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Q9BSK4

- FEM1A_HUMAN

UniProt

Q9BSK4 - FEM1A_HUMAN

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Protein

Protein fem-1 homolog A

Gene

FEM1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.By similarity

Pathwayi

GO - Molecular functioni

  1. EP4 subtype prostaglandin E2 receptor binding Source: UniProtKB
  2. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of inflammatory response Source: UniProtKB
  2. regulation of ubiquitin-protein transferase activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Prostaglandin E receptor 4-associated protein
Gene namesi
Name:FEM1A
Synonyms:EPRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16934. FEM1A.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Protein fem-1 homolog APRO_0000324525Add
BLAST

Proteomic databases

MaxQBiQ9BSK4.
PaxDbiQ9BSK4.
PRIDEiQ9BSK4.

PTM databases

PhosphoSiteiQ9BSK4.

Expressioni

Tissue specificityi

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).1 Publication

Inductioni

Frequently down-regulated in rhabdomyosarcoma.1 Publication

Gene expression databases

BgeeiQ9BSK4.
CleanExiHS_FEM1A.
GenevestigatoriQ9BSK4.

Organism-specific databases

HPAiHPA016565.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.By similarity1 Publication

Protein-protein interaction databases

BioGridi120699. 6 interactions.
IntActiQ9BSK4. 1 interaction.
STRINGi9606.ENSP00000269856.

Structurei

3D structure databases

ProteinModelPortaliQ9BSK4.
SMRiQ9BSK4. Positions 2-251, 531-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14531ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati182 – 21130ANK 6Add
BLAST
Repeati214 – 24330ANK 7Add
BLAST
Repeati298 – 33235TPR 1Add
BLAST
Repeati390 – 42334TPR 2Add
BLAST
Repeati534 – 57643ANK 8Add
BLAST
Repeati580 – 60930ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118867.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ9BSK4.
OMAiSYESCCP.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ9BSK4.
TreeFamiTF351376.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BSK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR
60 70 80 90 100
YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR
110 120 130 140 150
SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG
160 170 180 190 200
HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ
210 220 230 240 250
LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ
260 270 280 290 300
PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA
310 320 330 340 350
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY
360 370 380 390 400
SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY
410 420 430 440 450
ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA
460 470 480 490 500
AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH
510 520 530 540 550
LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV
560 570 580 590 600
GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL
610 620 630 640 650
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN
660
KIPYKGFIPE DLEAFIELH
Length:669
Mass (Da):73,639
Last modified:June 1, 2001 - v1
Checksum:iFF0010DE5207D48F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti500 – 5001H → Y May to be associated with polycystic ovary syndrome (PCOS); may be a common polymorphism. 1 Publication
VAR_039809

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY356352 mRNA. Translation: AAR10439.1.
AK315554 mRNA. Translation: BAG37930.1.
BC004988 mRNA. Translation: AAH04988.1.
AJ311359 mRNA. Translation: CAC85342.1.
AL365408 mRNA. Translation: CAB96952.1.
AL359589 mRNA. Translation: CAB94875.1.
CR749732 mRNA. Translation: CAH18491.1.
CCDSiCCDS12135.1.
PIRiT50619.
RefSeqiNP_061178.1. NM_018708.2.
UniGeneiHs.515082.

Genome annotation databases

EnsembliENST00000269856; ENSP00000269856; ENSG00000141965.
GeneIDi55527.
KEGGihsa:55527.
UCSCiuc002mbf.3. human.

Polymorphism databases

DMDMi74752305.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY356352 mRNA. Translation: AAR10439.1 .
AK315554 mRNA. Translation: BAG37930.1 .
BC004988 mRNA. Translation: AAH04988.1 .
AJ311359 mRNA. Translation: CAC85342.1 .
AL365408 mRNA. Translation: CAB96952.1 .
AL359589 mRNA. Translation: CAB94875.1 .
CR749732 mRNA. Translation: CAH18491.1 .
CCDSi CCDS12135.1.
PIRi T50619.
RefSeqi NP_061178.1. NM_018708.2.
UniGenei Hs.515082.

3D structure databases

ProteinModelPortali Q9BSK4.
SMRi Q9BSK4. Positions 2-251, 531-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120699. 6 interactions.
IntActi Q9BSK4. 1 interaction.
STRINGi 9606.ENSP00000269856.

PTM databases

PhosphoSitei Q9BSK4.

Polymorphism databases

DMDMi 74752305.

Proteomic databases

MaxQBi Q9BSK4.
PaxDbi Q9BSK4.
PRIDEi Q9BSK4.

Protocols and materials databases

DNASUi 55527.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269856 ; ENSP00000269856 ; ENSG00000141965 .
GeneIDi 55527.
KEGGi hsa:55527.
UCSCi uc002mbf.3. human.

Organism-specific databases

CTDi 55527.
GeneCardsi GC19P004791.
H-InvDB HIX0014672.
HGNCi HGNC:16934. FEM1A.
HPAi HPA016565.
MIMi 613538. gene.
neXtProti NX_Q9BSK4.
PharmGKBi PA134940973.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00760000118867.
HOGENOMi HOG000008180.
HOVERGENi HBG057774.
InParanoidi Q9BSK4.
OMAi SYESCCP.
OrthoDBi EOG7T4MJT.
PhylomeDBi Q9BSK4.
TreeFami TF351376.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi FEM1A. human.
GenomeRNAii 55527.
NextBioi 59954.
PROi Q9BSK4.
SOURCEi Search...

Gene expression databases

Bgeei Q9BSK4.
CleanExi HS_FEM1A.
Genevestigatori Q9BSK4.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
1.25.40.20. 4 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 9 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling."
    Takayama K., Sukhova G.K., Chin M.T., Libby P.
    Circ. Res. 98:499-504(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTGER4.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "Full length sequencing of an human and murine muscular transcripts (Telethon Italy project B41)."
    Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-669.
    Tissue: Skeletal muscle.
  5. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 470-669.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 576-669.
    Tissue: Melanoma.
  7. "The Fem1a gene is downregulated in Rhabdomyosarcoma."
    Ventura-Holman T., Hahn H., Subauste J.S., Maher J.F.
    Tumor Biol. 26:294-299(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. Cited for: VARIANT TYR-500.

Entry informationi

Entry nameiFEM1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK4
Secondary accession number(s): B2RDI3
, Q711P8, Q9NPN7, Q9NPW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3