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Protein

Transmembrane protein 204

Gene

TMEM204

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 204
Alternative name(s):
Claudin-like protein 24
Gene namesi
Name:TMEM204
Synonyms:C16orf30, CLP24
ORF Names:UNQ6509/PRO21434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14158. TMEM204.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Topological domaini27 – 10377ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Topological domaini125 – 13612CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 17013ExtracellularSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 22635CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406384.

Polymorphism and mutation databases

BioMutaiTMEM204.
DMDMi73917798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Transmembrane protein 204PRO_0000089865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BSN7.
PRIDEiQ9BSN7.

PTM databases

PhosphoSiteiQ9BSN7.

Expressioni

Tissue specificityi

Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.1 Publication

Inductioni

By hypoxia.

Gene expression databases

BgeeiQ9BSN7.
CleanExiHS_TMEM204.
GenevisibleiQ9BSN7. HS.

Organism-specific databases

HPAiHPA014028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253934.

Structurei

3D structure databases

ProteinModelPortaliQ9BSN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHK. Eukaryota.
ENOG410XRFW. LUCA.
GeneTreeiENSGT00390000015528.
HOGENOMiHOG000030900.
HOVERGENiHBG081251.
InParanoidiQ9BSN7.
OMAiSQCWEEA.
OrthoDBiEOG7Z0JXP.
PhylomeDBiQ9BSN7.
TreeFamiTF331492.

Sequencei

Sequence statusi: Complete.

Q9BSN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVQRLVAAA VLVALVSLIL NNVAAFTSNW VCQTLEDGRR RSVGLWRSCW
60 70 80 90 100
LVDRTRGGPS PGARAGQVDA HDCEALGWGS EAAGFQESRG TVKLQFDMMR
110 120 130 140 150
ACNLVATAAL TAGQLTFLLG LVGLPLLSPD APCWEEAMAA AFQLASFVLV
160 170 180 190 200
IGLVTFYRIG PYTNLSWSCY LNIGACLLAT LAAAMLIWNI LHKREDCMAP
210 220
RVIVISRSLT ARFRRGLDND YVESPC
Length:226
Mass (Da):24,540
Last modified:June 1, 2001 - v1
Checksum:i2CECA8A5823AE397
GO

Sequence cautioni

The sequence BAB14926.1 differs from that shown. Reason: Frameshift at position 161. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571G → A.
Corresponds to variant rs1057612 [ dbSNP | Ensembl ].
VAR_051435

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY676494 mRNA. Translation: AAT78423.1.
AY358178 mRNA. Translation: AAQ88545.1.
AK024551 mRNA. Translation: BAB14926.1. Frameshift.
AE006467 Genomic DNA. Translation: AAK61286.1.
CH471112 Genomic DNA. Translation: EAW85645.1.
CH471112 Genomic DNA. Translation: EAW85646.1.
BC004932 mRNA. Translation: AAH04932.1.
BC105785 mRNA. Translation: AAI05786.1.
CCDSiCCDS42098.1.
RefSeqiNP_001243470.1. NM_001256541.1.
NP_078876.2. NM_024600.5.
UniGeneiHs.459652.
Hs.94395.

Genome annotation databases

EnsembliENST00000253934; ENSP00000253934; ENSG00000131634.
ENST00000566264; ENSP00000454945; ENSG00000131634.
GeneIDi79652.
KEGGihsa:79652.
UCSCiuc002cmc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY676494 mRNA. Translation: AAT78423.1.
AY358178 mRNA. Translation: AAQ88545.1.
AK024551 mRNA. Translation: BAB14926.1. Frameshift.
AE006467 Genomic DNA. Translation: AAK61286.1.
CH471112 Genomic DNA. Translation: EAW85645.1.
CH471112 Genomic DNA. Translation: EAW85646.1.
BC004932 mRNA. Translation: AAH04932.1.
BC105785 mRNA. Translation: AAI05786.1.
CCDSiCCDS42098.1.
RefSeqiNP_001243470.1. NM_001256541.1.
NP_078876.2. NM_024600.5.
UniGeneiHs.459652.
Hs.94395.

3D structure databases

ProteinModelPortaliQ9BSN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253934.

PTM databases

PhosphoSiteiQ9BSN7.

Polymorphism and mutation databases

BioMutaiTMEM204.
DMDMi73917798.

Proteomic databases

PaxDbiQ9BSN7.
PRIDEiQ9BSN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253934; ENSP00000253934; ENSG00000131634.
ENST00000566264; ENSP00000454945; ENSG00000131634.
GeneIDi79652.
KEGGihsa:79652.
UCSCiuc002cmc.4. human.

Organism-specific databases

CTDi79652.
GeneCardsiTMEM204.
HGNCiHGNC:14158. TMEM204.
HPAiHPA014028.
MIMi611002. gene.
neXtProtiNX_Q9BSN7.
PharmGKBiPA162406384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHK. Eukaryota.
ENOG410XRFW. LUCA.
GeneTreeiENSGT00390000015528.
HOGENOMiHOG000030900.
HOVERGENiHBG081251.
InParanoidiQ9BSN7.
OMAiSQCWEEA.
OrthoDBiEOG7Z0JXP.
PhylomeDBiQ9BSN7.
TreeFamiTF331492.

Miscellaneous databases

GenomeRNAii79652.
NextBioi68818.
PROiQ9BSN7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BSN7.
CleanExiHS_TMEM204.
GenevisibleiQ9BSN7. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Endothelial cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Pancreas.

Entry informationi

Entry nameiTM204_HUMAN
AccessioniPrimary (citable) accession number: Q9BSN7
Secondary accession number(s): D3DU76, Q3KRC1, Q9H7G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.