Reviewed, UniProtKB/Swiss-Prot Q9BSU3 (ARD1B_HUMAN)

Names and origin

Protein names

Recommended name:
    N-terminal acetyltransferase complex ARD1 subunit homolog B
      Short name=hARD2
    EC=2.3.1.88

Gene names

Name:	ARD1B
Synonyms:	ARD2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In complex with NARG1, displays alpha (N-terminal) acetyltransferase activity. Ref.2
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NARG1 and HIF1A. Ref.2
Subcellular location	Cytoplasm. Nucleus. Ref.2
Tissue specificity	Present in several cell lines, with highest levels in MCF-7 cells (at protein level). Ref.2
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide alpha-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	N-terminal acetyltransferase complex ARD1 subunit homolog B		PRO_0000305009
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NARG1 By similarity
Amino acid modifications
	Modified residue	136	1	N6-acetyllysine Ref.3
Natural variations
	Natural variant	6	1	A → T: dbSNP rs3811765.		VAR_048164
	Natural variant	19	1	L → F: dbSNP rs17003712.		VAR_048165

Sequences

	Sequence		Length	Mass (Da)
	Q9BSU3-1 [UniParc]. Last modified October 2, 2007. Version 3. Checksum: F547D816A1E07ACE	FASTA	229	25,979
	10 20 30 40 50 60 MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRPALH 130 140 150 160 170 180 LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LSQMADELRR QMDLKKGGYV VLGSRENQET 190 200 210 220 QGSTLSDSEE ACQQKNPATE ESGSDSKEPK ESVESTNVQD SSESSDSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[2]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed: 16638120] [Abstract] Cited for: FUNCTION, INTERACTION WITH NARG1 AND HIF1A, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-136, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC004552 mRNA. Translation: AAH04552.2. Different initiation. BC063623 mRNA. Translation: AAH63623.1. Different initiation. BC080651 mRNA. Translation: AAH80651.1. Different initiation.
IPI	IPI00455623.
RefSeq	NP_116082.1.
UniGene	Hs.676048
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BSU3.
Proteomic databases
PRIDE	Q9BSU3.
Genome annotation databases
Ensembl	ENST00000286794; ENSP00000286794; ENSG00000156269; Homo sapiens. [Genome view]
GeneID	84779.
KEGG	hsa:84779.
UCSC	uc003hlt.2. human.
Organism-specific databases
CTD	84779.
GeneCards	GC04M080456.
HGNC	HGNC:28125. ARD1B.
PharmGKB	PA142672595.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9BSU3.
Enzyme and pathway databases
BRENDA	2.3.1.88. 247.
Gene expression databases
ArrayExpress	Q9BSU3.
Bgee	Q9BSU3.
CleanEx	HS_ARD1B.
Genevestigator	Q9BSU3.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74933.

Entry information

Entry name

ARD1B_HUMAN

Accession

Primary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	October 13, 2009
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.