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Protein

Transmembrane protein 204

Gene

TMEM204

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.

GO - Biological processi

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 204
Alternative name(s):
Claudin-like protein 24
Gene namesi
Name:TMEM204
Synonyms:C16orf30, CLP24
ORF Names:UNQ6509/PRO21434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000131634.13
HGNCiHGNC:14158 TMEM204
MIMi611002 gene
neXtProtiNX_Q9BSN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 103ExtracellularSequence analysisAdd BLAST77
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 136CytoplasmicSequence analysisAdd BLAST12
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 170ExtracellularSequence analysisAdd BLAST13
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 226CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131634
PharmGKBiPA162406384

Polymorphism and mutation databases

BioMutaiTMEM204
DMDMi73917798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898651 – 226Transmembrane protein 204Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BSN7
PeptideAtlasiQ9BSN7
PRIDEiQ9BSN7

PTM databases

iPTMnetiQ9BSN7
PhosphoSitePlusiQ9BSN7

Expressioni

Tissue specificityi

Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.1 Publication

Inductioni

By hypoxia.

Gene expression databases

BgeeiENSG00000131634
CleanExiHS_TMEM204
GenevisibleiQ9BSN7 HS

Organism-specific databases

HPAiHPA014028

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253934

Structurei

3D structure databases

ProteinModelPortaliQ9BSN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHK Eukaryota
ENOG410XRFW LUCA
GeneTreeiENSGT00390000015528
HOGENOMiHOG000030900
HOVERGENiHBG081251
InParanoidiQ9BSN7
OMAiDCEALGW
OrthoDBiEOG091G0LZU
PhylomeDBiQ9BSN7
TreeFamiTF331492

Family and domain databases

InterProiView protein in InterPro
IPR038992 TMEM204
PANTHERiPTHR14627 PTHR14627, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD444356 PD444356, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BSN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVQRLVAAA VLVALVSLIL NNVAAFTSNW VCQTLEDGRR RSVGLWRSCW
60 70 80 90 100
LVDRTRGGPS PGARAGQVDA HDCEALGWGS EAAGFQESRG TVKLQFDMMR
110 120 130 140 150
ACNLVATAAL TAGQLTFLLG LVGLPLLSPD APCWEEAMAA AFQLASFVLV
160 170 180 190 200
IGLVTFYRIG PYTNLSWSCY LNIGACLLAT LAAAMLIWNI LHKREDCMAP
210 220
RVIVISRSLT ARFRRGLDND YVESPC
Length:226
Mass (Da):24,540
Last modified:June 1, 2001 - v1
Checksum:i2CECA8A5823AE397
GO

Sequence cautioni

The sequence BAB14926 differs from that shown. Reason: Frameshift at position 161.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05143557G → A. Corresponds to variant dbSNP:rs1057612Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY676494 mRNA Translation: AAT78423.1
AY358178 mRNA Translation: AAQ88545.1
AK024551 mRNA Translation: BAB14926.1 Frameshift.
AE006467 Genomic DNA Translation: AAK61286.1
CH471112 Genomic DNA Translation: EAW85645.1
CH471112 Genomic DNA Translation: EAW85646.1
BC004932 mRNA Translation: AAH04932.1
BC105785 mRNA Translation: AAI05786.1
CCDSiCCDS42098.1
RefSeqiNP_001243470.1, NM_001256541.1
NP_078876.2, NM_024600.5
UniGeneiHs.459652
Hs.94395

Genome annotation databases

EnsembliENST00000253934; ENSP00000253934; ENSG00000131634
ENST00000566264; ENSP00000454945; ENSG00000131634
GeneIDi79652
KEGGihsa:79652
UCSCiuc002cmc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM204_HUMAN
AccessioniPrimary (citable) accession number: Q9BSN7
Secondary accession number(s): D3DU76, Q3KRC1, Q9H7G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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