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Q9BSK4 (FEM1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein fem-1 homolog A

Short name=FEM1a
Alternative name(s):
FEM1-alpha
Prostaglandin E receptor 4-associated protein
Gene names
Name:FEM1A
Synonyms:EPRAP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit By similarity. May participate in antiinflammatory signaling via its interaction with PTGER4.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of some E3 ubiquitin-protein ligase complex By similarity. Interacts with PTGER4. Ref.1

Subcellular location

Cytoplasm Probable.

Tissue specificity

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). Ref.1

Induction

Frequently down-regulated in rhabdomyosarcoma. Ref.7

Sequence similarities

Belongs to the fem-1 family.

Contains 9 ANK repeats.

Contains 2 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Protein fem-1 homolog A
PRO_0000324525

Regions

Repeat2 – 3130ANK 1
Repeat40 – 7031ANK 2
Repeat82 – 11130ANK 3
Repeat115 – 14531ANK 4
Repeat149 – 17830ANK 5
Repeat182 – 21130ANK 6
Repeat214 – 24330ANK 7
Repeat298 – 33235TPR 1
Repeat390 – 42334TPR 2
Repeat534 – 57643ANK 8
Repeat580 – 60930ANK 9

Natural variations

Natural variant5001H → Y May to be associated with polycystic ovary syndrome (PCOS); may be a common polymorphism. Ref.8
VAR_039809

Sequences

Sequence LengthMass (Da)Tools
Q9BSK4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FF0010DE5207D48F

FASTA66973,639
        10         20         30         40         50         60 
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL 

        70         80         90        100        110        120 
VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL 

       130        140        150        160        170        180 
RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS 

       190        200        210        220        230        240 
AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG 

       250        260        270        280        290        300 
QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA 

       310        320        330        340        350        360 
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL 

       370        380        390        400        410        420 
EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ 

       430        440        450        460        470        480 
QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ 

       490        500        510        520        530        540 
LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH 

       550        560        570        580        590        600 
MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL 

       610        620        630        640        650        660 
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE 


DLEAFIELH 

« Hide

References

« Hide 'large scale' references
[1]"A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling."
Takayama K., Sukhova G.K., Chin M.T., Libby P.
Circ. Res. 98:499-504(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]"Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)."
Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669.
Tissue: Skeletal muscle.
[5]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669.
Tissue: Melanoma.
[7]"The Fem1a gene is downregulated in Rhabdomyosarcoma."
Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F.
Tumor Biol. 26:294-299(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"FEM1A is a candidate gene for polycystic ovary syndrome."
Maher J.F., Hines R.S., Futterweit W., Crawford S., Lu D., Shen P., Oefner P., Kazi M., Wilson J.G., Subauste J.S., Cowan B.D.
Gynecol. Endocrinol. 21:330-335(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT TYR-500.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSCCDS12135.1.
PIRT50619.
RefSeqNP_061178.1. NM_018708.2.
UniGeneHs.515082.

3D structure databases

ProteinModelPortalQ9BSK4.
SMRQ9BSK4. Positions 2-309, 420-449, 531-662.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120699. 5 interactions.
IntActQ9BSK4. 1 interaction.
STRING9606.ENSP00000269856.

PTM databases

PhosphoSiteQ9BSK4.

Polymorphism databases

DMDM74752305.

Proteomic databases

MaxQBQ9BSK4.
PaxDbQ9BSK4.
PRIDEQ9BSK4.

Protocols and materials databases

DNASU55527.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269856; ENSP00000269856; ENSG00000141965.
GeneID55527.
KEGGhsa:55527.
UCSCuc002mbf.3. human.

Organism-specific databases

CTD55527.
GeneCardsGC19P004791.
H-InvDBHIX0014672.
HGNCHGNC:16934. FEM1A.
HPAHPA016565.
MIM613538. gene.
neXtProtNX_Q9BSK4.
PharmGKBPA134940973.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000008180.
HOVERGENHBG057774.
InParanoidQ9BSK4.
OMASYESCCP.
OrthoDBEOG7T4MJT.
PhylomeDBQ9BSK4.
TreeFamTF351376.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ9BSK4.
CleanExHS_FEM1A.
GenevestigatorQ9BSK4.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 2 hits.
PROSITEPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFEM1A. human.
GenomeRNAi55527.
NextBio59954.
PROQ9BSK4.
SOURCESearch...

Entry information

Entry nameFEM1A_HUMAN
AccessionPrimary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3 expand/collapse secondary AC list , Q711P8, Q9NPN7, Q9NPW8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM