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Protein

Protein fem-1 homolog A

Gene

FEM1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141965-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Prostaglandin E receptor 4-associated protein
Gene namesi
Name:FEM1A
Synonyms:EPRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16934. FEM1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55527.
OpenTargetsiENSG00000141965.
PharmGKBiPA134940973.

Polymorphism and mutation databases

BioMutaiFEM1A.
DMDMi74752305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245251 – 669Protein fem-1 homolog AAdd BLAST669

Proteomic databases

EPDiQ9BSK4.
MaxQBiQ9BSK4.
PaxDbiQ9BSK4.
PeptideAtlasiQ9BSK4.
PRIDEiQ9BSK4.

PTM databases

iPTMnetiQ9BSK4.
PhosphoSitePlusiQ9BSK4.

Expressioni

Tissue specificityi

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).1 Publication

Inductioni

Frequently down-regulated in rhabdomyosarcoma.1 Publication

Gene expression databases

BgeeiENSG00000141965.
CleanExiHS_FEM1A.
GenevisibleiQ9BSK4. HS.

Organism-specific databases

HPAiHPA016565.
HPA063622.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.By similarity1 Publication

GO - Molecular functioni

  • EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120699. 11 interactors.
IntActiQ9BSK4. 8 interactors.
STRINGi9606.ENSP00000269856.

Structurei

3D structure databases

ProteinModelPortaliQ9BSK4.
SMRiQ9BSK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 31ANK 1Add BLAST30
Repeati40 – 70ANK 2Add BLAST31
Repeati82 – 111ANK 3Add BLAST30
Repeati115 – 145ANK 4Add BLAST31
Repeati149 – 178ANK 5Add BLAST30
Repeati182 – 211ANK 6Add BLAST30
Repeati214 – 243ANK 7Add BLAST30
Repeati298 – 332TPR 1Add BLAST35
Repeati390 – 423TPR 2Add BLAST34
Repeati534 – 576ANK 8Add BLAST43
Repeati580 – 609ANK 9Add BLAST30

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ9BSK4.
OMAiCNARMER.
OrthoDBiEOG091G03I9.
PhylomeDBiQ9BSK4.
TreeFamiTF351376.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF48452. SSF48452. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR
60 70 80 90 100
YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR
110 120 130 140 150
SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG
160 170 180 190 200
HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ
210 220 230 240 250
LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ
260 270 280 290 300
PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA
310 320 330 340 350
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY
360 370 380 390 400
SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY
410 420 430 440 450
ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA
460 470 480 490 500
AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH
510 520 530 540 550
LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV
560 570 580 590 600
GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL
610 620 630 640 650
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN
660
KIPYKGFIPE DLEAFIELH
Length:669
Mass (Da):73,639
Last modified:June 1, 2001 - v1
Checksum:iFF0010DE5207D48F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039809500H → Y Found in a patient with polycystic ovary syndrome; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSiCCDS12135.1.
PIRiT50619.
RefSeqiNP_061178.1. NM_018708.2.
UniGeneiHs.515082.

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
GeneIDi55527.
KEGGihsa:55527.
UCSCiuc002mbf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSiCCDS12135.1.
PIRiT50619.
RefSeqiNP_061178.1. NM_018708.2.
UniGeneiHs.515082.

3D structure databases

ProteinModelPortaliQ9BSK4.
SMRiQ9BSK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120699. 11 interactors.
IntActiQ9BSK4. 8 interactors.
STRINGi9606.ENSP00000269856.

PTM databases

iPTMnetiQ9BSK4.
PhosphoSitePlusiQ9BSK4.

Polymorphism and mutation databases

BioMutaiFEM1A.
DMDMi74752305.

Proteomic databases

EPDiQ9BSK4.
MaxQBiQ9BSK4.
PaxDbiQ9BSK4.
PeptideAtlasiQ9BSK4.
PRIDEiQ9BSK4.

Protocols and materials databases

DNASUi55527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
GeneIDi55527.
KEGGihsa:55527.
UCSCiuc002mbf.4. human.

Organism-specific databases

CTDi55527.
DisGeNETi55527.
GeneCardsiFEM1A.
H-InvDBHIX0014672.
HGNCiHGNC:16934. FEM1A.
HPAiHPA016565.
HPA063622.
MIMi613538. gene.
neXtProtiNX_Q9BSK4.
OpenTargetsiENSG00000141965.
PharmGKBiPA134940973.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ9BSK4.
OMAiCNARMER.
OrthoDBiEOG091G03I9.
PhylomeDBiQ9BSK4.
TreeFamiTF351376.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000141965-MONOMER.

Miscellaneous databases

ChiTaRSiFEM1A. human.
GenomeRNAii55527.
PROiQ9BSK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141965.
CleanExiHS_FEM1A.
GenevisibleiQ9BSK4. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF48452. SSF48452. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEM1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3
, Q711P8, Q9NPN7, Q9NPW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.