Reviewed,
UniProtKB/Swiss-Prot Q9BSK4 (FEM1A_HUMAN)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Protein fem-1 homolog A Alternative name(s): FEM1-alpha Short name=FEM1a Prostaglandin E receptor 4-associated protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 669 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit By similarity. May participate in antiinflammatory signaling via its interaction with PTGER4. |
| Pathway | |
| Subunit structure | Component of some E3 ubiquitin-protein ligase complex By similarity. Interacts with PTGER4. |
| Subcellular location | Cytoplasm Probable. |
| Tissue specificity | Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). Ref.1 |
| Induction | Frequently down-regulated in rhabdomyosarcoma. Ref.7 |
| Sequence similarities | Belongs to the fem-1 family. Contains 9 ANK repeats. Contains 2 TPR repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Repeat TPR repeat |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of ubiquitin-protein ligase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 669 | 669 | Protein fem-1 homolog A | PRO_0000324525 | |||||
Regions | |||||||||
| Repeat | 2 – 31 | 30 | ANK 1 | ||||||
| Repeat | 40 – 70 | 31 | ANK 2 | ||||||
| Repeat | 82 – 111 | 30 | ANK 3 | ||||||
| Repeat | 115 – 145 | 31 | ANK 4 | ||||||
| Repeat | 149 – 178 | 30 | ANK 5 | ||||||
| Repeat | 182 – 211 | 30 | ANK 6 | ||||||
| Repeat | 214 – 243 | 30 | ANK 7 | ||||||
| Repeat | 298 – 332 | 35 | TPR 1 | ||||||
| Repeat | 390 – 423 | 34 | TPR 2 | ||||||
| Repeat | 534 – 576 | 43 | ANK 8 | ||||||
| Repeat | 580 – 609 | 30 | ANK 9 | ||||||
Natural variations | |||||||||
| Natural variant | 500 | 1 | H → Y May to be associated with polycystic ovary syndrome (PCOS); may be a common polymorphism. Ref.8 | VAR_039809 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling." Takayama K., Sukhova G.K., Chin M.T., Libby P. Circ. Res. 98:499-504(2006) [PubMed: 16424369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [4] | "Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)." Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669. Tissue: Skeletal muscle. |
| [5] | The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669. |
| [6] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669. Tissue: Melanoma. |
| [7] | "The Fem1a gene is downregulated in Rhabdomyosarcoma." Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F. Tumor Biol. 26:294-299(2005) [PubMed: 16254458] [Abstract] Cited for: INDUCTION. |
| [8] | "FEM1A is a candidate gene for polycystic ovary syndrome." Maher J.F., Hines R.S., Futterweit W., Crawford S., Lu D., Shen P., Oefner P., Kazi M., Wilson J.G., Subauste J.S., Cowan B.D. Gynecol. Endocrinol. 21:330-335(2005) [PubMed: 16390781] [Abstract] Cited for: VARIANT TYR-500. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY356352 mRNA. Translation: AAR10439.1. AK315554 mRNA. Translation: BAG37930.1. BC004988 mRNA. Translation: AAH04988.1. AJ311359 mRNA. Translation: CAC85342.1. AL365408 mRNA. Translation: CAB96952.1. AL359589 mRNA. Translation: CAB94875.1. CR749732 mRNA. Translation: CAH18491.1. | |
| IPI | IPI00013226. |
| PIR | T50619. |
| RefSeq | NP_061178.1. |
| UniGene | Hs.515082 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AWC based on UniProtKB Q00420. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9BSK4. |
Genome annotation databases | |
| Ensembl | ENSG00000141965. Homo sapiens. [Contig view] |
| GeneID | 55527. |
| KEGG | hsa:55527. |
Organism-specific databases | |
| GeneCards | GC19P004742. GC19P004743. |
| HGNC | HGNC:16934. FEM1A. |
| HPA | HPA016565. |
| PharmGKB | PA134940973. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9BSK4. |
| HOVERGEN | Q9BSK4. |
| OMA | Q9BSK4. RTTRTNS. |
Gene expression databases | |
| ArrayExpress | Q9BSK4. |
| Bgee | Q9BSK4. |
| CleanEx | HS_FEM1A. |
Family and domain databases | |
| InterPro | IPR002110. ANK. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 2 hits. |
| Pfam | PF00023. Ank. 9 hits. [Graphical view] |
| SMART | SM00248. ANK. 9 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 7 hits. PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 59954. |
Entry information
| Entry name | FEM1A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9BSK4 Secondary accession number(s): B2RDI3 Q9NPW8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


