Protein fem-1 homolog A - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Protein fem-1 homolog A
Alternative name(s):
    FEM1-alpha
      Short name=FEM1a
    Prostaglandin E receptor 4-associated protein

Gene names

Name:	FEM1A
Synonyms:	EPRAP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	669 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit By similarity. May participate in antiinflammatory signaling via its interaction with PTGER4.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Component of some E3 ubiquitin-protein ligase complex By similarity. Interacts with PTGER4.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). Ref.1
Induction	Frequently down-regulated in rhabdomyosarcoma. Ref.7
Sequence similarities	Belongs to the fem-1 family. Contains 9 ANK repeats. Contains 2 TPR repeats.

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Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat TPR repeat
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 669

669

Protein fem-1 homolog A

PRO_0000324525

Regions

Repeat

2 – 31

30

ANK 1

Repeat

40 – 70

31

ANK 2

Repeat

82 – 111

30

ANK 3

Repeat

115 – 145

31

ANK 4

Repeat

149 – 178

30

ANK 5

Repeat

182 – 211

30

ANK 6

Repeat

214 – 243

30

ANK 7

Repeat

298 – 332

35

TPR 1

Repeat

390 – 423

34

TPR 2

Repeat

534 – 576

43

ANK 8

Repeat

580 – 609

30

ANK 9

Natural variations

Natural variant

500

1

H → Y May to be associated with polycystic ovary syndrome (PCOS); may be a common polymorphism. Ref.8

VAR_039809

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9BSK4-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FF0010DE5207D48F
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FASTA

669

73,639

        10         20         30         40         50         60 
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL 

        70         80         90        100        110        120 
VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL 

       130        140        150        160        170        180 
RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS 

       190        200        210        220        230        240 
AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG 

       250        260        270        280        290        300 
QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA 

       310        320        330        340        350        360 
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL 

       370        380        390        400        410        420 
EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ 

       430        440        450        460        470        480 
QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ 

       490        500        510        520        530        540 
LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH 

       550        560        570        580        590        600 
MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL 

       610        620        630        640        650        660 
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE 


DLEAFIELH

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling." Takayama K., Sukhova G.K., Chin M.T., Libby P. Circ. Res. 98:499-504(2006) [PubMed: 16424369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	"Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)." Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669. Tissue: Skeletal muscle.
[5]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669. Tissue: Melanoma.
[7]	"The Fem1a gene is downregulated in Rhabdomyosarcoma." Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F. Tumor Biol. 26:294-299(2005) [PubMed: 16254458] [Abstract] Cited for: INDUCTION.
[8]	"FEM1A is a candidate gene for polycystic ovary syndrome." Maher J.F., Hines R.S., Futterweit W., Crawford S., Lu D., Shen P., Oefner P., Kazi M., Wilson J.G., Subauste J.S., Cowan B.D. Gynecol. Endocrinol. 21:330-335(2005) [PubMed: 16390781] [Abstract] Cited for: VARIANT TYR-500.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AY356352 mRNA. Translation: AAR10439.1. AK315554 mRNA. Translation: BAG37930.1. BC004988 mRNA. Translation: AAH04988.1. AJ311359 mRNA. Translation: CAC85342.1. AL365408 mRNA. Translation: CAB96952.1. AL359589 mRNA. Translation: CAB94875.1. CR749732 mRNA. Translation: CAH18491.1.
IPI	IPI00013226.
PIR	T50619.
RefSeq	NP_061178.1.
UniGene	Hs.515082
3D structure databases
HSSP	HSSP built from PDB template 1AWC based on UniProtKB Q00420.
ModBase	Search...
Proteomic databases
PRIDE	Q9BSK4.
Genome annotation databases
Ensembl	ENSG00000141965. Homo sapiens. [Contig view]
GeneID	55527.
KEGG	hsa:55527.
Organism-specific databases
GeneCards	GC19P004742. GC19P004743.
HGNC	HGNC:16934. FEM1A.
HPA	HPA016565.
PharmGKB	PA134940973.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9BSK4.
HOVERGEN	Q9BSK4.
OMA	Q9BSK4. RTTRTNS.
Gene expression databases
ArrayExpress	Q9BSK4.
Bgee	Q9BSK4.
CleanEx	HS_FEM1A.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 2 hits.
Pfam	PF00023. Ank. 9 hits. [Graphical view]
SMART	SM00248. ANK. 9 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 7 hits. PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	59954.

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Entry information

Entry name

FEM1A_HUMAN

Accession

Primary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3

Q9NPW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents