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Protein

Transmembrane protein 204

Gene

TMEM204

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 204
Alternative name(s):
Claudin-like protein 24
Gene namesi
Name:TMEM204
Synonyms:C16orf30, CLP24
ORF Names:UNQ6509/PRO21434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14158. TMEM204.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 103ExtracellularSequence analysisAdd BLAST77
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 136CytoplasmicSequence analysisAdd BLAST12
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 170ExtracellularSequence analysisAdd BLAST13
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 226CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131634.
PharmGKBiPA162406384.

Polymorphism and mutation databases

BioMutaiTMEM204.
DMDMi73917798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898651 – 226Transmembrane protein 204Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BSN7.
PeptideAtlasiQ9BSN7.
PRIDEiQ9BSN7.

PTM databases

iPTMnetiQ9BSN7.
PhosphoSitePlusiQ9BSN7.

Expressioni

Tissue specificityi

Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.1 Publication

Inductioni

By hypoxia.

Gene expression databases

BgeeiENSG00000131634.
CleanExiHS_TMEM204.
GenevisibleiQ9BSN7. HS.

Organism-specific databases

HPAiHPA014028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253934.

Structurei

3D structure databases

ProteinModelPortaliQ9BSN7.
SMRiQ9BSN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHK. Eukaryota.
ENOG410XRFW. LUCA.
GeneTreeiENSGT00390000015528.
HOGENOMiHOG000030900.
HOVERGENiHBG081251.
InParanoidiQ9BSN7.
OMAiSQCWEEA.
OrthoDBiEOG091G0LZU.
PhylomeDBiQ9BSN7.
TreeFamiTF331492.

Sequencei

Sequence statusi: Complete.

Q9BSN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVQRLVAAA VLVALVSLIL NNVAAFTSNW VCQTLEDGRR RSVGLWRSCW
60 70 80 90 100
LVDRTRGGPS PGARAGQVDA HDCEALGWGS EAAGFQESRG TVKLQFDMMR
110 120 130 140 150
ACNLVATAAL TAGQLTFLLG LVGLPLLSPD APCWEEAMAA AFQLASFVLV
160 170 180 190 200
IGLVTFYRIG PYTNLSWSCY LNIGACLLAT LAAAMLIWNI LHKREDCMAP
210 220
RVIVISRSLT ARFRRGLDND YVESPC
Length:226
Mass (Da):24,540
Last modified:June 1, 2001 - v1
Checksum:i2CECA8A5823AE397
GO

Sequence cautioni

The sequence BAB14926 differs from that shown. Reason: Frameshift at position 161.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05143557G → A.Corresponds to variant rs1057612dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY676494 mRNA. Translation: AAT78423.1.
AY358178 mRNA. Translation: AAQ88545.1.
AK024551 mRNA. Translation: BAB14926.1. Frameshift.
AE006467 Genomic DNA. Translation: AAK61286.1.
CH471112 Genomic DNA. Translation: EAW85645.1.
CH471112 Genomic DNA. Translation: EAW85646.1.
BC004932 mRNA. Translation: AAH04932.1.
BC105785 mRNA. Translation: AAI05786.1.
CCDSiCCDS42098.1.
RefSeqiNP_001243470.1. NM_001256541.1.
NP_078876.2. NM_024600.5.
UniGeneiHs.459652.
Hs.94395.

Genome annotation databases

EnsembliENST00000253934; ENSP00000253934; ENSG00000131634.
ENST00000566264; ENSP00000454945; ENSG00000131634.
GeneIDi79652.
KEGGihsa:79652.
UCSCiuc002cmc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY676494 mRNA. Translation: AAT78423.1.
AY358178 mRNA. Translation: AAQ88545.1.
AK024551 mRNA. Translation: BAB14926.1. Frameshift.
AE006467 Genomic DNA. Translation: AAK61286.1.
CH471112 Genomic DNA. Translation: EAW85645.1.
CH471112 Genomic DNA. Translation: EAW85646.1.
BC004932 mRNA. Translation: AAH04932.1.
BC105785 mRNA. Translation: AAI05786.1.
CCDSiCCDS42098.1.
RefSeqiNP_001243470.1. NM_001256541.1.
NP_078876.2. NM_024600.5.
UniGeneiHs.459652.
Hs.94395.

3D structure databases

ProteinModelPortaliQ9BSN7.
SMRiQ9BSN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253934.

PTM databases

iPTMnetiQ9BSN7.
PhosphoSitePlusiQ9BSN7.

Polymorphism and mutation databases

BioMutaiTMEM204.
DMDMi73917798.

Proteomic databases

PaxDbiQ9BSN7.
PeptideAtlasiQ9BSN7.
PRIDEiQ9BSN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253934; ENSP00000253934; ENSG00000131634.
ENST00000566264; ENSP00000454945; ENSG00000131634.
GeneIDi79652.
KEGGihsa:79652.
UCSCiuc002cmc.4. human.

Organism-specific databases

CTDi79652.
GeneCardsiTMEM204.
HGNCiHGNC:14158. TMEM204.
HPAiHPA014028.
MIMi611002. gene.
neXtProtiNX_Q9BSN7.
OpenTargetsiENSG00000131634.
PharmGKBiPA162406384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHK. Eukaryota.
ENOG410XRFW. LUCA.
GeneTreeiENSGT00390000015528.
HOGENOMiHOG000030900.
HOVERGENiHBG081251.
InParanoidiQ9BSN7.
OMAiSQCWEEA.
OrthoDBiEOG091G0LZU.
PhylomeDBiQ9BSN7.
TreeFamiTF331492.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131634-MONOMER.

Miscellaneous databases

GenomeRNAii79652.
PROiQ9BSN7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131634.
CleanExiHS_TMEM204.
GenevisibleiQ9BSN7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM204_HUMAN
AccessioniPrimary (citable) accession number: Q9BSN7
Secondary accession number(s): D3DU76, Q3KRC1, Q9H7G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.