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Protein

Protein fem-1 homolog A

Gene

FEM1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.By similarity

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Prostaglandin E receptor 4-associated protein
Gene namesi
Name:FEM1A
Synonyms:EPRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16934. FEM1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940973.

Polymorphism and mutation databases

BioMutaiFEM1A.
DMDMi74752305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Protein fem-1 homolog APRO_0000324525Add
BLAST

Proteomic databases

MaxQBiQ9BSK4.
PaxDbiQ9BSK4.
PRIDEiQ9BSK4.

PTM databases

PhosphoSiteiQ9BSK4.

Expressioni

Tissue specificityi

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).1 Publication

Inductioni

Frequently down-regulated in rhabdomyosarcoma.1 Publication

Gene expression databases

BgeeiQ9BSK4.
CleanExiHS_FEM1A.
GenevisibleiQ9BSK4. HS.

Organism-specific databases

HPAiHPA016565.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.By similarity1 Publication

Protein-protein interaction databases

BioGridi120699. 6 interactions.
IntActiQ9BSK4. 1 interaction.
STRINGi9606.ENSP00000269856.

Structurei

3D structure databases

ProteinModelPortaliQ9BSK4.
SMRiQ9BSK4. Positions 2-445, 531-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14531ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati182 – 21130ANK 6Add
BLAST
Repeati214 – 24330ANK 7Add
BLAST
Repeati298 – 33235TPR 1Add
BLAST
Repeati390 – 42334TPR 2Add
BLAST
Repeati534 – 57643ANK 8Add
BLAST
Repeati580 – 60930ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118867.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ9BSK4.
OMAiKYTTLAC.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ9BSK4.
TreeFamiTF351376.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR
60 70 80 90 100
YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR
110 120 130 140 150
SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG
160 170 180 190 200
HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ
210 220 230 240 250
LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ
260 270 280 290 300
PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA
310 320 330 340 350
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY
360 370 380 390 400
SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY
410 420 430 440 450
ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA
460 470 480 490 500
AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH
510 520 530 540 550
LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV
560 570 580 590 600
GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL
610 620 630 640 650
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN
660
KIPYKGFIPE DLEAFIELH
Length:669
Mass (Da):73,639
Last modified:June 1, 2001 - v1
Checksum:iFF0010DE5207D48F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti500 – 5001H → Y Found in a patient with polycystic ovary syndrome; unknown pathological significance. 1 Publication
VAR_039809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSiCCDS12135.1.
PIRiT50619.
RefSeqiNP_061178.1. NM_018708.2.
UniGeneiHs.515082.

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
GeneIDi55527.
KEGGihsa:55527.
UCSCiuc002mbf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSiCCDS12135.1.
PIRiT50619.
RefSeqiNP_061178.1. NM_018708.2.
UniGeneiHs.515082.

3D structure databases

ProteinModelPortaliQ9BSK4.
SMRiQ9BSK4. Positions 2-445, 531-606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120699. 6 interactions.
IntActiQ9BSK4. 1 interaction.
STRINGi9606.ENSP00000269856.

PTM databases

PhosphoSiteiQ9BSK4.

Polymorphism and mutation databases

BioMutaiFEM1A.
DMDMi74752305.

Proteomic databases

MaxQBiQ9BSK4.
PaxDbiQ9BSK4.
PRIDEiQ9BSK4.

Protocols and materials databases

DNASUi55527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
GeneIDi55527.
KEGGihsa:55527.
UCSCiuc002mbf.3. human.

Organism-specific databases

CTDi55527.
GeneCardsiGC19P004791.
H-InvDBHIX0014672.
HGNCiHGNC:16934. FEM1A.
HPAiHPA016565.
MIMi613538. gene.
neXtProtiNX_Q9BSK4.
PharmGKBiPA134940973.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118867.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ9BSK4.
OMAiKYTTLAC.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ9BSK4.
TreeFamiTF351376.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiFEM1A. human.
GenomeRNAii55527.
NextBioi59954.
PROiQ9BSK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BSK4.
CleanExiHS_FEM1A.
GenevisibleiQ9BSK4. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling."
    Takayama K., Sukhova G.K., Chin M.T., Libby P.
    Circ. Res. 98:499-504(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)."
    Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669.
    Tissue: Skeletal muscle.
  5. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669.
    Tissue: Melanoma.
  7. "The Fem1a gene is downregulated in Rhabdomyosarcoma."
    Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F.
    Tumor Biol. 26:294-299(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. Cited for: VARIANT TYR-500.

Entry informationi

Entry nameiFEM1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3
, Q711P8, Q9NPN7, Q9NPW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.