Q9BSU3 (NAA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 11
EC=2.3.1.88

Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
Short name=hARD2
NatA catalytic subunit

Gene names

Name:	NAA11
Synonyms:	ARD1B, ARD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Ref.2
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NAA15 and HIF1A. Ref.2
Subcellular location	Cytoplasm. Nucleus Ref.2.
Tissue specificity	Present in several cell lines, with highest levels in MCF-7 cells (at protein level). Ref.2
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.
Sequence caution	The sequence AAH04552.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH63623.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH80651.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA centrosome Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	peptide alpha-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	N-alpha-acetyltransferase 11		PRO_0000305009
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NAA15 By similarity
Natural variations
	Natural variant	6	1	A → T. Corresponds to variant rs3811765 [ dbSNP | Ensembl ].		VAR_048164
	Natural variant	19	1	L → F. Corresponds to variant rs17003712 [ dbSNP | Ensembl ].		VAR_048165

Sequences

	Sequence		Length	Mass (Da)
	Q9BSU3 [UniParc]. Last modified October 2, 2007. Version 3. Checksum: F547D816A1E07ACE	FASTA	229	25,979
	10 20 30 40 50 60 MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRPALH 130 140 150 160 170 180 LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LSQMADELRR QMDLKKGGYV VLGSRENQET 190 200 210 220 QGSTLSDSEE ACQQKNPATE ESGSDSKEPK ESVESTNVQD SSESSDSTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[2]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NAA15 AND HIF1A, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]	"A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates." Polevoda B., Arnesen T., Sherman F. BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC004552 mRNA. Translation: AAH04552.2. Different initiation. BC063623 mRNA. Translation: AAH63623.1. Different initiation. BC080651 mRNA. Translation: AAH80651.1. Different initiation.
IPI	IPI00455623.
RefSeq	NP_116082.1. NM_032693.2.
UniGene	Hs.676048.
3D structure databases
ProteinModelPortal	Q9BSU3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BSU3. 1 interaction.
STRING	9606.ENSP00000286794.
PTM databases
PhosphoSite	Q9BSU3.
Polymorphism databases
DMDM	158706520.
Proteomic databases
PaxDb	Q9BSU3.
PRIDE	Q9BSU3.
Protocols and materials databases
DNASU	84779.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286794; ENSP00000286794; ENSG00000156269.
GeneID	84779.
KEGG	hsa:84779.
UCSC	uc003hlt.4. human.
Organism-specific databases
CTD	84779.
GeneCards	GC04M080237.
HGNC	HGNC:28125. NAA11.
HPA	HPA035922.
neXtProt	NX_Q9BSU3.
PharmGKB	PA165664264.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0456.
HOGENOM	HOG000078523.
HOVERGEN	HBG050561.
InParanoid	Q9BSU3.
KO	K00670.
OMA	KEDAYSM.
Gene expression databases
ArrayExpress	Q9BSU3.
Bgee	Q9BSU3.
CleanEx	HS_ARD1B.
Genevestigator	Q9BSU3.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GNAT_dom. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84779.
NextBio	74933.

Entry information

Entry name

NAA11_HUMAN

Accession

Primary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.