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Protein

Protein fem-1 homolog A

Gene

FEM1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Prostaglandin E receptor 4-associated protein
Gene namesi
Name:FEM1A
Synonyms:EPRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000141965.4
HGNCiHGNC:16934 FEM1A
MIMi613538 gene
neXtProtiNX_Q9BSK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55527
OpenTargetsiENSG00000141965
PharmGKBiPA134940973

Polymorphism and mutation databases

BioMutaiFEM1A
DMDMi74752305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245251 – 669Protein fem-1 homolog AAdd BLAST669

Proteomic databases

EPDiQ9BSK4
MaxQBiQ9BSK4
PaxDbiQ9BSK4
PeptideAtlasiQ9BSK4
PRIDEiQ9BSK4
ProteomicsDBi78912

PTM databases

iPTMnetiQ9BSK4
PhosphoSitePlusiQ9BSK4

Expressioni

Tissue specificityi

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).1 Publication

Inductioni

Frequently down-regulated in rhabdomyosarcoma.1 Publication

Gene expression databases

BgeeiENSG00000141965
CleanExiHS_FEM1A
GenevisibleiQ9BSK4 HS

Organism-specific databases

HPAiHPA016565
HPA063622

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
INCA1Q0VD864EBI-2515349,EBI-6509505

GO - Molecular functioni

  • EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120699, 12 interactors
IntActiQ9BSK4, 14 interactors
STRINGi9606.ENSP00000269856

Structurei

3D structure databases

ProteinModelPortaliQ9BSK4
SMRiQ9BSK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 31ANK 1Add BLAST30
Repeati40 – 70ANK 2Add BLAST31
Repeati82 – 111ANK 3Add BLAST30
Repeati115 – 145ANK 4Add BLAST31
Repeati149 – 178ANK 5Add BLAST30
Repeati182 – 211ANK 6Add BLAST30
Repeati214 – 243ANK 7Add BLAST30
Repeati298 – 332TPR 1Add BLAST35
Repeati390 – 423TPR 2Add BLAST34
Repeati534 – 576ANK 8Add BLAST43
Repeati580 – 609ANK 9Add BLAST30

Sequence similaritiesi

Belongs to the fem-1 family.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000149051
HOGENOMiHOG000008180
HOVERGENiHBG057774
InParanoidiQ9BSK4
OMAiPEQEHQK
OrthoDBiEOG091G03I9
PhylomeDBiQ9BSK4
TreeFamiTF351376

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 9 hits
SUPFAMiSSF48403 SSF48403, 2 hits
SSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 7 hits

Sequencei

Sequence statusi: Complete.

Q9BSK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR
60 70 80 90 100
YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR
110 120 130 140 150
SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG
160 170 180 190 200
HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ
210 220 230 240 250
LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ
260 270 280 290 300
PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA
310 320 330 340 350
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY
360 370 380 390 400
SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY
410 420 430 440 450
ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA
460 470 480 490 500
AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH
510 520 530 540 550
LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV
560 570 580 590 600
GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL
610 620 630 640 650
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN
660
KIPYKGFIPE DLEAFIELH
Length:669
Mass (Da):73,639
Last modified:June 1, 2001 - v1
Checksum:iFF0010DE5207D48F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039809500H → Y Found in a patient with polycystic ovary syndrome; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY356352 mRNA Translation: AAR10439.1
AK315554 mRNA Translation: BAG37930.1
BC004988 mRNA Translation: AAH04988.1
AJ311359 mRNA Translation: CAC85342.1
AL365408 mRNA Translation: CAB96952.1
AL359589 mRNA Translation: CAB94875.1
CR749732 mRNA Translation: CAH18491.1
CCDSiCCDS12135.1
PIRiT50619
RefSeqiNP_061178.1, NM_018708.2
UniGeneiHs.515082

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965
GeneIDi55527
KEGGihsa:55527
UCSCiuc002mbf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFEM1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3
, Q711P8, Q9NPN7, Q9NPW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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