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Protein

UPF0183 protein C16orf70

Gene

C16orf70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0183 protein C16orf70
Gene namesi
Name:C16orf70
Synonyms:C16orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29564. C16orf70.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671552.

Polymorphism and mutation databases

BioMutaiC16orf70.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422UPF0183 protein C16orf70PRO_0000221083Add
BLAST

Proteomic databases

EPDiQ9BSU1.
MaxQBiQ9BSU1.
PaxDbiQ9BSU1.
PRIDEiQ9BSU1.

PTM databases

iPTMnetiQ9BSU1.
PhosphoSiteiQ9BSU1.

Expressioni

Gene expression databases

BgeeiQ9BSU1.
CleanExiHS_C16orf70.
ExpressionAtlasiQ9BSU1. baseline and differential.
GenevisibleiQ9BSU1. HS.

Organism-specific databases

HPAiHPA041131.
HPA041214.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN3P542522EBI-946080,EBI-946046
BCAS3Q9H6U6-23EBI-946080,EBI-10307911

Protein-protein interaction databases

BioGridi123204. 31 interactions.
IntActiQ9BSU1. 2 interactions.
MINTiMINT-2855413.
STRINGi9606.ENSP00000219139.

Structurei

3D structure databases

ProteinModelPortaliQ9BSU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0183 family.Curated

Phylogenomic databases

eggNOGiKOG2819. Eukaryota.
ENOG410XT40. LUCA.
GeneTreeiENSGT00390000015992.
HOGENOMiHOG000007940.
HOVERGENiHBG023195.
InParanoidiQ9BSU1.
OMAiNIYHRCD.
PhylomeDBiQ9BSU1.
TreeFamiTF313669.

Family and domain databases

InterProiIPR005373. UPF0183.
[Graphical view]
PfamiPF03676. UPF0183. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BSU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLDLEVVPER SLGNEQWEFT LGMPLAQAVA ILQKHCRIIK NVQVLYSEQS
60 70 80 90 100
PLSHDLILNL TQDGIKLMFD AFNQRLKVIE VCDLTKVKLK YCGVHFNSQA
110 120 130 140 150
IAPTIEQIDQ SFGATHPGVY NSAEQLFHLN FRGLSFSFQL DSWTEAPKYE
160 170 180 190 200
PNFAHGLASL QIPHGATVKR MYIYSGNSLQ DTKAPMMPLS CFLGNVYAES
210 220 230 240 250
VDVLRDGTGP AGLRLRLLAA GCGPGLLADA KMRVFERSVY FGDSCQDVLS
260 270 280 290 300
MLGSPHKVFY KSEDKMKIHS PSPHKQVPSK CNDYFFNYFT LGVDILFDAN
310 320 330 340 350
THKVKKFVLH TNYPGHYNFN IYHRCEFKIP LAIKKENADG QTETCTTYSK
360 370 380 390 400
WDNIQELLGH PVEKPVVLHR SSSPNNTNPF GSTFCFGLQR MIFEVMQNNH
410 420
IASVTLYGPP RPGSHLRTAE LP
Length:422
Mass (Da):47,524
Last modified:June 1, 2001 - v1
Checksum:iCEA42442E45A7E35
GO
Isoform 2 (identifier: Q9BSU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     118-118: G → GGKPSPSDSS...MLFSSPPPPT
     184-422: Missing.

