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Protein

N-alpha-acetyltransferase 11

Gene

NAA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.1 Publication

Catalytic activityi

Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)-acetyl-glycyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-alanyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-N(alpha)-acetyl-L-seryl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-N(alpha)-acetyl-L-valyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-cysteinyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-N(alpha)-acetyl-L-threonyl-[protein] + CoA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.88. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 11 (EC:2.3.1.255By similarity)
Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
Short name:
hARD2
NatA catalytic subunit Naa11
Gene namesi
Name:NAA11
Synonyms:ARD1B, ARD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000156269.4.
HGNCiHGNC:28125. NAA11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84779.
OpenTargetsiENSG00000156269.
PharmGKBiPA165664264.

Polymorphism and mutation databases

BioMutaiNAA11.
DMDMi158706520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050091 – 229N-alpha-acetyltransferase 11Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BSU3.
MaxQBiQ9BSU3.
PaxDbiQ9BSU3.
PeptideAtlasiQ9BSU3.
PRIDEiQ9BSU3.

PTM databases

iPTMnetiQ9BSU3.
PhosphoSitePlusiQ9BSU3.

Expressioni

Tissue specificityi

Present in several cell lines, with highest levels in MCF-7 cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000156269.
CleanExiHS_ARD1B.
ExpressionAtlasiQ9BSU3. baseline and differential.
GenevisibleiQ9BSU3. HS.

Organism-specific databases

HPAiHPA035922.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.Curated1 Publication

Protein-protein interaction databases

BioGridi124254. 1 interactor.
IntActiQ9BSU3. 9 interactors.
STRINGi9606.ENSP00000286794.

Structurei

3D structure databases

ProteinModelPortaliQ9BSU3.
SMRiQ9BSU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 152N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 58Interaction with NAA15By similarityAdd BLAST58

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3235. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00550000074803.
HOGENOMiHOG000078523.
HOVERGENiHBG050561.
InParanoidiQ9BSU3.
KOiK20791.
OMAiYIMARSL.
OrthoDBiEOG091G0JI1.
PhylomeDBiQ9BSU3.
TreeFamiTF300078.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BSU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG
60 70 80 90 100
KIVGYVLAKM EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE
110 120 130 140 150
NFNAKYVSLH VRKSNRPALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD
160 170 180 190 200
LSQMADELRR QMDLKKGGYV VLGSRENQET QGSTLSDSEE ACQQKNPATE
210 220
ESGSDSKEPK ESVESTNVQD SSESSDSTS
Length:229
Mass (Da):25,979
Last modified:October 2, 2007 - v3
Checksum:iF547D816A1E07ACE
GO

Sequence cautioni

Q9BSU3: The sequence AAH04552 differs from that shown. Reason: Erroneous initiation.Curated
Q9BSU3: The sequence AAH63623 differs from that shown. Reason: Erroneous initiation.Curated
Q9BSU3: The sequence AAH80651 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0481646A → T. Corresponds to variant dbSNP:rs3811765Ensembl.1
Natural variantiVAR_04816519L → F. Corresponds to variant dbSNP:rs17003712Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004552 mRNA. Translation: AAH04552.2. Different initiation.
BC063623 mRNA. Translation: AAH63623.1. Different initiation.
BC080651 mRNA. Translation: AAH80651.1. Different initiation.
CCDSiCCDS47084.1.
RefSeqiNP_116082.1. NM_032693.2.
XP_016864266.1. XM_017008777.1.
XP_016864267.1. XM_017008778.1.
XP_016864268.1. XM_017008779.1.
UniGeneiHs.676048.

Genome annotation databases

EnsembliENST00000286794; ENSP00000286794; ENSG00000156269.
GeneIDi84779.
KEGGihsa:84779.
UCSCiuc003hlt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNAA11_HUMAN
AccessioniPrimary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 27, 2017
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families