW7.
TreeFamiTF315600.

Miscellaneous databases

ChiTaRSiSYT17. human.
EvolutionaryTraceiQ9BSW7.
GenomeRNAii51760.
PROiQ9BSW7.

Gene expression databases

BgeeiENSG00000103528.
CleanExiHS_SYT17.
ExpressionAtlasiQ9BSW7. baseline and differential.
GenevisibleiQ9BSW7. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR014705. SYT17.
[Graphical view]
PANTHERiPTHR10024:SF251. PTHR10024:SF251. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT17_HUMAN
AccessioniPrimary (citable) accession number: Q9BSW7
Secondary accession number(s): O43330, Q9NZ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.