Q9BSR8 (YIPF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIPF4

Alternative name(s):
YIP1 family member 4

Gene names

Name:	YIPF4
ORF Names:	Nbla11189

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the YIP1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: LIFEdb integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	Protein YIPF4		PRO_0000242632
Regions
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9BSR8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: BEC6F8EA9892F612	FASTA	244	27,083
	10 20 30 40 50 60 MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST ATTFLRQRGY 70 80 90 100 110 120 GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP SLGFNRQVVR DNPDFWGPLA 130 140 150 160 170 180 VVLFFSMISL YGQFRVVSWI ITIWIFGSLT IFLLARVLGG EVAYGQVLGV IGYSLLPLIV 190 200 210 220 230 240 IAPVLLVVGS FEVVSTLIKL FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL YTGV

References

[1]	"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma." Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A. Cancer Lett. 197:63-68(2003) [PubMed: 12880961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastric mucosa.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB072898 mRNA. Translation: BAE45710.1. AK098486 mRNA. Translation: BAC05315.1. BC004875 mRNA. Translation: AAH04875.1.
IPI	IPI00031127.
RefSeq	NP_115688.1. NM_032312.3.
UniGene	Hs.468099.
3D structure databases
ProteinModelPortal	Q9BSR8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BSR8. 2 interactions.
MINT	MINT-1454288.
STRING	Q9BSR8.
Polymorphism databases
DMDM	74733045.
Proteomic databases
PRIDE	Q9BSR8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000238831; ENSP00000238831; ENSG00000119820.
GeneID	84272.
KEGG	hsa:84272.
UCSC	uc002rok.1. human.
Organism-specific databases
CTD	84272.
GeneCards	GC02P032502.
H-InvDB	HIX0200301.
HGNC	HGNC:28145. YIPF4.
HPA	HPA017884.
neXtProt	NX_Q9BSR8.
PharmGKB	PA142670547.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09022.
GeneTree	ENSGT00530000063514.
HOGENOM	HBG277756.
HOVERGEN	HBG056534.
InParanoid	Q9BSR8.
OMA	SWIITMW.
OrthoDB	EOG4K6G56.
PhylomeDB	Q9BSR8.
Gene expression databases
ArrayExpress	Q9BSR8.
Bgee	Q9BSR8.
CleanEx	HS_YIPF4.
Genevestigator	Q9BSR8.
GermOnline	ENSG00000119820. Homo sapiens.
Family and domain databases
InterPro	IPR006977. Yip1. [Graphical view]
Pfam	PF04893. Yip1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	73838.

Entry information

Entry name

YIPF4_HUMAN

Accession

Primary (citable) accession number: Q9BSR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.