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Q9BSK4

- FEM1A_HUMAN

UniProt

Q9BSK4 - FEM1A_HUMAN

Protein

Protein fem-1 homolog A

Gene

FEM1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit By similarity. May participate in antiinflammatory signaling via its interaction with PTGER4.By similarity

    Pathwayi

    GO - Molecular functioni

    1. EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB
    2. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of inflammatory response Source: UniProtKB
    2. regulation of ubiquitin-protein transferase activity Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein fem-1 homolog A
    Short name:
    FEM1a
    Alternative name(s):
    FEM1-alpha
    Prostaglandin E receptor 4-associated protein
    Gene namesi
    Name:FEM1A
    Synonyms:EPRAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16934. FEM1A.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134940973.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Protein fem-1 homolog APRO_0000324525Add
    BLAST

    Proteomic databases

    MaxQBiQ9BSK4.
    PaxDbiQ9BSK4.
    PRIDEiQ9BSK4.

    PTM databases

    PhosphoSiteiQ9BSK4.

    Expressioni

    Tissue specificityi

    Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).1 Publication

    Inductioni

    Frequently down-regulated in rhabdomyosarcoma.1 Publication

    Gene expression databases

    BgeeiQ9BSK4.
    CleanExiHS_FEM1A.
    GenevestigatoriQ9BSK4.

    Organism-specific databases

    HPAiHPA016565.

    Interactioni

    Subunit structurei

    Component of some E3 ubiquitin-protein ligase complex By similarity. Interacts with PTGER4.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120699. 5 interactions.
    IntActiQ9BSK4. 1 interaction.
    STRINGi9606.ENSP00000269856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BSK4.
    SMRiQ9BSK4. Positions 2-309, 420-449, 531-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 3130ANK 1Add
    BLAST
    Repeati40 – 7031ANK 2Add
    BLAST
    Repeati82 – 11130ANK 3Add
    BLAST
    Repeati115 – 14531ANK 4Add
    BLAST
    Repeati149 – 17830ANK 5Add
    BLAST
    Repeati182 – 21130ANK 6Add
    BLAST
    Repeati214 – 24330ANK 7Add
    BLAST
    Repeati298 – 33235TPR 1Add
    BLAST
    Repeati390 – 42334TPR 2Add
    BLAST
    Repeati534 – 57643ANK 8Add
    BLAST
    Repeati580 – 60930ANK 9Add
    BLAST

    Sequence similaritiesi

    Belongs to the fem-1 family.Curated
    Contains 9 ANK repeats.PROSITE-ProRule annotation
    Contains 2 TPR repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000008180.
    HOVERGENiHBG057774.
    InParanoidiQ9BSK4.
    OMAiSYESCCP.
    OrthoDBiEOG7T4MJT.
    PhylomeDBiQ9BSK4.
    TreeFamiTF351376.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    1.25.40.20. 4 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 9 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BSK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR    50
    YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR 100
    SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG 150
    HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ 200
    LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ 250
    PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA 300
    LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY 350
    SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY 400
    ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA 450
    AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH 500
    LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV 550
    GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL 600
    IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN 650
    KIPYKGFIPE DLEAFIELH 669
    Length:669
    Mass (Da):73,639
    Last modified:June 1, 2001 - v1
    Checksum:iFF0010DE5207D48F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti500 – 5001H → Y May to be associated with polycystic ovary syndrome (PCOS); may be a common polymorphism. 1 Publication
    VAR_039809

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY356352 mRNA. Translation: AAR10439.1.
    AK315554 mRNA. Translation: BAG37930.1.
    BC004988 mRNA. Translation: AAH04988.1.
    AJ311359 mRNA. Translation: CAC85342.1.
    AL365408 mRNA. Translation: CAB96952.1.
    AL359589 mRNA. Translation: CAB94875.1.
    CR749732 mRNA. Translation: CAH18491.1.
    CCDSiCCDS12135.1.
    PIRiT50619.
    RefSeqiNP_061178.1. NM_018708.2.
    UniGeneiHs.515082.

    Genome annotation databases

    EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
    GeneIDi55527.
    KEGGihsa:55527.
    UCSCiuc002mbf.3. human.

    Polymorphism databases

    DMDMi74752305.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY356352 mRNA. Translation: AAR10439.1 .
    AK315554 mRNA. Translation: BAG37930.1 .
    BC004988 mRNA. Translation: AAH04988.1 .
    AJ311359 mRNA. Translation: CAC85342.1 .
    AL365408 mRNA. Translation: CAB96952.1 .
    AL359589 mRNA. Translation: CAB94875.1 .
    CR749732 mRNA. Translation: CAH18491.1 .
    CCDSi CCDS12135.1.
    PIRi T50619.
    RefSeqi NP_061178.1. NM_018708.2.
    UniGenei Hs.515082.

    3D structure databases

    ProteinModelPortali Q9BSK4.
    SMRi Q9BSK4. Positions 2-309, 420-449, 531-662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120699. 5 interactions.
    IntActi Q9BSK4. 1 interaction.
    STRINGi 9606.ENSP00000269856.

    PTM databases

    PhosphoSitei Q9BSK4.

    Polymorphism databases

    DMDMi 74752305.

    Proteomic databases

    MaxQBi Q9BSK4.
    PaxDbi Q9BSK4.
    PRIDEi Q9BSK4.

    Protocols and materials databases

    DNASUi 55527.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269856 ; ENSP00000269856 ; ENSG00000141965 .
    GeneIDi 55527.
    KEGGi hsa:55527.
    UCSCi uc002mbf.3. human.

    Organism-specific databases

    CTDi 55527.
    GeneCardsi GC19P004791.
    H-InvDB HIX0014672.
    HGNCi HGNC:16934. FEM1A.
    HPAi HPA016565.
    MIMi 613538. gene.
    neXtProti NX_Q9BSK4.
    PharmGKBi PA134940973.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000008180.
    HOVERGENi HBG057774.
    InParanoidi Q9BSK4.
    OMAi SYESCCP.
    OrthoDBi EOG7T4MJT.
    PhylomeDBi Q9BSK4.
    TreeFami TF351376.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi FEM1A. human.
    GenomeRNAii 55527.
    NextBioi 59954.
    PROi Q9BSK4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BSK4.
    CleanExi HS_FEM1A.
    Genevestigatori Q9BSK4.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    1.25.40.20. 4 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 9 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling."
      Takayama K., Sukhova G.K., Chin M.T., Libby P.
      Circ. Res. 98:499-504(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. "Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)."
      Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669.
      Tissue: Skeletal muscle.
    5. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669.
      Tissue: Melanoma.
    7. "The Fem1a gene is downregulated in Rhabdomyosarcoma."
      Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F.
      Tumor Biol. 26:294-299(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. Cited for: VARIANT TYR-500.

    Entry informationi

    Entry nameiFEM1A_HUMAN
    AccessioniPrimary (citable) accession number: Q9BSK4
    Secondary accession number(s): B2RDI3
    , Q711P8, Q9NPN7, Q9NPW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3