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):28,657
Checksum:i5ABCC4B3B7E4AC16
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 2. 1 PublicationVSP_026623Add
BLAST
Alternative sequencei118 – 1181G → GGKPSPSDSSGHQWQFIAIN LPGSAIPPHFLESGSHRIVG LVLGCEGNILPLVFNLVGQF RNKPQGRCCQSLLPARLVYV SHFRCQSTMLFSSPPPPT in isoform 2. 1 PublicationVSP_026624
Alternative sequencei184 – 422239Missing in isoform 2. 1 PublicationVSP_026625Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176088 mRNA. Translation: AAK96888.1.
AK022138 mRNA. Translation: BAB13968.1.
BC004556 mRNA. Translation: AAH04556.1.
CCDSiCCDS10828.1. [Q9BSU1-1]
RefSeqiNP_001307469.1. NM_001320540.1. [Q9BSU1-1]
NP_001307470.1. NM_001320541.1. [Q9BSU1-1]
NP_001307471.1. NM_001320542.1. [Q9BSU1-1]
NP_001307472.1. NM_001320543.1.
NP_079463.2. NM_025187.4. [Q9BSU1-1]
UniGeneiHs.513666.
Hs.744158.

Genome annotation databases

EnsembliENST00000219139; ENSP00000219139; ENSG00000125149. [Q9BSU1-1]
ENST00000569600; ENSP00000455182; ENSG00000125149. [Q9BSU1-1]
GeneIDi80262.
KEGGihsa:80262.
UCSCiuc002erc.4. human. [Q9BSU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176088 mRNA. Translation: AAK96888.1.
AK022138 mRNA. Translation: BAB13968.1.
BC004556 mRNA. Translation: AAH04556.1.
CCDSiCCDS10828.1. [Q9BSU1-1]
RefSeqiNP_001307469.1. NM_001320540.1. [Q9BSU1-1]
NP_001307470.1. NM_001320541.1. [Q9BSU1-1]
NP_001307471.1. NM_001320542.1. [Q9BSU1-1]
NP_001307472.1. NM_001320543.1.
NP_079463.2. NM_025187.4. [Q9BSU1-1]
UniGeneiHs.513666.
Hs.744158.

3D structure databases

ProteinModelPortaliQ9BSU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123204. 31 interactions.
IntActiQ9BSU1. 2 interactions.
MINTiMINT-2855413.
STRINGi9606.ENSP00000219139.

PTM databases

iPTMnetiQ9BSU1.
PhosphoSiteiQ9BSU1.

Polymorphism and mutation databases

BioMutaiC16orf70.

Proteomic databases

EPDiQ9BSU1.
MaxQBiQ9BSU1.
PaxDbiQ9BSU1.
PRIDEiQ9BSU1.

Protocols and materials databases

DNASUi80262.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219139; ENSP00000219139; ENSG00000125149. [Q9BSU1-1]
ENST00000569600; ENSP00000455182; ENSG00000125149. [Q9BSU1-1]
GeneIDi80262.
KEGGihsa:80262.
UCSCiuc002erc.4. human. [Q9BSU1-1]

Organism-specific databases

CTDi80262.
GeneCardsiC16orf70.
HGNCiHGNC:29564. C16orf70.
HPAiHPA041131.
HPA041214.
neXtProtiNX_Q9BSU1.
PharmGKBiPA142671552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2819. Eukaryota.
ENOG410XT40. LUCA.
GeneTreeiENSGT00390000015992.
HOGENOMiHOG000007940.
HOVERGENiHBG023195.
InParanoidiQ9BSU1.
OMAiNIYHRCD.
PhylomeDBiQ9BSU1.
TreeFamiTF313669.

Miscellaneous databases

ChiTaRSiC16orf70. human.
GenomeRNAii80262.
PROiQ9BSU1.

Gene expression databases

BgeeiQ9BSU1.
CleanExiHS_C16orf70.
ExpressionAtlasiQ9BSU1. baseline and differential.
GenevisibleiQ9BSU1. HS.

Family and domain databases

InterProiIPR005373. UPF0183.
[Graphical view]
PfamiPF03676. UPF0183. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human homolog of rat lin-10."
    Lee Y.M., Kim W.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCP070_HUMAN
AccessioniPrimary (citable) accession number: Q9BSU1
Secondary accession number(s): Q9HA86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (Ref. 1) thought to be a lin-10 homolog.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.