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Protein

N-alpha-acetyltransferase 11

Gene

NAA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.1 Publication

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.88. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 11 (EC:2.3.1.88)
Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
Short name:
hARD2
NatA catalytic subunit Naa11
Gene namesi
Name:NAA11
Synonyms:ARD1B, ARD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28125. NAA11.

Subcellular locationi

GO - Cellular componenti

  • cytosolic ribosome Source: GO_Central
  • NatA complex Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664264.

Polymorphism and mutation databases

BioMutaiNAA11.
DMDMi158706520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229N-alpha-acetyltransferase 11PRO_0000305009Add
BLAST

Proteomic databases

EPDiQ9BSU3.
MaxQBiQ9BSU3.
PaxDbiQ9BSU3.
PRIDEiQ9BSU3.

PTM databases

iPTMnetiQ9BSU3.
PhosphoSiteiQ9BSU3.

Expressioni

Tissue specificityi

Present in several cell lines, with highest levels in MCF-7 cells (at protein level).1 Publication

Gene expression databases

BgeeiQ9BSU3.
CleanExiHS_ARD1B.
ExpressionAtlasiQ9BSU3. baseline and differential.
GenevisibleiQ9BSU3. HS.

Organism-specific databases

HPAiHPA035922.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.Curated1 Publication

Protein-protein interaction databases

BioGridi124254. 1 interaction.
IntActiQ9BSU3. 1 interaction.
STRINGi9606.ENSP00000286794.

Structurei

3D structure databases

ProteinModelPortaliQ9BSU3.
SMRiQ9BSU3. Positions 1-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 152152N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5858Interaction with NAA15By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3235. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00550000074803.
HOGENOMiHOG000078523.
HOVERGENiHBG050561.
InParanoidiQ9BSU3.
KOiK00670.
OMAiKGHAQPG.
PhylomeDBiQ9BSU3.
TreeFamiTF300078.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG
60 70 80 90 100
KIVGYVLAKM EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE
110 120 130 140 150
NFNAKYVSLH VRKSNRPALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD
160 170 180 190 200
LSQMADELRR QMDLKKGGYV VLGSRENQET QGSTLSDSEE ACQQKNPATE
210 220
ESGSDSKEPK ESVESTNVQD SSESSDSTS
Length:229
Mass (Da):25,979
Last modified:October 2, 2007 - v3
Checksum:iF547D816A1E07ACE
GO

Sequence cautioni

The sequence AAH04552.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH63623.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH80651.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → T.
Corresponds to variant rs3811765 [ dbSNP | Ensembl ].
VAR_048164
Natural varianti19 – 191L → F.
Corresponds to variant rs17003712 [ dbSNP | Ensembl ].
VAR_048165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004552 mRNA. Translation: AAH04552.2. Different initiation.
BC063623 mRNA. Translation: AAH63623.1. Different initiation.
BC080651 mRNA. Translation: AAH80651.1. Different initiation.
CCDSiCCDS47084.1.
RefSeqiNP_116082.1. NM_032693.2.
UniGeneiHs.676048.

Genome annotation databases

EnsembliENST00000286794; ENSP00000286794; ENSG00000156269.
GeneIDi84779.
KEGGihsa:84779.
UCSCiuc003hlt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004552 mRNA. Translation: AAH04552.2. Different initiation.
BC063623 mRNA. Translation: AAH63623.1. Different initiation.
BC080651 mRNA. Translation: AAH80651.1. Different initiation.
CCDSiCCDS47084.1.
RefSeqiNP_116082.1. NM_032693.2.
UniGeneiHs.676048.

3D structure databases

ProteinModelPortaliQ9BSU3.
SMRiQ9BSU3. Positions 1-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124254. 1 interaction.
IntActiQ9BSU3. 1 interaction.
STRINGi9606.ENSP00000286794.

PTM databases

iPTMnetiQ9BSU3.
PhosphoSiteiQ9BSU3.

Polymorphism and mutation databases

BioMutaiNAA11.
DMDMi158706520.

Proteomic databases

EPDiQ9BSU3.
MaxQBiQ9BSU3.
PaxDbiQ9BSU3.
PRIDEiQ9BSU3.

Protocols and materials databases

DNASUi84779.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286794; ENSP00000286794; ENSG00000156269.
GeneIDi84779.
KEGGihsa:84779.
UCSCiuc003hlt.5. human.

Organism-specific databases

CTDi84779.
GeneCardsiNAA11.
HGNCiHGNC:28125. NAA11.
HPAiHPA035922.
neXtProtiNX_Q9BSU3.
PharmGKBiPA165664264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3235. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00550000074803.
HOGENOMiHOG000078523.
HOVERGENiHBG050561.
InParanoidiQ9BSU3.
KOiK00670.
OMAiKGHAQPG.
PhylomeDBiQ9BSU3.
TreeFamiTF300078.

Enzyme and pathway databases

BRENDAi2.3.1.88. 2681.

Miscellaneous databases

GenomeRNAii84779.
PROiQ9BSU3.

Gene expression databases

BgeeiQ9BSU3.
CleanExiHS_ARD1B.
ExpressionAtlasiQ9BSU3. baseline and differential.
GenevisibleiQ9BSU3. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  2. "Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase."
    Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R.
    BMC Biochem. 7:13-13(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NAA15 AND HIF1A, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiNAA11_HUMAN
AccessioniPrimary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 8, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.